ES2532077T3 - Aparato para la neuromodulación renal - Google Patents

Aparato para la neuromodulación renal Download PDF

Info

Publication number
ES2532077T3
ES2532077T3 ES11192514.5T ES11192514T ES2532077T3 ES 2532077 T3 ES2532077 T3 ES 2532077T3 ES 11192514 T ES11192514 T ES 11192514T ES 2532077 T3 ES2532077 T3 ES 2532077T3
Authority
ES
Spain
Prior art keywords
renal
electrodes
catheter
stimulation
balloon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES11192514.5T
Other languages
English (en)
Inventor
Mark Deem
Hanson Gifford
Denise Demarais
Douglas Sutton
Erik Thai
Mark Gelfand
Howard R. Levin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Ardian Luxembourg SARL
Original Assignee
Medtronic Ardian Luxembourg SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37889643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2532077(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medtronic Ardian Luxembourg SARL filed Critical Medtronic Ardian Luxembourg SARL
Application granted granted Critical
Publication of ES2532077T3 publication Critical patent/ES2532077T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B18/1233—Generators therefor with circuits for assuring patient safety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0891—Clinical applications for diagnosis of blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36103—Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/00267—Expandable means emitting energy, e.g. by elements carried thereon having a basket shaped structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00404—Blood vessels other than those in or around the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00434—Neural system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00505—Urinary tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00505—Urinary tract
    • A61B2018/00511—Kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00904—Automatic detection of target tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/1246—Generators therefor characterised by the output polarity
    • A61B2018/126—Generators therefor characterised by the output polarity bipolar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1467—Probes or electrodes therefor using more than two electrodes on a single probe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A61N2007/003—Destruction of nerve tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Plasma & Fusion (AREA)
  • Pathology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Electromagnetism (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Rehabilitation Therapy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Surgical Instruments (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Saccharide Compounds (AREA)
  • External Artificial Organs (AREA)

Abstract

Aparato de neuromodulación renal (250), comprendiendo el aparato (250): un catéter (252) configurado para su colocación intravascular dentro de una arteria renal, en el que el catéter (252) comprende una cesta expansible (254); y una pluralidad de electrodos (256) adaptados para expandirse hasta entrar en contacto con una pared de la arteria renal, en el que los electrodos (256) están configurados para suministrar un campo eléctrico para conseguir la neuromodulación renal, por ejemplo desnervación renal, en el que el aparato comprende además un sensor de temperatura.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
5
10
15
20
25
30
35
40
45
50
E11192514
04-03-2015
La figura 5 es una vista lateral esquemática, parcialmente en sección, de un dispositivo intravascular que tiene un par de electrodos helicoidales de expansión dispuestos a una distancia deseada uno de otro según otra realización de la invención.
La figura 6 es una vista lateral esquemática, parcialmente en sección, de un dispositivo intravascular que tiene un primer electrodo sobre un balón expansible y un segundo electrodo sobre un cuerpo de catéter según otra realización de la invención.
La figura 7 es una vista lateral esquemática, parcialmente en sección, de un dispositivo intravascular que tiene un primer electrodo de expansión suministrado a través de la luz de un catéter y un segundo electrodo complementario llevado por el catéter según otra realización de la invención.
La figura 8 es una vista lateral esquemática, parcialmente en sección, de un dispositivo intravascular que tiene una cesta expansible y una pluralidad de electrodos en la cesta según otra realización de la invención.
La figura 9 es una vista de detalle esquemática del aparato de la figura 8 que ilustra una realización de los electrodos según otra realización de la invención.
La figura 10 es una vista lateral esquemática, parcialmente en sección, de un dispositivo intravascular que tiene electrodos de anillo expansibles para entrar en contacto con la pared del vaso y un elemento aislante opcional según otra realización de la invención.
La figuras 11A-11C son vistas de detalle esquemáticas de realizaciones de diferentes arrollamientos para los electrodos de anillo de la figura 10.
La figura 12 es una vista lateral esquemática, parcialmente en sección, de un dispositivo intravascular que tiene electrodos de anillo de la figura 10 con los arrollamientos mostrados en la figuras 11A-11C.
La figura 13 es una vista lateral esquemática, parcialmente en sección, de un dispositivo intravascular que tiene un electrodo de anillo y un electrodo suministrado luminalmente según otra realización de la invención.
La figura 14 es una vista lateral esquemática, parcialmente en sección, de un dispositivo intravascular que tiene un catéter de balón y electrodos de contacto de punta expansibles dispuestos de manera proximal y distal con respecto al balón según otra realización de la invención.
La figura 15 es una vista lateral esquemática de un dispositivo intravascular que tiene un catéter de balón y electrodos dispuestos de manera proximal y distal con respecto al balón según otra realización de la invención.
Las figuras 16A y 16B son vistas laterales esquemáticas, parcialmente en sección, que ilustran las fases de un método de uso del aparato de la figura 15 según una realización de la invención.
La figura 17 es una vista lateral esquemática de un dispositivo intravascular que tiene un catéter de balón y una pluralidad de electrodos que pueden accionarse dinámicamente según otra realización de la invención.
La figura 18 es una vista lateral esquemática de un dispositivo intravascular que tiene un electrodo distal desplegado a través de una luz del catéter de balón según otra realización de la invención.
La figuras 19A y 19B son vistas laterales, parcialmente en sección, que ilustran métodos de uso del dispositivo intravascular mostrado en la figura 18 para modular la actividad neural renal en pacientes con diversas vasculaturas renales.
La figura 20 es una vista lateral, parcialmente en sección, que ilustra un dispositivo intravascular que tiene una pluralidad de electrodos dispuestos a lo largo del cuerpo de, y en línea con, un elemento de centrado según otra realización de la invención.
La figura 21 es una vista lateral, parcialmente en sección, que ilustra un dispositivo intravascular que tiene electrodos configurados para recolocar radialmente de manera dinámica para facilitar el enfocado de un campo eléctrico pulsado según otra realización de la invención.
La figura 22 es una vista lateral, parcialmente en sección, de un dispositivo intravascular que tiene un catéter de infusión/aspiración según otra realización de la invención.
Las figuras 23A-23C son, respectivamente, una vista lateral, parcialmente en sección, y vistas en sección transversal a lo largo de la línea de corte A--A de la figura 23A, que ilustran un método de uso de un dispositivo intravascular según una realización de la invención configurado para hacer pasar electrodo(s) al menos parcialmente a través de la pared del vaso.
Las figuras 24A y 24B son vistas laterales, parcialmente en sección, que ilustran un dispositivo intravascular que tiene detectores para medir o monitorizar la eficacia del tratamiento según otra realización de la invención.
9 5
10
15
20
25
30
35
40
45
50
55
60
E11192514
04-03-2015
Descripción detallada
A. Visión general
La presente invención se refiere a métodos y aparatos para la neuromodulación renal y/u otra neuromodulación. Más particularmente, la presente invención se refiere a métodos y aparatos para la neuromodulación renal usando un campo eléctrico pulsado para efectuar electroporación o electrofusión. Tal como se usa en el presente documento, la electroporación y la electropermeabilización son métodos de manipulación de la membrana celular o aparatos intracelulares. Por ejemplo, pulsos breves de alta energía hacen que se abran poros en las membranas celulares. La magnitud de la porosidad en la membrana celular (por ejemplo, tamaño y número de poros) y la duración de los poros (por ejemplo, temporal o permanente) dependen de la intensidad de campo, el ancho de pulso, el ciclo de trabajo, la orientación del campo, el tipo de célula y otros parámetros. En general, los poros generalmente se cerrarán de manera espontánea al interrumpir campos de intensidad menor o anchos de pulso más cortos (definido en el presente documento como “electroporación reversible”). Cada tipo de célula tiene un umbral crítico por encima del cual los poros no se cierran de manera que la formación de poros ya no es reversible; este resultado se define como “electroporación irreversible”, “rotura irreversible” o “daño irreversible”. En este punto, la membrana celular se rompe y/o se producen desequilibrios químicos irreversibles provocados por la alta porosidad. Esta alta porosidad puede ser el resultado de un único orificio grande y/o de una pluralidad de orificios más pequeños. Determinados tipos de parámetros de energía de electroporación apropiados también para su uso en neuromodulación renal son pulsos de alta tensión con una duración de orden inferior a los microsegundos (campos eléctricos pulsados en nanosegundos, o nsPEF) que pueden dejar la membrana celular intacta, pero alterar el aparato intracelular o la función de la célula de maneras que provocan la muerte o alteración celular. Se ha mostrado que determinadas aplicaciones de nsPEF provocan muerte celular al inducir apoptosis, o muerte celular programada, en lugar de muerte celular aguda. Asimismo, el término “que comprende” se usa a lo largo de todo el documento con el significado de que incluye al menos la característica mencionada de manera que no se descarta cualquier número mayor de la misma característica y/o características de tipos adicionales.
Diversas realizaciones de la presente invención proporcionan dispositivos intravasculares para inducir neuromodulación renal, tal como un cambio temporal en los nervios diana que se disipa con el tiempo, un control continuo sobre la función neural y/o desnervación. Los aparatos y métodos descritos en el presente documento pueden utilizar cualquier señal eléctrica o parámetros de campo adecuados, por ejemplo, cualquier campo eléctrico, que consiga la neuromodulación deseada (por ejemplo, efecto electroporativo). Para entender mejor las estructuras de los dispositivos intravasculares y los métodos de uso de estos dispositivos para la neuromodulación, es útil entender la anatomía renal en seres humanos.
B. Realizaciones seleccionadas de métodos para la neuromodulación
Haciendo referencia ahora a la figura 1, la anatomía renal humana incluye riñones K a los que se les suministra sangre oxigenada mediante las arterias renales RA, que están conectadas al corazón mediante la aorta abdominal AA. La sangre desoxigenada fluye desde los riñones hasta el corazón a través de las venas renales RV y la vena cava inferior IVC. La figura 2 ilustra una parte de la anatomía renal en mayor detalle. Más específicamente, la anatomía renal también incluye nervios renales RN que se extienden longitudinalmente a lo largo de la dimensión longitudinal L de la arteria renal RA generalmente dentro de la adventicia de la arteria. La arteria renal RA tiene células de músculo liso SMC que rodean la espiral de la circunferencia arterial alrededor del eje angular  de la arteria, es decir, alrededor de la circunferencia de la arteria. Las células de músculo liso de la arteria renal tienen por consiguiente una dimensión longitudinal o más larga que se extiende de manera transversal (es decir, no paralela) a la dimensión longitudinal de la arteria renal. La desalineación de las dimensiones longitudinales de los nervios renales y las células de músculo liso se define como “desalineación celular”.
Haciendo referencia a la figura 3, la desalineación celular de los nervios renales y las células de músculo liso puede aprovecharse para afectar selectivamente a las células nerviosas renales con un efecto reducido sobre las células de músculo liso. Más específicamente, dado que células más grandes requieren menos energía para superar el umbral de irreversibilidad de la electroporación, diversas realizaciones de electrodos de la presente invención están configuradas para alinear al menos una parte de un campo eléctrico generado por los electrodos con o próximo a las dimensiones más largas de las células que van a verse afectadas. En realizaciones específicas, el dispositivo intravascular tiene electrodos configurados para crear un campo eléctrico alineado con o próximo a la dimensión longitudinal de la arteria renal RA para afectar a los nervios renales RN. Mediante la alineación de un campo eléctrico de modo que el campo afecta de manera preferencial al aspecto longitudinal de la célula en lugar de al aspecto diametral o radial de la célula, pueden usarse intensidades de campo más bajas para necrosar las células. Tal como se mencionó anteriormente, se espera que esto reduzca el consumo de energía y mitigue los efectos sobre células no diana en el campo eléctrico.
De manera similar, las dimensiones longitudinales o más largas de tejidos superpuestos o subyacentes al nervio diana son ortogonales o de otro modo están fuera del eje (por ejemplo, son transversales) con respecto a las dimensiones más largas de las células nerviosas. Por tanto, además de alinear el PEF con las dimensiones longitudinales o más largas de las células diana, el PEF puede propagarse a lo largo de las dimensiones laterales o más cortas de las células no diana (es decir de manera que el PEF se propaga al menos parcialmente de manera no
10
imagen8
imagen9
imagen10
imagen11
imagen12
5
10
15
20
25
30
35
40
45
50
55
60
E11192514
04-03-2015
configurados para la recolocación radial dinámica de uno o más de los electrodos con respecto a la pared de un vaso, facilitando así en enfoque de un campo eléctrico pulsado suministrado por los electrodos. El aparato 300 comprende un catéter 302 que tiene electrodos 304 dispuestos en línea con elementos expansibles encajados. Los elementos expansibles encajados comprenden un elemento expansible interno 306 y un elemento de centrado expansible externo 308. Los electrodos 304 se disponen a lo largo del elemento expansible interno, mientras que el elemento de centrado expansible externo está configurado para centrar y estabilizar el catéter 302 dentro del vaso. El elemento interno 306 puede expandirse en diversos grados, según lo que quiera el profesional médico, para alterar dinámicamente las posiciones radiales de los electrodos 304. Esta recolocación radial dinámica puede utilizarse para enfocar la energía suministrada por los electrodos 304 de manera que se suministra al tejido diana.
Los elementos encajados 306 y 308 pueden comprender una disposición de balón en balón, una disposición de cesta en cesta, alguna combinación de balón y cesta, o cualquier otra estructura expansible encajada. En la figura 21, el elemento expansible interno 306 comprende de manera ilustrativa una cesta expansible, mientras que el elemento de centrado expansible externo 308 comprende de manera ilustrativa un balón expansible. Los electrodos 302 se colocan a lo largo de la superficie del balón interno 306.
Opcionalmente cualquiera de las variaciones de la presente invención descritas en el presente documento puede estar configurada para la infusión de agentes a la zona de tratamiento antes, durante o después de la aplicación de energía, por ejemplo, para mejorar o modificar el efecto neurodestructivo o neuromodulatorio de la energía, para proteger o desplazar temporalmente células no diana y/o para facilitar la visualización. Resultarán evidentes aplicaciones adicionales de agentes infundidos. Si se desea, puede mejorarse la captación de agentes infundidos por las células mediante la iniciación de electroporación reversible en las células en presencia de los agentes infundidos. La infusión puede ser especialmente deseable cuando se utiliza un elemento de centrado de balón. El infundido puede comprender, por ejemplo, solución salina o solución salina heparinizada, agentes protectores, tales como Poloxamer-188, o agentes antiproliferativos. Variaciones de la presente invención pueden estar configuradas adicional o alternativamente para la aspiración. Por ejemplo, pueden proporcionarse orificios o salidas de infusión en un cuerpo de catéter adyacente a un dispositivo de centrado, el dispositivo de centrado puede ser poroso (por ejemplo, un balón “permeable”), o los largueros de la cesta pueden estar formados por hipotubos huecos y ranurados o perforados para permitir la infusión o la aspiración.
Haciendo referencia a la figura 22 se describe una variación de la presente invención que comprende un catéter de PEF de infusión/aspiración. El aparato 310 comprende un catéter 312 que tiene balones inflables proximal y distal 314a y 314b, respectivamente. Un electrodo de cuerpo proximal 316a está dispuesto entre los balones a lo largo del cuerpo del catéter 312, mientras que un electrodo distal 316b está dispuesto de manera distal a los balones a lo largo del cuerpo del catéter. Uno o más orificios de infusión o aspiración 318 están dispuestos a lo largo del cuerpo del catéter 312 entre los balones en las proximidades del electrodo proximal 316a.
El aparato 310 puede usarse de una diversidad de maneras. En un primer método de uso, el catéter 312 se dispone dentro del vaso diana, tal como la arteria renal RA, en una ubicación deseada. Se inflan uno o ambos balones 314, y se infunde un agente protector u otro infundido a través del/de los orificio(s) 318 entre los balones en las proximidades del electrodo 316a. Se suministra un PEF adecuado para la iniciación de la electroporación reversible a través de los electrodos 316 para facilitar la captación del infundido por células no diana en la pared del vaso. El suministro del agente protector puede mejorarse inflando en primer lugar el balón distal 314b, después infundiendo el agente protector, que desplaza la sangre, y después inflando el balón proximal 314a.
El infundido restante puede aspirarse opcionalmente de manera que no esté disponible durante una posterior aplicación del PEF cuando se inicia la electroporación irreversible de células nerviosas. La aspiración puede conseguirse desinflando al menos parcialmente un balón durante la aspiración. Alternativamente, la aspiración puede conseguirse con ambos balones inflados, por ejemplo, infundiendo solución salina junto con la aspiración para lavar el segmento de vaso entre los balones inflados. Tal lavado de sangre puede reducir el riesgo de formación de coágulos a lo largo del electrodo proximal 316a durante la aplicación del PEF. Además, el lavado durante la aplicación de energía puede enfriar el electrodo y/o las células de la pared de la arteria. Tal enfriamiento de las células de la pared puede proteger las células frente a un daño electroporativo irreversible, reduciendo posiblemente la necesidad de infusión de un agente protector.
Tras la infusión y la aspiración opcional, puede suministrarse un PEF adecuado para la iniciación de electroporación irreversible en células nerviosas diana a través de los electrodos 316 para desnervar o modular la actividad neural. En un método alternativo, la infusión de un agente protector puede realizarse durante o después de iniciarse la electroporación irreversible con el fin de proteger células no diana. El agente protector puede taponar o rellenar, por ejemplo, los poros formados en las células no diana por la electroporación irreversible.
En otro método alternativo, puede infundirse y aspirarse simultáneamente una disolución de solución salina heparinizada fría (es decir, a una temperatura inferior a la del organismo) entre los balones inflados para lavar la región entre los balones y disminuir la sensibilidad de las células de la pared del vaso células a la electroporación. Se espera que esto proteja adicionalmente las células durante la aplicación del PEF adecuado para la iniciación de la electroporación irreversible. Opcionalmente tal lavado puede ser continuo durante toda la aplicación del campo eléctrico pulsado. Puede colocarse opcionalmente un termopar u otro sensor de temperatura entre los balones de
16 5
10
15
20
25
30
35
40
45
50
55
E11192514
04-03-2015
manera que puede ajustarse la tasa de infusión de infundido frío para mantener una temperatura deseada. El infundido frío preferiblemente no enfría el tejido diana, por ejemplo, los nervios renales. Un agente protector, tal como el Poloxamer-188, puede infundirse opcionalmente tras el tratamiento como medida de seguridad adicional.
La infusión puede conseguirse alternativamente mediante un catéter de balón permeable. Todavía adicionalmente, puede utilizarse un catéter de balón criogénico que tiene al menos un electrodo. El balón criogénico puede inflarse dentro de un segmento de vaso para reducir localmente la temperatura del segmento de vaso, por ejemplo, para proteger el segmento y/o para inducir apoptosis térmica de la pared del vaso durante el suministro de un campo eléctrico. El campo eléctrico puede comprender, por ejemplo, un PEF o un campo eléctrico término no pulsado, tal como un campo RF térmico.
Haciendo referencia ahora a la figura 23 se describe una variación de un catéter de PEF configurado para el paso de un(os) electrodo(s) al menos parcialmente a través de la pared del vaso. Por ejemplo, el/los electrodo(s) puede(n) colocarse dentro de la vena renal y después hacerse pasar a través de la pared de la vena renal de manera que se dispongan en la fascia de Gerota o renal y cerca o al menos parcialmente alrededor de la arteria renal. De esta manera, el/los electrodo(s) puede(n) colocarse en estrecha proximidad con las fibras del nervio renal diana antes del suministro de un campo eléctrico pulsado.
Como se observa en la figura 23A, el aparato 320 comprende un catéter 322 que tiene orificios de aguja 324 y un elemento de centrado 326, de manera ilustrativa un balón inflable. El catéter 322 también puede comprender opcionalmente marcadores radiopacos 328. Los orificios de aguja 324 están configurados para el paso de agujas 330 a través de los mismos, mientras que las agujas 330 están configuradas para el paso de electrodos 340.
La vena renal RV discurre en paralelo a la arteria renal RA. Puede usarse una modalidad de obtención de imágenes, tal como ecografía intravascular, para identificar la posición de la arteria renal con respecto a la vena renal. Por ejemplo, pueden integrarse opcionalmente elementos de ecografía intravascular en el catéter 322. El catéter 322 puede colocarse dentro de la vena renal RV usando técnicas percutáneas muy conocidas y el elemento de centrado 326 puede expandirse para estabilizar el catéter dentro de la vena. Entonces pueden hacerse pasar las agujas 330 a través del catéter 322 y salir por los orificios de aguja 324 de una manera según la cual las agujas penetran en la pared de la vena renal y entran en la fascia de Gerota o renal F. Pueden visualizarse los marcadores radiopacos 328 con fluoroscopía para orientar apropiadamente los orificios de aguja 324 antes de desplegar las agujas 330.
Los electrodos 340 se despliegan a través de las agujas 330 hasta rodear al menos parcialmente la arteria renal RA, como en las figuras 23A y 23B. Haciendo avanzar adicionalmente los electrodos, puede rodearse adicionalmente la arteria, como en la figura 23C. Con los electrodos desplegados, pueden aplicarse estimulación y/o formas de onda de electroporación por PEF para desnervar o modular los nervios renales. Opcionalmente las agujas 330 pueden retraerse parcial o completamente antes del tratamiento de manera que los electrodos 340 rodean una mayor parte de la arteria renal. Adicionalmente, puede proporcionarse y/o accionarse un único electrodo 340 para proporcionar un PEF monopolar.
El infundido puede infundirse opcionalmente desde las agujas 330 al interior de la fascia F para facilitar la colocación de los electrodos 340 creando un espacio para la colocación de los electrodos. El infundido puede comprender, por ejemplo, fluidos, fluidos calientes o fríos, aire, CO2, solución salina, agentes de contraste, geles, fluidos conductores
o cualquier otro material que ocupe espacio, ya sea gas, sólido o líquido. También puede inyectarse solución salina heparinizada. La solución salina o la solución salina hipertónica pueden mejorar la conductividad entre electrodos
340. Además o alternativamente, pueden infundirse o colocarse fármacos y/o elementos de administración de fármacos al interior de la fascia a través de las agujas.
Tras el tratamiento, los electrodos 340 pueden retraerse dentro de las agujas 330, y las agujas 330 pueden retraerse dentro del catéter 322 a través de los orificios de aguja 324. Las agujas 330 preferiblemente son lo suficientemente pequeñas como para producir un sangrado mínimo y conseguir hemostasia bastante rápido. Opcionalmente el elemento de centrado de balón 326 puede permanecer inflado durante algún tiempo tras la retirada de las agujas 330 con el fin de bloquear el flujo sanguíneo y facilitar el proceso de coagulación. Alternativamente, puede hacerse avanzar un catéter de balón al interior de la vena renal e inflarse tras la retirada del aparato 320.
Haciendo referencia a la figura 24 se describen variaciones de la invención que comprenden detectores u otros elementos para medir o monitorizar la eficacia del tratamiento. Variaciones de la invención pueden estar configuradas para suministrar campos eléctricos de estimulación, además de los PEF de desnervación o modulación. Estos campos de estimulación pueden utilizarse para colocar apropiadamente el aparato para el tratamiento y/o para monitorizar la eficacia del tratamiento al modular la actividad neural. Esto puede conseguirse monitorizando las respuestas de parámetros fisiológicos que se sabe que se ven afectados por la estimulación de los nervios renales. Tales parámetros comprenden, por ejemplo, niveles de renina, niveles de sodio, flujo sanguíneo renal y tensión arterial. También puede usarse estimulación para comprobar la desnervación para monitorizar la eficacia del tratamiento: tras la desnervación de los nervios renales, las respuestas fisiológicas conocidas a la estimulación ya no deben producirse en respuesta a tal estimulación.
Las formas de onda de estimulación de los nervios eferentes pueden comprender, por ejemplo, frecuencias de
17 5
10
15
20
25
30
35
40
45
50
55
E11192514
04-03-2015
aproximadamente 1-10 Hz, mientras que las formas de onda de estimulación de los nervios aferentes pueden comprender, por ejemplo, frecuencias de hasta aproximadamente 50 Hz. Las amplitudes de forma de onda pueden oscilar, por ejemplo, hasta aproximadamente 50 V, mientras que las duraciones de pulso pueden oscilar, por ejemplo, hasta aproximadamente 20 milisegundos. Cuando las formas de onda de estimulación de los nervios se suministran por vía intravascular, como en varias realizaciones de la presente invención, parámetros de campo tales como frecuencia, amplitud y duración de pulso pueden modularse para facilitar el paso de las formas de onda por la pared del vaso para el suministro a los nervios diana. Además, aunque se han descrito parámetros a modo de ejemplo de formas de onda de estimulación, debe entenderse que puede utilizarse cualquier parámetro alternativo según se desee.
Los electrodos usados para suministrar PEF en cualquiera de las variaciones de la presente invención descritas anteriormente también pueden usarse para suministrar formas de onda de estimulación a la vasculatura renal. Alternativamente, las variaciones pueden comprender electrodos independientes configurados para la estimulación. Como otra alternativa, puede proporcionarse un aparato de estimulación independiente.
Una forma de usar la estimulación para identificar nervios renales es estimular los nervios de manera que el flujo sanguíneo renal se vea afectado, o se hubiese visto afecto si no se hubieran desnervado modulado los nervios renales. La estimulación actúa reduciendo el flujo sanguíneo renal, y esta respuesta puede atenuarse o anularse con la desnervación. Por tanto, se espera que la estimulación antes de la modulación neural reduzca el flujo sanguíneo, mientras que no se espera que la estimulación después de la modulación neural reduzca el flujo sanguíneo en la misma medida utilizando parámetros y ubicación/ubicaciones de estimulación similares a los de antes de la modulación neural. Este fenómeno puede utilizarse para cuantificar la magnitud de la neuromodulación renal. Variaciones de la presente invención pueden comprender elementos para monitorizar el flujo sanguíneo renal o para monitorizar cualquiera de los demás parámetros fisiológicos que se sabe que se ven afectados por la estimulación renal.
En la figura 24A se describe una variación del aparato 280 de la figura 16 que tiene un elemento para monitorizar el flujo sanguíneo renal. Se ha hecho avanzar un hilo guía 350 que tiene un sensor de ecografía Doppler 352 por la luz del catéter 282 para monitorizar el flujo sanguíneo dentro de la arteria renal RA. El sensor de ecografía Doppler 352 está configurado para medir la velocidad de flujo a través de la arteria. Entonces puede calcularse un caudal según la fórmula:
Q = VA (1)
en la que Q es igual al caudal, V es igual a la velocidad de flujo y A es igual al área de sección transversal. Puede determinarse un valor de referencia del flujo sanguíneo renal mediante mediciones del sensor 352 antes de suministrar una forma de onda de estimulación, después puede suministrarse la estimulación entre electrodos 286, preferiblemente con el balón 284 desinflado. La alteración, o no, del flujo sanguíneo renal con respecto al valor de referencia puede monitorizarse con el sensor 352 para identificar ubicaciones óptimas para la neuromodulación y/o desnervación de los nervios renales.
La figura 24B ilustra una variación del aparato de la figura 24A, en la que el sensor de ecografía Doppler 352 está acoplado al cuerpo del catéter 282. El sensor 352 está dispuesto de manera ilustrativa de manera proximal al balón 284, pero debe entenderse que el sensor puede disponerse alternativamente de manera distal al balón.
Además o como alternativa a la monitorización intravascular del flujo sanguíneo renal mediante ecografía Doppler, tal monitorización puede realizarse opcionalmente desde fuera del paciente, según lo cual el flujo sanguíneo renal se visualiza a través de la piel (por ejemplo, usando un transductor de ecografía). En otra variación, pueden usarse uno
o más transductores de presión intravascular para detectar cambios locales en la presión que pueden ser indicativos del flujo sanguíneo renal. Como aún otra alternativa, puede determinarse la velocidad de la sangre, por ejemplo, mediante termodilución midiendo el lapso de tiempo que tarda una entrada de temperatura intravascular en viajar entre puntos con una distancia de separación conocida.
Por ejemplo, puede incorporarse un termopar en, o preverse en las proximidades de, cada electrodo 286, y puede infundirse solución salina o fluido frío (es decir, a una temperatura inferior a la del organismo) de manera proximal al/a los termopar(es). Puede usarse el lapso de tiempo que tarda en registrarse el descenso de temperatura entre el/los termopar(es) para cuantificar característica(s) de flujo. Puede determinarse una estimación de valor de referencia de la(s) característica(s) de flujo de interés antes de la estimulación de los nervios renales y puede compararse con una segunda estimación de la(s) característica(s) determinada(s) tras la estimulación.
Pueden utilizarse opcionalmente dispositivos comercialmente disponibles para monitorizar el tratamiento. Tales dispositivos incluyen, por ejemplo, los dispositivos SmartWire™, FloWire™ y WaveWire™ disponibles de Volcano™ Therapeutics Inc., de Rancho Cordova, CA, así como el dispositivo PressureWire® disponible de RADI Medical Systems AB de Uppsala, Suecia. Resultarán evidentes dispositivos comercialmente disponibles adicionales. Adicional o alternativamente puede monitorizarse la magnitud de la electroporación usando directamente tomografía de impedancia eléctrica (“EIT”) u otras mediciones de impedancia eléctrica, tales como un índice de impedancia eléctrica.
18
imagen13

