ES2449445T3 - Dispositivos, sistemas y métodos mejorados para el tratamiento de muestras - Google Patents

Dispositivos, sistemas y métodos mejorados para el tratamiento de muestras Download PDF

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Publication number: ES2449445T3
Authority: ES; Spain
Prior art keywords: processing; thermal; processing chamber; processing chambers; electromagnetic energy
Prior art date: 2000-06-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES10185066T

Other languages

English (en)

Spanish (es)

Inventor

William Bedingham

Barry W. Robole

Raj Rajagopal

Kannan Seshadri

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

3M Innovative Properties Co

Original Assignee

3M Innovative Properties Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-28

Filing date

2001-06-28

Publication date

2014-03-19

2001-06-28 Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co

2014-03-19 Application granted granted Critical

2014-03-19 Publication of ES2449445T3 publication Critical patent/ES2449445T3/es

2021-06-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

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- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0874—Three dimensional network
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1861—Means for temperature control using radiation
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0661—Valves, specific forms thereof with moving parts shape memory polymer valves
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F27—FURNACES; KILNS; OVENS; RETORTS
- F27B—FURNACES, KILNS, OVENS OR RETORTS IN GENERAL; OPEN SINTERING OR LIKE APPARATUS
- F27B9/00—Furnaces through which the charge is moved mechanically, e.g. of tunnel type; Similar furnaces in which the charge moves by gravity
- F27B9/14—Furnaces through which the charge is moved mechanically, e.g. of tunnel type; Similar furnaces in which the charge moves by gravity characterised by the path of the charge during treatment; characterised by the means by which the charge is moved during treatment
- F27B9/16—Furnaces through which the charge is moved mechanically, e.g. of tunnel type; Similar furnaces in which the charge moves by gravity characterised by the path of the charge during treatment; characterised by the means by which the charge is moved during treatment the charge moving in a circular or arcuate path
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F27—FURNACES; KILNS; OVENS; RETORTS
- F27D—DETAILS OR ACCESSORIES OF FURNACES, KILNS, OVENS OR RETORTS, IN SO FAR AS THEY ARE OF KINDS OCCURRING IN MORE THAN ONE KIND OF FURNACE
- F27D5/00—Supports, screens or the like for the charge within the furnace

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Clinical Laboratory Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Dispersion Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Pathology (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Centrifugal Separators (AREA)
Manufacturing Of Magnetic Record Carriers (AREA)
Physical Or Chemical Processes And Apparatus (AREA)

ES10185066T 2000-06-28 2001-06-28 Dispositivos, sistemas y métodos mejorados para el tratamiento de muestras Expired - Lifetime ES2449445T3 (es)

Applications Claiming Priority (10)

Application Number	Priority Date	Filing Date
US21464200P	2000-06-28	2000-06-28
US21450800P	2000-06-28	2000-06-28
US214508P		2000-06-28
US23705100P	2000-10-02	2000-10-02
US237051P		2000-10-02
US26006301P	2001-01-06	2001-01-06
US260063P		2001-01-06
US28463701P	2001-04-18	2001-04-18
US284637P		2001-04-18
US214642P		2009-04-25

Publications (1)

Publication Number	Publication Date
ES2449445T3 true ES2449445T3 (es)	2014-03-19

Family

ID=27539684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES10185066T Expired - Lifetime ES2449445T3 (es)	2000-06-28	2001-06-28	Dispositivos, sistemas y métodos mejorados para el tratamiento de muestras

Country Status (5)

