ES2239368T3 - Antagonistas de taquicinina. - Google Patents

Antagonistas de taquicinina.

Info

Publication number: ES2239368T3
Authority: ES; Spain
Prior art keywords: formula; compound; salt; acid addition; agents
Prior art date: 1997-01-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES97953927T

Other languages

English (en)

Spanish (es)

Inventor

Christopher Simon John Walpole

Mahavir Prashad

Denis Har

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-14

Filing date

1997-12-29

Publication date

2005-09-16

1997-12-29 Application filed by Novartis AG filed Critical Novartis AG

2005-09-16 Application granted granted Critical

2005-09-16 Publication of ES2239368T3 publication Critical patent/ES2239368T3/es

2017-12-29 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000005557 antagonist Substances 0.000 title abstract description 8
150000001875 compounds Chemical class 0.000 claims abstract description 67
150000003839 salts Chemical class 0.000 claims abstract description 24
208000002193 Pain Diseases 0.000 claims abstract description 14
238000000034 method Methods 0.000 claims description 44
239000002253 acid Substances 0.000 claims description 23
238000006243 chemical reaction Methods 0.000 claims description 19
238000004519 manufacturing process Methods 0.000 claims description 12
239000001257 hydrogen Substances 0.000 claims description 11
229910052739 hydrogen Inorganic materials 0.000 claims description 11
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
125000004429 atom Chemical group 0.000 claims description 8
239000003814 drug Substances 0.000 claims description 7
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
229910052736 halogen Inorganic materials 0.000 claims description 6
150000002367 halogens Chemical class 0.000 claims description 6
229940079593 drug Drugs 0.000 claims description 5
239000000825 pharmaceutical preparation Substances 0.000 claims description 5
229940127557 pharmaceutical product Drugs 0.000 claims description 5
239000008194 pharmaceutical composition Substances 0.000 claims description 4
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 4
239000003085 diluting agent Substances 0.000 claims description 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
229910052799 carbon Inorganic materials 0.000 claims description 2
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
150000004820 halides Chemical class 0.000 claims 1
150000002431 hydrogen Chemical group 0.000 claims 1
230000000694 effects Effects 0.000 abstract description 5
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 55
239000003795 chemical substances by application Substances 0.000 description 39
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 21
125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 19
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 18
239000000203 mixture Substances 0.000 description 18
239000007787 solid Substances 0.000 description 16
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 15
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
-1 salts hydrochloride Chemical class 0.000 description 15
XATYNHYUNACWDZ-VIFPVBQESA-N (3S)-3-amino-1-(benzylamino)butan-2-one Chemical compound C[C@@H](C(=O)CNCC1=CC=CC=C1)N XATYNHYUNACWDZ-VIFPVBQESA-N 0.000 description 13
201000010099 disease Diseases 0.000 description 13
238000002360 preparation method Methods 0.000 description 13
239000000047 product Substances 0.000 description 13
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 12
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 12
239000002904 solvent Substances 0.000 description 12
238000012360 testing method Methods 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
239000000243 solution Substances 0.000 description 11
XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 9
239000007858 starting material Substances 0.000 description 9
229910052757 nitrogen Inorganic materials 0.000 description 8
239000012044 organic layer Substances 0.000 description 8
QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 description 7
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
102100024304 Protachykinin-1 Human genes 0.000 description 7
101800003906 Substance P Proteins 0.000 description 7
102000003141 Tachykinin Human genes 0.000 description 7
238000002512 chemotherapy Methods 0.000 description 7
239000000460 chlorine Substances 0.000 description 7
239000000377 silicon dioxide Substances 0.000 description 7
108060008037 tachykinin Proteins 0.000 description 7
208000004454 Hyperalgesia Diseases 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
125000001980 alanyl group Chemical group 0.000 description 6
208000006673 asthma Diseases 0.000 description 6
238000003818 flash chromatography Methods 0.000 description 6
239000010410 layer Substances 0.000 description 6
239000011541 reaction mixture Substances 0.000 description 6
208000035154 Hyperesthesia Diseases 0.000 description 5
208000019695 Migraine disease Diseases 0.000 description 5
