ES2309765T3 - Tetrahidropiridotiofenos. - Google Patents

Tetrahidropiridotiofenos. Download PDF

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Publication number
ES2309765T3
ES2309765T3 ES05749649T ES05749649T ES2309765T3 ES 2309765 T3 ES2309765 T3 ES 2309765T3 ES 05749649 T ES05749649 T ES 05749649T ES 05749649 T ES05749649 T ES 05749649T ES 2309765 T3 ES2309765 T3 ES 2309765T3
Authority
ES
Spain
Prior art keywords
cycloalkyl
alkyl
independently selected
har
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05749649T
Other languages
English (en)
Inventor
Klaus Pekari
Thomas Baer
Bjorn Bartels
Mathias Schmidt
Thomas Beckers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
4SC AG
Original Assignee
4SC AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4SC AG filed Critical 4SC AG
Application granted granted Critical
Publication of ES2309765T3 publication Critical patent/ES2309765T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compuestos de fórmula I (Ver fórmula) en la que Ra es -C(O)R1, -C(O)OR2, -C(O)SR2, -C(O)N(R3)R4, -S(O)2R1 o -S(O)2N(R3)R4; Rb es Q-alquenilo C2-4, en el que o bien Q está opcionalmente sustituido con Rba y/o Rbb y/o Rbc, y es fenilo o naftilo, o Q está opcionalmente sustituido con Rca y/o Rcb, y es Har, o bien Q es Cyc; en los que R1, R2 y R3 pueden ser iguales o diferentes y se seleccionan independientemente de entre el grupo constituido por: hidrógeno, alquilo C1-7, cicloalquilo C3-7, Ar, Har y Het, en los que cada uno de dicho alquilo C1-7, cicloalquilo C3-7, Ar, Har y Het puede estar no sustituido u opcionalmente sustituido con por lo menos un sustituyente seleccionado independientemente de R5; cada R4 se selecciona independientemente de entre el grupo constituido por: hidrógeno, alquilo C1-7 y cicloalquilo C3-7, en el que cada uno de dicho alquilo C1-7 y cicloalquilo C3-7 puede estar no sustituido u opcionalmente sustituido con por lo menos un sustituyente seleccionado independientemente de R5; R5, Rba, Rbb, Rbc, Rca y Rcb pueden ser iguales o diferentes y se seleccionan independientemente de entre el grupo constituido por: alquilo C1-7, cicloalquilo C3-7, Ar, Har, Het, halógeno, trifluorometilo, nitro, ciano, guanidino, amidino, -C(O)R6, -C(O)OR7, -C(O)N(R8)R9, -S(O)2R6, -S(O)2N(R8)R9, -N(R10)C(O)R6, -N(R10)C(O)OR7, -N(R10)C(O)N(R8)R9, -N(R10)S(O)2R6, -N(R10)S(O)2N(R8)R9, -OC(O)R6, -OC(O)N(R8)R9, -OR7, -N(R8)R9 y -SR7, en los que...
ES05749649T 2004-05-28 2005-05-25 Tetrahidropiridotiofenos. Expired - Lifetime ES2309765T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP04102413 2004-05-28
EP04102413 2004-05-28
EP04104193 2004-09-01
EP04104193 2004-09-01

Publications (1)

Publication Number Publication Date
ES2309765T3 true ES2309765T3 (es) 2008-12-16

Family

ID=35045196

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05749649T Expired - Lifetime ES2309765T3 (es) 2004-05-28 2005-05-25 Tetrahidropiridotiofenos.

Country Status (24)

