ES2477584T3 - Esterificación de aceite marino catalizada por lipasa - Google Patents

Esterificación de aceite marino catalizada por lipasa Download PDF

Info

Publication number
ES2477584T3
ES2477584T3 ES03776079.0T ES03776079T ES2477584T3 ES 2477584 T3 ES2477584 T3 ES 2477584T3 ES 03776079 T ES03776079 T ES 03776079T ES 2477584 T3 ES2477584 T3 ES 2477584T3
Authority
ES
Spain
Prior art keywords
lipase
esterification
marine oil
free fatty
oil catalyzed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03776079.0T
Other languages
English (en)
Inventor
Gudmundur G. Haraldsson
Arnar Halldorsson
Olav Thorstad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pronova Biopharma Norge AS
Original Assignee
Pronova Biopharma Norge AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pronova Biopharma Norge AS filed Critical Pronova Biopharma Norge AS
Application granted granted Critical
Publication of ES2477584T3 publication Critical patent/ES2477584T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
    • C11C3/10—Ester interchange
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/12—Refining fats or fatty oils by distillation
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B7/00—Separation of mixtures of fats or fatty oils into their constituents, e.g. saturated oils from unsaturated oils
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/02—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
    • C11C1/025—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by saponification and release of fatty acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/003—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento para separar una fracción de ester etilico o metilico enriquecida en EPA (acido eicosapentanoico, C20:5) y una fracción de acidos grasos libres enriquecida en DHA (acido docosahexanoico, C22:6), que comprende las etapas de una esterificacion directa de acidos grasos libres de aceite de pescado con etanol o metanol en presencia de una lipasa, y separar las fracciones mediante destilacion molecular.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8
imagen9
imagen10

Claims (1)

  1. imagen1
ES03776079.0T 2002-11-14 2003-10-31 Esterificación de aceite marino catalizada por lipasa Expired - Lifetime ES2477584T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20025456A NO319194B1 (no) 2002-11-14 2002-11-14 Lipase-katalysert forestringsfremgangsmate av marine oljer
NO20025456 2002-11-14
PCT/NO2003/000364 WO2004043894A1 (en) 2002-11-14 2003-10-31 Lipase-catalysed esterification of marine oil

Publications (1)

Publication Number Publication Date
ES2477584T3 true ES2477584T3 (es) 2014-07-17

Family

ID=19914177

Family Applications (2)

Application Number Title Priority Date Filing Date
ES13153895T Expired - Lifetime ES2702273T3 (es) 2002-11-14 2003-10-31 Esterificación catalizada por lipasa de aceite marino
ES03776079.0T Expired - Lifetime ES2477584T3 (es) 2002-11-14 2003-10-31 Esterificación de aceite marino catalizada por lipasa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES13153895T Expired - Lifetime ES2702273T3 (es) 2002-11-14 2003-10-31 Esterificación catalizada por lipasa de aceite marino

Country Status (10)