239000012267 brine Substances 0.000 description 5
239000013078 crystal Substances 0.000 description 5
208000035475 disorder Diseases 0.000 description 5
238000010438 heat treatment Methods 0.000 description 5
239000004530 micro-emulsion Substances 0.000 description 5
206010027599 migraine Diseases 0.000 description 5
230000000414 obstructive effect Effects 0.000 description 5
238000010992 reflux Methods 0.000 description 5
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 5
238000003756 stirring Methods 0.000 description 5
102100021260 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Human genes 0.000 description 4
101000894906 Homo sapiens Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Proteins 0.000 description 4
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 4
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 4
230000000202 analgesic effect Effects 0.000 description 4
239000000730 antalgic agent Substances 0.000 description 4
239000012141 concentrate Substances 0.000 description 4
238000001914 filtration Methods 0.000 description 4
230000002757 inflammatory effect Effects 0.000 description 4
INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 4
XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 4
238000002560 therapeutic procedure Methods 0.000 description 4
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 3
SDQJTWBNWQABLE-UHFFFAOYSA-N 1h-quinazoline-2,4-dione Chemical compound C1=CC=C2C(=O)NC(=O)NC2=C1 SDQJTWBNWQABLE-UHFFFAOYSA-N 0.000 description 3
208000024827 Alzheimer disease Diseases 0.000 description 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
206010020751 Hypersensitivity Diseases 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
206010047700 Vomiting Diseases 0.000 description 3
230000000735 allogeneic effect Effects 0.000 description 3
230000003110 anti-inflammatory effect Effects 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
125000004432 carbon atom Chemical group C* 0.000 description 3
229910052801 chlorine Inorganic materials 0.000 description 3
208000027866 inflammatory disease Diseases 0.000 description 3
210000004072 lung Anatomy 0.000 description 3
150000007530 organic bases Chemical class 0.000 description 3
239000000725 suspension Substances 0.000 description 3
TUQSVSYUEBNNKQ-UHFFFAOYSA-N 2,4-dichloroquinazoline Chemical compound C1=CC=CC2=NC(Cl)=NC(Cl)=C21 TUQSVSYUEBNNKQ-UHFFFAOYSA-N 0.000 description 2
CNGRGEDXKHIFIL-UHFFFAOYSA-N 2-chloro-1h-quinazolin-4-one Chemical compound C1=CC=C2NC(Cl)=NC(=O)C2=C1 CNGRGEDXKHIFIL-UHFFFAOYSA-N 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
206010001052 Acute respiratory distress syndrome Diseases 0.000 description 2
206010002383 Angina Pectoris Diseases 0.000 description 2
208000019901 Anxiety disease Diseases 0.000 description 2
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 2
108010040718 Neurokinin-1 Receptors Proteins 0.000 description 2
102000002002 Neurokinin-1 Receptors Human genes 0.000 description 2
CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 description 2
201000004681 Psoriasis Diseases 0.000 description 2
208000025747 Rheumatic disease Diseases 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
OKJPEAGHQZHRQV-UHFFFAOYSA-N Triiodomethane Natural products IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 2
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
206010047115 Vasculitis Diseases 0.000 description 2
229960001138 acetylsalicylic acid Drugs 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
208000002205 allergic conjunctivitis Diseases 0.000 description 2
208000026935 allergic disease Diseases 0.000 description 2
230000003042 antagnostic effect Effects 0.000 description 2
239000002260 anti-inflammatory agent Substances 0.000 description 2
229940121363 anti-inflammatory agent Drugs 0.000 description 2
230000000118 anti-neoplastic effect Effects 0.000 description 2
229940124344 antianaemic agent Drugs 0.000 description 2
239000003173 antianemic agent Substances 0.000 description 2
230000001363 autoimmune Effects 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
210000003169 central nervous system Anatomy 0.000 description 2
230000000973 chemotherapeutic effect Effects 0.000 description 2
238000004587 chromatography analysis Methods 0.000 description 2
230000001684 chronic effect Effects 0.000 description 2
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
238000001816 cooling Methods 0.000 description 2
239000000824 cytostatic agent Substances 0.000 description 2
230000001085 cytostatic effect Effects 0.000 description 2
238000002651 drug therapy Methods 0.000 description 2
IIEWJVIFRVWJOD-UHFFFAOYSA-N ethyl cyclohexane Natural products CCC1CCCCC1 IIEWJVIFRVWJOD-UHFFFAOYSA-N 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
230000001506 immunosuppresive effect Effects 0.000 description 2
229960003444 immunosuppressant agent Drugs 0.000 description 2
239000003018 immunosuppressive agent Substances 0.000 description 2
