NO20052074L - Substituerte benzoksazinoner og anvendelser derav. - Google Patents

Substituerte benzoksazinoner og anvendelser derav.

Info

Publication number
NO20052074L
NO20052074L NO20052074A NO20052074A NO20052074L NO 20052074 L NO20052074 L NO 20052074L NO 20052074 A NO20052074 A NO 20052074A NO 20052074 A NO20052074 A NO 20052074A NO 20052074 L NO20052074 L NO 20052074L
Authority
NO
Norway
Prior art keywords
substituted benzoxazinones
formula
benzoxazinones
methods
provides
Prior art date
Application number
NO20052074A
Other languages
English (en)
Inventor
Shu-Hai Zhao
Hans Maag
Meng Sui
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20052074L publication Critical patent/NO20052074L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Legemiddel Substituerte benzoksazinoner og anvendelser derav. Oppfinnelsen tilveiebringer en forbindelse med formel (1): og farmasøytisk akseptable salter eller prodrug derav, hvor Y, Z, R', R'^, r\ R\ R^, R* , R^, R*, R^, m, n, p og q er som definert her. Oppfinnelsen tilveiebringer også metoder for fremstilling av, preparater omfattende og metoder for anvendelse av Forbindelser med formel (I).
NO20052074A 2002-11-08 2005-04-27 Substituerte benzoksazinoner og anvendelser derav. NO20052074L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42494602P 2002-11-08 2002-11-08
PCT/EP2003/012278 WO2004041792A1 (en) 2002-11-08 2003-11-04 Substituted benzoxazinones and uses thereof

Publications (1)

Publication Number Publication Date
NO20052074L true NO20052074L (no) 2005-06-01

Family

ID=32312902

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052074A NO20052074L (no) 2002-11-08 2005-04-27 Substituerte benzoksazinoner og anvendelser derav.

Country Status (28)