Country Link
US (1) US7491522B2 (es)
EP (2) EP1560803B1 (es)
JP (1) JP2006506483A (es)
CN (1) CN100338010C (es)
AU (1) AU2003283872A1 (es)
CA (1) CA2506537C (es)
DK (2) DK2602308T3 (es)
ES (2) ES2702273T3 (es)
NO (1) NO319194B1 (es)
WO (1) WO2004043894A1 (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0202188D0 (sv) * 2002-07-11 2002-07-11 Pronova Biocare As A process for decreasing environmental pollutants in an oil or a fat, a volatile fat or oil environmental pollutants decreasing working fluid, a health supplement, and an animal feed product
EP2295529B2 (en) * 2002-07-11 2022-05-18 Basf As Use of a volatile environmental pollutants-decreasing working fluid for decreasing the amount of pollutants in a fat for alimentary or cosmetic use
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
JP5337479B2 (ja) 2005-05-04 2013-11-06 プロノヴァ・バイオファーマ・ノルゲ・アーエス 新規化合物
CN101356258B (zh) * 2005-05-23 2015-08-12 天然营养发展公司 通过与甘油的酶促反应浓缩脂肪酸烷基酯
EP1915443A4 (en) 2005-06-16 2009-09-23 Ocean Nutrition Canada Ltd IMMOBILIZED ENZYMES AND USE METHOD THEREFOR
ES2292341B1 (es) * 2006-03-13 2009-03-16 Universidad De Almeria "procedimiento para la purificacion de acido eicosapentaenoico (epa)".
HRP20110193T1 (hr) 2006-10-10 2011-05-31 Medivir Ab Inhibitor hcv nukleozida
US8399516B2 (en) 2006-11-01 2013-03-19 Pronova Biopharma Norge As Alpha-substituted omega-3 lipids that are activators or modulators of the peroxisome proliferators-activated receptor (PPAR)
EP1978102B1 (de) 2007-04-02 2010-07-07 Cognis IP Management GmbH Ein Gemisch enthaltend Fettsäureglyceride
EP1978101A1 (de) 2007-04-02 2008-10-08 Cognis IP Management GmbH Verfahren zur Anreicherung mehrfach ungesättigter Fettsäuren
CA2685272A1 (en) * 2007-04-26 2008-11-06 Patrick Adlercreutz A polyunsaturated fatty acid (pufa) enriched marine oil comprising eicosapentaenoic acid (epa) and docosahexaenoic acid (dha), and a process of production thereof
CL2008002020A1 (es) 2007-07-12 2008-11-14 Ocean Nutrition Canada Ltd Metodo de modificacion de un aceite, que comprende hidrolizar gliceridos con una solucion de lipasa thermomyces lanuginosus, separar la fraccion de acido graso saturado de la fraccion de glicerido hidrolizado y esterificar los gliceridos hidrolizados en la presencia de candida antarctica lipasa b; y composicion de aceite.
KR101502191B1 (ko) * 2007-07-30 2015-03-12 닛폰 스이산 가부시키가이샤 Ｅｐａ 농축유 및 ｄｈａ 농축유의 제조 방법
KR101034458B1 (ko) * 2008-03-03 2011-05-17 고려대학교 산학협력단 피놀레닌산 고함유 δ5-지방산의 제조방법
KR101357298B1 (ko) * 2008-06-20 2014-01-28 에이케이 앤 엠엔 바이오팜 주식회사 오메가-3계 고도불포화 지방산의 고순도 정제방법
PT2349250T (pt) 2008-10-31 2017-07-25 Lipid Pharmaceuticals Ehf Ácidos gordos para uso como um medicamento
CL2009001343A1 (es) * 2009-06-02 2009-07-10 Golden Omega S A Proceso de obtencion concentrado de esteres de epa y dha a partir de aceite marino, que comprende agregar al aceite alcali y agua a menos de 100 grados celsius, agregar solvente, separar fase de refinado, agregar acido, separar la fase no acuosa y agregar alcohol y un catalizador a menos de 150 grados celsius, desolventilizar y destilar.
US9321715B2 (en) 2009-12-30 2016-04-26 Basf Pharma (Callanish) Limited Simulated moving bed chromatographic separation process
CA2803477C (en) 2010-06-25 2019-04-30 Epax As Process for separating polyunsaturated fatty acids from long chain unsaturated or less saturated fatty acids
WO2012095749A1 (en) * 2011-01-14 2012-07-19 Pharma Marine As Removal of monoglycerides from fatty acid concentrates
JP5416861B2 (ja) * 2011-03-03 2014-02-12 日本水産株式会社 リパーゼによる高度不飽和脂肪酸含有油脂の製造方法
CN103415499B (zh) * 2011-03-08 2016-06-01 考格尼斯知识产权管理有限责任公司 脂肪酸酯的蒸馏方法
GB201107039D0 (en) * 2011-04-26 2011-06-08 Syngenta Ltd Formulation component
GB201111591D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Further new process
GB201111589D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New modified process
GB201111601D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New process