Claims (1)

  1. imagen1
ES11192514.5T 2004-10-05 2005-10-05 Aparato para la neuromodulación renal Expired - Lifetime ES2532077T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US61625404P 2004-10-05 2004-10-05
US616254P 2004-10-05
US62479304P 2004-11-02 2004-11-02
US624793P 2004-11-02
US11/129,765 US7653438B2 (en) 2002-04-08 2005-05-13 Methods and apparatus for renal neuromodulation
US129765 2005-05-13

Publications (1)

Publication Number Publication Date
ES2532077T3 true ES2532077T3 (es) 2015-03-24

Family

ID=37889643

Family Applications (10)

Application Number Title Priority Date Filing Date
ES12180431.4T Expired - Lifetime ES2494119T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES16183801T Expired - Lifetime ES2743974T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES16184488T Expired - Lifetime ES2740836T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES16160715.5T Expired - Lifetime ES2691040T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES12180432.2T Expired - Lifetime ES2534535T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES12180428.0T Expired - Lifetime ES2684499T3 (es) 2004-10-05 2005-10-05 Uso de un catéter para la neuromodulación renal
ES11192514.5T Expired - Lifetime ES2532077T3 (es) 2004-10-05 2005-10-05 Aparato para la neuromodulación renal
ES12180426.4T Expired - Lifetime ES2531888T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES12180427.2T Expired - Lifetime ES2538708T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES12180430T Expired - Lifetime ES2570927T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal

Family Applications Before (6)

Application Number Title Priority Date Filing Date
ES12180431.4T Expired - Lifetime ES2494119T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES16183801T Expired - Lifetime ES2743974T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES16184488T Expired - Lifetime ES2740836T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES16160715.5T Expired - Lifetime ES2691040T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES12180432.2T Expired - Lifetime ES2534535T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES12180428.0T Expired - Lifetime ES2684499T3 (es) 2004-10-05 2005-10-05 Uso de un catéter para la neuromodulación renal

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES12180426.4T Expired - Lifetime ES2531888T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES12180427.2T Expired - Lifetime ES2538708T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal
ES12180430T Expired - Lifetime ES2570927T3 (es) 2004-10-05 2005-10-05 Aparato para neuromodulación renal

Country Status (11)

Country Link
US (16) US7653438B2 (es)
EP (18) EP2457614B1 (es)
JP (7) JP5646135B2 (es)
CN (4) CN101084038B (es)
AT (1) ATE494039T1 (es)
CA (1) CA2583463C (es)
DE (9) DE202005022059U1 (es)
ES (10) ES2494119T3 (es)
MX (1) MX2007004238A (es)
PL (1) PL2561905T3 (es)
WO (1) WO2006041881A2 (es)

