ES2315713T3 - Sondas fluorescentes para su utilizacion en un ensayo de union de inhibidores de quinasas de proteinas. - Google Patents

Sondas fluorescentes para su utilizacion en un ensayo de union de inhibidores de quinasas de proteinas. Download PDF

Info

Publication number: ES2315713T3
Authority: ES; Spain
Prior art keywords: probe; kinase; baselineskip; group; fluorescent
Prior art date: 2003-10-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES04789404T

Other languages

English (en)

Spanish (es)

Inventor

Anthony S. Prokopowicz

Martha Priscilla Brown

Jessi Marie Jones-Wildeson

Scott Jakes

Mark E. Labadia

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharmaceuticals Inc

Original Assignee

Boehringer Ingelheim Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-03

Filing date

2004-09-30

Publication date

2009-04-01

2004-09-30 Application filed by Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharmaceuticals Inc

2009-04-01 Application granted granted Critical

2009-04-01 Publication of ES2315713T3 publication Critical patent/ES2315713T3/es

2024-09-30 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/10—Amino derivatives of triarylmethanes
- C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B55/00—Azomethine dyes
- C09B55/002—Monoazomethine dyes
- C09B55/003—Monoazomethine dyes with the -C=N- group attached to an heteroring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Cell Biology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Medicinal Chemistry (AREA)
Food Science & Technology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

ES04789404T 2003-10-03 2004-09-30 Sondas fluorescentes para su utilizacion en un ensayo de union de inhibidores de quinasas de proteinas. Expired - Lifetime ES2315713T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US50853903P	2003-10-03	2003-10-03
US508539P		2003-10-03

Publications (1)

Publication Number	Publication Date
ES2315713T3 true ES2315713T3 (es)	2009-04-01

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Application Number	Title	Priority Date	Filing Date
ES04789404T Expired - Lifetime ES2315713T3 (es)	2003-10-03	2004-09-30	Sondas fluorescentes para su utilizacion en un ensayo de union de inhibidores de quinasas de proteinas.

Country Status (8)

Country	Link
US (2)	US7125996B2 (de)
EP (1)	EP1670789B1 (de)
JP (1)	JP4949845B2 (de)
AT (1)	ATE414701T1 (de)
CA (1)	CA2541059C (de)
DE (1)	DE602004017884D1 (de)
ES (1)	ES2315713T3 (de)
WO (1)	WO2005033330A2 (de)

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CA2478156C (en) *	2002-03-26	2011-02-15	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
WO2004019935A1 (en) *	2002-08-29	2004-03-11	Boehringer Ingelheim Pharmaceuticals, Inc.	-3 (sulfonamidoethyl) -indole derivaties for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
UY28526A1 (es) *	2003-09-24	2005-04-29	Boehringer Ingelheim Pharma	Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7795272B2 (en) *	2004-03-13	2010-09-14	Boehringer Ingelheim Pharmaceutical, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
CA2592514A1 (en) *	2004-12-27	2006-07-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
WO2007057397A1 (en) *	2005-11-15	2007-05-24	Boehringer Ingelheim International Gmbh	Treatment of cancer
EE200600030A (et) *	2006-08-15	2008-04-15	Tartu �likool	Proteiinkinaasi fluorestsents-sond
AU2007329548A1 (en) *	2006-12-06	2008-06-12	Boehringer Ingelheim International Gmbh	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
WO2009097318A1 (en) *	2008-01-28	2009-08-06	Bristol-Myers Squibb Company	A fluorescence polarization binding assay for characterizing glucokinase ligands
EP2300472B1 (de) *	2008-06-06	2012-01-18	Boehringer Ingelheim International GmbH	Glucocorticoidmimetika, verfahren zu deren herstellung, pharmazeutische zusammensetzungen und anwendungen davon
EP2445969B1 (de)	2009-06-26	2014-08-27	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Neue fluorierte rhodamine als photostabile fluoreszensfarbstoffe für markierungsverfahren und zur bildgebung
EP2482072B1 (de)	2011-01-26	2016-07-06	University of Tartu	Photolumineszierenden sonde
EP2700946A1 (de) *	2012-08-24	2014-02-26	University of Tartu	Bisubstratfluoreszente Sonden für Proteinkinase CK2
CN114292281B (zh) *	2021-12-22	2023-10-24	东南大学	一种用于实现细胞内脂滴动态成像的小分子荧光探针及其制备方法和应用