Country	Link
EP (4)	EP1296764B1 (fr)
AU (2)	AU2001270248B2 (fr)
CA (1)	CA2412275C (fr)
ES (1)	ES2449445T3 (fr)
WO (1)	WO2002000347A2 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0004296D0 (sv)	2000-11-23	2000-11-23	Gyros Ab	Device and method for the controlled heating in micro channel systems
KR100450818B1 (ko) *	2002-03-09	2004-10-01	삼성전자주식회사	다챔버 ｐｃｒ 칩
US7083974B2 (en) *	2002-07-12	2006-08-01	Applera Corporation	Rotatable sample disk and method of loading a sample disk
US7169602B2 (en)	2002-12-04	2007-01-30	Applera Corporation	Sample substrate for use in biological testing and method for filling a sample substrate
US8641987B2 (en)	2003-01-24	2014-02-04	Applied Biosystems, Llc	Sample chamber array and method for processing a biological sample
US7332348B2 (en)	2003-02-28	2008-02-19	Applera Corporation	Sample substrate having a divided sample chamber and method of loading thereof
US20040258563A1 (en)	2003-06-23	2004-12-23	Applera Corporation	Caps for sample wells and microcards for biological materials
US7238269B2 (en)	2003-07-01	2007-07-03	3M Innovative Properties Company	Sample processing device with unvented channel
US7718133B2 (en)	2003-10-09	2010-05-18	3M Innovative Properties Company	Multilayer processing devices and methods
EP1535665A1 (fr)	2003-11-28	2005-06-01	STMicroelectronics S.r.l.	Microréacteur chimique integré, avec des canaux séparés pour l'isolation de fluides et procédé de sa fabrication
US20050130177A1 (en) *	2003-12-12	2005-06-16	3M Innovative Properties Company	Variable valve apparatus and methods
EP2172445A1 (fr)	2004-03-17	2010-04-07	Hikal Limited	Cis (Z) 4-t-butylgabapentine et sa synthèse
US7632864B2 (en)	2004-03-17	2009-12-15	Hikal Ltd.	Gabapentin analogues and process thereof
BRPI0606316A2 (pt)	2005-01-20	2017-06-27	3M Innovative Properties Co	método para formar uma película polimérica estruturada, e , artigo de processamento de amostra
KR100818274B1 (ko) *	2006-09-05	2008-04-01	삼성전자주식회사	미세유동 시스템 제어장치 및 그 방법, 및 미세유동 시스템
KR101335726B1 (ko)	2007-06-04	2013-12-04	삼성전자주식회사	면역혈청 검사 및 생화학 검사를 동시에 수행하는 디스크형미세유동장치
JP4739301B2 (ja)	2007-09-12	2011-08-03	信越化学工業株式会社	金属光沢を示す金属−セラミック複合材料の製造方法
CN102046807B (zh)	2008-04-24	2014-11-26	3M创新有限公司	利用小波变换分析核酸扩增曲线
BRPI0918358A2 (pt)	2008-12-19	2015-12-15	3M Innovative Properties Co	sistema e método para a concentração de amostras
BRPI0918357A2 (pt)	2008-12-19	2016-07-26	3M Innovative Properties Co	sistema e método para processamento de amostras
US8834792B2 (en)	2009-11-13	2014-09-16	3M Innovative Properties Company	Systems for processing sample processing devices
FR2955268B1 (fr) *	2010-01-20	2019-06-28	Apex Biosolutions	Dispositif de repartition, notamment pour un echantillon biologique
US9168523B2 (en)	2011-05-18	2015-10-27	3M Innovative Properties Company	Systems and methods for detecting the presence of a selected volume of material in a sample processing device
CN103501908B (zh)	2011-05-18	2016-03-16	3M创新有限公司	用于样品处理装置上阀调的系统和方法
AU2012255144B2 (en)	2011-05-18	2015-01-29	Diasorin Italia S.P.A.	Systems and methods for volumetric metering on a sample processing device
JP2014518394A (ja)	2011-06-30	2014-07-28	スリーエムイノベイティブプロパティズカンパニー	微細構造化表面を使用して、サンプル内の目的の検体を検出するためのシステム及び方法
CN103620373B (zh)	2011-06-30	2017-07-07	3M创新有限公司	利用过滤器和微结构化表面检测样品中所关注分析物的方法
WO2017019768A1 (fr)	2015-07-30	2017-02-02	The Regents Of The University Of California	Pcr au moyen d'une cavité optique
CN110291396B (zh) *	2016-10-07	2021-02-26	刘新宇	用于自主免疫测定的微流体分析平台
CA3099740A1 (fr) *	2018-05-14	2019-11-21	Microbedx Inc.	Systeme microfluidique portatif pour test biologique et analytique
EP3996846A4 (fr)	2019-07-09	2023-10-18	Kryptos Biotechnologies, Inc.	Réseau de récipients à réaction microfluidique à films à motifs
EP3763438A1 (fr) *	2019-07-12	2021-01-13	Curiosity Diagnostics sp. z o.o	Puce microfluidique, procédé de production et utilisations
JP2026510952A (ja) *	2023-03-21	2026-04-10	オートノマスメディカルデバイシーズインコーポレイテッド	サンプル分析のための回転可能ディスクおよびシステムおよび方法
USD1069156S1 (en)	2023-04-10	2025-04-01	Becton, Dickinson And Company	Dispensing device