Families Citing this family (903)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
US8016823B2 (en) 2003-01-18 2011-09-13 Tsunami Medtech, Llc Medical instrument and method of use
US7892229B2 (en) 2003-01-18 2011-02-22 Tsunami Medtech, Llc Medical instruments and techniques for treating pulmonary disorders
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US6300108B1 (en) 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
WO2001034018A2 (en) 1999-10-25 2001-05-17 Therus Corporation Use of focused ultrasound for vascular sealing
US6626855B1 (en) 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US8251986B2 (en) 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US9433457B2 (en) 2000-12-09 2016-09-06 Tsunami Medtech, Llc Medical instruments and techniques for thermally-mediated therapies
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
US8974446B2 (en) 2001-10-11 2015-03-10 St. Jude Medical, Inc. Ultrasound ablation apparatus with discrete staggered ablation zones
US8444636B2 (en) 2001-12-07 2013-05-21 Tsunami Medtech, Llc Medical instrument and method of use
US20070135875A1 (en) * 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US8131371B2 (en) * 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US20060206150A1 (en) 2002-04-08 2006-09-14 Ardian, Inc. Methods and apparatus for treating acute myocardial infarction
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US6978174B2 (en) * 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8774913B2 (en) * 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US20110207758A1 (en) 2003-04-08 2011-08-25 Medtronic Vascular, Inc. Methods for Therapeutic Renal Denervation
US7617005B2 (en) * 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
WO2004037341A2 (en) 2002-05-07 2004-05-06 Schroeppel Edward A Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US20100152607A1 (en) * 2003-02-21 2010-06-17 Kassab Ghassan S Devices, systems, and methods for measuring parallel tissue conductance, luminal cross-sectional areas, fluid velocity, and/or determining plaque vulnerability using temperature
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
DE202004021946U1 (de) 2003-09-12 2013-05-29 Vessix Vascular, Inc. Auswählbare exzentrische Remodellierung und/oder Ablation von atherosklerotischem Material
US8298222B2 (en) * 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
PL1696812T3 (pl) 2003-12-24 2015-12-31 Univ California Ablacja tkanki nieodwracalną elektroporacją
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US9707071B2 (en) 2004-11-24 2017-07-18 Contego Medical Llc Percutaneous transluminal angioplasty device with integral embolic filter
US9510930B2 (en) 2008-10-22 2016-12-06 Contego Medical, Llc Angioplasty device with embolic filter
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
ES2380487T3 (es) 2005-03-28 2012-05-14 Vessix Vascular, Inc. Caracterización de tejido eléctrico intraluminal y energía RF ajustada para el tratamiento selectivo de ateroma y de otros tejidos diana
US7499748B2 (en) * 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US8114070B2 (en) 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US20070032785A1 (en) 2005-08-03 2007-02-08 Jennifer Diederich Tissue evacuation device
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
US20070142879A1 (en) * 2005-12-20 2007-06-21 The Cleveland Clinic Foundation Apparatus and method for modulating the baroreflex system
EP1932462A4 (en) 2005-10-05 2013-02-27 Olympus Medical Systems Corp MEDICINE PRODUCT OF CAPSULE TYPE, GUIDANCE SYSTEM AND GUIDANCE METHOD AND DEVICE FOR INTRODUCTION TO A PATIENT TO BE INVESTIGATED
US8167805B2 (en) 2005-10-20 2012-05-01 Kona Medical, Inc. Systems and methods for ultrasound applicator station keeping
US10716749B2 (en) * 2005-11-03 2020-07-21 Palo Alto Investors Methods and compositions for treating a renal disease condition in a subject
US7519253B2 (en) 2005-11-18 2009-04-14 Omni Sciences, Inc. Broadband or mid-infrared fiber light sources
US7993334B2 (en) * 2005-12-29 2011-08-09 Boston Scientific Scimed, Inc. Low-profile, expanding single needle ablation probe
US20110077628A1 (en) * 2006-01-10 2011-03-31 Tsunami Medtech, Llc Medical system and method of use
AU2007212587B2 (en) 2006-02-03 2012-07-12 Synecor, Llc Intravascular device for neuromodulation
CA2643210C (en) * 2006-02-24 2018-05-01 Eastern Virginia Medical School Nanosecond pulsed electric fields cause melanomas to self-destruct
US8571650B2 (en) * 2006-03-03 2013-10-29 Palo Alto Investors Methods and compositions for treating a renal associated condition in a subject
US8401650B2 (en) * 2008-04-10 2013-03-19 Electrocore Llc Methods and apparatus for electrical treatment using balloon and electrode
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
US10499937B2 (en) 2006-05-19 2019-12-10 Recor Medical, Inc. Ablation device with optimized input power profile and method of using the same
US20080039746A1 (en) 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US7894906B2 (en) 2006-06-06 2011-02-22 Cardiac Pacemakers, Inc. Amelioration of chronic pain by endolymphatic stimulation
US7734341B2 (en) 2006-06-06 2010-06-08 Cardiac Pacemakers, Inc. Method and apparatus for gastrointestinal stimulation via the lymphatic system
US20070282376A1 (en) * 2006-06-06 2007-12-06 Shuros Allan C Method and apparatus for neural stimulation via the lymphatic system
US8126538B2 (en) 2006-06-06 2012-02-28 Cardiac Pacemakers, Inc. Method and apparatus for introducing endolymphatic instrumentation
CN105056408B (zh) * 2006-06-28 2018-09-25 美敦力Af卢森堡公司 用于热诱导的肾神经调制的系统
US8905999B2 (en) 2006-09-01 2014-12-09 Cardiac Pacemakers, Inc. Method and apparatus for endolymphatic drug delivery
WO2008048620A2 (en) 2006-10-16 2008-04-24 The Regents Of The University Of California Gels with predetermined conductivity used in irreversible electroporation of tissue
JP5312337B2 (ja) 2006-10-18 2013-10-09 べシックス・バスキュラー・インコーポレイテッド 標的組織の選択的な処置のための調節されたｒｆエネルギーおよび電気的な組織の特徴付け
EP2076194B1 (en) 2006-10-18 2013-04-24 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
ES2560006T3 (es) 2006-10-18 2016-02-17 Vessix Vascular, Inc. Inducción de efectos de temperatura deseables sobre tejido corporal
US20080119907A1 (en) * 2006-11-22 2008-05-22 Cardiac Pacemakers, Inc. Renal function modulation via application of electrical energy stimulation
US20080132885A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Methods for treating tissue sites using electroporation
US20080132884A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Systems for treating tissue sites using electroporation
US7744618B2 (en) 2006-12-07 2010-06-29 Cardiac Pacemakers, Inc. Device and method for modulating renal function
CA2877177C (en) 2007-01-29 2018-05-22 Simon Fraser University Transvascular nerve stimulation apparatus and methods
WO2008100974A2 (en) 2007-02-13 2008-08-21 Sharma Virender K Method and apparatus for electrical stimulation of the pancreatico-biliary system
US7655004B2 (en) 2007-02-15 2010-02-02 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US7815662B2 (en) 2007-03-08 2010-10-19 Ethicon Endo-Surgery, Inc. Surgical suture anchors and deployment device
US9072897B2 (en) 2007-03-09 2015-07-07 Mainstay Medical Limited Systems and methods for restoring muscle function to the lumbar spine
US11679261B2 (en) 2007-03-09 2023-06-20 Mainstay Medical Limited Systems and methods for enhancing function of spine stabilization muscles associated with a spine surgery intervention
US11679262B2 (en) 2007-03-09 2023-06-20 Mainstay Medical Limited Systems and methods for restoring muscle function to the lumbar spine
US8496653B2 (en) * 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US8075572B2 (en) 2007-04-26 2011-12-13 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus
US8100922B2 (en) 2007-04-27 2012-01-24 Ethicon Endo-Surgery, Inc. Curved needle suturing tool
WO2008134651A2 (en) * 2007-04-27 2008-11-06 St. Jude Medical, Atrial Fibrillation Division, Inc. Apparatus and method for positioning and retention of catheter
US8103359B2 (en) * 2007-05-17 2012-01-24 Cardiac Pacemakers, Inc. Systems and methods for fixating transvenously implanted medical devices
WO2008150941A2 (en) 2007-05-30 2008-12-11 The Cleveland Clinic Foundation Method for treating erectile dysfunction
WO2009009398A1 (en) 2007-07-06 2009-01-15 Tsunami Medtech, Llc Medical system and method of use
US8221401B2 (en) 2007-08-23 2012-07-17 Aegea Medical, Inc. Uterine therapy device and method
US8568410B2 (en) 2007-08-31 2013-10-29 Ethicon Endo-Surgery, Inc. Electrical ablation surgical instruments
US8262655B2 (en) 2007-11-21 2012-09-11 Ethicon Endo-Surgery, Inc. Bipolar forceps
US8579897B2 (en) 2007-11-21 2013-11-12 Ethicon Endo-Surgery, Inc. Bipolar forceps
CN101888874B (zh) * 2007-10-11 2013-11-13 京畿州海莱乌医院 用于改进的电场控制的电穿孔装置
US20090112059A1 (en) 2007-10-31 2009-04-30 Nobis Rudolph H Apparatus and methods for closing a gastrotomy
US8480657B2 (en) 2007-10-31 2013-07-09 Ethicon Endo-Surgery, Inc. Detachable distal overtube section and methods for forming a sealable opening in the wall of an organ
US8298216B2 (en) 2007-11-14 2012-10-30 Myoscience, Inc. Pain management using cryogenic remodeling
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8165669B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
US8160695B2 (en) 2007-12-05 2012-04-17 The Invention Science Fund I, Llc System for chemical modulation of neural activity
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8233976B2 (en) 2007-12-05 2012-07-31 The Invention Science Fund I, Llc System for transdermal chemical modulation of neural activity
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US9924992B2 (en) 2008-02-20 2018-03-27 Tsunami Medtech, Llc Medical system and method of use
US8262680B2 (en) 2008-03-10 2012-09-11 Ethicon Endo-Surgery, Inc. Anastomotic device
US20090247933A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California; Angiodynamics, Inc. Balloon catheter method for reducing restenosis via irreversible electroporation
US7925352B2 (en) 2008-03-27 2011-04-12 Synecor Llc System and method for transvascularly stimulating contents of the carotid sheath
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
EP2280741A4 (en) 2008-04-29 2012-06-13 Virginia Tech Intell Prop IRREVERSIBLE ELECTROPORATION FOR THE PRODUCTION OF TISSUE OBJECTS
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US10702326B2 (en) * 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US8926606B2 (en) 2009-04-09 2015-01-06 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
US20090281477A1 (en) 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
JP2011519699A (ja) 2008-05-09 2011-07-14 インノブアトイブエ プルモナルイ ソルウトイオンス，インコーポレイティッド 気管支樹の治療のためのシステム、アセンブリ、及び方法
US8679003B2 (en) 2008-05-30 2014-03-25 Ethicon Endo-Surgery, Inc. Surgical device and endoscope including same
US8652150B2 (en) 2008-05-30 2014-02-18 Ethicon Endo-Surgery, Inc. Multifunction surgical device
US8771260B2 (en) 2008-05-30 2014-07-08 Ethicon Endo-Surgery, Inc. Actuating and articulating surgical device
US8317806B2 (en) 2008-05-30 2012-11-27 Ethicon Endo-Surgery, Inc. Endoscopic suturing tension controlling and indication devices
US8070759B2 (en) 2008-05-30 2011-12-06 Ethicon Endo-Surgery, Inc. Surgical fastening device
US8114072B2 (en) 2008-05-30 2012-02-14 Ethicon Endo-Surgery, Inc. Electrical ablation device
US8721632B2 (en) 2008-09-09 2014-05-13 Tsunami Medtech, Llc Methods for delivering energy into a target tissue of a body
US8906035B2 (en) 2008-06-04 2014-12-09 Ethicon Endo-Surgery, Inc. Endoscopic drop off bag
US8403926B2 (en) 2008-06-05 2013-03-26 Ethicon Endo-Surgery, Inc. Manually articulating devices
US8713026B2 (en) * 2008-06-13 2014-04-29 Sandisk Technologies Inc. Method for playing digital media files with a digital media player using a plurality of playlists
US9173704B2 (en) 2008-06-20 2015-11-03 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US9681909B2 (en) 2008-06-23 2017-06-20 Angiodynamics, Inc. Treatment devices and methods
US8361112B2 (en) 2008-06-27 2013-01-29 Ethicon Endo-Surgery, Inc. Surgical suture arrangement
US8892210B2 (en) 2008-07-02 2014-11-18 Niveus Medical, Inc. Devices, systems, and methods for automated optimization of energy delivery
CA2727498C (en) * 2008-07-02 2020-04-21 Niveus Medical, Inc. Systems and methods for automated muscle stimulation
US8262563B2 (en) 2008-07-14 2012-09-11 Ethicon Endo-Surgery, Inc. Endoscopic translumenal articulatable steerable overtube
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
US8768469B2 (en) 2008-08-08 2014-07-01 Enteromedics Inc. Systems for regulation of blood pressure and heart rate
US9089700B2 (en) 2008-08-11 2015-07-28 Cibiem, Inc. Systems and methods for treating dyspnea, including via electrical afferent signal blocking
US8211125B2 (en) 2008-08-15 2012-07-03 Ethicon Endo-Surgery, Inc. Sterile appliance delivery device for endoscopic procedures
US9149386B2 (en) 2008-08-19 2015-10-06 Niveus Medical, Inc. Devices and systems for stimulation of tissues
EP2326273B1 (en) * 2008-08-20 2021-11-24 Prostacare Pty Ltd System including a catheter and deployable electrodes for the non-thermal ablation of tissue
US9597145B2 (en) 2008-08-20 2017-03-21 Prostacare Pty Ltd Non-thermal ablation system for treating tissue
US8529563B2 (en) 2008-08-25 2013-09-10 Ethicon Endo-Surgery, Inc. Electrical ablation devices
WO2010027874A2 (en) * 2008-08-26 2010-03-11 Niveus Medical, Inc. Device, system, and method to improve powered muscle stimulation performance in the presence of tissue edema
US8241204B2 (en) 2008-08-29 2012-08-14 Ethicon Endo-Surgery, Inc. Articulating end cap
US8480689B2 (en) 2008-09-02 2013-07-09 Ethicon Endo-Surgery, Inc. Suturing device
US8409200B2 (en) 2008-09-03 2013-04-02 Ethicon Endo-Surgery, Inc. Surgical grasping device
US8114119B2 (en) 2008-09-09 2012-02-14 Ethicon Endo-Surgery, Inc. Surgical grasping device
JP2012502773A (ja) 2008-09-22 2012-02-02 ディーセラピューティクス・エルエルシー 血流予備量比測定のための装置、システムおよび手法
EP2341839B1 (en) * 2008-09-22 2015-10-21 Vessix Vascular, Inc. System for vascular ultrasound treatments
US8337394B2 (en) 2008-10-01 2012-12-25 Ethicon Endo-Surgery, Inc. Overtube with expandable tip
US20100094270A1 (en) 2008-10-06 2010-04-15 Sharma Virender K Method and Apparatus for Tissue Ablation
US9561068B2 (en) 2008-10-06 2017-02-07 Virender K. Sharma Method and apparatus for tissue ablation
US10064697B2 (en) 2008-10-06 2018-09-04 Santa Anna Tech Llc Vapor based ablation system for treating various indications
US10695126B2 (en) 2008-10-06 2020-06-30 Santa Anna Tech Llc Catheter with a double balloon structure to generate and apply a heated ablative zone to tissue
US9561066B2 (en) 2008-10-06 2017-02-07 Virender K. Sharma Method and apparatus for tissue ablation
US10603489B2 (en) 2008-10-09 2020-03-31 Virender K. Sharma Methods and apparatuses for stimulating blood vessels in order to control, treat, and/or prevent a hemorrhage
US9079028B2 (en) 2008-10-09 2015-07-14 Virender K. Sharma Method and apparatus for stimulating the vascular system
US8386053B2 (en) * 2008-10-31 2013-02-26 Medtronic, Inc. Subclavian ansae stimulation
US20100114244A1 (en) * 2008-10-31 2010-05-06 Medtronic, Inc. Electrical renal autonomic blockade
US7910193B2 (en) * 2008-11-10 2011-03-22 Mkp Structural Design Associates, Inc. Three-dimensional auxetic structures and applications thereof
AU2009314159B2 (en) * 2008-11-11 2016-04-14 Shifamed Holdings, Llc Low profile electrode assembly
US9795442B2 (en) 2008-11-11 2017-10-24 Shifamed Holdings, Llc Ablation catheters
US11376061B2 (en) 2008-11-11 2022-07-05 Covidien Lp Energy delivery device and methods of use
US10987494B2 (en) 2008-11-11 2021-04-27 Covidien Lp Pleated or folded catheter-mounted balloon
EP2355737B1 (en) 2008-11-17 2021-08-11 Boston Scientific Scimed, Inc. Selective accumulation of energy without knowledge of tissue topography
US8382746B2 (en) 2008-11-21 2013-02-26 C2 Therapeutics, Inc. Cryogenic ablation system and method
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
US8923970B2 (en) 2008-12-09 2014-12-30 Nephera Ltd. Stimulation of the urinary system
US8725249B2 (en) 2008-12-09 2014-05-13 Nephera Ltd. Stimulation of the urinary system
US8172772B2 (en) 2008-12-11 2012-05-08 Ethicon Endo-Surgery, Inc. Specimen retrieval device
US20100152725A1 (en) * 2008-12-12 2010-06-17 Angiodynamics, Inc. Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US20100168739A1 (en) * 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8808345B2 (en) * 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
WO2010080886A1 (en) * 2009-01-09 2010-07-15 Recor Medical, Inc. Methods and apparatus for treatment of mitral valve in insufficiency
US8828031B2 (en) 2009-01-12 2014-09-09 Ethicon Endo-Surgery, Inc. Apparatus for forming an anastomosis
US8361066B2 (en) * 2009-01-12 2013-01-29 Ethicon Endo-Surgery, Inc. Electrical ablation devices
EP2389223A1 (en) * 2009-01-14 2011-11-30 Cardiac Pacemakers, Inc. Promoting diuresis and natriuresis by applying electric field
US8753335B2 (en) 2009-01-23 2014-06-17 Angiodynamics, Inc. Therapeutic energy delivery device with rotational mechanism
US9226772B2 (en) 2009-01-30 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical device
US8252057B2 (en) 2009-01-30 2012-08-28 Ethicon Endo-Surgery, Inc. Surgical access device
US8037591B2 (en) 2009-02-02 2011-10-18 Ethicon Endo-Surgery, Inc. Surgical scissors
US11284931B2 (en) 2009-02-03 2022-03-29 Tsunami Medtech, Llc Medical systems and methods for ablating and absorbing tissue
US8231603B2 (en) 2009-02-10 2012-07-31 Angiodynamics, Inc. Irreversible electroporation and tissue regeneration
EP3536287B1 (en) 2009-02-20 2021-12-29 Sage Products, LLC Systems of powered muscle stimulation using an energy guidance field
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
AU2010266027B2 (en) * 2009-06-24 2015-05-07 Shifamed Holdings, Llc Steerable medical delivery devices and methods of use
WO2011008903A2 (en) * 2009-07-15 2011-01-20 Uab Research Foundation Catheter having temperature controlled anchor and related methods
US8986211B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
US20160059044A1 (en) * 2009-10-12 2016-03-03 Kona Medical, Inc. Energy delivery to intraparenchymal regions of the kidney to treat hypertension
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
US20110092880A1 (en) * 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US8986231B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US8517962B2 (en) 2009-10-12 2013-08-27 Kona Medical, Inc. Energetic modulation of nerves
US8295912B2 (en) * 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US20110118600A1 (en) * 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US11998266B2 (en) 2009-10-12 2024-06-04 Otsuka Medical Devices Co., Ltd Intravascular energy delivery
AU2010307029B2 (en) * 2009-10-12 2014-07-31 Otsuka Medical Devices Co., Ltd. Energetic modulation of nerves
US20110093026A1 (en) * 2009-10-19 2011-04-21 Ramesh Wariar Method and apparatus for cardiorenal electrical stimulation
CA2779135C (en) 2009-10-27 2018-09-04 Innovative Pulmonary Solutions, Inc. Delivery devices with coolable energy emitting assemblies
US20110098704A1 (en) 2009-10-28 2011-04-28 Ethicon Endo-Surgery, Inc. Electrical ablation devices
WO2011053772A1 (en) * 2009-10-30 2011-05-05 Sound Interventions, Inc. Method and apparatus for non-invasive treatment of hypertension through ultrasound renal denervation
EP2995350B1 (en) 2009-10-30 2016-08-03 ReCor Medical, Inc. Apparatus for treatment of hypertension through percutaneous ultrasound renal denervation
US8608652B2 (en) 2009-11-05 2013-12-17 Ethicon Endo-Surgery, Inc. Vaginal entry surgical devices, kit, system, and method
US8900223B2 (en) * 2009-11-06 2014-12-02 Tsunami Medtech, Llc Tissue ablation systems and methods of use
US20110112400A1 (en) * 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
US20110112527A1 (en) * 2009-11-06 2011-05-12 Angiodynamics, Inc. Flexible medical ablation device and method of use
AU2010319602B2 (en) 2009-11-11 2015-09-24 Sage Products, Llc Synergistic muscle activation device
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
EP2842510B1 (en) 2009-11-11 2022-08-24 Nuvaira, Inc. Device for treating tissue and controlling stenosis
US8979839B2 (en) 2009-11-13 2015-03-17 St. Jude Medical, Inc. Assembly of staggered ablation elements
US20110118732A1 (en) 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
US8696698B2 (en) 2009-12-02 2014-04-15 Surefire Medical, Inc. Microvalve protection device and method of use for protection against embolization agent reflux
US9539081B2 (en) 2009-12-02 2017-01-10 Surefire Medical, Inc. Method of operating a microvalve protection device
AU2010332112B2 (en) 2009-12-14 2015-06-04 Mayo Foundation For Medical Education And Research Device and method for treating cardiac disorders by modulating autonomic response
US8496574B2 (en) 2009-12-17 2013-07-30 Ethicon Endo-Surgery, Inc. Selectively positionable camera for surgical guide tube assembly
US8353487B2 (en) 2009-12-17 2013-01-15 Ethicon Endo-Surgery, Inc. User interface support devices for endoscopic surgical instruments
US9028483B2 (en) 2009-12-18 2015-05-12 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US8506564B2 (en) 2009-12-18 2013-08-13 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
AU2010335043B2 (en) 2009-12-23 2016-07-21 Hitops Gmbh New use of pulsed radio frequency
US9161801B2 (en) * 2009-12-30 2015-10-20 Tsunami Medtech, Llc Medical system and method of use
US20110263921A1 (en) * 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
CA2786262A1 (en) 2010-01-07 2011-07-14 Cheetah Omni, Llc Fiber lasers and mid-infrared light sources in methods and systems for selective biological tissue processing and spectroscopy
US9072894B2 (en) * 2010-01-18 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus for radioablation of regular targets such as sympathetic nerves
US20110200171A1 (en) * 2010-01-19 2011-08-18 Ardian, Inc. Methods and apparatus for renal neuromodulation via stereotactic radiotherapy
EP2528649A1 (en) 2010-01-26 2012-12-05 Michael A. Evans Methods, devices, and agents for denervation
US20110190858A1 (en) * 2010-01-29 2011-08-04 Medtronic, Inc. Lead having expandable distal portion
US9005198B2 (en) 2010-01-29 2015-04-14 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US20110202052A1 (en) * 2010-02-12 2011-08-18 Daniel Gelbart System for treating benign prostatic hyperplasia
US20110208173A1 (en) * 2010-02-24 2011-08-25 Medtronic Vascular, Inc. Methods for Treating sleep apnea via renal Denervation
US8556891B2 (en) 2010-03-03 2013-10-15 Medtronic Ablation Frontiers Llc Variable-output radiofrequency ablation power supply
US11786725B2 (en) 2012-06-13 2023-10-17 Mainstay Medical Limited Systems and methods for restoring muscle function to the lumbar spine and kits for implanting the same
CA2792529C (en) 2010-03-11 2018-06-05 Mainstay Medical, Inc. Modular stimulator for treatment of back pain, implantable rf ablation system and methods of use
US12097365B2 (en) 2010-03-11 2024-09-24 Mainstay Medical Limited Electrical stimulator for the treatment of back pain and methods of use
US11684774B2 (en) * 2010-03-11 2023-06-27 Mainstay Medical Limited Electrical stimulator for treatment of back pain and methods of use
US8740898B2 (en) * 2010-03-22 2014-06-03 Covidien Lp Surgical forceps
US8840601B2 (en) 2010-03-24 2014-09-23 Shifamed Holdings, Llc Intravascular tissue disruption
CN103068330B (zh) 2010-04-09 2016-06-29 Vessix血管股份有限公司 用于治疗组织的功率发生和控制装置
CA2795933A1 (en) * 2010-04-14 2011-10-20 Boston Scientific Scimed, Inc. Renal artery denervation apparatus employing helical shaping arrangement
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