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JPH06172312A (ja) *	1992-03-04	1994-06-21	Wako Pure Chem Ind Ltd	１級アミノ基を有する化合物の蛍光標識化方法
JP3851706B2 (ja) *	1996-05-20	2006-11-29	日清紡績株式会社	蛍光性基含有カルボジイミド化合物
DE19816624A1 (de) *	1998-04-15	1999-10-21	Boehringer Ingelheim Pharma	Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6169106B1 (en)	1998-04-15	2001-01-02	Boehringer Ingelheim Pharma Kg	Indolinones having kinase inhibitory activity
HRP20010216A2 (en)	1998-09-25	2002-04-30	Boehringer Ingelheim Pharma	New substituted indolinones, their preparation and their use as medicaments
AU2002322775A1 (en)	2001-07-27	2003-02-17	The Regents Of The University Of California	Stk15 (stk6) gene polymorphism and methods of determining cancer risk
GB0124299D0 (en) *	2001-10-10	2001-11-28	Astrazeneca Ab	Crystal structure of enzyme and uses thereof
ATE407678T1 (de) *	2001-10-17	2008-09-15	Boehringer Ingelheim Pharma	Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung
US20040242613A1 (en) *	2003-01-30	2004-12-02	Boehringer Ingelheim Pharmaceuticals, Inc.	Pyrimidine derivatives useful as inhibitors of PKC-theta

2004
- 2004-09-30 CA CA2541059A patent/CA2541059C/en not_active Expired - Lifetime
- 2004-09-30 US US10/955,129 patent/US7125996B2/en not_active Expired - Lifetime
- 2004-09-30 EP EP04789404A patent/EP1670789B1/de not_active Expired - Lifetime
- 2004-09-30 DE DE602004017884T patent/DE602004017884D1/de not_active Expired - Lifetime
- 2004-09-30 WO PCT/US2004/032253 patent/WO2005033330A2/en not_active Ceased
- 2004-09-30 ES ES04789404T patent/ES2315713T3/es not_active Expired - Lifetime
- 2004-09-30 AT AT04789404T patent/ATE414701T1/de active
- 2004-09-30 JP JP2006534117A patent/JP4949845B2/ja not_active Expired - Lifetime
2006
- 2006-07-25 US US11/492,654 patent/US7588899B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US7125996B2 (en)	2006-10-24
JP4949845B2 (ja)	2012-06-13
EP1670789B1 (de)	2008-11-19
JP2007509845A (ja)	2007-04-19
WO2005033330A3 (en)	2005-07-28
US20050100978A1 (en)	2005-05-12
ATE414701T1 (de)	2008-12-15
WO2005033330A2 (en)	2005-04-14
DE602004017884D1 (de)	2009-01-02
CA2541059A1 (en)	2005-04-14
US20060263841A1 (en)	2006-11-23
EP1670789A2 (de)	2006-06-21
CA2541059C (en)	2013-09-17
US7588899B2 (en)	2009-09-15

Publication	Publication Date	Title
ES2315713T3 (es)	2009-04-01	Sondas fluorescentes para su utilizacion en un ensayo de union de inhibidores de quinasas de proteinas.
US9846168B2 (en)	2017-12-19	Fluorescent metal ion indicators with large stokes shifts
CN101983194B (zh)	2014-09-10	荧光团化合物
US8614294B2 (en)	2013-12-24	Pyrenyloxysulfonic acid fluorescent agents
US20050123935A1 (en)	2005-06-09	Pyrenyloxysulfonic acid fluorescent agents
JPS62174066A (ja)	1987-07-30	レゾルフイン誘導体並びにその製法
JP2012006935A (ja)	2012-01-12	蛍光タグ付きリガンド
US12570654B2 (en)	2026-03-10	Nanoluc suicide substrates
US20220206008A1 (en)	2022-06-30	Screening methods for parp modulators
JPS61227600A (ja)	1986-10-09	プロカインアミド検定、トレーサー、免疫原および抗体
CA2488819A1 (en)	2003-11-06	Bis-transition-metal-chelate-probes
CN103435625A (zh)	2013-12-11	红光发射罗丹明类离子荧光探针及其应用
CN121064228A (zh)	2025-12-05	一种基于NanoBRET筛选技术的CLKs能量转移探针及其制备方法和应用
WO2007057428A1 (en)	2007-05-24	Chromophore containing ligands for characterisation of receptors for binding and activation
WO2009156541A1 (es)	2009-12-30	Sensor fluorescente y su uso para la detección de inhibidores de kinasas dependientes de ciclinas y/o para la detección de ciclinas
Welsh et al.	2010	Antagonists of IAP-family anti-apoptotic proteins-Probe 1
BRPI0615615A2 (pt)	2012-04-17	composições farmacêuticas e tratamento de uma doença neoplástica ou distúrbio proliferativo em humanos à base de moduladores de theramutein