ES2437157T3 - Proceso para preparar la forma I de atorvastatina hemicálcica - Google Patents

Proceso para preparar la forma I de atorvastatina hemicálcica Download PDF

Info

Publication number: ES2437157T3
Authority: ES; Spain
Prior art keywords: atorvastatin; degrees; peaks; theta; diffraction pattern
Prior art date: 2000-11-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES10151205.1T

Other languages

English (en)

Spanish (es)

Inventor

Judith Aronhime

Rami Lidor-Hadas

Valerie Niddam-Hildesheim

Revital Lifshitz-Liron

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Teva Pharmaceutical Industries Ltd

Original Assignee

Teva Pharmaceutical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-30

Filing date

2001-11-29

Publication date

2014-01-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27540285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2437157(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-11-29 Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd

2014-01-09 Application granted granted Critical

2014-01-09 Publication of ES2437157T3 publication Critical patent/ES2437157T3/es

2021-11-29 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

229960005370 atorvastatin Drugs 0.000 title claims abstract description 133
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title claims abstract description 132
XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title claims abstract description 131
238000004519 manufacturing process Methods 0.000 title claims abstract description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
238000000634 powder X-ray diffraction Methods 0.000 claims abstract description 29
230000005855 radiation Effects 0.000 claims abstract description 29
239000000725 suspension Substances 0.000 claims abstract description 28
229910016523 CuKa Inorganic materials 0.000 claims abstract description 18
239000000843 powder Substances 0.000 claims abstract description 7
238000002441 X-ray diffraction Methods 0.000 claims abstract description 5
238000000034 method Methods 0.000 claims description 23
230000008569 process Effects 0.000 claims description 17
239000000428 dust Substances 0.000 claims description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 86
239000007787 solid Substances 0.000 description 38
239000000203 mixture Substances 0.000 description 37
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 35
150000003839 salts Chemical class 0.000 description 25
238000001914 filtration Methods 0.000 description 18
238000010992 reflux Methods 0.000 description 18
239000003814 drug Substances 0.000 description 12
229940079593 drug Drugs 0.000 description 11
239000000126 substance Substances 0.000 description 11
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 10
239000011541 reaction mixture Substances 0.000 description 10
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
238000004458 analytical method Methods 0.000 description 9
239000000243 solution Substances 0.000 description 8
230000001154 acute effect Effects 0.000 description 7
210000004027 cell Anatomy 0.000 description 7
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 7
238000002360 preparation method Methods 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
108010007622 LDL Lipoproteins Proteins 0.000 description 6
102000007330 LDL Lipoproteins Human genes 0.000 description 6
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 description 6
239000002244 precipitate Substances 0.000 description 6
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 5
238000009835 boiling Methods 0.000 description 5
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 5
238000006243 chemical reaction Methods 0.000 description 5
235000012000 cholesterol Nutrition 0.000 description 5
229910052802 copper Inorganic materials 0.000 description 5
239000010949 copper Substances 0.000 description 5
238000006073 displacement reaction Methods 0.000 description 5
239000000463 material Substances 0.000 description 5
238000001144 powder X-ray diffraction data Methods 0.000 description 5
239000000523 sample Substances 0.000 description 5
229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 4
238000005481 NMR spectroscopy Methods 0.000 description 4
108010062497 VLDL Lipoproteins Proteins 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
239000011575 calcium Substances 0.000 description 4
238000001035 drying Methods 0.000 description 4
238000005259 measurement Methods 0.000 description 4
230000000704 physical effect Effects 0.000 description 4
238000001556 precipitation Methods 0.000 description 4
238000001228 spectrum Methods 0.000 description 4
239000007858 starting material Substances 0.000 description 4
102100029077 3-hydroxy-3-methylglutaryl-coenzyme A reductase Human genes 0.000 description 3
208000024172 Cardiovascular disease Diseases 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
108010046315 IDL Lipoproteins Proteins 0.000 description 3
125000001931 aliphatic group Chemical group 0.000 description 3
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
125000003118 aryl group Chemical group 0.000 description 3
238000000227 grinding Methods 0.000 description 3
238000004128 high performance liquid chromatography Methods 0.000 description 3
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
210000004185 liver Anatomy 0.000 description 3
239000002245 particle Substances 0.000 description 3
230000009467 reduction Effects 0.000 description 3
238000005549 size reduction Methods 0.000 description 3
239000002904 solvent Substances 0.000 description 3
238000000341 synchrotron X-ray powder diffraction Methods 0.000 description 3
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
SWFBJYRYCRZMSB-KAYWLYCHSA-N Defluoroatorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 SWFBJYRYCRZMSB-KAYWLYCHSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
102000000853 LDL receptors Human genes 0.000 description 2
108010001831 LDL receptors Proteins 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
239000002253 acid Substances 0.000 description 2
239000012296 anti-solvent Substances 0.000 description 2
-1 atorvastatin trihydrate Chemical class 0.000 description 2
BWFCZHDTTAYGNN-CNZCJKERSA-N calcium;(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid Chemical compound [Ca].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 BWFCZHDTTAYGNN-CNZCJKERSA-N 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
238000011109 contamination Methods 0.000 description 2
238000011161 development Methods 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
239000011521 glass Substances 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
230000006872 improvement Effects 0.000 description 2
150000002596 lactones Chemical class 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000002093 peripheral effect Effects 0.000 description 2
238000000746 purification Methods 0.000 description 2
239000012453 solvate Substances 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
XUKUURHRXDUEBC-SVBPBHIXSA-N (3s,5s)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@H](O)C[C@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-SVBPBHIXSA-N 0.000 description 1
KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 description 1
238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
101710158485 3-hydroxy-3-methylglutaryl-coenzyme A reductase Proteins 0.000 description 1
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
208000035150 Hypercholesterolemia Diseases 0.000 description 1
RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 1
229930182558 Sterol Natural products 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
210000001789 adipocyte Anatomy 0.000 description 1
230000002411 adverse Effects 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
SHZPNDRIDUBNMH-NIJVSVLQSA-L atorvastatin calcium trihydrate Chemical compound O.O.O.[Ca+2].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1.C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 SHZPNDRIDUBNMH-NIJVSVLQSA-L 0.000 description 1
238000010533 azeotropic distillation Methods 0.000 description 1
230000017531 blood circulation Effects 0.000 description 1
239000012267 brine Substances 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
235000011148 calcium chloride Nutrition 0.000 description 1
229910001424 calcium ion Inorganic materials 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000001944 continuous distillation Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000013256 coordination polymer Substances 0.000 description 1
238000005384 cross polarization magic-angle spinning Methods 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
238000010908 decantation Methods 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
238000013461 design Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
238000004821 distillation Methods 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
125000001207 fluorophenyl group Chemical group 0.000 description 1
238000009472 formulation Methods 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
230000009878 intermolecular interaction Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
230000003902 lesion Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
229940002661 lipitor Drugs 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 1
238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
238000003825 pressing Methods 0.000 description 1
239000000047 product Substances 0.000 description 1
239000010453 quartz Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
229960002855 simvastatin Drugs 0.000 description 1
159000000000 sodium salts Chemical group 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
238000003756 stirring Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
238000010408 sweeping Methods 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
230000017105 transposition Effects 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pyrrole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES10151205.1T 2000-11-30 2001-11-29 Proceso para preparar la forma I de atorvastatina hemicálcica Expired - Lifetime ES2437157T3 (es)

