ES2250412T3 - Nuevas composiciones de minoxidil. - Google Patents

Nuevas composiciones de minoxidil.

Info

Publication number: ES2250412T3
Authority: ES; Spain
Prior art keywords: composition according; minoxidil; alcohol; group; solvent
Prior art date: 2000-08-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES01938910T

Other languages

English (en)

Spanish (es)

Inventor

Lorraine Elisabeth Pena

Maw-Sheng Wu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Health AB

Original Assignee

Pfizer Health AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-09

Filing date

2001-06-07

Publication date

2006-04-16

2001-06-07 Application filed by Pfizer Health AB filed Critical Pfizer Health AB

2006-04-16 Application granted granted Critical

2006-04-16 Publication of ES2250412T3 publication Critical patent/ES2250412T3/es

2021-06-07 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 250
ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 title claims abstract description 132
229960003632 minoxidil Drugs 0.000 title claims abstract description 130
239000002904 solvent Substances 0.000 claims abstract description 71
239000002562 thickening agent Substances 0.000 claims abstract description 70
229920000642 polymer Polymers 0.000 claims abstract description 31
150000003839 salts Chemical class 0.000 claims abstract description 12
235000010980 cellulose Nutrition 0.000 claims abstract description 6
229920002678 cellulose Polymers 0.000 claims abstract description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 104
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 78
239000003795 chemical substances by application Substances 0.000 claims description 60
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 50
230000003472 neutralizing effect Effects 0.000 claims description 48
239000000499 gel Substances 0.000 claims description 47
201000004384 Alopecia Diseases 0.000 claims description 45
229920002125 Sokalan® Polymers 0.000 claims description 36
238000000034 method Methods 0.000 claims description 33
229920005862 polyol Polymers 0.000 claims description 33
150000003077 polyols Chemical class 0.000 claims description 33
239000006185 dispersion Substances 0.000 claims description 31
230000003676 hair loss Effects 0.000 claims description 31
CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 26
229960004063 propylene glycol Drugs 0.000 claims description 24
-1 PEG-15-cocaine Chemical compound 0.000 claims description 21
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 20
229920001577 copolymer Polymers 0.000 claims description 18
208000024963 hair loss Diseases 0.000 claims description 18
229940058020 2-amino-2-methyl-1-propanol Drugs 0.000 claims description 16
229940048053 acrylate Drugs 0.000 claims description 15
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 claims description 13
229940043276 diisopropanolamine Drugs 0.000 claims description 13
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 12
UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 claims description 12
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 11
238000009472 formulation Methods 0.000 claims description 11
150000001875 compounds Chemical class 0.000 claims description 10
238000004519 manufacturing process Methods 0.000 claims description 9
238000002156 mixing Methods 0.000 claims description 9
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 8
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 8
SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 8
208000003024 Diffuse alopecia Diseases 0.000 claims description 8
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
SLINHMUFWFWBMU-UHFFFAOYSA-N Triisopropanolamine Chemical compound CC(O)CN(CC(C)O)CC(C)O SLINHMUFWFWBMU-UHFFFAOYSA-N 0.000 claims description 8
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 8
NSOXQYCFHDMMGV-UHFFFAOYSA-N Tetrakis(2-hydroxypropyl)ethylenediamine Chemical compound CC(O)CN(CC(C)O)CCN(CC(C)O)CC(C)O NSOXQYCFHDMMGV-UHFFFAOYSA-N 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 7
150000001298 alcohols Chemical class 0.000 claims description 7
206010068168 androgenetic alopecia Diseases 0.000 claims description 7
229960001631 carbomer Drugs 0.000 claims description 7
229940047670 sodium acrylate Drugs 0.000 claims description 7
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims description 6
230000003698 anagen phase Effects 0.000 claims description 6
201000002996 androgenic alopecia Diseases 0.000 claims description 6
235000014113 dietary fatty acids Nutrition 0.000 claims description 6
239000000194 fatty acid Substances 0.000 claims description 6
229930195729 fatty acid Natural products 0.000 claims description 6
239000003205 fragrance Substances 0.000 claims description 6
239000003607 modifier Substances 0.000 claims description 6
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 5
229920002126 Acrylic acid copolymer Polymers 0.000 claims description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
125000000217 alkyl group Chemical group 0.000 claims description 5
239000002537 cosmetic Substances 0.000 claims description 5
239000003995 emulsifying agent Substances 0.000 claims description 5
235000011187 glycerol Nutrition 0.000 claims description 5
239000003921 oil Substances 0.000 claims description 5
239000011734 sodium Substances 0.000 claims description 5
229910052708 sodium Inorganic materials 0.000 claims description 5
OTJFQRMIRKXXRS-UHFFFAOYSA-N (hydroxymethylamino)methanol Chemical compound OCNCO OTJFQRMIRKXXRS-UHFFFAOYSA-N 0.000 claims description 4
229940058015 1,3-butylene glycol Drugs 0.000 claims description 4
PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 claims description 4