EP2563255B1 (en) * 2010-04-26 2017-03-22 Medtronic Ardian Luxembourg S.à.r.l. Catheter apparatuses and systems for renal neuromodulation
CA2797130A1 (en) 2010-05-12 2011-11-17 Shifamed Holdings, Llc Low profile electrode assembly
US9655677B2 (en) 2010-05-12 2017-05-23 Shifamed Holdings, Llc Ablation catheters including a balloon and electrodes
WO2011150200A2 (en) * 2010-05-26 2011-12-01 University Of Miami Non occluding firing catheter for prolonged drug delivery
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US20120029512A1 (en) * 2010-07-30 2012-02-02 Willard Martin R Balloon with surface electrodes and integral cooling for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9155589B2 (en) * 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9554725B2 (en) 2010-08-03 2017-01-31 Medtronic Monitoring, Inc. Medical device and methods of monitoring a patient with renal dysfunction
EP3998030B1 (en) 2010-08-05 2025-09-24 Medtronic Ireland Manufacturing Unlimited Company Cryoablation apparatus for renal neuromodulation
US9943353B2 (en) 2013-03-15 2018-04-17 Tsunami Medtech, Llc Medical system and method of use
US20150150508A1 (en) * 2010-08-31 2015-06-04 Interventional Autonomics Corporation Intravascular electrodes and anchoring devices for transvascular stimulation
US8934956B2 (en) * 2010-08-31 2015-01-13 Interventional Autonomics Corporation Intravascular electrodes and anchoring devices for transvascular stimulation
WO2012149511A2 (en) 2011-04-28 2012-11-01 Synecor Llc Neuromodulation systems and methods for treating acute heart failure syndromes
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
US8696581B2 (en) 2010-10-18 2014-04-15 CardioSonic Ltd. Ultrasound transducer and uses thereof
US20130218054A1 (en) * 2010-10-18 2013-08-22 CardioSonic Ltd. Separation device for ultrasound element
US9566456B2 (en) 2010-10-18 2017-02-14 CardioSonic Ltd. Ultrasound transceiver and cooling thereof
US9028417B2 (en) 2010-10-18 2015-05-12 CardioSonic Ltd. Ultrasound emission element
JP2013543423A (ja) 2010-10-18 2013-12-05 カーディオソニック リミテッド 組織治療
US20120101413A1 (en) * 2010-10-20 2012-04-26 Medtronic Ardian Luxembourg S.a.r.I. Catheter apparatuses having expandable mesh structures for renal neuromodulation and associated systems and methods
US9084610B2 (en) 2010-10-21 2015-07-21 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
JP2013544131A (ja) * 2010-10-25 2013-12-12 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ 腎ニューロモジュレーションのためのマルチ電極アレイを有するカテーテル装置ならびに関連のシステムおよび方法
WO2012061150A1 (en) * 2010-10-25 2012-05-10 Medtronic Ardian Luxembourg S.a.r.I. Microwave catheter apparatuses, systems, and methods for renal neuromodulation
US8974451B2 (en) * 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
WO2012061153A1 (en) * 2010-10-25 2012-05-10 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems and methods for evaluation and feedback of neuromodulation treatment
US20120136344A1 (en) 2010-10-26 2012-05-31 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US20120109021A1 (en) * 2010-10-27 2012-05-03 Roger Hastings Renal denervation catheter employing acoustic wave generator arrangement
US9743974B2 (en) 2010-11-09 2017-08-29 Aegea Medical Inc. Positioning method and apparatus for delivering vapor to the uterus
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US10292754B2 (en) 2010-11-17 2019-05-21 Medtronic Ardian Luxembourg S.A.R.L. Therapeutic renal neuromodulation for treating dyspnea and associated systems and methods
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
JP6078471B2 (ja) 2010-11-19 2017-02-08 セント・ジュード・メディカル・エイトリアル・フィブリレーション・ディヴィジョン・インコーポレーテッド 直流組織治療のための不関電極を有する電極カテーテル機器
AU2011329669B2 (en) * 2010-11-19 2016-07-28 Boston Scientific Scimed, Inc. Renal nerve detection and ablation apparatus and method
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9770319B2 (en) 2010-12-01 2017-09-26 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
US20120157992A1 (en) * 2010-12-15 2012-06-21 Scott Smith Off-wall electrode device for renal nerve ablation
US10016233B2 (en) * 2010-12-06 2018-07-10 Biosense Webster (Israel) Ltd. Treatment of atrial fibrillation using high-frequency pacing and ablation of renal nerves
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US20120232409A1 (en) * 2010-12-15 2012-09-13 Stahmann Jeffrey E System and method for renal artery occlusion during renal denervation therapy
EP2656807A4 (en) 2010-12-21 2016-08-31 Terumo Corp BALLOON CATHETER AND POWER SUPPLY SYSTEM FOR IT
DK2658605T3 (en) * 2010-12-28 2016-11-14 Cibiem Inc CATH for endovascular ablation of glomus CAROTICUM FOR RESTORING sympathetic BALANCE WITH PATIENT
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
US10092291B2 (en) 2011-01-25 2018-10-09 Ethicon Endo-Surgery, Inc. Surgical instrument with selectively rigidizable features
WO2012112165A1 (en) 2011-02-18 2012-08-23 Recor Medical, Inc. Apparatus for effecting renal denervation using ultrasound
US9254169B2 (en) * 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9314620B2 (en) 2011-02-28 2016-04-19 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9233241B2 (en) 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US20140012251A1 (en) * 2011-03-07 2014-01-09 Tidal Wave Technology, Inc. Ablation devices and methods
WO2012122157A1 (en) * 2011-03-07 2012-09-13 Tidal Wave Technology, Inc. Radiofrequency ablation catheter device
WO2012125785A1 (en) 2011-03-17 2012-09-20 Ethicon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient
EP2677953A4 (en) * 2011-03-31 2014-10-08 Tidal Wave Technology Inc RADIO FREQUENCY ABLATION CATHETER DEVICE
WO2012135786A2 (en) * 2011-04-01 2012-10-04 The Regents Of The University Of California Cryoelectric systems and methods for treatment of biological matter
CN103517731B (zh) 2011-04-08 2016-08-31 柯惠有限合伙公司 用于去除肾交感神经和离子电渗式药物传递的离子电渗式药物传递系统和方法
US9237925B2 (en) * 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
US8663190B2 (en) 2011-04-22 2014-03-04 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
WO2012148969A2 (en) 2011-04-25 2012-11-01 Brian Kelly Apparatus and methods related to constrained deployment of cryogenic balloons for limited cryogenic ablation of vessel walls
CN106422025B (zh) 2011-05-03 2020-09-04 卡里拉医疗股份有限公司 可转向输送护套
CN102274074A (zh) * 2011-05-03 2011-12-14 上海微创电生理医疗科技有限公司 多极开放式射频消融导管
US20120323233A1 (en) 2011-05-09 2012-12-20 Cyberheart, Inc. Renovascular treatment device, system, and method for radiosurgically alleviating hypertension
US20120290024A1 (en) * 2011-05-11 2012-11-15 St. Jude Medical, Inc. Transvenous renal nerve modulation for treatment of hypertension, cardiovascular disorders, and chronic renal diseases
WO2012158864A1 (en) * 2011-05-18 2012-11-22 St. Jude Medical, Inc. Apparatus and method of assessing transvascular denervation
US8909316B2 (en) 2011-05-18 2014-12-09 St. Jude Medical, Cardiology Division, Inc. Apparatus and method of assessing transvascular denervation
US9220433B2 (en) 2011-06-30 2015-12-29 Biosense Webster (Israel), Ltd. Catheter with variable arcuate distal section
US9446240B2 (en) 2011-07-11 2016-09-20 Interventional Autonomics Corporation System and method for neuromodulation
US20130072995A1 (en) 2011-07-11 2013-03-21 Terrance Ransbury Catheter system for acute neuromodulation
EP2731671B1 (en) * 2011-07-11 2019-04-03 Interventional Autonomics Corporation Catheter system for acute neuromodulation
US12446942B2 (en) 2011-07-12 2025-10-21 Verve Medical, Inc. Treatment of kidney disease using renal nerve denervation via the renal pelvis
US20250177025A9 (en) 2011-07-12 2025-06-05 Verve Medical, Inc. Treatment of Kidney Disease Using Renal Nerve Denervation Via the Renal Pelvis
US12279800B2 (en) 2011-07-12 2025-04-22 Verve Medical, Inc. Methods and devices for treating polycystic kidney disease and its symptoms
JP2014525781A (ja) * 2011-07-12 2014-10-02 ベルブ メディカル， インコーポレイテッド 腎盂を通した腎神経の脱神経
WO2013013156A2 (en) 2011-07-20 2013-01-24 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
WO2013016203A1 (en) 2011-07-22 2013-01-31 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
US20130030430A1 (en) * 2011-07-29 2013-01-31 Stewart Mark T Intracardiac tools and methods for delivery of electroporation therapies
US9662169B2 (en) 2011-07-30 2017-05-30 Biosense Webster (Israel) Ltd. Catheter with flow balancing valve
US9278196B2 (en) 2011-08-24 2016-03-08 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US9056185B2 (en) 2011-08-24 2015-06-16 Ablative Solutions, Inc. Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
US20130053732A1 (en) * 2011-08-24 2013-02-28 Richard R. Heuser Devices and methods for treating hypertension with energy
EP2747690B1 (en) * 2011-08-24 2019-01-23 Boston Scientific Scimed, Inc. Device and methods for nerve modulation
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
ES2972941T3 (es) * 2011-08-26 2024-06-17 Symap Medical Suzhou Ltd Sistema para localizar e identificar nervios funcionales que inervan la pared de las arterias
US20230210593A1 (en) * 2011-08-26 2023-07-06 Symap Medical (Suzhou), Limited System and method for mapping the functional nerves innervating the wall of arteries, 3-d mapping and catheters for same
CN102949176B (zh) * 2011-08-26 2014-11-12 苏州信迈医疗器械有限公司 肾神经消融术中肾神经分布标测方法及用于该方法的导管
CN103271766B (zh) * 2012-08-24 2015-08-26 苏州信迈医疗器械有限公司 一种用于标测和消融位于肾动脉上所分布的肾神经的装置
US9820811B2 (en) * 2011-08-26 2017-11-21 Symap Medical (Suzhou), Ltd System and method for mapping the functional nerves innervating the wall of arteries, 3-D mapping and catheters for same
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9089668B2 (en) 2011-09-28 2015-07-28 Surefire Medical, Inc. Flow directional infusion device
US9427579B2 (en) 2011-09-29 2016-08-30 Pacesetter, Inc. System and method for performing renal denervation verification
KR20150143881A (ko) * 2011-09-30 2015-12-23 코비디엔 엘피 에너지 전달 장치 및 그 이용 방법
US20130090637A1 (en) * 2011-10-05 2013-04-11 St. Jude Medical, Inc. Catheter device and method for denervation
US8696584B2 (en) 2011-10-05 2014-04-15 3Dt Holdings, Llc Devices, systems and methods for determining fractional flow reserve in the presence of a catheter
EP2763617B1 (en) 2011-10-07 2017-12-06 Aegea Medical Inc. Integrity testing apparatus for delivering vapor to the uterus
EP2765942B1 (en) * 2011-10-10 2016-02-24 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
EP2765940B1 (en) 2011-10-11 2015-08-26 Boston Scientific Scimed, Inc. Off-wall electrode device for nerve modulation
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) * 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
WO2013059202A1 (en) 2011-10-18 2013-04-25 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
US9204916B2 (en) * 2011-10-27 2015-12-08 Medtronic Cryocath Lp Cryogenic balloon device with radiofrequency tip
US20130116737A1 (en) * 2011-11-07 2013-05-09 Medtronic Ardian Luxembourg S.A.R.L. Methods for Assessing Renal Neuromodulation Treatment and Associated Systems and Methods
EP2775899B1 (en) * 2011-11-07 2017-08-23 Medtronic Ardian Luxembourg S.à.r.l. Endovascular nerve monitoring devices and associated systems
EP2775948B1 (en) 2011-11-08 2018-04-04 Boston Scientific Scimed, Inc. Ostial renal nerve ablation
US20130116683A1 (en) * 2011-11-09 2013-05-09 Tsunami Medtech, Llc Medical system and method of use
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
GB201120023D0 (en) * 2011-11-21 2012-01-04 Univ Dundee Radio frequency surgical probe
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
JP5729660B2 (ja) * 2011-11-21 2015-06-03 株式会社ディナーヴ 腎動脈アブレーション用のカテーテルおよびシステム
US9192766B2 (en) 2011-12-02 2015-11-24 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation methods and devices for treatment of polycystic kidney disease
ITPD20110383A1 (it) * 2011-12-05 2013-06-06 Cardiac Impulse Srl Elettrocatetere per neurostimolazione
CA2856732A1 (en) 2011-12-09 2013-06-13 Metavention, Inc. Therapeutic neuromodulation of the hepatic system
US9844405B2 (en) 2011-12-20 2017-12-19 Cardiac Pacemakers, Inc. Method and apparatus for monitoring and ablating nerves
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
JP6130397B2 (ja) 2011-12-23 2017-05-17 べシックス・バスキュラー・インコーポレイテッド 身体通路の組織又は身体通路に隣接する組織をリモデリングするためのデバイス
US9433760B2 (en) 2011-12-28 2016-09-06 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
CN104159535A (zh) * 2012-01-17 2014-11-19 波士顿科学西美德公司 肾神经调节装置以及用于制造和使用该装置的方法
WO2013116380A1 (en) 2012-01-30 2013-08-08 Vytronus, Inc. Tissue necrosis methods and apparatus
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US8986199B2 (en) 2012-02-17 2015-03-24 Ethicon Endo-Surgery, Inc. Apparatus and methods for cleaning the lens of an endoscope
US9089341B2 (en) 2012-02-28 2015-07-28 Surefire Medical, Inc. Renal nerve neuromodulation device
EP2819604A1 (en) * 2012-03-01 2015-01-07 Boston Scientific Scimed, Inc. Off-wall and contact electrode devices and methods for nerve modulation
EP4070850B1 (en) 2012-03-05 2025-07-23 Lungpacer Medical Inc. Transvascular nerve stimulation apparatus
US10342592B2 (en) 2012-03-07 2019-07-09 Medtronic Ardian Luxembourg S.A.R.L. Selective modulation of renal nerves
EP2822648A2 (en) * 2012-03-07 2015-01-14 Enteromedics Inc. Devices for regulation of blood pressure and heart rate
AU2013230906A1 (en) 2012-03-08 2014-09-18 Medtronic Af Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the treatment of sexual dysfunction
WO2013134472A1 (en) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation methods and systems for treatment of hyperaldosteronism
AU2013230774B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Gastrointestinal neuromodulation and associated systems and methods
CN104271062B (zh) 2012-03-08 2017-07-07 美敦力Af卢森堡有限责任公司 采用神经调节装置的生物标志物取样和相关系统及方法
WO2013134548A2 (en) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
WO2013134543A1 (en) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg Sarl Immune system neuromodulation and associated systems and methods
US10737123B2 (en) 2012-03-08 2020-08-11 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the management of pain
US8934988B2 (en) 2012-03-16 2015-01-13 St. Jude Medical Ab Ablation stent with meander structure
JP5936409B2 (ja) * 2012-03-26 2016-06-22 国立研究開発法人国立循環器病研究センター 電極ユニットおよび組織刺激システム
JP2013198691A (ja) * 2012-03-26 2013-10-03 Olympus Corp 神経刺激電極および神経刺激システム
US9259261B2 (en) * 2012-04-12 2016-02-16 Vanderbilt University Ablation catheter having temperature-controlled anchor and related methods
US9439598B2 (en) 2012-04-12 2016-09-13 NeuroMedic, Inc. Mapping and ablation of nerves within arteries and tissues
US8961550B2 (en) 2012-04-17 2015-02-24 Indian Wells Medical, Inc. Steerable endoluminal punch
WO2013157011A2 (en) 2012-04-18 2013-10-24 CardioSonic Ltd. Tissue treatment
US9113929B2 (en) 2012-04-19 2015-08-25 St. Jude Medical, Cardiology Division, Inc. Non-electric field renal denervation electrode
CN104519817B (zh) 2012-04-24 2017-11-10 西比姆公司 用于颈动脉体摘除的血管内导管和方法
US9848950B2 (en) 2012-04-27 2017-12-26 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for localized disease treatment by ablation
US10258791B2 (en) 2012-04-27 2019-04-16 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods
WO2013162721A1 (en) 2012-04-27 2013-10-31 Medtronic Ardian Luxembourg Sarl Methods and devices for localized inhibition of inflammation by ablation
ES2741699T3 (es) 2012-04-27 2020-02-12 Medtronic Ardian Luxembourg Dispositivos crioterapéuticos para la neuromodulación renal
US9241752B2 (en) 2012-04-27 2016-01-26 Medtronic Ardian Luxembourg S.A.R.L. Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods
WO2013165920A1 (en) * 2012-04-29 2013-11-07 Synecor Llc Intravascular electrode arrays for neuromodulation
US11395921B2 (en) 2012-04-29 2022-07-26 Nuxcel2 Llc Intravascular electrode arrays for neuromodulation
WO2013165935A1 (en) * 2012-05-03 2013-11-07 Sound Interventions, Inc. Apparatus and method for uniform renal denervation
WO2013169927A1 (en) 2012-05-08 2013-11-14 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US9717555B2 (en) 2012-05-14 2017-08-01 Biosense Webster (Israel), Ltd. Catheter with helical end section for vessel ablation
US9439722B2 (en) 2012-05-09 2016-09-13 Biosense Webster (Israel) Ltd. Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension
MX2014013323A (es) 2012-05-11 2015-01-22 Medtronic Ardian Luxembourg Ensamblajes de cateter de multiples electrodos para neuromodulacion renal y sistemas y metodos asociados.
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
EP2854680A4 (en) 2012-06-01 2016-07-20 Cibiem Inc METHODS AND DEVICES FOR ABLATION OF CRYOGENIC CAROTID BODY
US10206616B2 (en) * 2012-06-14 2019-02-19 Autonomix Medical, Inc. Devices, systems, and methods for diagnosis and treatment of overactive bladder
CA2877049C (en) 2012-06-21 2022-08-16 Simon Fraser University Transvascular diaphragm pacing systems and methods of use
US8951296B2 (en) 2012-06-29 2015-02-10 Medtronic Ardian Luxembourg S.A.R.L. Devices and methods for photodynamically modulating neural function in a human
US9955946B2 (en) 2014-03-12 2018-05-01 Cibiem, Inc. Carotid body ablation with a transvenous ultrasound imaging and ablation catheter
US9078662B2 (en) 2012-07-03 2015-07-14 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US9295842B2 (en) 2012-07-05 2016-03-29 Mc10, Inc. Catheter or guidewire device including flow sensing and use thereof
JP2015521894A (ja) * 2012-07-05 2015-08-03 エムシー１０ インコーポレイテッドＭｃ１０，Ｉｎｃ． 流量センシングを含むカテーテルデバイス
US9381063B2 (en) 2012-07-13 2016-07-05 Magnetecs Inc. Method and apparatus for magnetically guided catheter for renal denervation employing MOSFET sensor array
WO2014015065A1 (en) * 2012-07-17 2014-01-23 Boston Scientific Scimed, Inc. Renal nerve modulation catheter design
US9144459B2 (en) 2012-07-19 2015-09-29 Cook Medical Technologies Llc Endoscopic ultrasound ablation needle
JP6235011B2 (ja) * 2012-07-24 2017-11-22 クリアストリーム・テクノロジーズ・リミテッド 位置確認性能が向上されたバルーンカテーテル
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US10314649B2 (en) 2012-08-02 2019-06-11 Ethicon Endo-Surgery, Inc. Flexible expandable electrode and method of intraluminal delivery of pulsed power
US9572623B2 (en) 2012-08-02 2017-02-21 Ethicon Endo-Surgery, Inc. Reusable electrode and disposable sheath
EP2882336B1 (en) 2012-08-09 2019-06-26 University of Iowa Research Foundation Catheter systems for puncturing through a tissue structure
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
CN103584909B (zh) * 2012-08-17 2016-01-27 王涛 开放式网状射频消融电极
US20140058372A1 (en) * 2012-08-22 2014-02-27 Amir Belson Treatment for renal failure
CN102784006B (zh) * 2012-08-24 2015-11-25 邹英华 用于治疗高血压的射频消融电极
US10321946B2 (en) 2012-08-24 2019-06-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices with weeping RF ablation balloons
WO2014039925A2 (en) 2012-09-07 2014-03-13 Yale University Brian cooling system
JP2014054430A (ja) 2012-09-13 2014-03-27 Nippon Koden Corp カテーテル
US8612022B1 (en) * 2012-09-13 2013-12-17 Invatec S.P.A. Neuromodulation catheters and associated systems and methods
US9173696B2 (en) 2012-09-17 2015-11-03 Boston Scientific Scimed, Inc. Self-positioning electrode system and method for renal nerve modulation
WO2014047355A1 (en) 2012-09-19 2014-03-27 Denervx LLC Cooled microwave denervation
WO2014047411A1 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
US10549127B2 (en) 2012-09-21 2020-02-04 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
CN104869930B (zh) 2012-10-10 2020-12-25 波士顿科学国际有限公司 肾神经调制装置和方法
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
US20140114215A1 (en) * 2012-10-20 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Methods for Renal Neuromodulation and Associated Systems and Devices
US9044575B2 (en) 2012-10-22 2015-06-02 Medtronic Adrian Luxembourg S.a.r.l. Catheters with enhanced flexibility and associated devices, systems, and methods
US9399115B2 (en) 2012-10-22 2016-07-26 Medtronic Ardian Luxembourg S.A.R.L. Catheters with enhanced flexibility and associated devices, systems, and methods
US10945787B2 (en) 2012-10-29 2021-03-16 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
US9526827B2 (en) 2012-10-29 2016-12-27 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US9554849B2 (en) 2012-10-29 2017-01-31 Ablative Solutions, Inc. Transvascular method of treating hypertension
US9301795B2 (en) 2012-10-29 2016-04-05 Ablative Solutions, Inc. Transvascular catheter for extravascular delivery
US8740849B1 (en) 2012-10-29 2014-06-03 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US10881458B2 (en) 2012-10-29 2021-01-05 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
US10226278B2 (en) 2012-10-29 2019-03-12 Ablative Solutions, Inc. Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US10736656B2 (en) 2012-10-29 2020-08-11 Ablative Solutions Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US12208224B2 (en) 2012-11-02 2025-01-28 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
EP4230162B1 (en) 2012-11-02 2024-10-09 Neurotronic, Inc. Chemical ablation formulations for various diseases
US9770593B2 (en) 2012-11-05 2017-09-26 Pythagoras Medical Ltd. Patient selection using a transluminally-applied electric current
US10004557B2 (en) 2012-11-05 2018-06-26 Pythagoras Medical Ltd. Controlled tissue ablation
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
US9017317B2 (en) 2012-12-06 2015-04-28 Medtronic Ardian Luxembourg S.A.R.L. Refrigerant supply system for cryotherapy including refrigerant recompression and associated devices, systems, and methods
US20140172034A1 (en) * 2012-12-18 2014-06-19 Pacesetter, Inc. Intra-cardiac implantable medical device with ic device extension for lv pacing/sensing
US10238875B2 (en) * 2012-12-19 2019-03-26 Adi Mashiach Systems and methods for hypertension control
WO2014097300A1 (en) 2012-12-20 2014-06-26 Shlomo Ben-Haim Multi point treatment probes and methods of using thereof
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US10537286B2 (en) 2013-01-08 2020-01-21 Biosense Webster (Israel) Ltd. Catheter with multiple spines of different lengths arranged in one or more distal assemblies
EP2945556A4 (en) 2013-01-17 2016-08-31 Virender K Sharma METHOD AND DEVICE FOR TISSUE REMOVAL
JP6134008B2 (ja) * 2013-01-18 2017-05-24 エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ 固定神経ブロックカテーテル
US9888956B2 (en) 2013-01-22 2018-02-13 Angiodynamics, Inc. Integrated pump and generator device and method of use
EP2759314A1 (de) * 2013-01-28 2014-07-30 Biotronik AG Katheter zur Modulation der renalen Nerven
US20140228875A1 (en) 2013-02-08 2014-08-14 Nidus Medical, Llc Surgical device with integrated visualization and cauterization
US10098527B2 (en) 2013-02-27 2018-10-16 Ethidcon Endo-Surgery, Inc. System for performing a minimally invasive surgical procedure
US20140303617A1 (en) * 2013-03-05 2014-10-09 Neuro Ablation, Inc. Intravascular nerve ablation devices & methods
US9179997B2 (en) 2013-03-06 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Thermochromic polyvinyl alcohol based hydrogel artery
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter
WO2015061621A1 (en) * 2013-10-24 2015-04-30 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses for pulmonary artery neuromodulation
WO2014143571A1 (en) 2013-03-11 2014-09-18 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9956033B2 (en) 2013-03-11 2018-05-01 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US10716914B2 (en) 2013-03-12 2020-07-21 St. Jude Medical, Cardiology Division, Inc. Catheter system
EP2777741A3 (en) 2013-03-12 2015-01-21 St. Jude Medical, Cardiology Division, Inc. Catheter system
EP2777740A3 (en) 2013-03-12 2015-01-21 St. Jude Medical, Cardiology Division, Inc. Catheter system
US9510902B2 (en) 2013-03-13 2016-12-06 St. Jude Medical, Cardiology Division, Inc. Ablation catheters and systems including rotational monitoring means