Applications Claiming Priority (10)

Application Number	Priority Date	Filing Date
US25007200P	2000-11-30	2000-11-30
US250072P		2000-11-30
US26789701P	2001-02-09	2001-02-09
US267897P		2001-02-09
US28187201P	2001-04-05	2001-04-05
US281872P		2001-04-05
US31214401P	2001-08-13	2001-08-13
US312144P		2001-08-13
US32652901P	2001-10-01	2001-10-01
US326529P		2001-10-01

Publications (1)

Publication Number	Publication Date
ES2437157T3 true ES2437157T3 (es)	2014-01-09

Family

ID=27540285

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES10151205.1T Expired - Lifetime ES2437157T3 (es)	2000-11-30	2001-11-29	Proceso para preparar la forma I de atorvastatina hemicálcica
ES01998348T Pending ES2215495T1 (es)	2000-11-30	2001-11-29	Nuevas formas cristalinas del atorvastatin hemi-calcico y procedimientos para su preparacion asi como nuevos procedimientos para la preparacion de otras formas.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES01998348T Pending ES2215495T1 (es)	2000-11-30	2001-11-29	Nuevas formas cristalinas del atorvastatin hemi-calcico y procedimientos para su preparacion asi como nuevos procedimientos para la preparacion de otras formas.