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1097442B (it) *	1977-08-18	1985-08-31	Guigan Jean	Dispositivo di condizionamento di un campione di liquido in preparazione della sua analisi
DE3712624A1 (de) *	1987-04-14	1988-11-03	Holzer Walter	Kleinzentrifuge
US5173262A (en) *	1987-07-17	1992-12-22	Martin Marietta Energy Systems, Inc.	Rotor assembly and method for automatically processing liquids
JP2502132B2 (ja)	1988-09-30	1996-05-29	三菱重工業株式会社	形状記憶ポリウレタンエラストマ―成形体
JPH0739506B2 (ja)	1988-09-30	1995-05-01	三菱重工業株式会社	形状記憶ポリマー発泡体
JPH066342B2 (ja)	1988-10-14	1994-01-26	三菱重工業株式会社	形状記憶性フィルム及びその使用法
US5135786A (en)	1988-10-14	1992-08-04	Mitsubishi Jukogyo Kabushiki Kaisha	Shape memory Transparent body and method of using the same
JPH0723572B2 (ja)	1988-10-17	1995-03-15	三菱重工業株式会社	形状記憶性ポリマーによる織布
CA2011740A1 (fr)	1989-04-07	1990-10-07	Glen Connell	Materiaux pouvant etre chauffes par hyperfrequences
KR100236506B1 (ko) *	1990-11-29	2000-01-15	퍼킨-엘머시터스인스트루먼츠	폴리머라제 연쇄 반응 수행 장치
AU656556B2 (en)	1991-03-13	1995-02-09	Minnesota Mining And Manufacturing Company	Radio frequency induction heatable compositions
US5278377A (en)	1991-11-27	1994-01-11	Minnesota Mining And Manufacturing Company	Electromagnetic radiation susceptor material employing ferromagnetic amorphous alloy particles
US5882774A (en)	1993-12-21	1999-03-16	Minnesota Mining And Manufacturing Company	Optical film
US6101032A (en)	1994-04-06	2000-08-08	3M Innovative Properties Company	Light fixture having a multilayer polymeric film
US5639428A (en) *	1994-07-19	1997-06-17	Becton Dickinson And Company	Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US5585069A (en) *	1994-11-10	1996-12-17	David Sarnoff Research Center, Inc.	Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
CN1098772C (zh)	1995-03-29	2003-01-15	美国3M公司	吸收电磁波的复合材料
AU702403B2 (en) *	1995-12-05	1999-02-18	Gamera Bioscience	Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US20010055812A1 (en)	1995-12-05	2001-12-27	Alec Mian	Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US5721123A (en)	1996-01-05	1998-02-24	Microfab Technology, Inc.	Methods and apparatus for direct heating of biological material
US5863502A (en) *	1996-01-24	1999-01-26	Sarnoff Corporation	Parallel reaction cassette and associated devices
FR2744803B1 (fr) *	1996-02-12	1998-03-13	Bio Merieux	Procede et dispositif de traitement d'une carte d'analyse
ES2253778T3 (es) *	1996-06-04	2006-06-01	University Of Utah Research Foundation	Sistema y metodos de monitorizacion de una amplificacion de adn mediante fluorescencia.
WO1998053311A2 (fr) *	1997-05-23	1998-11-26	Gamera Bioscience Corporation	Dispositifs et procedes permettant d'utiliser l'acceleration centripete pour commander le deplacement de fluides sur un systeme microfluidique
EP1004015B1 (fr)	1997-08-15	2004-01-02	Alexion Pharmaceuticals, Inc.	Dispositif permettant de realiser des dosages au niveau de sites reactionnels
US6157490A (en)	1998-01-13	2000-12-05	3M Innovative Properties Company	Optical film with sharpened bandedge
US6207260B1 (en)	1998-01-13	2001-03-27	3M Innovative Properties Company	Multicomponent optical body
US6179948B1 (en)	1998-01-13	2001-01-30	3M Innovative Properties Company	Optical film and process for manufacture thereof
KR100601228B1 (ko)	1998-01-13	2006-07-19	미네소타 마이닝 앤드 매뉴팩춰링 캄파니	다층 광학 필름의 제조 방법
US6531230B1 (en)	1998-01-13	2003-03-11	3M Innovative Properties Company	Color shifting film
DE19858443A1 (de) *	1998-12-17	2000-07-06	Inst Mikrotechnik Mainz Gmbh	Verfahren zum Abgeben eines Fluids, fluidisches Bauteil sowie Vorrichtung zur Handhabung solcher Bauteile
US6414136B1 (en)	1999-10-06	2002-07-02	Prolinx, Inc.	Removal of dye-labeled dideoxy terminators from DNA sequencing reactions