Country Link
US (2) US7723523B2 (es)
EP (1) EP1753512B1 (es)
JP (1) JP4881297B2 (es)
KR (1) KR20070037578A (es)
CN (1) CN1988934B (es)
AT (1) ATE400319T1 (es)
AU (1) AU2005249718B2 (es)
BR (1) BRPI0511461A (es)
CA (1) CA2567648A1 (es)
CY (1) CY1108399T1 (es)
DE (1) DE602005008050D1 (es)
DK (1) DK1753512T3 (es)
EA (1) EA012280B1 (es)
ES (1) ES2309765T3 (es)
HR (1) HRP20080499T3 (es)
IL (1) IL178727A (es)
MX (1) MXPA06013383A (es)
NO (1) NO20065907L (es)
NZ (1) NZ550513A (es)
PL (1) PL1753512T3 (es)
PT (1) PT1753512E (es)
RS (1) RS50613B (es)
SI (1) SI1753512T1 (es)
WO (1) WO2005118071A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2309765T3 (es) 2004-05-28 2008-12-16 4Sc Ag Tetrahidropiridotiofenos.
WO2005118592A1 (en) 2004-06-04 2005-12-15 Altana Pharma Ag Tetrahydropyridothiophenes for use in the treatment of cancer
US7714134B2 (en) 2004-06-11 2010-05-11 4Sc Ag Compounds and use of tetrahydropyridothiophenes
EP1851229A1 (en) 2005-02-09 2007-11-07 Nycomed GmbH Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
US7763728B2 (en) 2005-05-25 2010-07-27 4Sc Ag Tetrahydropyridothiophenes
US7714136B2 (en) 2005-05-25 2010-05-11 4Sc Ag Tetrahydropyridothiophenes
WO2008020024A1 (en) * 2006-08-16 2008-02-21 4Sc Ag Ntetrahydropyridothiophene derivatives for the treatment of cancer
WO2008020045A1 (en) * 2006-08-16 2008-02-21 4Sc Ag Tetrahydrobenzothiophene derivatives
TWI492759B (zh) 2008-03-05 2015-07-21 Otsuka Pharma Co Ltd 膽甾烷醇衍生物之併用用途
TW201005466A (en) * 2008-07-24 2010-02-01 Advanced Analog Technology Inc Low dropout regulator
HRP20120822T1 (hr) * 2008-10-24 2012-11-30 Grünenthal GmbH Supstituirani 4,5,6,7-tetrahidrotienopiridini kao kcnq2/3 modulatori za lijeäśenje boli, epilepsije i urinarne inkontinencije
NZ594996A (en) * 2009-03-04 2014-02-28 Otsuka Pharma Co Ltd Cholestanol derivative for combined use
CN104478850A (zh) * 2014-12-08 2015-04-01 上海应用技术学院 一种2-氨基噻吩-3甲酰胺的衍生物的制备方法
BR112020025696A2 (pt) 2018-06-19 2021-03-16 Novartis Ag Derivados de tetra-hidrotienopiridina n-substituída e usos dos mesmos

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JPS5498337A (en) 1978-01-06 1979-08-03 Dai Ichi Seiyaku Co Ltd Anticarcinogenic and/or antimetastatic agent
DD272078A1 (de) 1986-04-15 1989-09-27 Dresden Arzneimittel Verfahren zur herstellung von 6-substituierten 2-acylamio-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridin-3-carbonsaeure-derivaten
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WO2005118592A1 (en) 2004-06-04 2005-12-15 Altana Pharma Ag Tetrahydropyridothiophenes for use in the treatment of cancer
US7714134B2 (en) 2004-06-11 2010-05-11 4Sc Ag Compounds and use of tetrahydropyridothiophenes
SE0401970D0 (sv) 2004-08-02 2004-08-02 Astrazeneca Ab Novel compounds
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WO2008020045A1 (en) 2006-08-16 2008-02-21 4Sc Ag Tetrahydrobenzothiophene derivatives

Also Published As

Publication number Publication date
EA200602157A1 (ru) 2007-06-29
CA2567648A1 (en) 2005-12-15
WO2005118071A2 (en) 2005-12-15
NZ550513A (en) 2009-10-30
US20070244112A1 (en) 2007-10-18
AU2005249718A1 (en) 2005-12-15
JP4881297B2 (ja) 2012-02-22
IL178727A0 (en) 2007-02-11
US7723523B2 (en) 2010-05-25
NO20065907L (no) 2006-12-19
WO2005118071A3 (en) 2006-06-01
EP1753512B1 (en) 2008-07-09
US20090270378A1 (en) 2009-10-29
RS50613B (sr) 2010-06-30
CN1988934B (zh) 2011-01-05
EP1753512A2 (en) 2007-02-21
IL178727A (en) 2010-12-30
JP2008500993A (ja) 2008-01-17
MXPA06013383A (es) 2007-01-23
HK1106171A1 (en) 2008-03-07
ATE400319T1 (de) 2008-07-15
EA012280B1 (ru) 2009-08-28
US7803945B2 (en) 2010-09-28
CN1988934A (zh) 2007-06-27
KR20070037578A (ko) 2007-04-05
DK1753512T3 (da) 2008-11-17
BRPI0511461A (pt) 2007-12-26
SI1753512T1 (sl) 2008-12-31
DE602005008050D1 (de) 2008-08-21
PT1753512E (pt) 2008-10-14
AU2005249718B2 (en) 2011-01-27
CY1108399T1 (el) 2014-02-12
HRP20080499T3 (en) 2008-11-30
PL1753512T3 (pl) 2009-03-31

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