Country Status (23)

Country	Link
US (15)	US20020183378A1 (2)
EP (5)	EP1783113A3 (2)
JP (2)	JP2004514694A (2)
KR (1)	KR100765871B1 (2)
CN (1)	CN1489463A (2)
AU (1)	AU2002217927A1 (2)
BG (1)	BG107856A (2)
BR (1)	BR0115892A (2)
CA (3)	CA2625277A1 (2)
CZ (1)	CZ20031766A3 (2)
DE (1)	DE01998348T1 (2)
ES (2)	ES2437157T3 (2)
HR (2)	HRP20130545A2 (2)
HU (1)	HUP0600538A3 (2)
IL (2)	IL156055A0 (2)
IS (1)	IS6829A (2)
MX (1)	MXPA03004844A (2)
NO (1)	NO20032425L (2)
PL (1)	PL363228A1 (2)
SK (1)	SK8062003A3 (2)
TR (1)	TR200400815T3 (2)
WO (1)	WO2002043732A1 (2)
YU (1)	YU42803A (2)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE36268E (en) *	1988-03-15	1999-08-17	Boehringer Mannheim Corporation	Method and apparatus for amperometric diagnostic analysis
US7411075B1 (en)	2000-11-16	2008-08-12	Teva Pharmaceutical Industries Ltd.	Polymorphic form of atorvastatin calcium
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US20070032665A1 (en) *	2005-08-04	2007-02-08	Srinivasulu Gudipati	Preparation of atorvastatin calcium form i

2001
- 2001-10-29 IL IL15605501A patent/IL156055A0/xx unknown
- 2001-11-29 CA CA002625277A patent/CA2625277A1/en not_active Abandoned
- 2001-11-29 CA CA2689915A patent/CA2689915A1/en not_active Abandoned
- 2001-11-29 WO PCT/US2001/044636 patent/WO2002043732A1/en not_active Ceased
- 2001-11-29 EP EP06024449A patent/EP1783113A3/en not_active Ceased
- 2001-11-29 SK SK806-2003A patent/SK8062003A3/sk unknown
- 2001-11-29 AU AU2002217927A patent/AU2002217927A1/en not_active Abandoned
- 2001-11-29 HR HRP20130545AA patent/HRP20130545A2/hr not_active Application Discontinuation
- 2001-11-29 ES ES10151205.1T patent/ES2437157T3/es not_active Expired - Lifetime
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- 2001-11-29 MX MXPA03004844A patent/MXPA03004844A/es active IP Right Grant
- 2001-11-29 TR TR2004/00815T patent/TR200400815T3/xx unknown
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- 2001-11-29 HU HU0600538A patent/HUP0600538A3/hu unknown
- 2001-11-29 CZ CZ20031766A patent/CZ20031766A3/cs unknown
- 2001-11-29 JP JP2002545702A patent/JP2004514694A/ja active Pending
- 2001-11-29 EP EP10151206A patent/EP2194041A1/en not_active Withdrawn
- 2001-11-29 DE DE0001363621T patent/DE01998348T1/de active Pending
- 2001-11-29 ES ES01998348T patent/ES2215495T1/es active Pending
- 2001-11-29 CA CA002429590A patent/CA2429590C/en not_active Expired - Fee Related
- 2001-11-29 EP EP01998348A patent/EP1363621A4/en not_active Ceased
- 2001-11-29 YU YU42803A patent/YU42803A/sh unknown
- 2001-11-29 PL PL01363228A patent/PL363228A1/xx not_active Application Discontinuation
- 2001-11-29 KR KR1020037007298A patent/KR100765871B1/ko not_active Expired - Fee Related
- 2001-11-29 CN CNA018223400A patent/CN1489463A/zh active Pending
- 2001-11-29 EP EP10152443A patent/EP2192113A1/en not_active Withdrawn
- 2001-11-29 US US09/997,126 patent/US20020183378A1/en not_active Abandoned
- 2001-11-29 HR HR20030523A patent/HRP20030523A2/hr not_active Application Discontinuation
2003
- 2003-05-21 IL IL156055A patent/IL156055A/en not_active IP Right Cessation
- 2003-05-27 IS IS6829A patent/IS6829A/is unknown
- 2003-05-28 NO NO20032425A patent/NO20032425L/no not_active Application Discontinuation
- 2003-05-29 BG BG107856A patent/BG107856A/xx unknown
2004
- 2004-07-28 US US10/901,845 patent/US6992194B2/en not_active Expired - Fee Related
- 2004-11-19 US US10/994,142 patent/US7144916B2/en not_active Expired - Fee Related
2005
- 2005-07-29 US US11/193,089 patent/US7256212B2/en not_active Expired - Fee Related
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- 2005-07-29 US US11/192,707 patent/US7151183B2/en not_active Expired - Fee Related
- 2005-07-29 US US11/192,674 patent/US7456297B2/en not_active Expired - Fee Related
- 2005-07-29 US US11/192,672 patent/US7161012B2/en not_active Expired - Fee Related
- 2005-10-24 US US11/257,808 patent/US20060106231A1/en not_active Abandoned
- 2005-10-24 US US11/257,886 patent/US20060100267A1/en not_active Abandoned
- 2005-10-24 US US11/257,979 patent/US7468444B2/en not_active Expired - Fee Related
- 2005-10-24 US US11/257,821 patent/US7342120B2/en not_active Expired - Fee Related
- 2005-10-24 US US11/257,828 patent/US7488750B2/en not_active Expired - Fee Related
- 2005-10-24 US US11/257,815 patent/US20060106232A1/en not_active Abandoned
2007
- 2007-10-23 US US11/977,387 patent/US20080214650A1/en not_active Abandoned
2009
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Also Published As