2001
- 2001-06-28 CA CA002412275A patent/CA2412275C/fr not_active Expired - Lifetime
- 2001-06-28 EP EP01948818A patent/EP1296764B1/fr not_active Expired - Lifetime
- 2001-06-28 WO PCT/US2001/020707 patent/WO2002000347A2/fr not_active Ceased
- 2001-06-28 AU AU2001270248A patent/AU2001270248B2/en not_active Expired
- 2001-06-28 EP EP10185070A patent/EP2316569A1/fr not_active Withdrawn
- 2001-06-28 EP EP10185063.4A patent/EP2295141B1/fr not_active Expired - Lifetime
- 2001-06-28 AU AU7024801A patent/AU7024801A/xx active Pending
- 2001-06-28 EP EP10185066.7A patent/EP2388074B1/fr not_active Expired - Lifetime
- 2001-06-28 ES ES10185066T patent/ES2449445T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU2001270248B2 (en)	2006-10-05
AU7024801A (en)	2002-01-08
EP2295141A1 (fr)	2011-03-16
CA2412275C (fr)	2009-12-08
EP1296764A2 (fr)	2003-04-02
EP2316569A1 (fr)	2011-05-04
WO2002000347A3 (fr)	2002-10-10
EP1296764B1 (fr)	2012-08-01
EP2388074A1 (fr)	2011-11-23
CA2412275A1 (fr)	2002-01-03
WO2002000347A2 (fr)	2002-01-03
EP2295141B1 (fr)	2014-10-29
EP2388074B1 (fr)	2013-12-11

Publication	Publication Date	Title
ES2449445T3 (es)	2014-03-19	Dispositivos, sistemas y métodos mejorados para el tratamiento de muestras
US6734401B2 (en)	2004-05-11	Enhanced sample processing devices, systems and methods
EP2107944B1 (fr)	2013-03-27	Dispositifs, systèmes et procédés de traitement d'échantillons améliorés
AU2001270248A1 (en)	2002-03-28	Sample processing devices, systems and methods
ES2653916T3 (es)	2018-02-09	Dispositivo centrípeto fluídico
US6720187B2 (en)	2004-04-13	Multi-format sample processing devices
ES2753136T3 (es)	2020-04-07	Métodos de transferencia térmica para sistemas microfluídicos
ES2755078T3 (es)	2020-04-21	Sistemas y métodos para medición volumétrica en un dispositivo de procesamiento de muestra
JP4773035B2 (ja)	2011-09-14	強化サンプル処理装置、システムおよび方法
WO2009085884A1 (fr)	2009-07-09	Dispositif de traitement d'échantillon muni d'éléments optiques
CA2680676A1 (fr)	2002-01-03	Dispositifs, systemes et procede ameliores de traitement d'echantillons