ES2400965T8 - Ensayo mejorado de activación de monocitos con mayor capacidad para detectar contaminantes pirogénicos no endotoxínicos en productos médicos - Google Patents
Ensayo mejorado de activación de monocitos con mayor capacidad para detectar contaminantes pirogénicos no endotoxínicos en productos médicos Download PDFInfo
- Publication number
- ES2400965T8 ES2400965T8 ES06846727T ES06846727T ES2400965T8 ES 2400965 T8 ES2400965 T8 ES 2400965T8 ES 06846727 T ES06846727 T ES 06846727T ES 06846727 T ES06846727 T ES 06846727T ES 2400965 T8 ES2400965 T8 ES 2400965T8
- Authority
- ES
- Spain
- Prior art keywords
- medical products
- activation assay
- greater ability
- detect non
- monocyte activation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000004913 activation Effects 0.000 title 1
- 238000003556 assay Methods 0.000 title 1
- 239000000356 contaminant Substances 0.000 title 1
- 239000002158 endotoxin Substances 0.000 title 1
- 229940127554 medical product Drugs 0.000 title 1
- 210000001616 monocyte Anatomy 0.000 title 1
- 230000001698 pyrogenic effect Effects 0.000 title 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5055—Cells of the immune system involving macrophages
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5412—IL-6
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7095—Inflammation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Physiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75297005P | 2005-12-22 | 2005-12-22 | |
| US752970P | 2005-12-22 | ||
| PCT/US2006/062424 WO2007076411A1 (en) | 2005-12-22 | 2006-12-20 | Improved monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2400965T3 ES2400965T3 (es) | 2013-04-15 |
| ES2400965T8 true ES2400965T8 (es) | 2013-06-04 |
Family
ID=37913652
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06846727T Active ES2400965T3 (es) | 2005-12-22 | 2006-12-20 | Ensayo mejorado de activación de monicitos con mayor capacidad para detectar contaminantes pirotécnicos no endotoxínicos en productos médicos |
| ES11003878.3T Active ES2477588T3 (es) | 2005-12-22 | 2006-12-20 | Ensayo de activación de monocitos perfeccionado capaz de detectar contaminantes pirogénicos no endotoxínicos en productos médicos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11003878.3T Active ES2477588T3 (es) | 2005-12-22 | 2006-12-20 | Ensayo de activación de monocitos perfeccionado capaz de detectar contaminantes pirogénicos no endotoxínicos en productos médicos |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7736863B2 (es) |
| EP (2) | EP1977252B1 (es) |
| JP (1) | JP4686611B2 (es) |
| KR (1) | KR101352222B1 (es) |
| CN (2) | CN103901208B (es) |
| AU (1) | AU2006330562B2 (es) |
| BR (1) | BRPI0620434A2 (es) |
| CA (1) | CA2633523A1 (es) |
| DK (2) | DK1977252T3 (es) |
| ES (2) | ES2400965T3 (es) |
| HK (1) | HK1199753A1 (es) |
| MX (1) | MX2008008138A (es) |
| PL (2) | PL2360479T3 (es) |
| PT (2) | PT2360479E (es) |
| SG (1) | SG179468A1 (es) |
| WO (1) | WO2007076411A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101352222B1 (ko) * | 2005-12-22 | 2014-02-04 | 백스터 인터내셔널 인코포레이티드 | 의료용 제품에서 비-내독소 발열성 오염물을 보다 잘검출할 수 있는 개선된 단핵구 활성화 시험 |
| DE102006031483B4 (de) * | 2006-07-07 | 2009-12-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Zellulärer Pyrogentest |
| JP4148367B1 (ja) * | 2007-08-02 | 2008-09-10 | 富山県 | 細胞のスクリーニング方法 |