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
WO2013035113A1 (en) 2011-09-06 2013-03-14 Lipid Pharmaceuticals Ehf. Coated suppositories
US8258330B1 (en) 2012-01-04 2012-09-04 Naturalis, S.A. Carrier fluid composition comprising fatty acids ethyl esters and process for reducing the concentration of persistent organic pollutants in fish oil
CN107050457A (zh) 2012-01-06 2017-08-18 翁特拉制药公司 游离酸形式的ω‑3多不饱和脂肪酸的富含dpa组合物
KR20150028233A (ko) 2012-05-07 2015-03-13 옴테라 파마슈티칼스, 인크. 스타틴 및 오메가-３ 지방산의 조성물
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
CN104130860B (zh) * 2013-05-03 2020-03-31 丰益(上海)生物技术研发中心有限公司 利用固定化疏棉状嗜热丝孢菌脂肪酶富集长链多不饱和脂肪酸的方法
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
JP6302310B2 (ja) * 2013-08-30 2018-03-28 備前化成株式会社 高純度オメガ３系脂肪酸エチルエステルの生産方法
EP2883860B1 (fr) 2013-12-11 2016-08-24 Novasep Process Procédé chromatographique de production d'acides gras polyinsaturés
JP6303017B2 (ja) 2014-01-07 2018-03-28 ノヴァセプ プロセスＮｏｖａｓｅｐ Ｐｒｏｃｅｓｓ 芳香族アミノ酸を精製する方法
US9163198B2 (en) 2014-01-17 2015-10-20 Orochem Technologies, Inc. Process for purification of EPA (eicosapentanoic acid) ethyl ester from fish oil
CN104031950B (zh) * 2014-05-07 2017-06-16 威海博宇食品有限公司 一种制备富含n‑3多不饱和脂肪酸磷脂的方法
CN105779140A (zh) * 2014-12-23 2016-07-20 浙江医药股份有限公司新昌制药厂 一种高含量epa乙酯型鱼油的制备方法
US9546125B2 (en) 2015-02-11 2017-01-17 Orochem Technologies, Inc. Continuous process for extraction of unsaturated triglycerides from fish oil
JP2018085931A (ja) * 2015-04-01 2018-06-07 キユーピー株式会社 低級アルコール脂肪酸エステル化物含有組成物の製造方法および低級アルコール脂肪酸エステル化物含有組成物
HK1258568A1 (zh) * 2015-10-05 2019-11-15 Dsm Ip Assets B.V. 油组合物和制备方法
CN105349587B (zh) * 2015-11-10 2019-05-31 浙江工业大学 一种提高甘油酯型鱼油中epa和dha含量的方法
JP7213184B2 (ja) 2016-12-19 2023-01-26 トランス バイオ － ディーゼル リミテッド グリセリドの形態におけるｎ－３脂肪酸の酵素的濃縮
CN108265090B (zh) * 2016-12-30 2021-06-15 中粮集团有限公司 南极磷虾油替代物的制备方法
EP3666082B1 (en) * 2018-12-12 2022-05-04 Nippon Suisan Kaisha, Ltd. A composition containing highly unsaturated fatty acid or alkyl ester thereof and a method for producing the same
CN110029133B (zh) * 2019-03-12 2021-03-19 自然资源部第三海洋研究所 一种分离dha藻油中饱和脂肪酸和不饱和脂肪酸的方法
CN110438171A (zh) * 2019-07-18 2019-11-12 武汉大学深圳研究院 一种磷脂型dha的酶法制备方法
CN114057574A (zh) * 2021-12-03 2022-02-18 浙江工商大学 一种制备高纯度epa乙酯的方法
JP2024004585A (ja) * 2022-06-29 2024-01-17 日清ファルマ株式会社 ω－３高度不飽和脂肪酸含有組成物の製造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6291188A (ja) 1985-10-17 1987-04-25 Nisshin Oil Mills Ltd:The 高度不飽和脂肪酸グリセリドの製造法
JPH0225447A (ja) * 1988-07-13 1990-01-26 Nippon Oil & Fats Co Ltd 高度不飽和脂肪酸類の製造方法
DK95490D0 (da) 1990-04-18 1990-04-18 Novo Nordisk As Fremgangsmaade til fremstilling af triglycerid og triglyceridsammensaetning
JP2715633B2 (ja) * 1990-07-17 1998-02-18 鐘淵化学工業株式会社 ファットブルーム耐性向上剤、及びこれを含有してなるハードバター、並びにそれらを用いたチョコレート類．
JPH06192683A (ja) * 1992-12-24 1994-07-12 Shokuhin Sangyo High Separeeshiyon Syst Gijutsu Kenkyu Kumiai 遊離脂肪酸の分離方法
GB9404483D0 (en) * 1994-03-08 1994-04-20 Norsk Hydro As Refining marine oil compositions
DE4425987A1 (de) 1994-07-22 1996-01-25 Bosch Gmbh Robert Verfahren und Vorrichtung zur Ansteuerung eines elektromagnetischen Verbrauchers
AU6610996A (en) 1995-05-24 1996-12-11 Loders Croklaan B.V. Production of materials high in long chain polyunsaturated f atty acids
JP3785467B2 (ja) * 1996-07-10 2006-06-14 旭電化工業株式会社 油脂組成物の製造方法
JP3773315B2 (ja) * 1996-11-22 2006-05-10 大阪市 ω−３系高度不飽和脂肪酸エステルの精製方法
JP3734905B2 (ja) * 1996-12-18 2006-01-11 大阪市 ω−３系高度不飽和脂肪酸の精製方法
NO312973B1 (no) * 1999-02-17 2002-07-22 Norsk Hydro As Lipase-katalysert forestring av marine oljer
CA2273570A1 (en) 1999-05-31 2000-11-30 Jfs Envirohealth Ltd. Concentration and purification of polyunsaturated fatty acid esters by distillation-enzymatic transesterification coupling
GB2350610A (en) * 1999-06-01 2000-12-06 Jfs Envirohealth Ltd Preparation of pure unsaturated fatty acids
JP4210437B2 (ja) * 2000-09-27 2009-01-21 池田食研株式会社 食品用ステロール脂肪酸エステルの製造方法