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US9861431B2 (en) * 2013-03-13 2018-01-09 Kyphon SÀRL Radiofrequency inflatable device
EP2971232A1 (en) 2013-03-14 2016-01-20 ReCor Medical, Inc. Methods of plating or coating ultrasound transducers
CN105188848B (zh) 2013-03-14 2019-12-10 瑞蔻医药有限公司 基于超声波的神经调制系统
US8876813B2 (en) 2013-03-14 2014-11-04 St. Jude Medical, Inc. Methods, systems, and apparatus for neural signal detection
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations
US10016229B2 (en) 2013-03-15 2018-07-10 Myoscience, Inc. Methods and systems for treatment of occipital neuralgia
AU2014237950B2 (en) 2013-03-15 2017-04-13 Boston Scientific Scimed, Inc. Control unit for use with electrode pads and a method for estimating an electrical leakage
US9066726B2 (en) 2013-03-15 2015-06-30 Medtronic Ardian Luxembourg S.A.R.L. Multi-electrode apposition judgment using pressure elements
US9179974B2 (en) * 2013-03-15 2015-11-10 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
US10543037B2 (en) 2013-03-15 2020-01-28 Medtronic Ardian Luxembourg S.A.R.L. Controlled neuromodulation systems and methods of use
WO2014146126A1 (en) 2013-03-15 2014-09-18 Myoscience, Inc. Cryogenic blunt dissection methods and devices
US9186212B2 (en) * 2013-03-15 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods utilizing two or more sites along denervation catheter
WO2014150553A1 (en) 2013-03-15 2014-09-25 Boston Scientific Scimed, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
US9179973B2 (en) 2013-03-15 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods for renal denervation utilizing balloon catheter
US9713490B2 (en) 2013-03-15 2017-07-25 St. Jude Medical, Cardiology Division, Inc. Ablation system, methods, and controllers
US9295512B2 (en) * 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US9173701B2 (en) 2013-03-15 2015-11-03 Warsaw Orthopedic, Inc. RF enabled inflatable bone tamp
WO2014150425A1 (en) 2013-03-15 2014-09-25 St. Jude Medical, Cardiology Division, Inc. Multi-electrode ablation system with a controller for determining a thermal gain of each electrode
US9974477B2 (en) 2013-03-15 2018-05-22 St. Jude Medical, Cardiology Division, Inc. Quantification of renal denervation via alterations in renal blood flow pre/post ablation
US20140276756A1 (en) * 2013-03-15 2014-09-18 Boston Scientific Scimed, Inc. Wall-sparing renal nerve ablation catheter with spaced electrode structures
US20140275993A1 (en) * 2013-03-15 2014-09-18 Medtronic Ardian Luxembourg S.a.r.I. Devices, Systems, and Methods for Specialization of Neuromodulation Treatment
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
US9233247B2 (en) * 2013-03-15 2016-01-12 Boston Scientific Neuromodulation Corporation Neuromodulation of renal nerve for treatment of hypertension
US10004458B2 (en) 2013-03-27 2018-06-26 Autonomix Medical, Inc. Systems and methods for neurological traffic and/or receptor functional evaluation and/or modification
US10349824B2 (en) 2013-04-08 2019-07-16 Apama Medical, Inc. Tissue mapping and visualization systems
US10098694B2 (en) 2013-04-08 2018-10-16 Apama Medical, Inc. Tissue ablation and monitoring thereof
WO2014168987A1 (en) 2013-04-08 2014-10-16 Shifamed Holdings, Llc Cardiac ablation catheters and methods of use thereof
EP2986243B1 (en) 2013-04-15 2020-06-17 Mayo Foundation for Medical Education and Research Apparatus for percutaneous epicardial ablation of cardiac ganglionated plexi without myocardial injury
US10350002B2 (en) 2013-04-25 2019-07-16 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system
CN105392519A (zh) * 2013-05-02 2016-03-09 道格拉斯·C·哈灵顿 用于检测和治疗主动脉肾神经节的设备以及方法
WO2014189794A1 (en) 2013-05-18 2014-11-27 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with shafts for enhanced flexibility and control and associated devices, systems, and methods
AU2014268737A1 (en) * 2013-05-20 2015-12-03 Mayo Foundation For Medical Education And Research Devices and methods for ablation of tissue
EP2999411B1 (en) 2013-05-23 2020-10-07 Cardiosonic Ltd. Devices for renal denervation and assessment thereof
US10016600B2 (en) 2013-05-30 2018-07-10 Neurostim Solutions, Llc Topical neurological stimulation
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
CA2913346A1 (en) 2013-06-05 2014-12-11 Metavention, Inc. Modulation of targeted nerve fibers
WO2014205129A1 (en) * 2013-06-18 2014-12-24 Enterowave, Inc. Method and apparatus for minimally invasive implantable modulators
JP2016523147A (ja) 2013-06-21 2016-08-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 同乗型電極支持体を備えた腎除神経バルーンカテーテル
WO2014205399A1 (en) 2013-06-21 2014-12-24 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation having rotatable shafts
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
US9872728B2 (en) 2013-06-28 2018-01-23 St. Jude Medical, Cardiology Division, Inc. Apparatuses and methods for affixing electrodes to an intravascular balloon
WO2015002787A1 (en) 2013-07-01 2015-01-08 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US20150011991A1 (en) 2013-07-03 2015-01-08 St. Jude Medical, Cardiology Division, Inc. Electrode Assembly For Catheter System
EP3019105B1 (en) * 2013-07-11 2017-09-13 Boston Scientific Scimed, Inc. Devices for nerve modulation
CN105377170A (zh) * 2013-07-11 2016-03-02 波士顿科学国际有限公司 具有可伸展电极组件的医疗装置
WO2015010074A1 (en) 2013-07-19 2015-01-22 Boston Scientific Scimed, Inc. Spiral bipolar electrode renal denervation balloon
WO2015013205A1 (en) 2013-07-22 2015-01-29 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
CN105392435B (zh) 2013-07-22 2018-11-09 波士顿科学国际有限公司 具有扭绞球囊的肾神经消融导管
US20150031946A1 (en) 2013-07-24 2015-01-29 Nidus Medical, Llc Direct vision cryosurgical probe and methods of use
US10154869B2 (en) 2013-08-02 2018-12-18 Gary M. Onik System and method for creating radio-frequency energy electrical membrane breakdown for tissue ablation
WO2017123981A1 (en) 2016-01-15 2017-07-20 Rfemb Holdings, Llc Immunologic treatment of cancer
WO2015022668A2 (en) * 2013-08-14 2015-02-19 La Vita Technologies Ltd. Methods and apparatuses for treating auto-immune diseases by ablative neuromodulation
WO2015027096A1 (en) 2013-08-22 2015-02-26 Boston Scientific Scimed, Inc. Flexible circuit having improved adhesion to a renal nerve modulation balloon
US9326816B2 (en) 2013-08-30 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods
US9339332B2 (en) 2013-08-30 2016-05-17 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with nerve monitoring features for transmitting digital neural signals and associated systems and methods
CN105555218B (zh) 2013-09-04 2019-01-15 波士顿科学国际有限公司 具有冲洗和冷却能力的射频(rf)球囊导管
US20150073515A1 (en) 2013-09-09 2015-03-12 Medtronic Ardian Luxembourg S.a.r.I. Neuromodulation Catheter Devices and Systems Having Energy Delivering Thermocouple Assemblies and Associated Methods
US9138578B2 (en) 2013-09-10 2015-09-22 Medtronic Ardian Luxembourg S.A.R.L. Endovascular catheters with tuned control members and associated systems and methods
US10952790B2 (en) 2013-09-13 2021-03-23 Boston Scientific Scimed, Inc. Ablation balloon with vapor deposited cover layer
WO2015048806A2 (en) 2013-09-30 2015-04-02 Nidus Medical, Llc Apparatus and methods for treating rhinitis
JP2016531612A (ja) * 2013-09-30 2016-10-13 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ らせん状トラックを有する血管内神経調節デバイス及び関連方法
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
EP3057488B1 (en) 2013-10-14 2018-05-16 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
AU2014334574B2 (en) 2013-10-15 2017-07-06 Boston Scientific Scimed, Inc. Medical device balloon
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
EP3057521B1 (en) 2013-10-18 2020-03-25 Boston Scientific Scimed, Inc. Balloon catheters with flexible conducting wires
USD914883S1 (en) 2013-10-23 2021-03-30 St. Jude Medical, Cardiology Division, Inc. Ablation generator
US10856936B2 (en) 2013-10-23 2020-12-08 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system including thermoplastic-based struts
USD774043S1 (en) 2013-10-23 2016-12-13 St. Jude Medical, Cardiology Division, Inc. Display screen with graphical user interface for ablation generator
US10433902B2 (en) 2013-10-23 2019-10-08 Medtronic Ardian Luxembourg S.A.R.L. Current control methods and systems
USD747491S1 (en) 2013-10-23 2016-01-12 St. Jude Medical, Cardiology Division, Inc. Ablation generator
WO2015061052A1 (en) 2013-10-24 2015-04-30 St. Jude Medical, Cardiology Division, Inc. Flexible catheter shaft and method of manufacture
US10034705B2 (en) 2013-10-24 2018-07-31 St. Jude Medical, Cardiology Division, Inc. High strength electrode assembly for catheter system including novel electrode
EP3060151A1 (en) 2013-10-24 2016-08-31 St. Jude Medical, Cardiology Division, Inc. Flexible catheter shaft and method of manufacture
US10271898B2 (en) 2013-10-25 2019-04-30 Boston Scientific Scimed, Inc. Embedded thermocouple in denervation flex circuit
US9931046B2 (en) 2013-10-25 2018-04-03 Ablative Solutions, Inc. Intravascular catheter with peri-vascular nerve activity sensors
US9949652B2 (en) 2013-10-25 2018-04-24 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
US10390881B2 (en) 2013-10-25 2019-08-27 Denervx LLC Cooled microwave denervation catheter with insertion feature
US10517666B2 (en) 2013-10-25 2019-12-31 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
WO2015065636A1 (en) 2013-10-28 2015-05-07 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system including interlinked struts
US9861433B2 (en) 2013-11-05 2018-01-09 St. Jude Medical, Cardiology Division, Inc. Helical-shaped ablation catheter and methods of use
US20150133918A1 (en) * 2013-11-08 2015-05-14 Contego Medical, Llc Percutaneous catheter-based arterial denervation with integral emobolic filter
US9242088B2 (en) 2013-11-22 2016-01-26 Simon Fraser University Apparatus and methods for assisted breathing by transvascular nerve stimulation
AU2014360318B2 (en) 2013-12-05 2019-10-31 Rfemb Holdings, Llc Cancer immunotherapy by radiofrequency electrical membrane breakdown (RF-EMB)
WO2015088972A1 (en) * 2013-12-09 2015-06-18 Ryan Kendall Pierce Devices and methods for treating cardiovascular and metabolic disease
US20160331447A1 (en) * 2013-12-20 2016-11-17 The Johns Hopkins University Method and apparatus for selective treatment inside a body lumen
EP3089686A4 (en) * 2014-01-03 2017-11-22 Mc10, Inc. Catheter or guidewire device including flow sensing and use thereof
EP3091923A1 (en) * 2014-01-06 2016-11-16 Boston Scientific Scimed, Inc. Sympathetic nerve ablation devices with an expansion-limiting member
WO2015103574A1 (en) 2014-01-06 2015-07-09 Iowa Approach Inc. Apparatus and methods for renal denervation ablation
WO2015103617A1 (en) 2014-01-06 2015-07-09 Boston Scientific Scimed, Inc. Tear resistant flex circuit assembly
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
US9511228B2 (en) 2014-01-14 2016-12-06 Cyberonics, Inc. Implantable neurostimulator-implemented method for managing hypertension through renal denervation and vagus nerve stimulation
US20150202444A1 (en) 2014-01-17 2015-07-23 Cardiac Pacemakers, Inc. Systems and methods for selective stimulation of nerve fibers in carotid sinus
AU2015206540B2 (en) * 2014-01-17 2017-05-11 Cardiac Pacemakers, Inc. Depletion block to block nerve communication
EP3096835B1 (en) 2014-01-21 2019-08-07 Lungpacer Medical Inc. Systems for optimization of multi-electrode nerve pacing
US20150209107A1 (en) 2014-01-24 2015-07-30 Denervx LLC Cooled microwave denervation catheter configuration
WO2015113034A1 (en) 2014-01-27 2015-07-30 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters having jacketed neuromodulation elements and related devices, systems, and methods
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
EP3102136B1 (en) 2014-02-04 2018-06-27 Boston Scientific Scimed, Inc. Alternative placement of thermal sensors on bipolar electrode
US20240099988A1 (en) 2014-02-07 2024-03-28 Verve Medical, Inc. Treatment of Kidney Disease by Renal Pelvis Ablation
WO2015120340A1 (en) 2014-02-07 2015-08-13 Verve Medical, Inc. Methods and systems for ablation of the renal pelvis
US9855402B2 (en) * 2014-02-15 2018-01-02 Rex Medical, L.P. Apparatus for delivering fluid to treat renal hypertension
US10004913B2 (en) 2014-03-03 2018-06-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for power conversion and data transmission in implantable sensors, stimulators, and actuators
US10492842B2 (en) 2014-03-07 2019-12-03 Medtronic Ardian Luxembourg S.A.R.L. Monitoring and controlling internally administered cryotherapy
US20170056104A1 (en) * 2014-03-10 2017-03-02 Mayo Foundation For Medical Education And Research Hemodynamic measurement devices and techniques
US10463424B2 (en) 2014-03-11 2019-11-05 Medtronic Ardian Luxembourg S.A.R.L. Catheters with independent radial-expansion members and associated devices, systems, and methods
US9579149B2 (en) 2014-03-13 2017-02-28 Medtronic Ardian Luxembourg S.A.R.L. Low profile catheter assemblies and associated systems and methods
US9968740B2 (en) 2014-03-25 2018-05-15 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
US9889031B1 (en) 2014-03-25 2018-02-13 Surefire Medical, Inc. Method of gastric artery embolization
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US20150289750A1 (en) * 2014-04-11 2015-10-15 Jeremy Stigall Imaging and treatment device
US20170027460A1 (en) * 2015-07-29 2017-02-02 NeuroMedic, Inc. Intraluminal microneurography probe
US9999463B2 (en) 2014-04-14 2018-06-19 NeuroMedic, Inc. Monitoring nerve activity
US12350050B2 (en) 2014-04-14 2025-07-08 Recor Medical, Inc. Intraluminal microneurography probes and related systems and methods
US10398501B2 (en) 2014-04-24 2019-09-03 St. Jude Medical, Cardiology Division, Inc. Ablation systems including pulse rate detector and feedback mechanism and methods of use
EP4371512A3 (en) 2014-04-24 2024-08-14 Medtronic Ardian Luxembourg S.à.r.l. Neuromodulation catheters having braided shafts and associated systems and methods
US10610292B2 (en) 2014-04-25 2020-04-07 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems, and methods for monitoring and/or controlling deployment of a neuromodulation element within a body lumen and related technology
US10709490B2 (en) * 2014-05-07 2020-07-14 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods
EP3139997B1 (en) 2014-05-07 2018-09-19 Farapulse, Inc. Apparatus for selective tissue ablation
WO2015170281A1 (en) 2014-05-07 2015-11-12 Rainbow Medical Ltd Controlled tissue ablation techniques
WO2015171213A1 (en) 2014-05-09 2015-11-12 The Board Of Trustees Of The Leland Stanford Junior University Autofocus wireless power transfer to implantable devices in freely moving animals
ES3010493T3 (en) 2014-05-12 2025-04-03 Virginia Tech Intellectual Properties Inc Selective modulation of intracellular effects of cells using pulsed electric fields
AU2015258956B2 (en) * 2014-05-16 2018-11-15 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and methods for modulating renal nerve tissue
EP3142584A1 (en) 2014-05-16 2017-03-22 Iowa Approach Inc. Methods and apparatus for multi-catheter tissue ablation
ES2991295T3 (es) 2014-05-22 2024-12-03 Coopersurgical Inc Sistemas para realizar la ablación endometrial
US10179019B2 (en) 2014-05-22 2019-01-15 Aegea Medical Inc. Integrity testing method and apparatus for delivering vapor to the uterus
EP3154463B1 (en) 2014-06-12 2019-03-27 Farapulse, Inc. Apparatus for rapid and selective transurethral tissue ablation
EP3154464B1 (en) 2014-06-12 2025-03-12 Boston Scientific Scimed, Inc. Apparatus for rapid and selective tissue ablation with cooling
US10835134B2 (en) 2014-06-13 2020-11-17 Palo Alto Investors Methods and compositions for restoring homeostatic capacity of a subject
WO2016007750A1 (en) * 2014-07-09 2016-01-14 Arapeen Medical, LLC Renal denervation with staged assessment
JP6342247B2 (ja) * 2014-07-18 2018-06-13 オリンパス株式会社 超音波エネルギ治療装置
US9763743B2 (en) 2014-07-25 2017-09-19 Arrinex, Inc. Apparatus and method for treating rhinitis
CA2994800A1 (en) * 2014-08-06 2016-02-11 Nero Tronik Ip Holding (Jersey) Limited Electrodes and electrode positioning systems for transvascular neuromodulation
US20160045257A1 (en) * 2014-08-14 2016-02-18 Ablative Solutions, Inc. Method for selection and treatment of hypertensive patients with renal denervation
US11464971B2 (en) 2014-08-26 2022-10-11 Avent, Inc. Selective nerve fiber block method and system
US20160058503A1 (en) * 2014-08-28 2016-03-03 Medtronic Ardian Luxembourg S.a.r.I. Methods for modulating renal nerve tissue and associated systems and devices
WO2016033543A1 (en) 2014-08-28 2016-03-03 Medtronic Ardian Luxembourg S.A.R.L. Methods for assessing efficacy of renal neuromodulation and associated systems and devices
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
JP2017195910A (ja) * 2014-09-12 2017-11-02 テルモ株式会社 アブレーションカテーテル
EP3200712B1 (en) 2014-10-01 2020-11-25 Medtronic Ardian Luxembourg S.à.r.l. Systems for evaluating neuromodulation therapy via hemodynamic responses
EP3206613B1 (en) 2014-10-14 2019-07-03 Farapulse, Inc. Apparatus for rapid and safe pulmonary vein cardiac ablation
JP2016077801A (ja) * 2014-10-22 2016-05-16 オリンパス株式会社 電極ユニットおよび神経刺激システム
CN113040895A (zh) 2014-10-30 2021-06-29 纽敦力公司 治疗多种疾病的化学消融和方法
US10925579B2 (en) 2014-11-05 2021-02-23 Otsuka Medical Devices Co., Ltd. Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
EP3217904B1 (en) 2014-11-14 2021-09-08 Medtronic Ardian Luxembourg S.à.r.l. Catheter apparatuses for modulation of nerves in communication with the pulmonary system and associated systems
US20180326227A1 (en) * 2014-11-26 2018-11-15 Sonievie Ltd. Devices and methods for pulmonary hypertension treatment
WO2016090175A1 (en) 2014-12-03 2016-06-09 Metavention, Inc. Systems and methods for modulating nerves or other tissue
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
US10271893B2 (en) 2014-12-15 2019-04-30 Medtronic Ablation Frontiers Llc Timed energy delivery
WO2016100720A1 (en) 2014-12-17 2016-06-23 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for assessing sympathetic nervous system tone for renal neuromodulation therapy
US9974946B2 (en) * 2015-04-07 2018-05-22 NeuroTronik IP Holding (Jersey) Limited Inflatable intravascular electrode supports for neuromodulation
US10568687B2 (en) * 2015-01-16 2020-02-25 The Regents Of The University Of California Integrated intraoperative diagnosis and thermal therapy system
ES2968797T3 (es) 2015-01-23 2024-05-14 Contego Medical Inc Dispositivo de intervención con un filtro embólico integrado
KR102128856B1 (ko) 2015-01-30 2020-07-02 알에프이엠비 홀딩스, 엘엘씨 고주파 전기적 막 파괴를 이용하여 생명체의 바람직하지 않은 연조직을 절제하는 시스템
US10376308B2 (en) 2015-02-05 2019-08-13 Axon Therapies, Inc. Devices and methods for treatment of heart failure by splanchnic nerve ablation
CN107530004A (zh) 2015-02-20 2018-01-02 Mc10股份有限公司 基于贴身状况、位置和/或取向的可穿戴式设备的自动检测和构造
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
KR102054003B1 (ko) * 2015-02-27 2019-12-12 주식회사 한독칼로스메디칼 카테터 및 이를 포함하는 신경차단 장치
US10820864B2 (en) * 2015-03-02 2020-11-03 Valencia Technologies Corporation Methods and systems for predicting patient responsiveness to subcutaneous neuromodulation therapy as a treatment for hypertension
WO2016141962A1 (en) * 2015-03-06 2016-09-15 Imperial Innovations Limited Probe deployment device
EP3274037B1 (en) 2015-03-27 2021-11-03 Kalila Medical, Inc. Steerable medical devices
US20160287839A1 (en) 2015-03-31 2016-10-06 Surefire Medical, Inc. Apparatus and Method for Infusing an Immunotherapy Agent to a Solid Tumor for Treatment
CA3021573A1 (en) * 2015-04-13 2016-10-20 NeuroTronik IP Holding (Jersey) Limited Systems and methods for generating therapeutic electric fields for capture of nervous system targets
US12035961B2 (en) 2015-04-13 2024-07-16 Carlos Fernando Bazoberry Radiofrequency denervation needle and method
US10786300B2 (en) 2015-04-13 2020-09-29 Carlos Fernando Bazoberry Radiofrequency denervation needle and method
WO2016172706A1 (en) 2015-04-24 2016-10-27 Shifamed Holdings, Llc Steerable medical devices, systems, and methods of use
US10383685B2 (en) 2015-05-07 2019-08-20 Pythagoras Medical Ltd. Techniques for use with nerve tissue
US12268433B2 (en) 2015-05-12 2025-04-08 National University Of Ireland, Galway Devices for therapeutic nasal neuromodulation and associated methods and systems
EP3294410B1 (en) * 2015-05-12 2024-08-21 National University of Ireland Galway Devices for therapeutic nasal neuromodulation
US20160338769A1 (en) * 2015-05-18 2016-11-24 Biosense Webster (Israel) Ltd. Catheter with anchoring balloon assembly
AU2016275556A1 (en) * 2015-06-10 2017-12-14 Cathrx Ltd Double shape catheter
US10799287B2 (en) 2015-07-07 2020-10-13 Boston Scientific Scimed, Inc. Medical device having extenable members
JP6998295B2 (ja) * 2015-07-21 2022-01-18 コーニンクレッカ フィリップス エヌ ヴェ 腎神経を刺激するシステム
DE202016009215U1 (de) 2015-08-06 2024-04-29 Medtronic, Inc. Herzablation mittels gepulsten Feldes
EP3347085B1 (en) 2015-09-11 2023-07-26 Nalu Medical, Inc. Apparatus for peripheral or spinal stimulation
US10660691B2 (en) 2015-10-07 2020-05-26 Angiodynamics, Inc. Multiple use subassembly with integrated fluid delivery system for use with single or dual-lumen peristaltic tubing
US10207110B1 (en) 2015-10-13 2019-02-19 Axon Therapies, Inc. Devices and methods for treatment of heart failure via electrical modulation of a splanchnic nerve
WO2017074920A1 (en) 2015-10-27 2017-05-04 Mayo Foundation For Medical Education And Research Devices and methods for ablation of tissue
US10933221B2 (en) 2015-11-09 2021-03-02 Kalila Medical, Inc. Steering assemblies for medical devices, and methods of use
EP3376936B1 (en) 2015-11-16 2024-01-03 Boston Scientific Scimed, Inc. Energy delivery devices
US10675085B2 (en) 2015-11-23 2020-06-09 Boston Scientific Scimed, Inc. Devices and methods for enhanced denervation procedures
US20170150922A1 (en) 2015-11-30 2017-06-01 Palo Alto Investors Methods of Enhancing Homeostatic Capacity in a Subject by Increasing Homeostatic System Component Responsiveness, and Devices for Use in Practicing the Same
AU2016362114B2 (en) * 2015-12-01 2020-07-16 Symap Medical (Suzhou), Ltd System and method for mapping functional nerves innervating wall of arteries,3-D mapping and catheters for same
US20170188308A1 (en) * 2015-12-23 2017-06-29 Intel Corporation Extending an operational lifetime of an internet of things (IOT) device
US12144541B2 (en) 2016-01-05 2024-11-19 Boston Scientific Scimed, Inc. Systems, apparatuses and methods for delivery of ablative energy to tissue
US10130423B1 (en) 2017-07-06 2018-11-20 Farapulse, Inc. Systems, devices, and methods for focal ablation
US10660702B2 (en) 2016-01-05 2020-05-26 Farapulse, Inc. Systems, devices, and methods for focal ablation
US10172673B2 (en) 2016-01-05 2019-01-08 Farapulse, Inc. Systems devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue
EP4606419A3 (en) * 2016-01-05 2025-11-05 Boston Scientific Scimed, Inc. System for delivery of pulsed electric field ablative energy to endocardial tissue
US20170189097A1 (en) 2016-01-05 2017-07-06 Iowa Approach Inc. Systems, apparatuses and methods for delivery of ablative energy to tissue
US10624554B2 (en) * 2016-01-14 2020-04-21 Biosense Webster (Israel) Ltd. Non-overlapping loop-type or spline-type catheter to determine activation source direction and activation source type
US11006887B2 (en) 2016-01-14 2021-05-18 Biosense Webster (Israel) Ltd. Region of interest focal source detection using comparisons of R-S wave magnitudes and LATs of RS complexes
EP3403092A4 (en) * 2016-01-15 2019-08-28 University of Cincinnati ADVANCED ELECTROPORATION DEVICES AND METHODS FOR ANALYTICAL ACCESS IN BIOFLUIDS