BFIAIMMAHAIVFT-UHFFFAOYSA-N 1-[bis(2-hydroxybutyl)amino]butan-2-ol Chemical compound CCC(O)CN(CC(O)CC)CC(O)CC BFIAIMMAHAIVFT-UHFFFAOYSA-N 0.000 claims description 4
239000004475 Arginine Substances 0.000 claims description 4
241000416162 Astragalus gummifer Species 0.000 claims description 4
SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 4
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 4
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 4
229920000604 Polyethylene Glycol 200 Polymers 0.000 claims description 4
229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 4
229920001615 Tragacanth Polymers 0.000 claims description 4
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 4
239000000654 additive Substances 0.000 claims description 4
208000004631 alopecia areata Diseases 0.000 claims description 4
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
235000019437 butane-1,3-diol Nutrition 0.000 claims description 4
FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 4
229960003920 cocaine Drugs 0.000 claims description 4
229920006037 cross link polymer Polymers 0.000 claims description 4
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 4
229940043279 diisopropylamine Drugs 0.000 claims description 4
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 4
229940113120 dipropylene glycol Drugs 0.000 claims description 4
229940051250 hexylene glycol Drugs 0.000 claims description 4
239000004615 ingredient Substances 0.000 claims description 4
JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 claims description 4
229920002401 polyacrylamide Polymers 0.000 claims description 4
201000001297 telogen effluvium Diseases 0.000 claims description 4
235000010487 tragacanth Nutrition 0.000 claims description 4
239000000196 tragacanth Substances 0.000 claims description 4
229940116362 tragacanth Drugs 0.000 claims description 4
YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 claims description 4
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 4
229960000281 trometamol Drugs 0.000 claims description 4
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
244000215068 Acacia senegal Species 0.000 claims description 3
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 3
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 3
IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims description 3
239000005977 Ethylene Substances 0.000 claims description 3
108010010803 Gelatin Proteins 0.000 claims description 3
229920000084 Gum arabic Polymers 0.000 claims description 3
229920000569 Gum karaya Polymers 0.000 claims description 3
244000208060 Lawsonia inermis Species 0.000 claims description 3
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
OPKOKAMJFNKNAS-UHFFFAOYSA-N N-methylethanolamine Chemical compound CNCCO OPKOKAMJFNKNAS-UHFFFAOYSA-N 0.000 claims description 3
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
229920001100 Polydextrose Polymers 0.000 claims description 3
229920000289 Polyquaternium Polymers 0.000 claims description 3
239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
229930003427 Vitamin E Natural products 0.000 claims description 3
235000010489 acacia gum Nutrition 0.000 claims description 3
239000000205 acacia gum Substances 0.000 claims description 3
235000010443 alginic acid Nutrition 0.000 claims description 3
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229940008099 dimethicone Drugs 0.000 claims description 3
239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
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239000000975 dye Substances 0.000 claims description 3
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150000004665 fatty acids Chemical class 0.000 claims description 3
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
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235000019322 gelatine Nutrition 0.000 claims description 3
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229960003160 hyaluronic acid Drugs 0.000 claims description 3
239000002085 irritant Substances 0.000 claims description 3
235000010494 karaya gum Nutrition 0.000 claims description 3
229940101267 panthenol Drugs 0.000 claims description 3
235000020957 pantothenol Nutrition 0.000 claims description 3
239000011619 pantothenol Substances 0.000 claims description 3
230000035515 penetration Effects 0.000 claims description 3
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 3
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239000004094 surface-active agent Substances 0.000 claims description 3
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235000019165 vitamin E Nutrition 0.000 claims description 3
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UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 2
229920000161 Locust bean gum Polymers 0.000 claims description 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
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SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
239000005018 casein Substances 0.000 claims description 2
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
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IPFIEHIRBSTAKA-UHFFFAOYSA-N 6-piperidin-1-ylpyrimidine-2,4-diamine Chemical compound NC1=NC(N)=CC(N2CCCCC2)=N1 IPFIEHIRBSTAKA-UHFFFAOYSA-N 0.000 description 2
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Chemical Kinetics & Catalysis (AREA)
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ES01938910T 2000-08-09 2001-06-07 Nuevas composiciones de minoxidil. Expired - Lifetime ES2250412T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/634,399 US7442369B1 (en)	2000-08-09	2000-08-09	Compositions of minoxidil
US634399		2000-08-09

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ES2250412T3 true ES2250412T3 (es)	2006-04-16