239000003701 inert diluent Substances 0.000 description 2
239000012442 inert solvent Substances 0.000 description 2
206010023332 keratitis Diseases 0.000 description 2
201000010666 keratoconjunctivitis Diseases 0.000 description 2
230000001404 mediated effect Effects 0.000 description 2
239000002609 medium Substances 0.000 description 2
239000012528 membrane Substances 0.000 description 2
208000015122 neurodegenerative disease Diseases 0.000 description 2
230000002981 neuropathic effect Effects 0.000 description 2
201000001119 neuropathy Diseases 0.000 description 2
230000003040 nociceptive effect Effects 0.000 description 2
210000000578 peripheral nerve Anatomy 0.000 description 2
239000000902 placebo Substances 0.000 description 2
229940068196 placebo Drugs 0.000 description 2
206010035653 pneumoconiosis Diseases 0.000 description 2
239000002574 poison Substances 0.000 description 2
231100000614 poison Toxicity 0.000 description 2
239000000843 powder Substances 0.000 description 2
230000002685 pulmonary effect Effects 0.000 description 2
206010039073 rheumatoid arthritis Diseases 0.000 description 2
206010039083 rhinitis Diseases 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
239000011734 sodium Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 2
235000015112 vegetable and seed oil Nutrition 0.000 description 2
239000008158 vegetable oil Substances 0.000 description 2
239000008096 xylene Substances 0.000 description 2
BBVQDWDBTWSGHQ-UHFFFAOYSA-N 2-chloro-1,3-benzoxazole Chemical compound C1=CC=C2OC(Cl)=NC2=C1 BBVQDWDBTWSGHQ-UHFFFAOYSA-N 0.000 description 1
AYPSHJCKSDNETA-UHFFFAOYSA-N 2-chloro-1h-benzimidazole Chemical compound C1=CC=C2NC(Cl)=NC2=C1 AYPSHJCKSDNETA-UHFFFAOYSA-N 0.000 description 1
YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 description 1
SGKWBZJYUSNOEB-UHFFFAOYSA-N 4h-3,1-benzoxazin-2-ylcyanamide Chemical compound C1=CC=C2COC(=NC#N)NC2=C1 SGKWBZJYUSNOEB-UHFFFAOYSA-N 0.000 description 1
208000030507 AIDS Diseases 0.000 description 1
102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 description 1
208000007848 Alcoholism Diseases 0.000 description 1
206010027654 Allergic conditions Diseases 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
241001124076 Aphididae Species 0.000 description 1
208000032467 Aplastic anaemia Diseases 0.000 description 1
208000006820 Arthralgia Diseases 0.000 description 1
208000033116 Asbestos intoxication Diseases 0.000 description 1
208000009657 Aspirin-Induced Asthma Diseases 0.000 description 1
206010003557 Asthma exercise induced Diseases 0.000 description 1
208000023275 Autoimmune disease Diseases 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 1
208000033222 Biliary cirrhosis primary Diseases 0.000 description 1
206010004663 Biliary colic Diseases 0.000 description 1
208000003174 Brain Neoplasms Diseases 0.000 description 1
206010056695 Bronchial oedema Diseases 0.000 description 1
241000700198 Cavia Species 0.000 description 1
208000017667 Chronic Disease Diseases 0.000 description 1
206010008909 Chronic Hepatitis Diseases 0.000 description 1
208000000094 Chronic Pain Diseases 0.000 description 1
206010009900 Colitis ulcerative Diseases 0.000 description 1
206010010741 Conjunctivitis Diseases 0.000 description 1
206010010744 Conjunctivitis allergic Diseases 0.000 description 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
108010036949 Cyclosporine Proteins 0.000 description 1
206010012289 Dementia Diseases 0.000 description 1
208000016192 Demyelinating disease Diseases 0.000 description 1
206010012335 Dependence Diseases 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
206010012442 Dermatitis contact Diseases 0.000 description 1
206010048768 Dermatosis Diseases 0.000 description 1
208000032131 Diabetic Neuropathies Diseases 0.000 description 1
201000010374 Down Syndrome Diseases 0.000 description 1
206010060742 Endocrine ophthalmopathy Diseases 0.000 description 1
208000004657 Exercise-Induced Asthma Diseases 0.000 description 1
206010016654 Fibrosis Diseases 0.000 description 1
208000018522 Gastrointestinal disease Diseases 0.000 description 1
206010018364 Glomerulonephritis Diseases 0.000 description 1
108010068370 Glutens Proteins 0.000 description 1
201000005569 Gout Diseases 0.000 description 1
206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
208000003807 Graves Disease Diseases 0.000 description 1
208000015023 Graves' disease Diseases 0.000 description 1
206010019755 Hepatitis chronic active Diseases 0.000 description 1
101000600903 Homo sapiens Substance-P receptor Proteins 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
206010062016 Immunosuppression Diseases 0.000 description 1
206010021639 Incontinence Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
208000022559 Inflammatory bowel disease Diseases 0.000 description 1
206010065390 Inflammatory pain Diseases 0.000 description 1
206010024453 Ligament sprain Diseases 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 description 1