JP7125349B2 (ja) 2016-02-11 2022-08-24 アリネックス， インコーポレイテッド 画像誘導後鼻神経アブレーションの方法およびデバイス
CN109069064B (zh) 2016-02-19 2022-05-13 埃杰亚医疗公司 用于确定体腔的完整性的方法和设备
AU2017221321B2 (en) 2016-02-19 2021-04-15 Nalu Medical, Inc. Apparatus with enhanced stimulation waveforms
CN115175014A (zh) 2016-02-22 2022-10-11 美谛达解决方案公司 贴身传感器系统
EP3216488B1 (en) 2016-03-10 2023-07-12 BIOTRONIK SE & Co. KG Delivery system for implantable stimulation devices and corresponding catheters
WO2017173089A1 (en) * 2016-03-31 2017-10-05 Memorial Sloan Kettering Cancer Center Systems and methods for enhancing delivery of diagnostic and/or therapeutic compositions in vivo using electric pulses
DE102016106478A1 (de) 2016-04-08 2017-10-12 Biotronik Ag Vorrichtung zur Energieabgabe und/oder Messung von elektrischer Aktivität
WO2017184705A1 (en) 2016-04-19 2017-10-26 Mc10, Inc. Method and system for measuring perspiration
CN109310390B (zh) * 2016-04-27 2022-03-25 纽克斯科技公司 电疗治疗
US10736692B2 (en) 2016-04-28 2020-08-11 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the treatment of cancer
US12364537B2 (en) 2016-05-02 2025-07-22 Santa Anna Tech Llc Catheter with a double balloon structure to generate and apply a heated ablative zone to tissue
EP4349396A3 (en) 2016-05-13 2024-05-01 Pacira CryoTech, Inc. Systems for locating and treating with cold therapy
WO2017199240A2 (en) 2016-05-18 2017-11-23 Pythagoras Medical Ltd. Helical catheter
US11331140B2 (en) 2016-05-19 2022-05-17 Aqua Heart, Inc. Heated vapor ablation systems and methods for treating cardiac conditions
EP3457969B1 (en) 2016-05-20 2024-07-03 Pentax of America, Inc. Cryogenic ablation system with rotatable and translatable catheter
CN107440788A (zh) * 2016-06-01 2017-12-08 四川锦江电子科技有限公司 一种具有极间放电功能的消融导管及消融装置
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
EP3471638B1 (en) 2016-06-15 2025-01-29 Arrinex, Inc. Devices for treating a lateral surface of a nasal cavity
EP3471631A4 (en) 2016-06-16 2020-03-04 Farapulse, Inc. Systems, apparatuses, and methods for guide wire delivery
WO2017223264A1 (en) 2016-06-23 2017-12-28 St. Jude Medical, Cardiology Division, Inc. Catheter system and electrode assembly for intraprocedural evaluation of renal denervation
CA3029260A1 (en) 2016-06-27 2018-01-04 Gala Therapeutics, Inc. Generator and a catheter with an electrode and a method for treating a lung passageway
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
JP7075922B2 (ja) * 2016-07-11 2022-05-26 レトロバスキュラー インコーポレイテッド 双極型組織切除装置及びその使用方法
WO2018017463A1 (en) 2016-07-18 2018-01-25 Nalu Medical, Inc. Methods and systems for treating pelvic disorders and pain conditions
CA3031766A1 (en) 2016-07-29 2018-02-01 Howard Levin Devices, systems, and methods for treatment of heart failure by splanchnic nerve ablation
US10447347B2 (en) 2016-08-12 2019-10-15 Mc10, Inc. Wireless charger and high speed data off-loader
DE102016116871A1 (de) * 2016-09-08 2018-03-08 Phenox Gmbh Vorrichtung und Verfahren zur Vorbeugung und Behandlung eines Vasospasmus
US11400263B1 (en) 2016-09-19 2022-08-02 Trisalus Life Sciences, Inc. System and method for selective pressure-controlled therapeutic delivery
US10780250B1 (en) 2016-09-19 2020-09-22 Surefire Medical, Inc. System and method for selective pressure-controlled therapeutic delivery
US11253312B2 (en) 2016-10-17 2022-02-22 Arrinex, Inc. Integrated nasal nerve detector ablation-apparatus, nasal nerve locator, and methods of use
US10537709B2 (en) 2016-10-18 2020-01-21 Boston Scientific Scimed, Inc. Guide extension catheter
WO2018075924A1 (en) 2016-10-20 2018-04-26 Retrovascular, Inc. Method and device for enhanced composition delivery
US10231784B2 (en) 2016-10-28 2019-03-19 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics
EP3531899A4 (en) * 2016-10-31 2020-11-04 General Electric Company NEUROMODULATION TECHNIQUES
US11382513B2 (en) 2016-11-08 2022-07-12 Palo Alto Investors Methods and compositions for treating a condition in a subject
US10806942B2 (en) 2016-11-10 2020-10-20 Qoravita LLC System and method for applying a low frequency magnetic field to biological tissues
CN110191674B (zh) 2016-11-11 2023-04-07 爱尔兰国立高威大学 用于专门化，监测，和/或评估治疗性鼻神经调节的装置，系统，和方法
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
ES2922929T3 (es) * 2016-12-20 2022-09-21 Galvani Bioelectronics Ltd Dispositivo de neuromodulación
JP2018102650A (ja) * 2016-12-27 2018-07-05 京セラ株式会社 腎神経用超音波カテーテル
WO2018127796A1 (en) * 2017-01-05 2018-07-12 Yuval Taff Thrombectomy devices
US10646713B2 (en) 2017-02-22 2020-05-12 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and associated methods for treating patients via renal neuromodulation to reduce a risk of developing cognitive impairment
WO2018156953A1 (en) 2017-02-24 2018-08-30 Nalu Medical, Inc. Apparatus with sequentially implanted stimulators
CN110505900A (zh) 2017-03-20 2019-11-26 索尼伟业有限公司 用于通过改善患者的射血分数来治疗心力衰竭的方法
US10588636B2 (en) 2017-03-20 2020-03-17 Surefire Medical, Inc. Dynamic reconfigurable microvalve protection device
CN106901831A (zh) * 2017-03-23 2017-06-30 深圳市惠泰医疗器械有限公司 肾动脉刺激消融电极导管
EP3606612A4 (en) * 2017-04-03 2021-05-26 MDSG Innovation Ltd. DEVICE AND METHOD FOR TREATMENT OF KIDNEY
US20190091475A1 (en) * 2017-04-16 2019-03-28 Jose Carlos Pachon-Mateos Extracardiac autonomic nerve stimulation
US9987081B1 (en) 2017-04-27 2018-06-05 Iowa Approach, Inc. Systems, devices, and methods for signal generation
US10617867B2 (en) * 2017-04-28 2020-04-14 Farapulse, Inc. Systems, devices, and methods for delivery of pulsed electric field ablative energy to esophageal tissue
EP3614940B1 (en) 2017-04-28 2024-11-20 Arrinex, Inc. Systems for locating blood vessels in the treatment of rhinitis
WO2018208992A1 (en) 2017-05-09 2018-11-15 Nalu Medical, Inc. Stimulation apparatus
US10293164B2 (en) 2017-05-26 2019-05-21 Lungpacer Medical Inc. Apparatus and methods for assisted breathing by transvascular nerve stimulation
GB2563386A (en) * 2017-06-08 2018-12-19 Creo Medical Ltd Electrosurgical instrument
EP4115942B1 (en) 2017-06-30 2024-04-24 Lungpacer Medical Inc. System for prevention, moderation, and/or treatment of cognitive injury
AU2018204842B2 (en) 2017-07-05 2023-07-27 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating depression in patients via renal neuromodulation
AU2018204843B2 (en) 2017-07-05 2023-07-27 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating anxiety disorders in patients via renal neuromodulation
AU2018204841B2 (en) 2017-07-05 2023-08-10 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating post-traumatic stress disorder in patients via renal neuromodulation
JP6377219B2 (ja) * 2017-07-14 2018-08-22 株式会社リバーセイコー 医療用アブレーションカテーテルの製造方法
US10195429B1 (en) 2017-08-02 2019-02-05 Lungpacer Medical Inc. Systems and methods for intravascular catheter positioning and/or nerve stimulation
US10940308B2 (en) 2017-08-04 2021-03-09 Lungpacer Medical Inc. Systems and methods for trans-esophageal sympathetic ganglion recruitment
CN109464187B (zh) * 2017-09-08 2023-12-12 泽丹医疗股份有限公司 治疗肺部肿瘤的装置和方法
CN109464186B (zh) 2017-09-08 2023-12-22 泽丹医疗股份有限公司 治疗肺部肿瘤的装置和方法
JP7586706B2 (ja) * 2017-09-12 2024-11-19 ボストン サイエンティフィック サイムド，インコーポレイテッド 心室フォーカルアブレーションのためのシステム、装置、及び方法
US12403306B2 (en) * 2017-10-23 2025-09-02 Cardiac Pacemakers, Inc. Electric field shaping leads for treatment of cancer
US11338135B2 (en) 2017-10-23 2022-05-24 Cardiac Pacemakers, Inc. Medical devices for cancer therapy with electric field shaping elements
WO2019083982A1 (en) * 2017-10-23 2019-05-02 Mayo Foundation For Medical Education And Research ELECTROPORATION SYSTEMS AND METHODS
US20190117971A1 (en) * 2017-10-23 2019-04-25 Cardiac Pacemakers, Inc. Volume-filling leads for treatment of cancer with electric fields
CN111601636A (zh) 2017-11-07 2020-08-28 Oab神经电疗科技公司 具有自适应电路的非侵入性神经激活器
WO2019099677A1 (en) 2017-11-15 2019-05-23 Myoscience, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
CN111511302B (zh) 2017-11-17 2024-09-17 美敦力Af卢森堡有限责任公司 用于具有增强的神经靶向的神经调节的系统、设备以及相关联的方法
SG11202006666XA (en) 2017-11-27 2020-08-28 Prostacare Pty Ltd An apparatus and a method for the treatment of a prostatic disease
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US20190175908A1 (en) 2017-12-11 2019-06-13 Lungpacer Medical Inc. Systems and methods for strengthening a respiratory muscle
US10561461B2 (en) 2017-12-17 2020-02-18 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
US10786306B2 (en) 2018-01-24 2020-09-29 Medtronic Ardian Luxembourg S.A.R.L. Denervation therapy
US11478298B2 (en) 2018-01-24 2022-10-25 Medtronic Ardian Luxembourg S.A.R.L. Controlled irrigation for neuromodulation systems and associated methods
US11253189B2 (en) 2018-01-24 2022-02-22 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and methods for evaluating neuromodulation therapy via detection of magnetic fields
US12458435B2 (en) 2018-01-24 2025-11-04 Medtronic Ireland Manufacturing Unlimited Company Multielectrode catheter
US20190223946A1 (en) 2018-01-24 2019-07-25 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and associated methods for neuromodulation in heterogeneous tissue environments
US12082917B2 (en) 2018-01-24 2024-09-10 Medtronic Ireland Manufacturing Unlimited Company Systems, devices, and methods for assessing efficacy of renal neuromodulation therapy
US11116561B2 (en) 2018-01-24 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Devices, agents, and associated methods for selective modulation of renal nerves
US10959669B2 (en) 2018-01-24 2021-03-30 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for assessing the efficacy of neuromodulation therapy
US11751939B2 (en) 2018-01-26 2023-09-12 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
JP6905230B2 (ja) * 2018-01-31 2021-07-21 国立大学法人広島大学 塞栓術装置
EP4275738B1 (en) 2018-02-08 2025-12-17 Boston Scientific Scimed, Inc. Apparatus for controlled delivery of pulsed electric field ablative energy to tissue
CN111801062B (zh) * 2018-02-21 2024-12-31 美敦力公司 局灶脉冲场消融设备和方法
US11224474B2 (en) 2018-02-28 2022-01-18 Prostacare Pty Ltd System for managing high impedance changes in a non-thermal ablation system for BPH
CA3093231A1 (en) 2018-03-07 2019-09-12 Soovu Labs, Inc. Systems and methods for improved pain relief from stimulation of thermal fibers
US12390262B2 (en) 2018-03-13 2025-08-19 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US10940312B2 (en) * 2018-03-15 2021-03-09 Avent, Inc. Treatment kit to percutaneously block painful sensations hosted by a peripheral nerve
US12279790B2 (en) * 2018-04-20 2025-04-22 Stent Tek Limited Apparatus for orientation display and alignment in percutaneous devices
US20190336198A1 (en) 2018-05-03 2019-11-07 Farapulse, Inc. Systems, devices, and methods for ablation using surgical clamps
WO2019217317A1 (en) 2018-05-07 2019-11-14 Farapulse, Inc. Systems, apparatuses, and methods for filtering high voltage noise induced by pulsed electric field ablation
CN115836908A (zh) 2018-05-07 2023-03-24 波士顿科学医学有限公司 用于将消融能量递送到组织的系统、设备和方法
EP4410228A3 (en) 2018-05-07 2024-11-06 Boston Scientific Scimed, Inc. Epicardial ablation catheter
US11806066B2 (en) 2018-06-01 2023-11-07 Santa Anna Tech Llc Multi-stage vapor-based ablation treatment methods and vapor generation and delivery systems
US20240398462A1 (en) 2018-06-01 2024-12-05 Aqua Medical, Inc. Duodenal Ablation with Improved Depth and Consistency of Ablation
US11413084B2 (en) 2018-07-03 2022-08-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating eating disorders in patients via renal neuromodulation
US10849685B2 (en) 2018-07-18 2020-12-01 Ablative Solutions, Inc. Peri-vascular tissue access catheter with locking handle
US11553960B2 (en) 2018-07-31 2023-01-17 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating patients with catheter-based renal neuromodulation
US11850398B2 (en) 2018-08-01 2023-12-26 Trisalus Life Sciences, Inc. Systems and methods for pressure-facilitated therapeutic agent delivery
US11633120B2 (en) 2018-09-04 2023-04-25 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for assessing efficacy of renal neuromodulation therapy
JP7619937B2 (ja) 2018-09-20 2025-01-22 ボストン サイエンティフィック サイムド，インコーポレイテッド 心内膜組織へのパルス電界アブレーションエネルギーの送達のためのシステム、装置、および方法
US11832965B2 (en) 2018-10-06 2023-12-05 Symap Medical (Suzhou), Limited System and method for mapping the functional nerves innervating the wall of arteries, 3-D mapping and catheters for same
US11338117B2 (en) 2018-10-08 2022-05-24 Trisalus Life Sciences, Inc. Implantable dual pathway therapeutic agent delivery port
JP7368009B2 (ja) * 2018-10-17 2023-10-24 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 心臓切除の間の食道の温度の制御
US12114919B2 (en) 2018-10-24 2024-10-15 Boston Scientific Scimed, Inc. Movable electrodes for controlled irreversible electroporation ablative volumes
EP4548964A1 (en) 2018-11-08 2025-05-07 Lungpacer Medical Inc. Stimulation systems and related user interfaces
JP7404622B2 (ja) * 2018-11-30 2023-12-26 ニプロ株式会社 測定用カテーテル
US11684414B2 (en) 2018-12-11 2023-06-27 Neurent Medical Limited Systems and methods for therapeutic nasal neuromodulation
CN109394211B (zh) * 2018-12-18 2021-08-06 新乡医学院 一种在体电生理记录金属电极的制备方法
US12447343B2 (en) 2018-12-20 2025-10-21 Galvani Bioelectronics Limited Neurostimulation device for blocking blood flow between electrodes
WO2020185421A1 (en) * 2019-03-08 2020-09-17 Mayo Foundation For Medical Education And Research Systems and methods for stellate ganglion simulation and ablation
US12383730B2 (en) * 2019-03-18 2025-08-12 Rambam Medtech Ltd Alternating charge to inhibit sorption to surfaces exposed to biological materials
CN113660972A (zh) * 2019-04-08 2021-11-16 尤迪安·帕特尔 在具有旁路通路的导管上的可充胀球囊
WO2020219336A1 (en) 2019-04-22 2020-10-29 Boston Scientific Scimed, Inc. Electrical stimulation devices for cancer treatment
EP4397361B1 (en) 2019-04-22 2025-11-05 Boston Scientific Scimed, Inc. Devices for administering electrical stimulation to treat cancer
US12109412B2 (en) 2019-04-22 2024-10-08 Boston Scientific Scimed, Inc. Combination electrical and chemotherapeutic treatment of cancer
JP7476231B2 (ja) 2019-04-23 2024-04-30 ボストン サイエンティフィック サイムド，インコーポレイテッド 温熱療法又は熱モニタと共に行われる電気刺激
CN113747936B (zh) 2019-04-23 2024-06-18 波士顿科学国际有限公司 用于电刺激来治疗癌症的电极
WO2020219517A2 (en) 2019-04-23 2020-10-29 Boston Scientific Scimed, Inc. Electrical stimulation for cancer treatment with internal and external electrodes
EP3968932B1 (en) 2019-05-16 2025-07-02 Lungpacer Medical Inc. Systems for sensing and stimulation
US12433597B2 (en) 2019-06-04 2025-10-07 Trisalus Life Sciences, Inc. Atraumatic occlusive system with compartment for measurement of vascular pressure change
WO2020252037A1 (en) 2019-06-12 2020-12-17 Lungpacer Medical Inc. Circuitry for medical stimulation systems
ES2969524T3 (es) 2019-06-20 2024-05-21 Axon Therapies Inc Dispositivos para la ablación endovascular de un nervio esplácnico
EP3990100A4 (en) 2019-06-26 2023-07-19 Neurostim Technologies LLC NON-INVASIVE NERVE ACTIVATOR WITH ADAPTIVE CIRCUIT
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
EP3993866A4 (en) 2019-07-02 2023-07-12 Nalu Medical, Inc. Stimulation apparatus
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
US10625080B1 (en) 2019-09-17 2020-04-21 Farapulse, Inc. Systems, apparatuses, and methods for detecting ectopic electrocardiogram signals during pulsed electric field ablation
JP7702389B2 (ja) 2019-10-09 2025-07-03 トランスミューラル システムズ エルエルシー 組織切除、切断及び除去システム及び方法
US11925677B2 (en) 2021-07-12 2024-03-12 Penland Foundation Treatment of diabetes and chronic pancreatitis using botulinum toxin
WO2021231666A1 (en) 2020-05-15 2021-11-18 Penland Foundation Treatment of asthma using botulinum toxin
US10960061B1 (en) 2019-10-18 2021-03-30 Penland Foundation Treatment of amyotrophic lateral sclerosis using botulinum toxin
US10967052B1 (en) 2019-10-18 2021-04-06 Penland Foundation Treatment of dyslexia using botulinum toxin
CA3227431A1 (en) 2019-10-18 2021-04-22 Penland Foundation Use of a botulinum toxin for treating autism and/or tolerance to narcotics
US11738071B2 (en) 2021-07-12 2023-08-29 Penland Foundation Treatment of acute and chronic kidney disease
US11291500B2 (en) * 2019-11-05 2022-04-05 Sirona Medical Technologies, Inc. Multi-modal catheter for improved electrical mapping and ablation
US11497541B2 (en) 2019-11-20 2022-11-15 Boston Scientific Scimed, Inc. Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses
US11065047B2 (en) 2019-11-20 2021-07-20 Farapulse, Inc. Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses
US10842572B1 (en) 2019-11-25 2020-11-24 Farapulse, Inc. Methods, systems, and apparatuses for tracking ablation devices and generating lesion lines
US11730958B2 (en) 2019-12-16 2023-08-22 Neurostim Solutions, Llc Non-invasive nerve activator with boosted charge delivery
US11413090B2 (en) 2020-01-17 2022-08-16 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
WO2021173509A1 (en) 2020-02-24 2021-09-02 Boston Scientific Scimed, Inc. Systems and methods for treatment of pancreatic cancer
WO2021173215A1 (en) * 2020-02-28 2021-09-02 St. Jude Medical, Cardiology Division, Inc. Electrode assembly including expandable isolation member
EP4272674A3 (en) * 2020-02-28 2024-01-10 St. Jude Medical, Cardiology Division, Inc. Electrode assembly including expandable isolation member
US20210307815A1 (en) * 2020-04-07 2021-10-07 Biosense Webster (Israel) Ltd. Basket Catheter with Solid Conducting Spines as Electrodes for IRE
WO2021205230A1 (en) 2020-04-09 2021-10-14 Neurent Medical Limited Systems and methods for therapeutic nasal treatment
US11883091B2 (en) 2020-04-09 2024-01-30 Neurent Medical Limited Systems and methods for improving sleep with therapeutic nasal treatment
CN113855173A (zh) * 2020-06-29 2021-12-31 上海形状记忆合金材料有限公司 电极导管系统
WO2022020592A1 (en) * 2020-07-24 2022-01-27 Boston Scientific Scimed Inc Electroporation catheter having tissue-contactless electrodes
EP4185228A1 (en) 2020-07-24 2023-05-31 Boston Scientific Scimed Inc. Electric field application for single shot cardiac ablation by irreversible electroporation
US12310652B2 (en) 2020-07-24 2025-05-27 Boston Scientific Scimed, Inc. Hybrid electroporation ablation catheter
US12558154B2 (en) * 2020-08-14 2026-02-24 Biosense Webster (Israel) Ltd. Balloon catheter having ablation and return electrodes
EP4153081B1 (en) * 2020-08-26 2024-03-27 St. Jude Medical, Cardiology Division, Inc. Device and method for delivering electroporation therapy
JP7617250B2 (ja) 2020-09-08 2025-01-17 ボストン サイエンティフィック サイムド，インコーポレイテッド パルス電界アブレーションのための輪郭成形電極、ならびにそのシステム、デバイス、および方法
US20220087736A1 (en) * 2020-09-23 2022-03-24 Biosense Webster (Israel) Ltd. Electrode shorting
US12082875B2 (en) 2020-09-24 2024-09-10 Biosense Webster (Israel) Ltd Balloon catheter having a coil for sensing tissue temperature and position of the balloon
EP4221610A2 (en) 2020-09-30 2023-08-09 Boston Scientific Scimed Inc. Pretreatment waveform for irreversible electroporation
US20220117719A1 (en) * 2020-10-21 2022-04-21 Leonhardt Ventures Llc Pulsatile vascular stent graft
US12485279B2 (en) 2020-11-25 2025-12-02 Virginia Tech Intellectual Properties, Inc. Methods for modulating temporal infrastructure of pulsed electric fields
EP4284276A1 (en) 2021-01-27 2023-12-06 Boston Scientific Scimed, Inc. Voltage controlled pulse sequences for irreversible electroporation ablations
JP7678417B2 (ja) * 2021-02-09 2025-05-16 国立大学法人 筑波大学 神経組織の活動の検知又は刺激に用いられる装置
US12419662B2 (en) 2021-02-19 2025-09-23 Otsuka Medical Devices Co., Ltd. Selectively insulated ultrasound transducers
US20240123232A1 (en) * 2021-02-23 2024-04-18 Inspire Medical Systems, Inc. Integrating stimulation therapy, patient management, and external patient monitoring
USD964406S1 (en) 2021-02-23 2022-09-20 Inspire Medical Systems, Inc. Display screen or portion thereof with a graphical user interface
PL4056135T3 (pl) 2021-03-09 2023-10-02 Circle Safe Stymulacja nerwu przeponowego
JP2021090892A (ja) * 2021-03-22 2021-06-17 京セラ株式会社 腎神経用超音波カテーテル
US20240108406A1 (en) * 2021-04-05 2024-04-04 Nu Eyne Co.,Ltd Renal denervation catheter
US12446944B2 (en) 2021-04-26 2025-10-21 Pulse Biosciences, Inc. Mapping and ablation applicators
US12564440B2 (en) 2021-04-26 2026-03-03 Pulse Biosciences, Inc. Multi-strut ablation and sensing catheter devices and methods
KR20230161488A (ko) * 2021-04-26 2023-11-27 펄스 바이오사이언스, 인크. 원주 방향 절제 장치 및 방법
JP7707320B2 (ja) * 2021-05-28 2025-07-14 ボストン サイエンティフィック サイムド，インコーポレイテッド マッピング及びエレクトロポレーションアブレーション用のカテーテル
US20220409273A1 (en) * 2021-06-24 2022-12-29 Paul J. Coates Chemical neuromodulation agent delivery
US20240285305A1 (en) 2021-07-05 2024-08-29 VeinWay Ltd. Vessel blockage passing
US20230027712A1 (en) 2021-07-19 2023-01-26 Otsuka Medical Devices Co., Ltd. Methods and systems for determining body lumen size
CN113633282A (zh) * 2021-07-19 2021-11-12 上海安通医疗科技有限公司 一种肾动脉交感神经活性测量系统
US12440165B2 (en) 2021-07-28 2025-10-14 Otsuka Medical Devices Co., Ltd. Catheter for neural measurements and treatment and related systems and methods
CN113633283A (zh) * 2021-07-29 2021-11-12 上海安通医疗科技有限公司 一种介入式肾动脉交感神经活性检测系统
US12575775B2 (en) 2021-09-27 2026-03-17 Medtronic, Inc. Intra-body electrode with a poly(3,4-ethylenedioxythiophene)-based coating
CN113768616B (zh) * 2021-10-20 2023-02-24 四川锦江电子医疗器械科技股份有限公司 一种用于心脏消融的综合系统
EP4419191A1 (en) * 2021-10-22 2024-08-28 BIOTRONIK SE & Co. KG Intravascular implant for stimulating of blood pressure
USD1029001S1 (en) 2021-12-02 2024-05-28 Inspire Medical Systems, Inc. Display screen or portion thereof with a graphical user interface
USD1029026S1 (en) 2021-12-02 2024-05-28 Inspire Medical Systems, Inc. Display screen or portion thereof with a graphical user interface
USD1029027S1 (en) 2021-12-02 2024-05-28 Inspire Medical Systems, Inc. Display screen or portion thereof with a graphical user interface
US12533183B2 (en) * 2022-01-18 2026-01-27 Koninklijke Philips N.V. Guided renal denervation using nerve stimulation with blood pressure and renal blood velocity measurements, and associated systems, device, and methods
EP4487757A4 (en) * 2022-03-02 2025-07-16 Eul Joon Park METHOD FOR EVALUATING THE RESULT OF RENAL DENERVATION
US12582816B2 (en) 2022-03-22 2026-03-24 Mainstay Medical Limited Systems and methods for extracting an electrode lead
CN114767263A (zh) * 2022-04-12 2022-07-22 杭州睿笛生物科技有限公司 一种肾动脉消融系统
USD1027999S1 (en) 2022-05-13 2024-05-21 Inspire Medical Systems, Inc. Display screen or portion thereof with an animated graphical user interface
US20230380890A1 (en) * 2022-05-26 2023-11-30 Biosense Webster (Israel) Ltd. Transseptal tissue puncture apparatuses, systems, and methods
AU2023297473A1 (en) 2022-07-01 2025-02-13 Artha Partners B.V. Systems and methods of denervation around subclavian arteries
KR102805140B1 (ko) * 2022-09-16 2025-05-13 재단법인 아산사회복지재단 고주파 국소 소작을 위한 풍선카테터 장치
EP4445855A1 (en) * 2023-04-13 2024-10-16 BIOTRONIK SE & Co. KG Method and catheter for renal denervation
USD1112256S1 (en) * 2023-05-11 2026-02-10 Otsuka Medical Devices Co., Ltd. Display screen or portion thereof with graphical user interface
FR3149762B1 (fr) * 2023-06-16 2025-08-01 Electroducer Ensemble à fil-guide bipolaire, de stimulation trans-vasculaire d’une partie d’un système nerveux autonome d’un corps humain, notamment de stimulation trans-vasculaire nerveuse rénale ou de stimulation du glomus carotidien.
FR3149763B1 (fr) * 2023-06-16 2025-07-18 Electroducer Cathéter de stimulation trans-vasculaire et de dénervation d’une partie d’un système nerveux autonome d’un corps humain, notamment de stimulation trans-vasculaire nerveuse rénale ou de stimulation du glomus carotidien.
CN119367037A (zh) * 2023-07-26 2025-01-28 上海鸿电医疗科技有限公司 消融系统及其控制方法
USD1084316S1 (en) 2023-11-20 2025-07-15 Angiodynamics, Inc. Ferrule
DE102024108889A1 (de) 2024-03-28 2025-10-02 Stockert Gmbh Vorrichtung und Verfahren zur irreversiblen Elektroporation von Gewebe

