ES2282062T1 - Composicion farmaceutica que contiene irbesartan. - Google Patents
Composicion farmaceutica que contiene irbesartan. Download PDFInfo
- Publication number
- ES2282062T1 ES2282062T1 ES05775601T ES05775601T ES2282062T1 ES 2282062 T1 ES2282062 T1 ES 2282062T1 ES 05775601 T ES05775601 T ES 05775601T ES 05775601 T ES05775601 T ES 05775601T ES 2282062 T1 ES2282062 T1 ES 2282062T1
- Authority
- ES
- Spain
- Prior art keywords
- approximately
- composition according
- composition
- irbesartan
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002947 C09CA04 - Irbesartan Substances 0.000 title claims abstract 24
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 title claims abstract 24
- 229960002198 irbesartan Drugs 0.000 title claims abstract 24
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 66
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract 14
- 238000004090 dissolution Methods 0.000 claims abstract 6
- 239000011230 binding agent Substances 0.000 claims 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 10
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 8
- 239000003085 diluting agent Substances 0.000 claims 8
- 239000000314 lubricant Substances 0.000 claims 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 8
- 229940069328 povidone Drugs 0.000 claims 8
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 7
- 229920000881 Modified starch Polymers 0.000 claims 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 7
- 229960001681 croscarmellose sodium Drugs 0.000 claims 7
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 7
- 239000004094 surface-active agent Substances 0.000 claims 6
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical group CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 claims 5
- 235000019359 magnesium stearate Nutrition 0.000 claims 5
- 229920001993 poloxamer 188 Polymers 0.000 claims 5
- 229940044519 poloxamer 188 Drugs 0.000 claims 5
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical group C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims 4
- 229960002003 hydrochlorothiazide Drugs 0.000 claims 4
- 239000000377 silicon dioxide Substances 0.000 claims 4
- 235000012239 silicon dioxide Nutrition 0.000 claims 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- 229920002472 Starch Polymers 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 239000008107 starch Substances 0.000 claims 3
- 235000019698 starch Nutrition 0.000 claims 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims 2
- 239000011777 magnesium Substances 0.000 claims 2
- 229910052749 magnesium Inorganic materials 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical group CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 claims 1
- 229920003084 Avicel® PH-102 Polymers 0.000 claims 1
- MWOZJZDNRDLJMG-UHFFFAOYSA-N [Si].O=C=O Chemical compound [Si].O=C=O MWOZJZDNRDLJMG-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 230000001882 diuretic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 238000005550 wet granulation Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Composición que comprende más del 70% de irbesartán p/p y por lo menos un excipiente farmacéuticamente aceptable.
Claims (40)
1. Composición que comprende más del 70% de
irbesartán p/p y por lo menos un excipiente farmacéuticamente
aceptable.
2. Composición según la reivindicación 1, que
presenta un perfil de disolución según el cual más de
aproximadamente el 85% del irbesartán está disuelto en
aproximadamente 30 minutos utilizando el aparato 2 de USP, colocando
el comprimido en 1000 ml de ácido clorhídrico 0,1 N a 37ºC con una
velocidad del agitador de 50 rpm.
3. Composición que comprende más del 70% de
irbesartán, en la que dicha composición presenta un perfil de
disolución según el cual más de aproximadamente el 85% del
irbesartán está disuelto en aproximadamente 30 minutos utilizando
el aparato 2 de USP, colocando el comprimido en 1000 ml de ácido
clorhídrico 0,1 N a 37ºC con una velocidad del agitador de 50
rpm.
4. Composición según la reivindicación 3, que
comprende más del 75% p/p de irbesartán y por lo menos un
excipiente farmacéuticamente
aceptable.
aceptable.
5. Composición según cualquiera de las
reivindicaciones 1 a 4, en forma de comprimido.
6. Composición según cualquiera de las
reivindicaciones 1 a 5, en la que dicha composición comprende un
aglutinante.
7. Composición según la reivindicación 6, en
la que el aglutinante es povidona o almidón pregelatinizado.
8. Composición según la reivindicación 7, en
la que el aglutinante es povidona.
9. Composición según la reivindicación 8, en
la que la povidona está comprendida entre aproximadamente 1,0 y
aproximadamente 7,0% p/p de la composición.