206010029164 Nephrotic syndrome Diseases 0.000 description 1
206010030113 Oedema Diseases 0.000 description 1
229910019213 POCl3 Inorganic materials 0.000 description 1
206010033664 Panic attack Diseases 0.000 description 1
208000018737 Parkinson disease Diseases 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
241000223960 Plasmodium falciparum Species 0.000 description 1
206010065159 Polychondritis Diseases 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
208000012654 Primary biliary cholangitis Diseases 0.000 description 1
201000001263 Psoriatic Arthritis Diseases 0.000 description 1
208000036824 Psoriatic arthropathy Diseases 0.000 description 1
208000028017 Psychotic disease Diseases 0.000 description 1
206010038419 Renal colic Diseases 0.000 description 1
208000037656 Respiratory Sounds Diseases 0.000 description 1
206010039085 Rhinitis allergic Diseases 0.000 description 1
206010039966 Senile dementia Diseases 0.000 description 1
201000010001 Silicosis Diseases 0.000 description 1
208000010040 Sprains and Strains Diseases 0.000 description 1
241000223996 Toxoplasma Species 0.000 description 1
241000223997 Toxoplasma gondii Species 0.000 description 1
206010052779 Transplant rejections Diseases 0.000 description 1
206010044688 Trisomy 21 Diseases 0.000 description 1
201000006704 Ulcerative Colitis Diseases 0.000 description 1
208000024780 Urticaria Diseases 0.000 description 1
206010046851 Uveitis Diseases 0.000 description 1
206010047924 Wheezing Diseases 0.000 description 1
208000016807 X-linked intellectual disability-macrocephaly-macroorchidism syndrome Diseases 0.000 description 1
229960000583 acetic acid Drugs 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
201000007930 alcohol dependence Diseases 0.000 description 1
150000008044 alkali metal hydroxides Chemical class 0.000 description 1
150000001350 alkyl halides Chemical class 0.000 description 1
201000009961 allergic asthma Diseases 0.000 description 1
230000007815 allergy Effects 0.000 description 1
208000028462 aluminosis Diseases 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
238000000540 analysis of variance Methods 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
208000010123 anthracosis Diseases 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
230000001093 anti-cancer Effects 0.000 description 1
230000000843 anti-fungal effect Effects 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
230000003502 anti-nociceptive effect Effects 0.000 description 1
230000000842 anti-protozoal effect Effects 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
239000002111 antiemetic agent Substances 0.000 description 1
229940125683 antiemetic agent Drugs 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000003096 antiparasitic agent Substances 0.000 description 1
229940125687 antiparasitic agent Drugs 0.000 description 1
239000003904 antiprotozoal agent Substances 0.000 description 1
230000036506 anxiety Effects 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
206010003246 arthritis Diseases 0.000 description 1
206010003441 asbestosis Diseases 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
208000010668 atopic eczema Diseases 0.000 description 1
201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
239000002585 base Substances 0.000 description 1
239000012455 biphasic mixture Substances 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
230000008499 blood brain barrier function Effects 0.000 description 1
230000017531 blood circulation Effects 0.000 description 1
210000001218 blood-brain barrier Anatomy 0.000 description 1
206010006451 bronchitis Diseases 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
208000015114 central nervous system disease Diseases 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
229960001265 ciclosporin Drugs 0.000 description 1
229960003920 cocaine Drugs 0.000 description 1
208000010247 contact dermatitis Diseases 0.000 description 1
229940124558 contraceptive agent Drugs 0.000 description 1
239000003433 contraceptive agent Substances 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
239000006071 cream Substances 0.000 description 1
239000012043 crude product Substances 0.000 description 1
229930182912 cyclosporin Natural products 0.000 description 1
230000006378 damage Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
201000001981 dermatomyositis Diseases 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
RCJVRSBWZCNNQT-UHFFFAOYSA-N dichloridooxygen Chemical compound ClOCl RCJVRSBWZCNNQT-UHFFFAOYSA-N 0.000 description 1
230000010339 dilation Effects 0.000 description 1
229910001873 dinitrogen Inorganic materials 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000004064 dysfunction Effects 0.000 description 1
201000006549 dyspepsia Diseases 0.000 description 1
239000003480 eluent Substances 0.000 description 1
JPGQOUSTVILISH-UHFFFAOYSA-N enflurane Chemical compound FC(F)OC(F)(F)C(F)Cl JPGQOUSTVILISH-UHFFFAOYSA-N 0.000 description 1