Family Cites Families (1272)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1026407A (en) 1908-12-21 1912-05-14 Steel Shoe Company Footwear.
US1017857A (en) 1910-03-25 1912-02-20 Amphion Piano Player Company Valve for pneumatic actions.
US2130758A (en) 1935-06-01 1938-09-20 E J Rose Mfg Company Of Califo Electrode for diathermy treatment and the like
US2276995A (en) 1938-01-22 1942-03-17 A J Ginsberg Electrotherapy
US2276996A (en) 1940-11-30 1942-03-17 A J Ginsberg Non-radio-interfering therapeutic apparatus
US2389453A (en) 1943-04-15 1945-11-20 Sun Oil Co Amides
US3181535A (en) 1957-10-04 1965-05-04 Diapulse Mfg Corp Of America Athermapeutic apparatus
US3043310A (en) 1959-04-24 1962-07-10 Diapulse Mfg Corp Of America Treatment head for athermapeutic apparatus
US3127895A (en) 1962-07-02 1964-04-07 Dynapower System Corp Therapeutic pulse generation and control circuit
US3270746A (en) 1963-08-26 1966-09-06 Dynapower Systems Corp High-performance electrotherapeutic treatment head
US3329149A (en) 1964-10-28 1967-07-04 Dynapower Systems Corp Of Cali Supporting arm for electrotherapeutic treatment head
US3563246A (en) 1967-04-24 1971-02-16 Intelectron Corp Method and apparatus for improving neural performance in human subjects by electrotherapy
US3522811A (en) 1969-02-13 1970-08-04 Medtronic Inc Implantable nerve stimulator and method of use
SE346468B (es) 1969-02-24 1972-07-10 Lkb Medical Ab
JPS499882Y1 (es) 1969-09-11 1974-03-08
US3670737A (en) 1970-07-02 1972-06-20 Diapulse Corp Of America Ultra-short wave athermapeutic apparatus
US3760812A (en) 1971-03-19 1973-09-25 Univ Minnesota Implantable spiral wound stimulation electrodes
US3774620A (en) 1971-06-14 1973-11-27 Nemectron Gmbh Electromedicinal apparatus for interference current therapy
US3895639A (en) 1971-09-07 1975-07-22 Rodler Ing Hans Apparatus for producing an interference signal at a selected location
US3800802A (en) 1972-01-07 1974-04-02 Int Medical Electronics Ltd Short-wave therapy apparatus
US3752162A (en) 1972-04-10 1973-08-14 Dow Corning Artificial cutaneous stoma
US3794022A (en) 1972-06-30 1974-02-26 E Nawracaj Dual oscillator, variable pulse duration electrotherapeutic device
US3803463A (en) 1972-07-10 1974-04-09 J Cover Weapon for immobilization and capture
GB1456509A (en) 1973-02-20 1976-11-24 Dow Corning Ltd Bonding silicone rubber to wood and masonry
US3897789A (en) 1973-09-13 1975-08-05 Stanley J Blanchard Acupuncture apparatus
US3894532A (en) 1974-01-17 1975-07-15 Acupulse Inc Instruments for transcutaneous and subcutaneous investigation and treatment
US3911930A (en) 1974-03-01 1975-10-14 Stimulation Tech Method and structure of preventing and treating ileus, and reducing acute pain by electrical pulse stimulation
US4011861A (en) 1974-04-03 1977-03-15 Case Western Reserve University Implantable electric terminal for organic tissue
US4055190A (en) 1974-12-19 1977-10-25 Michio Tany Electrical therapeutic apparatus
US3952751A (en) 1975-01-08 1976-04-27 W. Denis Kendall High-performance electrotherapeutic apparatus
US4026300A (en) 1975-03-14 1977-05-31 Liberty Mutual Method and apparatus for interfacing to nerves
US3987790A (en) 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4315503A (en) 1976-11-17 1982-02-16 Electro-Biology, Inc. Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment
US4105017A (en) 1976-11-17 1978-08-08 Electro-Biology, Inc. Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective change in electrical environment
US4266532A (en) 1976-11-17 1981-05-12 Electro-Biology, Inc. Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment
US4071033A (en) 1976-12-20 1978-01-31 Nawracaj Edward P Electrotherapeutic device with modulated dual signals
US4141365A (en) 1977-02-24 1979-02-27 The Johns Hopkins University Epidural lead electrode and insertion needle
US4154246A (en) 1977-07-25 1979-05-15 Leveen Harry H Field intensification in radio frequency thermotherapy
US4169464A (en) 1977-12-16 1979-10-02 Cordis Corporation Catheter for selective catheterization of aortic branches
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4305115A (en) 1979-03-14 1981-12-08 Harry H. Leveen Electrostatic shield
JPS55137141A (en) 1979-04-13 1980-10-25 Teijin Ltd Porous polyamide membrane and production thereof
US4332259A (en) 1979-09-19 1982-06-01 Mccorkle Jr Charles E Intravenous channel cardiac electrode and lead assembly and method
US4692147A (en) 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
US4405305A (en) 1980-10-27 1983-09-20 University Of Utah Research Foundation Subcutaneous peritoneal injection catheter
US4379462A (en) 1980-10-29 1983-04-12 Neuromed, Inc. Multi-electrode catheter assembly for spinal cord stimulation
CS226514B1 (en) 1981-01-28 1984-04-16 Petr Ing Csc Slovak Apparatus for stimulating live tissues
US4419819A (en) 1982-01-29 1983-12-13 Medtronic, Inc. Method of making biomedical lead with lobed lead anchor
US4454883A (en) 1982-02-16 1984-06-19 Therafield Holdings Limited Electrotherapeutic apparatus
US4617939A (en) 1982-04-30 1986-10-21 The University Of Sheffield Tomography
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4467808A (en) 1982-09-17 1984-08-28 Biolectron, Inc. Method for preventing and treating osteoporosis in a living body by using electrical stimulation non-invasively
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
DE3300668A1 (de) 1983-01-11 1984-07-12 Siemens AG, 1000 Berlin und 8000 München Elektrode fuer medizinische anwendungen
FR2541902B1 (fr) 1983-03-04 1986-02-07 Cofrem International Sa Appareil therapeutique athermique
EP0132344A3 (en) 1983-07-20 1986-01-22 Purdue Research Foundation Improved catheter based cardiac output sensor
US4531943A (en) 1983-08-08 1985-07-30 Angiomedics Corporation Catheter with soft deformable tip
WO1985001213A1 (en) 1983-09-14 1985-03-28 Jacob Zabara Neurocybernetic prosthesis
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4816016A (en) 1984-03-16 1989-03-28 Pudenz-Schulte Medical Research Corp. Subcutaneous infusion reservoir and pump system
US4587975A (en) 1984-07-02 1986-05-13 Cardiac Pacemakers, Inc. Dimension sensitive angioplasty catheter
US4674482A (en) 1984-09-12 1987-06-23 Irt, Inc. Pulse electro-magnetic field therapy device with auto bias circuit
US4602624A (en) 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation
US4649936A (en) 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US4608985A (en) 1984-10-11 1986-09-02 Case Western Reserve University Antidromic pulse generating wave form for collision blocking
JPS61116595A (ja) 1984-11-12 1986-06-04 Riso Kagaku Corp 感熱孔版印刷用原紙
JPS61151245A (ja) 1984-12-25 1986-07-09 Sumitomo Electric Ind Ltd 多孔性薄膜材料の表面処理方法
JPS61176324A (ja) * 1985-01-31 1986-08-08 フクダ電子株式会社 電極装置
US4706671A (en) 1985-05-02 1987-11-17 Weinrib Harry P Catheter with coiled tip
US4660571A (en) 1985-07-18 1987-04-28 Cordis Corporation Percutaneous lead having radially adjustable electrode
US5449343A (en) 1985-07-30 1995-09-12 Advanced Cardiovascular Systems, Inc. Steerable dilatation catheter
FR2592791A1 (fr) 1986-01-14 1987-07-17 Ire Celltarg Sa Composition pharmaceutique, contenant un anesthesique local et/ou un analgesique central encapsule dans des liposomes
US4865845A (en) 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
JPS62181225U (es) 1986-05-07 1987-11-17
US4709698A (en) 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
US4998532A (en) 1986-05-23 1991-03-12 Lti Biomedical, Inc. Portable electro-therapy system
US5014699A (en) 1986-05-23 1991-05-14 Trustees Of The University Of Pennsylvania Electromagnetic method and apparatus for healing living tissue
US4715852A (en) 1986-07-21 1987-12-29 Eaton Corporation Implanted medication infusion device
US4774967A (en) 1986-09-09 1988-10-04 American Biointerface Corporation Method and apparatus for mammalian nerve regeneration
US4796643A (en) 1986-09-30 1989-01-10 Telectronics N.V. Medical electrode leads
US5365926A (en) 1986-11-14 1994-11-22 Desai Jawahar M Catheter for mapping and ablation and method therefor
US5231995A (en) 1986-11-14 1993-08-03 Desai Jawahar M Method for catheter mapping and ablation
US4834724A (en) 1987-04-06 1989-05-30 Geiss Alan C Device for aspirating fluids from a body cavity or hollow organ
US4781682A (en) 1987-08-13 1988-11-01 Patel Piyush V Catheter having support flaps and method of inserting catheter
US4791931A (en) 1987-08-13 1988-12-20 Pacesetter Infusion, Ltd. Demand pacemaker using an artificial baroreceptor reflex
US5154705A (en) 1987-09-30 1992-10-13 Lake Region Manufacturing Co., Inc. Hollow lumen cable apparatus
US4819661A (en) 1987-10-26 1989-04-11 Cardiac Pacemakers, Inc. Positive fixation cardiac electrode with drug elution capabilities
US4860769A (en) 1987-11-12 1989-08-29 Thomas J. Fogarty Implantable defibrillation electrode
US4852573A (en) 1987-12-04 1989-08-01 Kennedy Philip R Implantable neural electrode
US4957118A (en) 1988-01-15 1990-09-18 Jay Erlebacher Electrode lead
ATE131081T1 (de) 1988-01-21 1995-12-15 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US4926875A (en) * 1988-01-25 1990-05-22 Baylor College Of Medicine Implantable and extractable biological sensor probe
US4890623A (en) 1988-03-14 1990-01-02 C. R. Bard, Inc. Biopotential sensing device and method for making
CA1319174C (en) 1988-04-21 1993-06-15 Lawrence E. Bertolucci Electrical nerve stimulation device for nausea control
WO1989011889A1 (en) 1988-06-06 1989-12-14 Sumitomo Electric Industries, Ltd. Catheter
GB8814898D0 (en) 1988-06-22 1988-07-27 Evans J M Catheters & methods of manufacture
US4921484A (en) 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US5249585A (en) 1988-07-28 1993-10-05 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
US4920979A (en) 1988-10-12 1990-05-01 Huntington Medical Research Institute Bidirectional helical electrode for nerve stimulation
US4995868A (en) 1988-10-12 1991-02-26 Bard Limited Catheter
US4955377A (en) 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US4966597A (en) 1988-11-04 1990-10-30 Cosman Eric R Thermometric cardiac tissue ablation electrode with ultra-sensitive temperature detection
US5094242A (en) 1988-11-07 1992-03-10 Regents Of The University Of California Implantable nerve stimulation device
US5011488A (en) 1988-12-07 1991-04-30 Robert Ginsburg Thrombus extraction system
US5057318A (en) 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5059423A (en) 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5458631A (en) 1989-01-06 1995-10-17 Xavier; Ravi Implantable catheter with electrical pulse nerve stimulators and drug delivery system
WO1990007303A1 (en) 1989-01-06 1990-07-12 Angioplasty Systems, Inc. Electrosurgical catheter for resolving atherosclerotic plaque
JP2513289B2 (ja) 1989-01-06 1996-07-03 日本電気株式会社 変調装置
US5203772A (en) 1989-01-09 1993-04-20 Pilot Cardiovascular Systems, Inc. Steerable medical device
US5037391A (en) 1989-01-09 1991-08-06 Pilot Cardiovascular Systems, Inc. Steerable angioplasty device
US5779698A (en) 1989-01-18 1998-07-14 Applied Medical Resources Corporation Angioplasty catheter system and method for making same
US4928688A (en) 1989-01-23 1990-05-29 Mieczyslaw Mirowski Method and apparatus for treating hemodynamic disfunction
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5125928A (en) 1989-04-13 1992-06-30 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5078717A (en) 1989-04-13 1992-01-07 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5006119A (en) 1989-05-25 1991-04-09 Engineering & Research Associates, Inc. Hollow core coaxial catheter
US20030220521A1 (en) 1989-07-27 2003-11-27 G.D. Searle & Co. Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension
US5282484A (en) 1989-08-18 1994-02-01 Endovascular Instruments, Inc. Method for performing a partial atherectomy
US5071424A (en) 1989-08-18 1991-12-10 Evi Corporation Catheter atherotome
US5211651A (en) 1989-08-18 1993-05-18 Evi Corporation Catheter atherotome
US5156610A (en) 1989-08-18 1992-10-20 Evi Corporation Catheter atherotome
US5002067A (en) 1989-08-23 1991-03-26 Medtronic, Inc. Medical electrical lead employing improved penetrating electrode
DE69029141T2 (de) 1989-09-08 1997-04-10 Boston Scientific Corp., Natick, Mass. Angioplastie mit niedrigem physiologischen stress
US5016808A (en) * 1989-09-14 1991-05-21 Cardiac Pacemakers, Inc. Implantable tapered spiral endocardial lead for use in internal defibrillation
US5133365A (en) 1989-09-14 1992-07-28 Cardiac Pacemakers, Inc. Implantable tapered spiral endocardial lead for use in internal defibrillation
US5112614A (en) 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5231386A (en) 1990-07-24 1993-07-27 Home Row, Inc. Keyswitch-integrated pointing assembly
RU1785710C (en) 1989-10-06 1993-01-07 Vremennyj Nauchnyj Kollektiv O Microwave resonant therapeutic device
US4979511A (en) 1989-11-03 1990-12-25 Cyberonics, Inc. Strain relief tether for implantable electrode
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5209723A (en) 1990-01-08 1993-05-11 The Curators Of The University Of Missouri Multiple lumen catheter for hemodialysis
US5158564A (en) 1990-02-14 1992-10-27 Angiomed Ag Atherectomy apparatus
US5851206A (en) 1990-03-13 1998-12-22 The Regents Of The University Of California Method and apparatus for endovascular thermal thrombosis and thermal cancer treatment
US5052998A (en) 1990-04-04 1991-10-01 Zimmon David S Indwelling stent and method of use
US5071407A (en) 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
US5193048A (en) 1990-04-27 1993-03-09 Kaufman Dennis R Stun gun with low battery indicator and shutoff timer
US5054501A (en) 1990-05-16 1991-10-08 Brigham & Women's Hospital Steerable guide wire for cannulation of tubular or vascular organs
US5184617A (en) 1990-06-05 1993-02-09 Staodyn, Inc. Output pulse compensation for therapeutic-type electronic devices
US5095905A (en) 1990-06-07 1992-03-17 Medtronic, Inc. Implantable neural electrode
US5190540A (en) 1990-06-08 1993-03-02 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
GB9013177D0 (en) * 1990-06-13 1990-08-01 Brown Brian H Real-time imaging, etc.
US5499971A (en) 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
AU8074591A (en) 1990-06-15 1992-01-07 Cortrak Medical, Inc. Drug delivery apparatus and method
US5498238A (en) 1990-06-15 1996-03-12 Cortrak Medical, Inc. Simultaneous angioplasty and phoretic drug delivery
US5234692A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234693A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5188602A (en) 1990-07-12 1993-02-23 Interventional Thermodynamics, Inc. Method and device for delivering heat to hollow body organs
US5058584A (en) 1990-08-30 1991-10-22 Medtronic, Inc. Method and apparatus for epidural burst stimulation for angina pectoris
US5170803A (en) 1990-09-28 1992-12-15 Brunswick Biomedical Technologies, Inc. Esophageal displacement electrode
US5111815A (en) 1990-10-15 1992-05-12 Cardiac Pacemakers, Inc. Method and apparatus for cardioverter/pacer utilizing neurosensing
JP3041967B2 (ja) 1990-12-13 2000-05-15 ソニー株式会社 ディジタル信号符号化装置
EP0491979A1 (de) 1990-12-22 1992-07-01 Peter Dr. Ing. Osypka Herzschrittmacher-Katheter mit zwei Polen
US5163928A (en) 1991-01-07 1992-11-17 Franklin Electronic Publishers, Incorporated Self-centering catheter
US5170802A (en) 1991-01-07 1992-12-15 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5263480A (en) 1991-02-01 1993-11-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5345936A (en) * 1991-02-15 1994-09-13 Cardiac Pathways Corporation Apparatus with basket assembly for endocardial mapping
AU660444B2 (en) 1991-02-15 1995-06-29 Ingemar H. Lundquist Torquable catheter and method
US5425364A (en) 1991-02-15 1995-06-20 Cardiac Pathways Corporation Flexible strip assembly without feedthrough holes and device utilizing the same
US5329923A (en) 1991-02-15 1994-07-19 Lundquist Ingemar H Torquable catheter
US5465717A (en) 1991-02-15 1995-11-14 Cardiac Pathways Corporation Apparatus and Method for ventricular mapping and ablation
US5156151A (en) * 1991-02-15 1992-10-20 Cardiac Pathways Corporation Endocardial mapping and ablation system and catheter probe
US5228442A (en) * 1991-02-15 1993-07-20 Cardiac Pathways Corporation Method for mapping, ablation, and stimulation using an endocardial catheter
US5269303A (en) 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
US5199428A (en) 1991-03-22 1993-04-06 Medtronic, Inc. Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload
US5188619A (en) 1991-04-24 1993-02-23 Gene E. Myers Enterprises, Inc. Internal thoractic artery catheter
DE4113703C2 (de) 1991-04-26 1995-05-04 Thomas Osypka Führungskatheter mit vorgebogenem Endbereich
US5215086A (en) 1991-05-03 1993-06-01 Cyberonics, Inc. Therapeutic treatment of migraine symptoms by stimulation
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5299569A (en) 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US5330496A (en) 1991-05-06 1994-07-19 Alferness Clifton A Vascular catheter assembly for tissue penetration and for cardiac stimulation and methods thereof
WO1992020291A1 (en) * 1991-05-24 1992-11-26 Applied Medical Resources, Inc. Articulating tissue cutter assembly
US5458568A (en) 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US5137727A (en) 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5213098A (en) 1991-07-26 1993-05-25 Medtronic, Inc. Post-extrasystolic potentiation stimulation with physiologic sensor feedback
US5222494A (en) 1991-07-31 1993-06-29 Cyberonics, Inc. Implantable tissue stimulator output stabilization system
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
JPH066170B2 (ja) * 1991-08-28 1994-01-26 中島 博 ペースメーカのペーシング・リード
EP0606390A4 (en) 1991-10-03 1994-12-07 Gen Hospital Corp DEVICE AND METHOD FOR VASILIZATION.
US5215089A (en) 1991-10-21 1993-06-01 Cyberonics, Inc. Electrode assembly for nerve stimulation
US5628775A (en) 1991-11-08 1997-05-13 Ep Technologies, Inc. Flexible bond for sleeves enclosing a bendable electrode tip assembly
CA2106410C (en) 1991-11-08 2004-07-06 Stuart D. Edwards Ablation electrode with insulated temperature sensing elements
US5304206A (en) 1991-11-18 1994-04-19 Cyberonics, Inc. Activation techniques for implantable medical device
US5193539A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
US5193540A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5358514A (en) 1991-12-18 1994-10-25 Alfred E. Mann Foundation For Scientific Research Implantable microdevice with self-attaching electrodes
US5203326A (en) 1991-12-18 1993-04-20 Telectronics Pacing Systems, Inc. Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy
US5301683A (en) 1991-12-23 1994-04-12 Durkan John A Diagnosing carpal tunnel syndrome
US5683366A (en) 1992-01-07 1997-11-04 Arthrocare Corporation System and method for electrosurgical tissue canalization
US5697882A (en) 1992-01-07 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
US5509411A (en) 1993-01-29 1996-04-23 Cardima, Inc. Intravascular sensing device
US5327905A (en) 1992-02-14 1994-07-12 Boaz Avitall Biplanar deflectable catheter for arrhythmogenic tissue ablation
US5354297A (en) 1992-02-14 1994-10-11 Boaz Avitall Biplanar deflectable catheter for arrhythmogenic tissue ablation
US5263493A (en) 1992-02-24 1993-11-23 Boaz Avitall Deflectable loop electrode array mapping and ablation catheter for cardiac chambers
US5300099A (en) 1992-03-06 1994-04-05 Urologix, Inc. Gamma matched, helical dipole microwave antenna
WO1993018415A1 (en) 1992-03-09 1993-09-16 University Of Washington Image neurography and diffusion anisotropy imaging
US5239999A (en) 1992-03-27 1993-08-31 Cardiac Pathways Corporation Helical endocardial catheter probe
AU4026793A (en) 1992-04-10 1993-11-18 Cardiorhythm Shapable handle for steerable electrode catheter
US5318525A (en) 1992-04-10 1994-06-07 Medtronic Cardiorhythm Steerable electrode catheter
US5345031A (en) 1992-04-16 1994-09-06 The Trustees Of Princeton University Reduction of aromatic halide content
US5300068A (en) 1992-04-21 1994-04-05 St. Jude Medical, Inc. Electrosurgical apparatus
US5263492A (en) 1992-04-30 1993-11-23 Guy Voyce Recording goniometer
US5562720A (en) * 1992-05-01 1996-10-08 Vesta Medical, Inc. Bipolar/monopolar endometrial ablation device and method
US5443470A (en) * 1992-05-01 1995-08-22 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US5370680A (en) 1992-05-27 1994-12-06 Magnetic Resonance Therapeutics, Inc. Athermapeutic apparatus employing electro-magnetic fields
US5324284A (en) 1992-06-05 1994-06-28 Cardiac Pathways, Inc. Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method
AU2259292A (en) 1992-06-24 1994-01-24 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
EP0647147B1 (en) 1992-06-26 2000-03-15 Schneider (Usa) Inc. Catheter with expandable wire mesh tip
US5782239A (en) 1992-06-30 1998-07-21 Cordis Webster, Inc. Unique electrode configurations for cardiovascular electrode catheter with built-in deflection method and central puller wire
US5772590A (en) * 1992-06-30 1998-06-30 Cordis Webster, Inc. Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5507724A (en) 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5399164A (en) 1992-11-02 1995-03-21 Catheter Imaging Systems Catheter having a multiple durometer
US5542916A (en) 1992-08-12 1996-08-06 Vidamed, Inc. Dual-channel RF power delivery system
US5484400A (en) 1992-08-12 1996-01-16 Vidamed, Inc. Dual channel RF delivery system
US6623516B2 (en) 1992-08-13 2003-09-23 Mark A. Saab Method for changing the temperature of a selected body region
US5437288A (en) 1992-09-04 1995-08-01 Mayo Foundation For Medical Education And Research Flexible catheter guidewire
DE4229693A1 (de) 1992-09-05 1994-03-10 Achim Dr Hansjuergens Elektrotherapeutisches Gerät
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
WO1994005265A1 (en) 1992-09-10 1994-03-17 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US5478303A (en) 1992-09-18 1995-12-26 Foley-Nolan; Darragh Electromagnetic apparatus for use in therapy
US5338662A (en) 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
US5553611A (en) 1994-01-06 1996-09-10 Endocardial Solutions, Inc. Endocardial measurement method
JPH08504333A (ja) * 1992-09-25 1996-05-14 イーピー・テクノロジーズ・インコーポレーテッド 心臓系統のための電極支持スプライン
WO1994007446A1 (en) 1992-10-05 1994-04-14 Boston Scientific Corporation Device and method for heating tissue
US5634899A (en) 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
US5336178A (en) * 1992-11-02 1994-08-09 Localmed, Inc. Intravascular catheter with infusion array
US5807306A (en) 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
US5334193A (en) 1992-11-13 1994-08-02 American Cardiac Ablation Co., Inc. Fluid cooled ablation catheter
US5441483A (en) 1992-11-16 1995-08-15 Avitall; Boaz Catheter deflection control