Publication number	Publication date
JP2009120624A (ja)	2009-06-04
US20060106231A1 (en)	2006-05-18
KR100765871B1 (ko)	2007-10-11
JP2004514694A (ja)	2004-05-20
US20050004206A1 (en)	2005-01-06
CA2429590C (en)	2008-06-10
BG107856A (en)	2004-11-30
CA2689915A1 (en)	2002-06-06
AU2002217927A1 (en)	2002-06-11
US20050267198A1 (en)	2005-12-01
US20060106232A1 (en)	2006-05-18
NO20032425L (no)	2003-07-25
EP2194041A1 (en)	2010-06-09
US20080214650A1 (en)	2008-09-04
HUP0600538A2 (en)	2006-09-28
EP1363621A4 (en)	2005-12-28
US20020183378A1 (en)	2002-12-05
US7144916B2 (en)	2006-12-05
US20060100267A1 (en)	2006-05-11
EP2192113A1 (en)	2010-06-02
US7488750B2 (en)	2009-02-10
HRP20130545A2 (hr)	2013-11-08
US7468444B2 (en)	2008-12-23
WO2002043732A1 (en)	2002-06-06
US7456297B2 (en)	2008-11-25
EP2192112A1 (en)	2010-06-02
DE01998348T1 (de)	2004-08-26
CA2429590A1 (en)	2002-06-06
US20060058533A1 (en)	2006-03-16
EP1783113A2 (en)	2007-05-09
US6992194B2 (en)	2006-01-31
US20050261361A1 (en)	2005-11-24
EP2192112B1 (en)	2013-08-28
CN1489463A (zh)	2004-04-14
US7161012B2 (en)	2007-01-09
HUP0600538A3 (en)	2010-09-28
US7342120B2 (en)	2008-03-11
PL363228A1 (en)	2004-11-15
US20060100445A1 (en)	2006-05-11
EP1363621A1 (en)	2003-11-26
EP1783113A3 (en)	2007-05-30
ES2215495T1 (es)	2004-10-16
US20050090542A1 (en)	2005-04-28
MXPA03004844A (es)	2005-04-19
BR0115892A (pt)	2003-10-28
US20050261360A1 (en)	2005-11-24
US20050282885A1 (en)	2005-12-22
US7256212B2 (en)	2007-08-14
US20050261359A1 (en)	2005-11-24
US7189861B2 (en)	2007-03-13
CA2625277A1 (en)	2002-06-06
TR200400815T3 (tr)	2004-07-21
IL156055A (en)	2010-12-30
IL156055A0 (en)	2003-12-23
CZ20031766A3 (cs)	2004-08-18
US7151183B2 (en)	2006-12-19
US20060100446A1 (en)	2006-05-11
NO20032425D0 (no)	2003-05-28
SK8062003A3 (en)	2004-07-07
YU42803A (sh)	2006-05-25
IS6829A (is)	2003-05-27
KR20030059297A (ko)	2003-07-07
HRP20030523A2 (en)	2005-06-30

Publication	Publication Date	Title
ES2437157T3 (es)	2014-01-09	Proceso para preparar la forma I de atorvastatina hemicálcica
US20090143459A1 (en)	2009-06-04	Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
EP1562583A1 (en)	2005-08-17	Atorvastatin calcium form vi or hydrates thereof
WO2007133597A1 (en)	2007-11-22	Crystalline form of atorvastatin calcium stable after storage
US20060020137A1 (en)	2006-01-26	Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
AU2007205725A1 (en)	2007-08-30	Novel cyrstal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
MX2008000375A (en)	2008-10-03	Crystalline form of atorvastatin calcium stable after storage
ZA200303976B (en)	2004-11-22	Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms.
LT5196B (lt)	2005-02-25	Naujos atorvastatino pusiau kalcio kristalinės formos ir jų gavimo būdai, taip pat ir nauji kitų formų gavimo būdai