229960000305 enflurane Drugs 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
208000024695 exercise-induced bronchoconstriction Diseases 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
208000024711 extrinsic asthma Diseases 0.000 description 1
230000004761 fibrosis Effects 0.000 description 1
206010016766 flatulence Diseases 0.000 description 1
239000006260 foam Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000012458 free base Substances 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
208000021302 gastroesophageal reflux disease Diseases 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000012362 glacial acetic acid Substances 0.000 description 1
235000021312 gluten Nutrition 0.000 description 1
210000002216 heart Anatomy 0.000 description 1
208000014951 hematologic disease Diseases 0.000 description 1
208000007475 hemolytic anemia Diseases 0.000 description 1
125000000623 heterocyclic group Chemical group 0.000 description 1
239000008241 heterogeneous mixture Substances 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
210000004276 hyalin Anatomy 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
230000035874 hyperreactivity Effects 0.000 description 1
230000009610 hypersensitivity Effects 0.000 description 1
208000016036 idiopathic nephrotic syndrome Diseases 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
230000001861 immunosuppressant effect Effects 0.000 description 1
230000004968 inflammatory condition Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
238000001802 infusion Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
208000014674 injury Diseases 0.000 description 1
201000010659 intrinsic asthma Diseases 0.000 description 1
208000002551 irritable bowel syndrome Diseases 0.000 description 1
JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
229940011051 isopropyl acetate Drugs 0.000 description 1
GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
208000017169 kidney disease Diseases 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000003120 macrolide antibiotic agent Substances 0.000 description 1
238000010907 mechanical stirring Methods 0.000 description 1
230000005906 menstruation Effects 0.000 description 1
CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 description 1
ATFKBWNEVZUSKC-UHFFFAOYSA-N methyl 2-isocyanatobenzoate Chemical compound COC(=O)C1=CC=CC=C1N=C=O ATFKBWNEVZUSKC-UHFFFAOYSA-N 0.000 description 1
210000003097 mucus Anatomy 0.000 description 1
201000006417 multiple sclerosis Diseases 0.000 description 1
206010028417 myasthenia gravis Diseases 0.000 description 1
230000004770 neurodegeneration Effects 0.000 description 1
239000002742 neurokinin 1 receptor antagonist Substances 0.000 description 1
230000007823 neuropathy Effects 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
201000008482 osteoarthritis Diseases 0.000 description 1
208000019906 panic disease Diseases 0.000 description 1
230000035515 penetration Effects 0.000 description 1
208000033808 peripheral neuropathy Diseases 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
208000019899 phobic disease Diseases 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
239000008389 polyethoxylated castor oil Substances 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
230000000506 psychotropic effect Effects 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000000552 rheumatic effect Effects 0.000 description 1
201000000306 sarcoidosis Diseases 0.000 description 1
201000000980 schizophrenia Diseases 0.000 description 1
210000003497 sciatic nerve Anatomy 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
208000004003 siderosis Diseases 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
229910000108 silver(I,III) oxide Inorganic materials 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
230000000392 somatic effect Effects 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000003890 substance P antagonist Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000011477 surgical intervention Methods 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
201000000596 systemic lupus erythematosus Diseases 0.000 description 1
239000002462 tachykinin receptor antagonist Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
230000008733 trauma Effects 0.000 description 1
125000005270 trialkylamine group Chemical group 0.000 description 1
230000001457 vasomotor Effects 0.000 description 1
230000002455 vasospastic effect Effects 0.000 description 1
201000005539 vernal conjunctivitis Diseases 0.000 description 1
208000018464 vernal keratoconjunctivitis Diseases 0.000 description 1
238000010792 warming Methods 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Psychiatry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Pain & Pain Management (AREA)
Genetics & Genomics (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Addiction (AREA)
Rheumatology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