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US (1)	US7442369B1 (de)
EP (1)	EP1307181B1 (de)
JP (2)	JP2004505906A (de)
KR (1)	KR20030020446A (de)
CN (1)	CN1450890B (de)
AR (1)	AR030088A1 (de)
AT (1)	ATE308316T1 (de)
AU (2)	AU6448101A (de)
BR (1)	BR0113087A (de)
CA (1)	CA2417630C (de)
DE (1)	DE60114634T2 (de)
DK (1)	DK1307181T3 (de)
ES (1)	ES2250412T3 (de)
HU (1)	HUP0301816A2 (de)
NO (1)	NO20030610L (de)
NZ (1)	NZ523878A (de)
PE (1)	PE20020397A1 (de)
RU (1)	RU2287330C2 (de)
TW (1)	TWI253940B (de)
WO (1)	WO2002011698A1 (de)
ZA (1)	ZA200300884B (de)

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2000
- 2000-08-09 US US09/634,399 patent/US7442369B1/en not_active Expired - Fee Related
2001
- 2001-06-07 DE DE60114634T patent/DE60114634T2/de not_active Expired - Lifetime
- 2001-06-07 BR BR0113087-0A patent/BR0113087A/pt not_active Application Discontinuation
- 2001-06-07 JP JP2002517035A patent/JP2004505906A/ja active Pending
- 2001-06-07 AT AT01938910T patent/ATE308316T1/de not_active IP Right Cessation
- 2001-06-07 DK DK01938910T patent/DK1307181T3/da active
- 2001-06-07 CN CN018150721A patent/CN1450890B/zh not_active Expired - Fee Related
- 2001-06-07 AU AU6448101A patent/AU6448101A/xx active Pending
- 2001-06-07 CA CA002417630A patent/CA2417630C/en not_active Expired - Fee Related
- 2001-06-07 HU HU0301816A patent/HUP0301816A2/hu unknown
- 2001-06-07 ES ES01938910T patent/ES2250412T3/es not_active Expired - Lifetime
- 2001-06-07 EP EP01938910A patent/EP1307181B1/de not_active Expired - Lifetime
- 2001-06-07 RU RU2003106430/15A patent/RU2287330C2/ru not_active IP Right Cessation
- 2001-06-07 NZ NZ523878A patent/NZ523878A/en not_active IP Right Cessation
- 2001-06-07 AU AU2001264481A patent/AU2001264481B2/en not_active Ceased
- 2001-06-07 KR KR10-2003-7001736A patent/KR20030020446A/ko not_active Withdrawn
- 2001-06-07 WO PCT/SE2001/001269 patent/WO2002011698A1/en not_active Ceased
- 2001-07-06 PE PE2001000674A patent/PE20020397A1/es not_active Application Discontinuation
- 2001-07-31 AR ARP010103654A patent/AR030088A1/es not_active Application Discontinuation
- 2001-08-22 TW TW090120654A patent/TWI253940B/zh not_active IP Right Cessation
2003
- 2003-01-31 ZA ZA200300884A patent/ZA200300884B/en unknown
- 2003-02-07 NO NO20030610A patent/NO20030610L/no not_active Application Discontinuation
2009
- 2009-08-26 JP JP2009195116A patent/JP2010006829A/ja active Pending

Also Published As

Publication number	Publication date
CN1450890B (zh)	2010-04-21
AR030088A1 (es)	2003-08-13
BR0113087A (pt)	2003-07-08
ZA200300884B (en)	2004-02-19
AU2001264481B2 (en)	2005-03-24
KR20030020446A (ko)	2003-03-08
JP2010006829A (ja)	2010-01-14
TWI253940B (en)	2006-05-01
WO2002011698A1 (en)	2002-02-14
NO20030610L (no)	2003-04-09
DK1307181T3 (da)	2006-01-30
DE60114634D1 (de)	2005-12-08
RU2287330C2 (ru)	2006-11-20
WO2002011698A9 (en)	2003-04-03
NZ523878A (en)	2004-09-24
CA2417630C (en)	2009-01-06
NO20030610D0 (no)	2003-02-07
EP1307181A1 (de)	2003-05-07
US7442369B1 (en)	2008-10-28
DE60114634T2 (de)	2006-09-07
EP1307181B1 (de)	2005-11-02
AU6448101A (en)	2002-02-18
PE20020397A1 (es)	2002-06-24
JP2004505906A (ja)	2004-02-26
HUP0301816A2 (hu)	2003-09-29
ATE308316T1 (de)	2005-11-15
CN1450890A (zh)	2003-10-22
CA2417630A1 (en)	2002-02-14

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KR20140020895A (ko)	2014-02-19	모발 성장 증진 방법
JP2004059587A (ja)	2004-02-26	医薬溶液
JP2014510042A5 (de)	2015-03-26
CA2780925A1 (en)	2011-05-12	Compositions for enhancing hair growth
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JP2008247754A (ja)	2008-10-16	外用組成物
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JP7312527B2 (ja)	2023-07-21	乳化組成物
JP2021070671A (ja)	2021-05-06	外用液剤
CN119385929A (zh)	2025-02-07	用于治疗脱发的局部外用药物组合物及其制备方法和用途
HK1056515A (en)	2004-02-20	Novel compositions of minoxidil
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JP2016164146A (ja)	2016-09-08	外用組成物
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