10. Composición según cualquiera de las
reivindicaciones 6 a 9, en la que un aglutinante es almidón
pregelatinizado (almidón 1500).
11. Composición según la reivindicación 10, en
la que el almidón pregelatinizado (almidón 1500) está comprendido
entre aproximadamente 1,0 y aproximadamente 10,0% p/p de la
composición.
12. Composición según cualquiera de las
reivindicaciones 1 a 11, en la que dicha composición comprende un
disgregador.
13. Composición según la reivindicación 12, en
la que un disgregador es la croscarmelosa sódica.
14. Composición según la reivindicación 13, en
la que la croscarmelosa sódica es
Ac-Di-Sol y está comprendida entre
aproximadamente el 1,0% y aproximadamente el 7,0% p/p de la
composición.
15. Composición según cualquiera de las
reivindicaciones 1 a 14, en la que dicha composición comprende un
tensioactivo.
16. Composición según la reivindicación 15, en
la que dicho tensioactivo es poloxámero 188.
17. Composición según la reivindicación 16, en
la que el poloxámero 188 está comprendido aproximadamente entre el
0,2 y aproximadamente el 6,0% p/p de la composición.
18. Composición según cualquiera de las
reivindicaciones 1 a 17, en la que dicha composición comprende un
diluyente.
19. Composición según la reivindicación 18, en
la que dicho diluyente es celulosa microcristalina.
20. Composición según la reivindicación 19, en
la que la celulosa microcristalina es Avicel PH 102 FMC y comprende
entre aproximadamente el 2,0 y aproximadamente el 10,0% p/p de la
composición.
21. Composición según cualquiera de las
reivindicaciones 1 a 20, en la que dicha composición comprende un
antiadherente.
22. Composición según la reivindicación 21, en
la que el antiadherente es dióxido de silicio.
23. Composición según la reivindicación 22, en
la que el dióxido de silicio es syloid 244 y comprende entre
aproximadamente 0,4% p/p y aproximadamente el 0,5% p/p de la
composición.
24. Composición según cualquiera de las
reivindicaciones 1 a 23, en la que dicha composición comprende un
lubricante.
25. Composición según la reivindicación 24, en
la que dicho lubricante es estearato de magnesio.
26. Composición según la reivindicación 25, en
la que el estearato de magnesio comprende entre aproximadamente el
0,2% y aproximadamente el 2,0% p/p de la composición.
27. Composición según cualquiera de las
reivindicaciones 1 a 26, en la que además dicha composición
comprende por lo menos un agente farmacéutico activo adicional.
28. Composición según la reivindicación 27, en
la que el agente farmacéutico activo adicional es un agente
diurético.
29. Composición según la reivindicación 27 ó
28, en la que el agente activo adicional es hidroclorotiazida.
30. Composición según la reivindicación 1, en
la que la composición comprende, en peso, 75% de irbesartán, y en
peso, aproximadamente 10% de aglutinante, aproximadamente 7,5% de
diluyente, aproximadamente 4% de disgregador, aproximadamente 2% de
tensioactivo, aproximadamente 1% de lubricante y aproximadamente
0,5% de antiadherente; en la que dicho aglutinante consiste en
almidón pregelatinizado y povidona; dicho diluyente es microcelulosa
cristalina y dicho disgregador es croscarmelosa sódica, dicho
tensioactivo es poloxámero 188, dicho lubricante es estearato de
magnesio y dicho antiadherente es dióxido de silicio.
31. Composición según la reivindicación 1, en
la que la composición comprende, en peso, 79,79% de irbesartán, y
los excipientes farmacéuticos comprenden en peso, aproximadamente
8,5% de aglutinante, aproximadamente 5,9% de diluyente,
aproximadamente 3,1% de disgregador, aproximadamente 1% de
tensioactivo, aproximadamente 1% de lubricante y aproximadamente
0,5% de antiadherente; en la que dicho aglutinante consiste en
almidón pregelatinizado y povidona; dicho diluyente es
microcelulosa cristalina, dicho disgregador es croscarmelosa sódica,
dicho tensioactivo es poloxámero 188, dicho lubricante es estearato
de magnesio y dicho antiadherente es dióxido de silicio.