ES97953927T 1997-01-14 1997-12-29 Antagonistas de taquicinina. Expired - Lifetime ES2239368T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9700597.9A GB9700597D0 (en)	1997-01-14	1997-01-14	Organic compounds
GB9700597		1997-01-14

Publications (1)

Publication Number	Publication Date
ES2239368T3 true ES2239368T3 (es)	2005-09-16

Family

ID=10805904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES97953927T Expired - Lifetime ES2239368T3 (es)	1997-01-14	1997-12-29	Antagonistas de taquicinina.

Country Status (14)

Country	Link
US (1)	US6107293A (2)
EP (1)	EP0964867B1 (2)
JP (2)	JP4306804B2 (2)
AR (1)	AR011521A1 (2)
AT (1)	ATE290546T1 (2)
AU (1)	AU5764298A (2)
CA (1)	CA2278057C (2)
CO (1)	CO4950614A1 (2)
DE (1)	DE69732715T2 (2)
ES (1)	ES2239368T3 (2)
GB (1)	GB9700597D0 (2)
PT (1)	PT964867E (2)
WO (1)	WO1998031704A2 (2)
ZA (1)	ZA98256B (2)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6426331B1 (en)	1998-07-08	2002-07-30	Tularik Inc.	Inhibitors of STAT function
GB9815696D0 (en) *	1998-07-20	1998-09-16	Pfizer Ltd	Heterocyclics
WO2000048623A1 (en)	1999-02-18	2000-08-24	Kaken Pharmaceutical Co., Ltd.	Novel amide derivatives as growth hormone secretagogues
WO2001083517A1 (en) *	2000-05-03	2001-11-08	Tularik Inc.	Stat4 and stat6 binding dipeptide derivatives
US6884782B2 (en)	2000-11-08	2005-04-26	Amgen Inc.	STAT modulators
US20070219214A1 (en) *	2006-02-01	2007-09-20	Solvay Pharmaceuticals Gmbh	Dual NK2/NK3-antagonists, pharmaceutical compositions comprising them, and processes for their preparation
KR20090071581A (ko)	2006-10-16	2009-07-01	라이온 가부시키가이샤	Ｎｋ１ 수용체 앤태고니스트 조성물
ES2672099T3 (es)	2011-07-04	2018-06-12	Irbm - Science Park S.P.A.	Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
EP3758688B1 (en)	2018-02-26	2024-03-27	Ospedale San Raffaele S.r.l.	Nk-1 antagonists for use in the treatment of ocular pain
EP4117673A1 (en)	2020-03-11	2023-01-18	Ospedale San Raffaele S.r.l.	Treatment of stem cell deficiency

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ210669A (en) *	1983-12-27	1988-05-30	Syntex Inc	Benzoxazin-4-one derivatives and pharmaceutical compositions
GB8929070D0 (en) *	1989-12-22	1990-02-28	Fujisawa Pharmaceutical Co	Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
FR2719312B1 (fr) *	1994-04-28	1996-06-14	Adir	Nouveau pseudopeptides dérivés de neurokinines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