| WO2009063307A2 (en) * | 2007-11-14 | 2009-05-22 | Bio-Technology General (Israel) Ltd. | Inflammatory activity detection method using il-6 |
| MX340916B (es) | 2008-01-18 | 2016-07-29 | President And Fellows Of Harvard College * | Metodos para detectar señales de identificacion de enfermedad o condiciones en fluidos corporales. |
| JP5438751B2 (ja) | 2008-03-20 | 2014-03-12 | バクスター・インターナショナル・インコーポレイテッド | 酵素消化による微生物生成物の破壊 |
| US20090239819A1 (en) * | 2008-03-20 | 2009-09-24 | Run Wang | Peritoneal dialysis solution test method |
| US20090239238A1 (en) * | 2008-03-20 | 2009-09-24 | Baxter International Inc. | Methods for measuring pro-inflammatory substance levels in dialysis solutions and dialysis components |
| EP3309556B1 (en) * | 2009-06-25 | 2020-04-08 | Prometheus Biosciences, Inc. | Methods for diagnosing irritable bowel syndrome |
| US20130203624A1 (en) | 2010-07-23 | 2013-08-08 | President And Fellows Of Harvard College | Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| SG194005A1 (en) | 2011-04-08 | 2013-11-29 | Roquette Freres | Methods for detecting contaminants in solutions containing glucose polymers |
| FR2978774B1 (fr) * | 2011-08-02 | 2015-02-20 | Roquette Freres | Methodes de detection des contaminants des circuits de production de polymeres de glucose |
| US20140295477A1 (en) * | 2011-09-01 | 2014-10-02 | Fresenius Medical Care Holdings, Inc | Kit For Sampling And Detection Of Endotoxin In Aqueous Solution |
| CA2845674C (en) | 2011-12-21 | 2018-01-16 | Grifols, S.A. | Identification of atypical antibodies in human blood and blood products |
| JP6244356B2 (ja) * | 2012-05-29 | 2017-12-06 | ロケット フレールＲｏｑｕｅｔｔｅ Ｆｒｅｒｅｓ | グルコースポリマーおよびグルコースポリマー加水分解物の製造回路の除染方法 |
| WO2014052593A1 (en) * | 2012-09-26 | 2014-04-03 | Cook Biotech Incorporated | Medical device design, manufacture and testing systems |
| EP3119813B1 (fr) | 2014-03-21 | 2023-01-04 | Roquette Frères | Procede optimise de decontamination de production de polymeres de glucose et d'hydrolysats de polymeres de glucose |
| BR112017020149A8 (pt) | 2015-03-27 | 2023-05-02 | Regeneron Pharma | Derivados de maitansinoide, conjugados dos mesmos e métodos de uso |
| FR3037063B1 (fr) | 2015-06-04 | 2017-05-19 | Roquette Freres | Procede optimise de decontamination de l'amidon utilise comme matiere premiere pour l'obtention de polymeres de glucose destines a la dialyse peritoneale |
| EP3171170A1 (en) * | 2015-11-17 | 2017-05-24 | Lionex GmbH | Device for use in elispot |
| ES3046537T3 (en) | 2016-11-08 | 2025-12-02 | Regeneron Pharma | Steroids and protein-conjugates thereof |
| WO2021100828A1 (ja) * | 2019-11-19 | 2021-05-27 | マイキャン・テクノロジーズ株式会社 | ヒト不死化ミエロイド系細胞を使用したｉｎ ｖｉｔｒｏにおける物質の安全性評価方法 |
| EP4006546A1 (en) * | 2020-11-30 | 2022-06-01 | Medizinische Hochschule Hannover | Application of stem-cell derived monocytes in a monocyte activation test (mat) for the assessment of pyrogenicity and inflammatory potential |
| CA3266655A1 (en) * | 2022-09-06 | 2024-03-14 | Mat Research B.V. | IMPROVED MONOCYTE ACTIVATION TEST |
| JPWO2024204725A1 (es) * | 2023-03-30 | 2024-10-03 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4434237A (en) | 1982-03-31 | 1984-02-28 | Dinarello Charles A | Human leukocytic pyrogen test for the detection of exogenous fever-producing substances |
| FR2615622B1 (fr) | 1987-05-19 | 1994-05-06 | Ire Medgenix Sa | Dosage plasmatique de monokines |