32. Composición según la reivindicación 30 ó
31, en la que dicha composición es un comprimido, de modo que el
comprimido tiene un rendimiento de disolución de modo que más del
85% del irbesartán contenido en la misma se disuelve en 30 minutos
en las condiciones siguientes: aparato 2 de USP, colocando el
comprimido en 1000 ml de ácido clorhídrico 0,1 N a 37ºC con una
velocidad del agitador de
50 rpm.
50 rpm.
33. Composición según la reivindicación 5, en
la que el comprimido se prepara mediante un procedimiento de
granulación en húmedo.
34. Composición según la reivindicación 1, que
presenta un perfil de disolución según el cual más del 80% del
irbesartán se disuelve en 10 minutos utilizando el aparato 2 de USP,
colocando el comprimido en 1000 ml de ácido clorhídrico 0,1 N a
37ºC con una velocidad del agitador de 50 rpm.
35. Composición según la reivindicación 1, que
presenta un perfil de disolución según el cual más del 85% del
irbesartán se disuelve en aproximadamente 10 minutos utilizando el
aparato 2 de USP, colocando el comprimido en 1000 ml de ácido
clorhídrico 0,1 N a 37ºC con una velocidad del agitador de 50
rpm.
36. Composición según la reivindicación 1, que
presenta un perfil de disolución según el cual por lo menos
aproximadamente el 75% del irbesartán se disuelve en aproximadamente
5 minutos, por lo menos aproximadamente el 85% del irbesartán se
disuelve en aproximadamente 10 minutos y por lo menos
aproximadamente el 95% del irbesartán se disuelve en
aproximadamente 20 minutos utilizando el aparato 2 de USP, colocando
el comprimido en 1000 ml de ácido clorhídrico 0,1 N a 37ºC con una
velocidad del agitador de 50 rpm.
37. Composición según la reivindicación 1, en
la que la composición comprende, en peso, 79,79% de irbesartán,
entre aproximadamente el 3% y aproximadamente el 7% de
hidroclorotiazida, entre aproximadamente 5,3% y aproximadamente
7,5% de aglutinante, entre aproximadamente 3,5% y aproximadamente 6%
de diluyente, entre aproximadamente 3% y aproximadamente 3,2% de
disgregador, entre aproximadamente 1% y aproximadamente 1,1% de
lubricante, y entre aproximadamente 0,4% y aproximadamente 0,5% de
antiadherente; en la que dicho aglutinante consiste en almidón
pregelatinizado y povidona; dicho diluyente es microcelulosa
cristalina, dicho disgregador es croscarmelosa sódica, dicho
lubricante es estearato de magnesio y dicho antiadherente es dióxido
de silicio.
38. Composición según la reivindicación 36, en
la que la composición comprende, en peso, 79,79% de irbesartán,
2,13% de povidona, 6,38% de almidón pregelatinizado, 3,15% de
croscarmelosa sódica, 1,01% de poloxámero 188, 5,96% de celulosa
microcristalina, 1,01% de estearato de magnesio y 0,43% de dióxido
de silicio.
39. Composición según la reivindicación 37, en
la que la composición comprende 150 mg de irbesartán y 12,5 mg de
hidroclorotiazida.