1997
- 1997-01-14 GB GBGB9700597.9A patent/GB9700597D0/en active Pending
- 1997-12-29 US US09/341,626 patent/US6107293A/en not_active Expired - Lifetime
- 1997-12-29 ES ES97953927T patent/ES2239368T3/es not_active Expired - Lifetime
- 1997-12-29 CA CA002278057A patent/CA2278057C/en not_active Expired - Fee Related
- 1997-12-29 EP EP97953927A patent/EP0964867B1/en not_active Expired - Lifetime
- 1997-12-29 PT PT97953927T patent/PT964867E/pt unknown
- 1997-12-29 AU AU57642/98A patent/AU5764298A/en not_active Abandoned
- 1997-12-29 DE DE69732715T patent/DE69732715T2/de not_active Expired - Lifetime
- 1997-12-29 AT AT97953927T patent/ATE290546T1/de not_active IP Right Cessation
- 1997-12-29 WO PCT/EP1997/007307 patent/WO1998031704A2/en not_active Ceased
- 1997-12-29 JP JP53360998A patent/JP4306804B2/ja not_active Expired - Fee Related
1998
- 1998-01-09 AR ARP980100097A patent/AR011521A1/es active IP Right Grant
- 1998-01-13 ZA ZA98256A patent/ZA98256B/xx unknown
- 1998-01-13 CO CO98001002A patent/CO4950614A1/es unknown
2005
- 2005-11-29 JP JP2005344056A patent/JP3817256B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AR011521A1 (es)	2000-08-30
PT964867E (pt)	2005-07-29
CA2278057A1 (en)	1998-07-23
CO4950614A1 (es)	2000-09-01
EP0964867A2 (en)	1999-12-22
DE69732715D1 (de)	2005-04-14
JP4306804B2 (ja)	2009-08-05
CA2278057C (en)	2004-05-04
WO1998031704A2 (en)	1998-07-23
JP3817256B2 (ja)	2006-09-06
JP2006089499A (ja)	2006-04-06
ZA98256B (en)	1998-07-14
EP0964867B1 (en)	2005-03-09
ATE290546T1 (de)	2005-03-15
DE69732715T2 (de)	2006-04-13
WO1998031704A3 (en)	1998-09-11
JP2000516257A (ja)	2000-12-05
US6107293A (en)	2000-08-22
GB9700597D0 (en)	1997-03-05
AU5764298A (en)	1998-08-07

Publication	Publication Date	Title
ES2275935T3 (es)	2007-06-16	Derivados de naftiridina, su preparacion y su uso como inhibidores de la isoenzima fosfodiesterasa 4 (pde4).
EP0797583A1 (en)	1997-10-01	Tachykinin antagonists
EP0354583B1 (en)	1993-11-03	DC-88A derivatives
ES2249884T3 (es)	2006-04-01	Derivados del acido indolil-3-glioxilico con efecto antitumoral.
CA3154608A1 (en)	2021-03-25	Il-17a modulators and uses thereof
CA3149926A1 (en)	2021-03-11	Rip1 inhibitory compounds and methods for making and using the same
JP2718637B2 (ja)	1998-02-25	ガランタミン誘導体、それらの製法および医薬としてのそれらの使用
CN107207485A (zh)	2017-09-26	(S)‑5‑苄基‑N‑(5‑甲基‑4‑氧代‑2,3,4,5‑四氢苯并[b][1,4]氧氮杂环庚三烯‑3‑基)‑4H‑1,2,4‑三唑‑3‑甲酰胺的晶型
ES2344655T3 (es)	2010-09-02	Inhibidores mif.
JP2000327575A (ja)	2000-11-28	ジケトピペラジン誘導体含有炎症疾患治療剤および新規なジケトピペラジン誘導体
JPH0419208B2 (2)	1992-03-30
PL123822B1 (en)	1982-11-30	Process for preparing novel tripeptideamides
EP0497001B1 (en)	1997-03-26	Oxidized-type glutathione alkyl ester
WO2005121138A2 (en)	2005-12-22	Heterotricyclic compounds for use as hcv inhibitors
EP0964867B1 (en)	2005-03-09	Tachykinin antagonists
CA2649762C (en)	2015-09-29	Synthesis and uses of pyroglutamic acid derivatives
EP0425669B1 (en)	1995-01-25	1-amino-5-halogenouracils, process for their preparation, and central nervous system depressants containing same as active ingredient
HU202548B (en)	1991-03-28	Process for producing epipodophyllotoxin-glycoside-4'-acyl derivatives and pharmaceutical compositions comprising such compounds
SK6562002A3 (en)	2002-08-06	Beta-d-5-thioxylose derivatives, preparation method and therapeutic use
CN117343064B (zh)	2024-04-16	一种具有抗病毒作用的嘧啶衍生物的制备与应用
JPH0211592A (ja)	1990-01-16	光学活性なジヒドロピリジンホスホン酸エステル
WO1997008191A1 (en)	1997-03-06	Polymorphs of the prodrug 6-n-(l-ala-l-ala)-trovafloxacin
WO2020210246A1 (en)	2020-10-15	Heterocyclic compounds as rsv inhibitors
MXPA97003957A (en)	1998-07-03	Antagonists of taquicin
WO2019071105A1 (en)	2019-04-11	CRYSTALLINE COMPOUNDS AND METHODS FOR TREATING VIRAL INFECTIONS