Also Published As

Publication number Publication date
US20060148047A1 (en) 2006-07-06
DK2602308T3 (en) 2019-01-14
US7491522B2 (en) 2009-02-17
WO2004043894A8 (en) 2004-08-26
ES2702273T3 (es) 2019-02-28
CA2506537C (en) 2011-02-22
DK1560803T3 (da) 2014-06-23
AU2003283872A1 (en) 2004-06-03
EP2602308A2 (en) 2013-06-12
EP1560803B1 (en) 2014-04-23
CA2506537A1 (en) 2004-05-27
CN100338010C (zh) 2007-09-19
NO20025456D0 (no) 2002-11-14
WO2004043894A1 (en) 2004-05-27
JP2006506483A (ja) 2006-02-23
EP1560803A1 (en) 2005-08-10
CN1726181A (zh) 2006-01-25
NO319194B1 (no) 2005-06-27
EP2602308B1 (en) 2018-10-03
EP2602308A3 (en) 2014-04-02

Similar Documents

Publication Publication Date Title
Katan et al. Effect of plant-based diets with varying ratios of ω6 to ω3 fatty acids on growth performance, tissue composition, fatty acid biosynthesis and lipid-related gene expression in Atlantic salmon (Salmo salar)
ATE75502T1 (de) Verfahren zur herstellung von polyungesaettigten fettsaeuren.
BRPI0408006A (pt) uso de ácidos graxos Èmega -3 no tratamento de pacientes diabéticos
AR022612A1 (es) Procedimiento para el fraccionamiento de dibutenos y empleo de las fracciones obtenidas con el mismo
ES2179156T3 (es) Composicion nutricional que incluye grasas para el tratamiento del sindrome metabolico.
EP0292846A3 (en) A process for the extraction of polyunsaturated fatty acid esters from fish oils and pharmaceutical and/or dietetic compositions containing said esters
CY1105119T1 (el) Χρηση πολυακορεστων λιπαρων οξεων για την πρωτογενη προληψη σοβαρων καρδιαγγειακων επεισοδιων
IS7005A (is) Kóensím Q og eikósapentansýra
CA2506537A1 (en) Lipase-catalysed esterification of marine oil
DE602005021668D1 (de) Pharmazeutische formulierung mit statinmikrokapseln in alkylestern mehrfach ungesättigter fettsäuren
WO2007073177A3 (en) Composition comprising polyunsaturated fatty acids for improving membrane composition
DE60137308D1 (de) Marine fettzusammensetzung zur fuetterung von wasserorganismen
EP1385500A4 (en) FATTY ALCOHOLS AND FATTY ACID ESTERS FOR TREATING INFLAMMATION
DE69701014D1 (de) Verfahren zur Herstellung von Fettsäureäthylestern
Stanley-Samuelson et al. Polyunsaturated fatty acids in the lipids from adult Galleria mellonella reared on diets to which only one unsaturated fatty acid had been added
ATE440935T1 (de) Verfahren zur herstellung von fettsäureethylestern aus triglyceriden und alkoholen
DK1809125T3 (da) Næringsmiddel, der indeholder en fedtblanding
AR071128A1 (es) Metodo para producir gliceridos monoinsaturados
ATE525344T1 (de) Verfahren zur herstellung von biodiesel
ES2143067T3 (es) Procedimiento para la preparacion de esteres acrilicos refinados.
NO20034557L (no) Anti-inflammatoriske fettalkoholer og fettsyreestere nyttige som antigenb¶rere
Kuo et al. Concentration of docosahexaenoic and eicosapentaenoic acid from cobia liver oil by acetone fractionation of fatty acid salts
ES2531599T3 (es) Utilización de triglicéridos docosahexaenoicos para el tratamiento de enfermedades tumorales
RU2000127781A (ru) Способ получения концентрата этиловых эфиров полиненасыщенных высших жирных кислот
Birringer Wilson/Wagner