Country Link
US (1) US7141562B2 (no)
EP (1) EP1562918B1 (no)
JP (1) JP4401297B2 (no)
KR (1) KR100683361B1 (no)
CN (1) CN100390157C (no)
AR (1) AR042002A1 (no)
AT (1) ATE384054T1 (no)
AU (1) AU2003293653B2 (no)
BR (1) BR0315302A (no)
CA (1) CA2505334A1 (no)
DE (1) DE60318733T2 (no)
DK (1) DK1562918T3 (no)
ES (1) ES2298609T3 (no)
GT (1) GT200300241A (no)
HR (1) HRP20050390A2 (no)
IL (1) IL168343A (no)
MX (1) MXPA05004758A (no)
MY (1) MY136824A (no)
NO (1) NO20052074L (no)
NZ (1) NZ539508A (no)
PA (1) PA8587501A1 (no)
PE (1) PE20040828A1 (no)
PL (1) PL377770A1 (no)
PT (1) PT1562918E (no)
RU (1) RU2328490C2 (no)
TW (1) TWI285639B (no)
WO (1) WO2004041792A1 (no)
ZA (1) ZA200503248B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7504395B2 (en) * 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
SI1497266T1 (sl) 2002-03-27 2008-10-31 Glaxo Group Ltd Derivati kinolina in njihova uporaba kot ligandi 5-ht6
EP1558582B1 (en) 2003-07-22 2005-12-21 Arena Pharmaceuticals, Inc. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
JP4527730B2 (ja) * 2003-12-09 2010-08-18 エフ．ホフマン−ラ ロシュ アーゲー ベンゾオキサジン誘導体及びその使用
US7713954B2 (en) * 2004-09-30 2010-05-11 Roche Palo Alto Llc Compositions and methods for treating cognitive disorders
ES2348467T3 (es) * 2004-09-30 2010-12-07 F. Hoffmann-La Roche Ag Derivados y usos de la benzoxazina y la quinoxalina.
CA2615007A1 (en) * 2005-07-13 2007-01-18 F. Hoffmann-La Roche Ag Benzimidazole derivatives as 5-ht6,5-ht24
EP1954689A4 (en) * 2005-09-15 2009-09-02 Korea Res Inst Chem Tech N-SUBSTITUTED 1H-CHINOLIN-2,4-DIONE, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF
TWI385161B (zh) * 2006-02-02 2013-02-11 Mitsubishi Tanabe Pharma Corp 含氮雜雙環化合物
WO2007147883A1 (en) * 2006-06-23 2007-12-27 Laboratorios Del Dr. Esteve, S.A. Combination of a cholinesterase inhibitor and a compound with 5-ht6 receptor affinity
EP2254564A1 (en) 2007-12-12 2010-12-01 Glaxo Group Limited Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
ITMI20131782A1 (it) * 2013-10-25 2015-04-26 Dipharma Francis Srl Procedimento per la preparazione di un agonista della trombopoietina
HK1245660A1 (zh) 2015-06-12 2018-08-31 Axovant Sciences Gmbh 有用於预防和治疗rem睡眠行为障碍的二芳基脲和芳基脲衍生物
WO2017011767A2 (en) 2015-07-15 2017-01-19 Axovant Sciences Ltd. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
RU2624978C2 (ru) * 2015-07-27 2017-07-11 Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный медицинский университет им. Н.Н. Бурденко" Министерства здравоохранения Российской Федерации Способ лечения умеренного когнитивного снижения
SI3649124T1 (sl) * 2017-08-07 2021-09-30 Suven Life Sciences Limited Fluoropiperidinske spojine kot čisti 5-HT6 receptor antagonisti
CN111559990B (zh) * 2020-05-29 2021-03-09 四川大学华西医院 一种小分子噁噻嗪类衍生物及其应用
CN112047898A (zh) * 2020-10-14 2020-12-08 兰州大学 一种苯并[c][1,2]噁嗪骨架类新化合物及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU784769A3 (ru) * 1977-03-17 1980-11-30 Шел Интернэшнл Рисерч Маатсхаппии Б.В. (Фирма) Способ получени бензоксазинкарбоксамидов
DE3586794T2 (de) 1984-12-21 1993-05-27 Duphar Int Res Arzneimittel mit psychotroper wirkung.
AU605304B2 (en) * 1987-06-22 1991-01-10 Nihon Tokushu Nayaku Seizo K.K. Benzo-fused cyclic compounds
FR2667068B1 (fr) * 1990-09-26 1994-09-09 Adir Nouvelles amines alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5955470A (en) * 1991-06-11 1999-09-21 Merrell Pharmaceuticals, Inc. Derivatives of amide analogs of certain methano bridged quinolizines
AU708053B2 (en) 1996-03-29 1999-07-29 Duphar International Research B.V. Piperazine and piperidine compounds
ATE253058T1 (de) 1997-09-02 2003-11-15 Duphar Int Res Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten
IL148218A0 (en) * 1999-08-23 2002-09-12 Solvay Pharm Bv New phenylpiperazines
EP1255743A1 (en) 2000-02-01 2002-11-13 Millenium Pharmaceuticals, Inc. 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa
WO2001072725A1 (en) 2000-03-24 2001-10-04 Cor Therapeutics, Inc. BICYCLIC SULFONYL AMINO INHIBITORS OF FACTOR Xa
DE10031391A1 (de) 2000-07-03 2002-02-07 Knoll Ag Bicyclische Verbindungen und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
HUP0301458A2 (hu) * 2000-10-26 2003-10-28 Smithkline Beecham Plc. Benzoxazinonszármazékok, eljárás előállításukra és a vegyületek felhasználása
CA2456250A1 (en) * 2001-08-10 2003-02-20 F. Hoffmann-La Roche Ag Arylsulfonyl derivatives with 5-ht6 receptor affinity
DE60303376T2 (de) * 2002-05-13 2006-11-16 F. Hoffmann-La Roche Ag Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen

Also Published As

Publication number Publication date
PE20040828A1 (es) 2004-11-25
KR20050072479A (ko) 2005-07-11
TWI285639B (en) 2007-08-21
MY136824A (en) 2008-11-28
DE60318733D1 (de) 2008-03-06
IL168343A (en) 2010-05-31
TW200418846A (en) 2004-10-01
CN1723205A (zh) 2006-01-18
HRP20050390A2 (en) 2006-12-31
EP1562918B1 (en) 2008-01-16
RU2328490C2 (ru) 2008-07-10
US7141562B2 (en) 2006-11-28
ES2298609T3 (es) 2008-05-16
GT200300241A (es) 2004-06-03
WO2004041792A1 (en) 2004-05-21
EP1562918A1 (en) 2005-08-17
RU2005117965A (ru) 2006-01-27
NZ539508A (en) 2007-05-31
ZA200503248B (en) 2006-02-22
PT1562918E (pt) 2008-03-12
CN100390157C (zh) 2008-05-28
AU2003293653A1 (en) 2004-06-07
ATE384054T1 (de) 2008-02-15
PL377770A1 (pl) 2006-02-20
AR042002A1 (es) 2005-06-08
BR0315302A (pt) 2005-08-23
KR100683361B1 (ko) 2007-02-15
MXPA05004758A (es) 2005-08-02
JP4401297B2 (ja) 2010-01-20
DK1562918T3 (da) 2008-05-05
PA8587501A1 (es) 2004-05-26
JP2006514615A (ja) 2006-05-11
US20040092512A1 (en) 2004-05-13
AU2003293653B2 (en) 2009-05-14
DE60318733T2 (de) 2009-01-15
CA2505334A1 (en) 2004-05-21

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