| US5281540A (en) | 1988-08-02 | 1994-01-25 | Abbott Laboratories | Test array for performing assays |
| FR2679659B1 (fr) | 1991-07-23 | 1993-11-19 | Medgenix Diagnostic Sa | Procede de dosage in vitro de molecules au niveau de leur site de production par des cellules en culture et format technologique adapte. |
| JPH07509783A (ja) | 1992-10-30 | 1995-10-26 | ティー セル ダイアグノスティックス，インコーポレーテッド | 試料中の全分子の測定及びそれに基づく方法 |
| FR2699283B1 (fr) | 1992-12-15 | 1995-03-03 | Medgenix Diagnostic | Test de pyrogénicite et kit de mise en Óoeuvre. |
| JPH09510437A (ja) | 1993-12-28 | 1997-10-21 | カイロン ミモトープス プロプライエトリー リミテッド | Ｔ細胞エピトープ |
| DE19516247A1 (de) * | 1995-05-03 | 1996-11-07 | Albrecht Prof Dr Wendel | Pyrogen-Untersuchungsverfahren |
| US5910287A (en) * | 1997-06-03 | 1999-06-08 | Aurora Biosciences Corporation | Low background multi-well plates with greater than 864 wells for fluorescence measurements of biological and biochemical samples |
| EP2295968B1 (en) * | 1999-12-03 | 2012-09-19 | Baxter International Inc. | Pyrogenicity test for use with automated immunoassay systems |
| CA2430868A1 (en) * | 2000-12-12 | 2002-06-20 | Australian Institute Of Marine Science | Assay for paralytic shellfish toxin |
| EP1474511B1 (en) * | 2002-02-12 | 2005-04-27 | Biotage AB | Separating method and an apparatus performing such a method |
| GB0207350D0 (en) * | 2002-03-28 | 2002-05-08 | Univ Sheffield | Surface |
| KR101352222B1 (ko) * | 2005-12-22 | 2014-02-04 | 백스터 인터내셔널 인코포레이티드 | 의료용 제품에서 비-내독소 발열성 오염물을 보다 잘검출할 수 있는 개선된 단핵구 활성화 시험 |
-
2006
- 2006-12-20 KR KR1020087017829A patent/KR101352222B1/ko active Active
- 2006-12-20 PT PT110038783T patent/PT2360479E/pt unknown
- 2006-12-20 PL PL11003878T patent/PL2360479T3/pl unknown
- 2006-12-20 US US11/613,866 patent/US7736863B2/en active Active
- 2006-12-20 EP EP06846727A patent/EP1977252B1/en active Active
- 2006-12-20 CN CN201310252724.0A patent/CN103901208B/zh not_active Expired - Fee Related
- 2006-12-20 CN CN2006800488729A patent/CN101346630B/zh not_active Expired - Fee Related
- 2006-12-20 DK DK06846727.3T patent/DK1977252T3/da active
- 2006-12-20 JP JP2008547757A patent/JP4686611B2/ja not_active Expired - Fee Related
- 2006-12-20 EP EP11003878.3A patent/EP2360479B1/en active Active
- 2006-12-20 AU AU2006330562A patent/AU2006330562B2/en not_active Ceased
- 2006-12-20 PT PT68467273T patent/PT1977252E/pt unknown
- 2006-12-20 WO PCT/US2006/062424 patent/WO2007076411A1/en not_active Ceased
- 2006-12-20 DK DK11003878.3T patent/DK2360479T3/da active
- 2006-12-20 CA CA002633523A patent/CA2633523A1/en not_active Abandoned
- 2006-12-20 MX MX2008008138A patent/MX2008008138A/es active IP Right Grant
- 2006-12-20 PL PL06846727T patent/PL1977252T3/pl unknown
- 2006-12-20 BR BRPI0620434-1A patent/BRPI0620434A2/pt not_active IP Right Cessation
- 2006-12-20 ES ES06846727T patent/ES2400965T3/es active Active
- 2006-12-20 SG SG2012017133A patent/SG179468A1/en unknown
- 2006-12-20 ES ES11003878.3T patent/ES2477588T3/es active Active
-
2010
- 2010-04-26 US US12/767,537 patent/US8053200B2/en active Active
- 2010-04-26 US US12/767,514 patent/US8058021B2/en active Active
-
2011
- 2011-11-10 US US13/293,868 patent/US9023647B2/en active Active
-
2015
- 2015-01-02 HK HK15100025.2A patent/HK1199753A1/xx unknown
- 2015-04-06 US US14/679,651 patent/US9671411B2/en active Active
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