40. Composición según la reivindicación 37 en
la que la composición comprende, en peso, 79% de irbesartán,
aproximadamente 3,3% de hidroclorotiazida, aproximadamente 3,1% de
almidón pregelatinizado, aproximadamente 2,1% de povidona,
aproximadamente 5,3% de celulosa microcristalina, aproximadamente
4,7% de croscarmelosa sódica, aproximadamente 0,4% de dióxido de
silicio y aproximadamente 1% de estearato de magnesio.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57742704P | 2004-06-04 | 2004-06-04 | |
| US577427P | 2004-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2282062T1 true ES2282062T1 (es) | 2007-10-16 |
Family
ID=35463389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05775601T Pending ES2282062T1 (es) | 2004-06-04 | 2005-06-02 | Composicion farmaceutica que contiene irbesartan. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8226977B2 (es) |
| EP (1) | EP1750862B1 (es) |
| JP (2) | JP4880591B2 (es) |
| AT (1) | ATE493973T1 (es) |
| AU (1) | AU2005249794A1 (es) |
| CA (1) | CA2568640C (es) |
| DE (1) | DE602005025755D1 (es) |
| ES (1) | ES2282062T1 (es) |
| IL (1) | IL179718A0 (es) |
| PL (1) | PL1750862T3 (es) |
| WO (1) | WO2005118166A2 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1806130T3 (pl) * | 2006-01-09 | 2010-08-31 | Krka D D Novo Mesto | Kompozycja farmaceutyczna w postaci stałej zawierająca irbesartan |
| DE102006006588A1 (de) * | 2006-02-13 | 2007-08-16 | Ratiopharm Gmbh | Schnell freisetzende Irbesartan-haltige pharmazeutische Zusammensetzung |
| GB0612540D0 (en) * | 2006-06-23 | 2006-08-02 | Novartis Ag | Galenical formulations of organic compounds |
| GB0617171D0 (en) * | 2006-08-31 | 2006-10-11 | Generics Uk Ltd | Novel compositions and methods |
| CA2563690C (en) * | 2006-10-12 | 2014-10-07 | Pharmascience Inc. | Pharmaceutical compositions comprising intra- and extra- granular fractions |
| JP5527921B2 (ja) * | 2006-12-22 | 2014-06-25 | エスエス製薬株式会社 | 苦味を隠蔽した経口固形組成物 |
| WO2008102235A1 (en) * | 2007-02-20 | 2008-08-28 | Aurobindo Pharma Limited | Controlled release formulations of alfuzosin |
| RU2010104960A (ru) * | 2007-08-01 | 2011-09-10 | Тева Фармасьютикал Индастриес Лтд. (Il) | Фармацевтическая композиция кандесартана |
| PT2065035E (pt) | 2007-11-28 | 2010-10-04 | Lesvi Laboratorios Sl | Formulações farmacêuticas contendo irbesartan |
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-
2005
- 2005-06-02 CA CA2568640A patent/CA2568640C/en not_active Expired - Fee Related
- 2005-06-02 DE DE602005025755T patent/DE602005025755D1/de not_active Expired - Lifetime
- 2005-06-02 ES ES05775601T patent/ES2282062T1/es active Pending
- 2005-06-02 JP JP2007514218A patent/JP4880591B2/ja not_active Expired - Fee Related
- 2005-06-02 AU AU2005249794A patent/AU2005249794A1/en not_active Abandoned
- 2005-06-02 EP EP05775601A patent/EP1750862B1/en not_active Expired - Lifetime
- 2005-06-02 US US11/143,556 patent/US8226977B2/en not_active Expired - Fee Related
- 2005-06-02 WO PCT/IB2005/002689 patent/WO2005118166A2/en not_active Ceased
- 2005-06-02 PL PL05775601T patent/PL1750862T3/pl unknown
- 2005-06-02 AT AT05775601T patent/ATE493973T1/de not_active IP Right Cessation
-
2006
- 2006-11-30 IL IL179718A patent/IL179718A0/en unknown
-
2011
- 2011-08-19 JP JP2011179762A patent/JP2011252022A/ja not_active Withdrawn
-
2012
- 2012-05-31 US US13/485,493 patent/US8414920B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20120238555A1 (en) | 2012-09-20 |
| US8226977B2 (en) | 2012-07-24 |
| JP4880591B2 (ja) | 2012-02-22 |
| CA2568640C (en) | 2011-08-09 |
| JP2008501680A (ja) | 2008-01-24 |
| US8414920B2 (en) | 2013-04-09 |
| PL1750862T3 (pl) | 2011-06-30 |
| IL179718A0 (en) | 2007-05-15 |
| WO2005118166A2 (en) | 2005-12-15 |
| JP2011252022A (ja) | 2011-12-15 |
| WO2005118166A3 (en) | 2006-07-27 |
| CA2568640A1 (en) | 2005-12-15 |
| EP1750862A4 (en) | 2008-06-11 |
| US20050271720A1 (en) | 2005-12-08 |
| DE602005025755D1 (de) | 2011-02-17 |
| ATE493973T1 (de) | 2011-01-15 |
| EP1750862A2 (en) | 2007-02-14 |
| AU2005249794A1 (en) | 2005-12-15 |
| EP1750862B1 (en) | 2011-01-05 |
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