ES2374370B1 - Método para la detección de daño renal. - Google Patents
Método para la detección de daño renal. Download PDFInfo
- Publication number
- ES2374370B1 ES2374370B1 ES201031407A ES201031407A ES2374370B1 ES 2374370 B1 ES2374370 B1 ES 2374370B1 ES 201031407 A ES201031407 A ES 201031407A ES 201031407 A ES201031407 A ES 201031407A ES 2374370 B1 ES2374370 B1 ES 2374370B1
- Authority
- ES
- Spain
- Prior art keywords
- renal
- detection
- damage
- renal damage
- ribonuclease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000001514 detection method Methods 0.000 title abstract 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000003589 nefrotoxic effect Effects 0.000 abstract 2
- 231100000381 nephrotoxic Toxicity 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102100027962 2-5A-dependent ribonuclease Human genes 0.000 abstract 1
- 108010000834 2-5A-dependent ribonuclease Proteins 0.000 abstract 1
- 208000009304 Acute Kidney Injury Diseases 0.000 abstract 1
- 102100038910 Alpha-enolase Human genes 0.000 abstract 1
- 101710113777 Aminoacylase-1A Proteins 0.000 abstract 1
- 102100028879 COP9 signalosome complex subunit 8 Human genes 0.000 abstract 1
- 102000007437 Fetuin-B Human genes 0.000 abstract 1
- 108010086121 Fetuin-B Proteins 0.000 abstract 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 1
- 229930182566 Gentamicin Natural products 0.000 abstract 1
- 101000916502 Homo sapiens COP9 signalosome complex subunit 8 Proteins 0.000 abstract 1
- 102000005705 Keratin-5 Human genes 0.000 abstract 1
- 108010070553 Keratin-5 Proteins 0.000 abstract 1
- 102100031119 Parvalbumin alpha Human genes 0.000 abstract 1
- 101710180659 Parvalbumin alpha Proteins 0.000 abstract 1
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 abstract 1
- 101710094755 Ras-related GTP-binding protein A Proteins 0.000 abstract 1
- 102100031424 Ras-related protein Ral-A Human genes 0.000 abstract 1
- 208000033626 Renal failure acute Diseases 0.000 abstract 1
- 101710133826 Ribonuclease UK114 Proteins 0.000 abstract 1
- 201000011040 acute kidney failure Diseases 0.000 abstract 1
- 208000012998 acute renal failure Diseases 0.000 abstract 1
- 229940126574 aminoglycoside antibiotic Drugs 0.000 abstract 1
- 239000002647 aminoglycoside antibiotic agent Substances 0.000 abstract 1
- 229960002518 gentamicin Drugs 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 108010066490 ribonuclease 4 Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Método para la detección de daño renal.#La invención se refiere a un método para determinar la presencia de daño renal en un individuo así como un método para predecir la progresión de dicho daño renal por medio de la detección de Reg3B así como adicionalmente, por medio de la detección de una o varias proteínas que se seleccionan de la lista que comprende, fetuina B, Ras-related GTP-binding proteín A, inhibidor de la proteína serina A3L, subunidad 1 de COP9, subunidad gamma de la ATP sintasa, ribonucleasa UK114, aminoacilasa 1A, alfa-enolasa, queratina 5, parvalbúmina alfa, ribonucleasa 4 o inhibidor de la proteína serina A3K. El daño renal puede ser un fallo renal agudo. Dichas patologías renales pueden ser causadas por la administración de un agente nefrotóxico, donde el agente nefrotóxico puede ser un antibiótico aminoglucósido como por ejemplo la gentamicina.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201031407A ES2374370B1 (es) | 2010-08-04 | 2010-08-04 | Método para la detección de daño renal. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201031407A ES2374370B1 (es) | 2010-08-04 | 2010-08-04 | Método para la detección de daño renal. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2374370A1 ES2374370A1 (es) | 2012-02-16 |
| ES2374370B1 true ES2374370B1 (es) | 2013-01-08 |
Family
ID=45540589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201031407A Active ES2374370B1 (es) | 2010-08-04 | 2010-08-04 | Método para la detección de daño renal. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2374370B1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160039877A1 (en) | 2013-03-15 | 2016-02-11 | Shenzhen Hightide Biopharmaceutical, Ltd. | Compositions and methods of using islet neogenesis peptides and analogs thereof |
| CN116904586B (zh) * | 2023-09-12 | 2023-12-22 | 上海益诺思生物技术股份有限公司 | 一种检测血浆来源的外泌体lncRNA的试剂在制备检测肾损伤的诊断剂中的应用 |
-
2010
- 2010-08-04 ES ES201031407A patent/ES2374370B1/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2374370A1 (es) | 2012-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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