US5328442A (en) * 1992-11-20 1994-07-12 Siemens Pacesetter, Inc. System and method for stimulating a heart having undergone cardiac myoplasty using a single-chamber pacemaker
CA2109980A1 (en) 1992-12-01 1994-06-02 Mir A. Imran Steerable catheter with adjustable bend location and/or radius and method
SE9203733D0 (sv) 1992-12-11 1992-12-11 Siemens Elema Ab Defibrilleringselektrod
US5256141A (en) 1992-12-22 1993-10-26 Nelson Gencheff Biological material deployment method and apparatus
US5317155A (en) 1992-12-29 1994-05-31 The Electrogesic Corporation Corona discharge apparatus
US5429634A (en) 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
US5387233A (en) 1993-01-11 1995-02-07 Incontrol, Inc. Intravenous cardiac lead with improved fixation and method
IT1266217B1 (it) 1993-01-18 1996-12-27 Xtrode Srl Elettrocatetere per la mappatura e l'intervento su cavita' cardiache.
US6620188B1 (en) 1998-08-24 2003-09-16 Radiant Medical, Inc. Methods and apparatus for regional and whole body temperature modification
US5792187A (en) 1993-02-22 1998-08-11 Angeion Corporation Neuro-stimulation to control pain during cardioversion defibrillation
US5569274A (en) 1993-02-22 1996-10-29 Heartport, Inc. Endoscopic vascular clamping system and method
US5476495A (en) 1993-03-16 1995-12-19 Ep Technologies, Inc. Cardiac mapping and ablation systems
US5636634A (en) 1993-03-16 1997-06-10 Ep Technologies, Inc. Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes
WO1994021168A1 (en) 1993-03-16 1994-09-29 Ep Technologies, Inc. Cardiac mapping and ablation systems
JP3345786B2 (ja) 1993-03-17 2002-11-18 ジャパンゴアテックス株式会社 可とう性チューブ及びその製造方法
US5383856A (en) 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
US5397338A (en) 1993-03-29 1995-03-14 Maven Labs, Inc. Electrotherapy device
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
FR2704151B1 (fr) 1993-04-21 1995-07-13 Klotz Antoine Olivier Dispositif électronique destiné à la stimulation adrénergique du système sympathique relatif à la média veineuse.
EP0702723B1 (fr) 1993-04-21 2002-09-04 Institut Pasteur Implant biocompatible pour l'expression et la secretion in vivo d'un compose therapeutique
US5716410A (en) 1993-04-30 1998-02-10 Scimed Life Systems, Inc. Temporary stent and method of use
US6517811B2 (en) 1993-05-06 2003-02-11 Research Corporation Technologies, Inc. Compounds for cancer imaging and therapy
US5693082A (en) 1993-05-14 1997-12-02 Fidus Medical Technology Corporation Tunable microwave ablation catheter system and method
US5611777A (en) 1993-05-14 1997-03-18 C.R. Bard, Inc. Steerable electrode catheter
US5584863A (en) 1993-06-24 1996-12-17 Electropharmacology, Inc. Pulsed radio frequency electrotherapeutic system
US5860974A (en) 1993-07-01 1999-01-19 Boston Scientific Corporation Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft
EP0706345B1 (en) 1993-07-01 2003-02-19 Boston Scientific Limited Imaging, electrical potential sensing, and ablation catheters
US5487757A (en) 1993-07-20 1996-01-30 Medtronic Cardiorhythm Multicurve deflectable catheter
US5545200A (en) 1993-07-20 1996-08-13 Medtronic Cardiorhythm Steerable electrophysiology catheter
US5458585A (en) 1993-07-28 1995-10-17 Cardiovascular Imaging Systems, Inc. Tracking tip for a work element in a catheter system
US5415633A (en) 1993-07-28 1995-05-16 Active Control Experts, Inc. Remotely steered catheterization device
US5405374A (en) 1993-08-25 1995-04-11 Medtronic, Inc. Transvenous defibrillation lead and method of use
US5431649A (en) * 1993-08-27 1995-07-11 Medtronic, Inc. Method and apparatus for R-F ablation
US5980516A (en) 1993-08-27 1999-11-09 Medtronic, Inc. Method and apparatus for R-F ablation
US5807395A (en) 1993-08-27 1998-09-15 Medtronic, Inc. Method and apparatus for RF ablation and hyperthermia
US5507791A (en) 1993-08-31 1996-04-16 Sit'ko; Sergei P. Microwave resonance therapy
US5427118A (en) 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
ATE320282T1 (de) 1993-10-14 2006-04-15 Boston Scient Ltd Elektroden zur erzeugung bestimmter muster von pathologisch verändertem gewebe
US5673695A (en) 1995-08-02 1997-10-07 Ep Technologies, Inc. Methods for locating and ablating accessory pathways in the heart
US6129724A (en) 1993-10-14 2000-10-10 Ep Technologies, Inc. Systems and methods for forming elongated lesion patterns in body tissue using straight or curvilinear electrode elements
US5582609A (en) 1993-10-14 1996-12-10 Ep Technologies, Inc. Systems and methods for forming large lesions in body tissue using curvilinear electrode elements
WO1995010319A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Electrodes for creating lesions in body tissue
WO1995010225A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Multiple electrode element for mapping and ablating
US5545193A (en) 1993-10-15 1996-08-13 Ep Technologies, Inc. Helically wound radio-frequency emitting electrodes for creating lesions in body tissue
US5575810A (en) 1993-10-15 1996-11-19 Ep Technologies, Inc. Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like
US5400784A (en) 1993-10-15 1995-03-28 Case Western Reserve University Slowly penetrating inter-fascicular nerve cuff electrode and method of using
WO1995010322A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Creating complex lesion patterns in body tissue
US5397308A (en) 1993-10-22 1995-03-14 Scimed Life Systems, Inc. Balloon inflation measurement apparatus
US5470352A (en) 1993-10-29 1995-11-28 Northeastern University Balloon angioplasty device
US5433739A (en) 1993-11-02 1995-07-18 Sluijter; Menno E. Method and apparatus for heating an intervertebral disc for relief of back pain
US5571147A (en) 1993-11-02 1996-11-05 Sluijter; Menno E. Thermal denervation of an intervertebral disc for relief of back pain
US5564440A (en) 1993-11-03 1996-10-15 Daig Corporation Method for mopping and/or ablation of anomalous conduction pathways
US5575766A (en) 1993-11-03 1996-11-19 Daig Corporation Process for the nonsurgical mapping and treatment of atrial arrhythmia using catheters guided by shaped guiding introducers
US5497774A (en) 1993-11-03 1996-03-12 Daig Corporation Guiding introducer for left atrium
US5599346A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment system
US5507743A (en) 1993-11-08 1996-04-16 Zomed International Coiled RF electrode treatment apparatus
DE69419172T2 (de) 1993-11-10 2000-02-24 Medtronic Cardiorhythm, San Jose Elektrodenanordnung für katheter
US5487385A (en) 1993-12-03 1996-01-30 Avitall; Boaz Atrial mapping and ablation catheter system
US5730127A (en) 1993-12-03 1998-03-24 Avitall; Boaz Mapping and ablation catheter system
JPH07157424A (ja) 1993-12-03 1995-06-20 Lintec Corp 局所麻酔用ゲル製剤
CA2138076A1 (en) 1993-12-17 1995-06-18 Philip E. Eggers Monopolar electrosurgical instruments
US5458626A (en) 1993-12-27 1995-10-17 Krause; Horst E. Method of electrical nerve stimulation for acceleration of tissue healing
US6099524A (en) 1994-01-28 2000-08-08 Cardiac Pacemakers, Inc. Electrophysiological mapping and ablation catheter and method
US5462545A (en) 1994-01-31 1995-10-31 New England Medical Center Hospitals, Inc. Catheter electrodes
US5697975A (en) 1994-02-09 1997-12-16 The University Of Iowa Research Foundation Human cerebral cortex neural prosthetic for tinnitus
US6858024B1 (en) 1994-02-14 2005-02-22 Scimed Life Systems, Inc. Guide catheter having selected flexural modulus segments
AU1937795A (en) * 1994-03-08 1995-09-25 Cardima, Inc. Intravascular rf occlusion catheter
GB9407135D0 (en) 1994-04-11 1994-06-01 Aberdeen University And Plasma Treatment of osteoporosis
US5505201A (en) 1994-04-20 1996-04-09 Case Western Reserve University Implantable helical spiral cuff electrode
US5882333A (en) 1994-05-13 1999-03-16 Cardima, Inc. Catheter with deflectable distal section
WO1995033514A1 (en) 1994-06-09 1995-12-14 Magnetic Resonance Therapeutics, Inc. Electro-therapeutic method
US5505700A (en) * 1994-06-14 1996-04-09 Cordis Corporation Electro-osmotic infusion catheter
US5421349A (en) 1994-06-16 1995-06-06 Cordis Corporation Atraumatic proximal guidewire end
US5617854A (en) 1994-06-22 1997-04-08 Munsif; Anand Shaped catheter device and method
US6056744A (en) * 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US6009877A (en) 1994-06-24 2000-01-04 Edwards; Stuart D. Method for treating a sphincter
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
EP0768842A4 (en) 1994-06-27 1998-05-13 Ep Technologies SYSTEMS AND METHODS FOR TEMPERATURE MEASUREMENT IN THE BODY
WO1996000036A1 (en) 1994-06-27 1996-01-04 Ep Technologies, Inc. System for controlling tissue ablation using temperature sensors
US5680860A (en) 1994-07-07 1997-10-28 Cardiac Pathways Corporation Mapping and/or ablation catheter with coilable distal extremity and method for using same
US5690611A (en) 1994-07-08 1997-11-25 Daig Corporation Process for the treatment of atrial arrhythima using a catheter guided by shaped giding introducers
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5514092A (en) 1994-08-08 1996-05-07 Schneider (Usa) Inc. Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration
US5810802A (en) 1994-08-08 1998-09-22 E.P. Technologies, Inc. Systems and methods for controlling tissue ablation using multiple temperature sensing elements
US5454782A (en) 1994-08-11 1995-10-03 Perkins; Rodney C. Translumenal circumferential energy delivery device
US5476498A (en) 1994-08-15 1995-12-19 Incontrol, Inc. Coronary sinus channel lead and method
EP0776235A4 (en) 1994-08-17 1999-08-25 Magnetic Resonance Therapeutic ELECTROTHERAPEUTIC SYSTEM
US5609151A (en) 1994-09-08 1997-03-11 Medtronic, Inc. Method for R-F ablation
US5519172A (en) 1994-09-13 1996-05-21 W. L. Gore & Associates, Inc. Jacket material for protection of electrical conductors
US5531778A (en) 1994-09-20 1996-07-02 Cyberonics, Inc. Circumneural electrode assembly
US5545475A (en) 1994-09-20 1996-08-13 W. L. Gore & Associates Microfiber-reinforced porous polymer film and a method for manufacturing the same and composites made thereof
US5540734A (en) 1994-09-28 1996-07-30 Zabara; Jacob Cranial nerve stimulation treatments using neurocybernetic prosthesis
US5509909A (en) 1994-10-06 1996-04-23 Moy; Grant G. Bent chest tube assembly
US6142994A (en) 1994-10-07 2000-11-07 Ep Technologies, Inc. Surgical method and apparatus for positioning a diagnostic a therapeutic element within the body
US5885278A (en) 1994-10-07 1999-03-23 E.P. Technologies, Inc. Structures for deploying movable electrode elements
WO1996011723A1 (en) 1994-10-17 1996-04-25 Australasian Medical Technology Limited Devices and methods for implementation of pulsed electromagnetic field therapy
US5722401A (en) 1994-10-19 1998-03-03 Cardiac Pathways Corporation Endocardial mapping and/or ablation catheter probe
US5810742A (en) 1994-10-24 1998-09-22 Transcan Research & Development Co., Ltd. Tissue characterization based on impedance images and on impedance measurements
US5660848A (en) 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
PT788351E (pt) 1994-11-10 2003-06-30 Univ Kentucky Res Foundation T Dispositivo implantavel recarregavel de libertacaocontrolada para administrar medicamentos direc tamente numa porcao interna do corpo
US5571150A (en) 1994-12-19 1996-11-05 Cyberonics, Inc. Treatment of patients in coma by nerve stimulation
US5569198A (en) 1995-01-23 1996-10-29 Cortrak Medical Inc. Microporous catheter
GB9501424D0 (en) 1995-01-25 1995-03-15 Carrie Len Epidural catheter
US5595183A (en) * 1995-02-17 1997-01-21 Ep Technologies, Inc. Systems and methods for examining heart tissue employing multiple electrode structures and roving electrodes
DE19507929A1 (de) 1995-02-24 1996-09-05 Biotronik Mess & Therapieg Elektrodensystem zur Messung des monophasischen Aktionspotentials
EP0827383B1 (en) 1995-02-28 2007-05-30 Boston Scientific Corporation Polymer implements for torque transmission
DE69518337T2 (de) 1995-03-10 2001-02-01 Impra Inc., Tempe Endoluminal eingekapselter stent und herstellverfahren
US5676662A (en) 1995-03-17 1997-10-14 Daig Corporation Ablation catheter
US5916178A (en) 1995-03-30 1999-06-29 Medtronic, Inc. Steerable high support guidewire with thin wall nitinol tube
NL1000183C2 (nl) 1995-04-20 1996-10-22 Clemens Josephus Jacobs Catheter.
AU5558096A (en) 1995-05-01 1996-11-21 Medtronic Cardiorhythm Dual curve ablation catheter and method
US5681280A (en) 1995-05-02 1997-10-28 Heart Rhythm Technologies, Inc. Catheter control system
AU5727096A (en) 1995-05-04 1996-11-21 Eric R. Cosman Cool-tip electrode thermosurgery system
AU5956896A (en) 1995-06-02 1996-12-18 Guided Medical Systems, Inc. Composite guide catheter of adjustable shape
US5984907A (en) 1995-06-05 1999-11-16 Ep Technologies, Inc. Transition sleeve assembly for catheters
US5540730A (en) 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
WO1996039993A1 (en) 1995-06-07 1996-12-19 Gore Hybrid Technologies, Inc. An implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein
US6041252A (en) 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US6090104A (en) 1995-06-07 2000-07-18 Cordis Webster, Inc. Catheter with a spirally wound flat ribbon electrode
US6322558B1 (en) 1995-06-09 2001-11-27 Engineering & Research Associates, Inc. Apparatus and method for predicting ablation depth
ATE267587T1 (de) 1995-06-09 2004-06-15 Euro Celtique Sa Formulierungen und verfahren für eine verlängerte lokalanästhesie
US5983131A (en) 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5672174A (en) 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5711326A (en) 1995-08-25 1998-01-27 Whirlpool Corporation Dishwasher accumulator soil removal grating for a filter system
US5860922A (en) * 1995-09-07 1999-01-19 Technion Research And Development Foundation Ltd. Determining blood flow by measurement of temperature
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
CA2231425A1 (en) 1995-09-20 1997-03-27 Texas Heart Institute Detecting thermal discrepancies in vessel walls
US6615071B1 (en) 1995-09-20 2003-09-02 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US5700282A (en) 1995-10-13 1997-12-23 Zabara; Jacob Heart rhythm stabilization using a neurocybernetic prosthesis
ATE275880T1 (de) 1995-10-13 2004-10-15 Transvascular Inc Vorrichtung zur umgehung von arteriellen verengungen und/oder zur ausführung anderer transvaskularer eingriffe
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US6283960B1 (en) 1995-10-24 2001-09-04 Oratec Interventions, Inc. Apparatus for delivery of energy to a surgical site
US5755750A (en) 1995-11-13 1998-05-26 University Of Florida Method and apparatus for selectively inhibiting activity in nerve fibers
US6073048A (en) 1995-11-17 2000-06-06 Medtronic, Inc. Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure
US5823955A (en) 1995-11-20 1998-10-20 Medtronic Cardiorhythm Atrioventricular valve tissue ablation catheter and method
SE9504333D0 (sv) 1995-12-04 1995-12-04 Pacesetter Ab Styrtrådsenhet
US6010613A (en) 1995-12-08 2000-01-04 Cyto Pulse Sciences, Inc. Method of treating materials with pulsed electrical fields
DE19546941A1 (de) 1995-12-15 1997-06-19 Biotronik Mess & Therapieg Einzel-Elektrode für Zweikammer-Herzschrittmachersysteme, insbesondere für DDD-Herzschrittmachersysteme
CN2291164Y (zh) 1996-12-23 1998-09-16 祝强 降压仪
EP1238659B1 (en) 1996-02-02 2004-09-29 ALZA Corporation Sustained delivery of an active agent using an implantable system
ATE247429T1 (de) 1996-02-02 2003-09-15 Transvascular Inc System für interstitielle transvaskuläre chirurgische eingriffe
US5895398A (en) 1996-02-02 1999-04-20 The Regents Of The University Of California Method of using a clot capture coil
US5807249A (en) 1996-02-16 1998-09-15 Medtronic, Inc. Reduced stiffness, bidirectionally deflecting catheter assembly
US6051017A (en) 1996-02-20 2000-04-18 Advanced Bionics Corporation Implantable microstimulator and systems employing the same
US5913876A (en) 1996-02-20 1999-06-22 Cardiothoracic Systems, Inc. Method and apparatus for using vagus nerve stimulation in surgery
US6436056B1 (en) 1996-02-28 2002-08-20 Boston Scientific Corporation Polymeric implements for torque transmission
US6036687A (en) 1996-03-05 2000-03-14 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency
US6032077A (en) 1996-03-06 2000-02-29 Cardiac Pathways Corporation Ablation catheter with electrical coupling via foam drenched with a conductive fluid
US5755760A (en) 1996-03-11 1998-05-26 Medtronic, Inc. Deflectable catheter
US5997526A (en) 1996-03-25 1999-12-07 The Uab Research Foundation Shape memory catheter
JP3529537B2 (ja) 1996-03-25 2004-05-24 テルモ株式会社 電極カテーテル
US5747060A (en) 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US5690681A (en) 1996-03-29 1997-11-25 Purdue Research Foundation Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US5755761A (en) 1996-04-26 1998-05-26 Pharmatarget, Inc. Atrial pacing catheter and method having multiple electrodes in the right atrium and coronary sinus
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6735471B2 (en) 1996-04-30 2004-05-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US6449507B1 (en) 1996-04-30 2002-09-10 Medtronic, Inc. Method and system for nerve stimulation prior to and during a medical procedure
US5690691A (en) 1996-05-08 1997-11-25 The Center For Innovative Technology Gastro-intestinal pacemaker having phased multi-point stimulation
US5713923A (en) 1996-05-13 1998-02-03 Medtronic, Inc. Techniques for treating epilepsy by brain stimulation and drug infusion
US6042578A (en) 1996-05-13 2000-03-28 Schneider (Usa) Inc. Catheter reinforcing braids
US5938690A (en) 1996-06-07 1999-08-17 Advanced Neuromodulation Systems, Inc. Pain management system and method
US5824026A (en) 1996-06-12 1998-10-20 The Spectranetics Corporation Catheter for delivery of electric energy and a process for manufacturing same
US5861021A (en) 1996-06-17 1999-01-19 Urologix Inc Microwave thermal therapy of cardiac tissue
US6546280B2 (en) 1996-06-18 2003-04-08 Cook Incorporated Indwelling catheter
US5727555A (en) 1996-06-18 1998-03-17 Cook Incorporated Indwelling catheter
US6223070B1 (en) 1998-03-16 2001-04-24 Cook, Inc. Indwelling catheter
US5827242A (en) 1996-06-21 1998-10-27 Medtronic, Inc. Reinforced catheter body and method for its fabrication
US20020040204A1 (en) 1996-06-24 2002-04-04 Dev Nagendu B. Electroporation-enhanced inhibition of vascular neointimal hyperplasia
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US5983141A (en) 1996-06-27 1999-11-09 Radionics, Inc. Method and apparatus for altering neural tissue function
US6246912B1 (en) 1996-06-27 2001-06-12 Sherwood Services Ag Modulated high frequency tissue modification
US5882346A (en) 1996-07-15 1999-03-16 Cardiac Pathways Corporation Shapable catheter using exchangeable core and method of use
US5972019A (en) 1996-07-25 1999-10-26 Target Therapeutics, Inc. Mechanical clot treatment device
US5924997A (en) 1996-07-29 1999-07-20 Campbell; Thomas Henderson Catheter and method for the thermal mapping of hot spots in vascular lesions of the human body
US6245026B1 (en) 1996-07-29 2001-06-12 Farallon Medsystems, Inc. Thermography catheter
US6058328A (en) 1996-08-06 2000-05-02 Pacesetter, Inc. Implantable stimulation device having means for operating in a preemptive pacing mode to prevent tachyarrhythmias and method thereof
US5800494A (en) 1996-08-20 1998-09-01 Fidus Medical Technology Corporation Microwave ablation catheters having antennas with distal fire capabilities
US5906636A (en) 1996-09-20 1999-05-25 Texas Heart Institute Heat treatment of inflamed tissue
US5697928A (en) 1996-09-23 1997-12-16 Uab Research Foundation Cardic electrode catheter
US5954740A (en) 1996-09-23 1999-09-21 Boston Scientific Corporation Catheter balloon having raised radial segments
US5891134A (en) 1996-09-24 1999-04-06 Goble; Colin System and method for applying thermal energy to tissue
US5800464A (en) 1996-10-03 1998-09-01 Medtronic, Inc. System for providing hyperpolarization of cardiac to enhance cardiac function
US5814079A (en) 1996-10-04 1998-09-29 Medtronic, Inc. Cardiac arrhythmia management by application of adnodal stimulation for hyperpolarization of myocardial cells
US5704908A (en) 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
US7052493B2 (en) 1996-10-22 2006-05-30 Epicor Medical, Inc. Methods and devices for ablation
US6096036A (en) 1998-05-05 2000-08-01 Cardiac Pacemakers, Inc. Steerable catheter with preformed distal shape and method for use
US5827268A (en) 1996-10-30 1998-10-27 Hearten Medical, Inc. Device for the treatment of patent ductus arteriosus and method of using the device
US5893885A (en) 1996-11-01 1999-04-13 Cordis Webster, Inc. Multi-electrode ablation catheter
US6091995A (en) 1996-11-08 2000-07-18 Surx, Inc. Devices, methods, and systems for shrinking tissues
US5941893A (en) 1996-12-02 1999-08-24 Angiotrax, Inc. Apparatus for transluminally performing surgery
US5954719A (en) 1996-12-11 1999-09-21 Irvine Biomedical, Inc. System for operating a RF ablation generator
US5910129A (en) 1996-12-19 1999-06-08 Ep Technologies, Inc. Catheter distal assembly with pull wires
US6076012A (en) 1996-12-19 2000-06-13 Ep Technologies, Inc. Structures for supporting porous electrode elements
US6048329A (en) 1996-12-19 2000-04-11 Ep Technologies, Inc. Catheter distal assembly with pull wires
US5871449A (en) 1996-12-27 1999-02-16 Brown; David Lloyd Device and method for locating inflamed plaque in an artery
US6026326A (en) 1997-01-13 2000-02-15 Medtronic, Inc. Apparatus and method for treating chronic constipation
ATE274974T1 (de) 1997-01-13 2004-09-15 Neurodan As Implantierbare elektrode zur nervenstimulation
US5744710A (en) * 1997-01-17 1998-04-28 Lockheed Martin Corp. Fast maximum likelihood processor for means wind velocity estimation
SE9700373L (sv) 1997-02-04 1998-07-13 Stig Bengmark Sond för åstadkommande av fluidumförbindelse med tunntarmen
US5730741A (en) 1997-02-07 1998-03-24 Eclipse Surgical Technologies, Inc. Guided spiral catheter
US5873865A (en) 1997-02-07 1999-02-23 Eclipse Surgical Technologies, Inc. Spiral catheter with multiple guide holes
EP1006908A2 (en) 1997-02-12 2000-06-14 Oratec Interventions, Inc. Concave probe for arthroscopic surgery
US6208894B1 (en) 1997-02-26 2001-03-27 Alfred E. Mann Foundation For Scientific Research And Advanced Bionics System of implantable devices for monitoring and/or affecting body parameters
WO1998037926A1 (en) 1997-02-26 1998-09-03 Alfred E. Mann Foundation For Scientific Research Battery-powered patient implantable device
US5899898A (en) 1997-02-27 1999-05-04 Cryocath Technologies Inc. Cryosurgical linear ablation
US6086582A (en) 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
US6416510B1 (en) 1997-03-13 2002-07-09 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
AU6942198A (en) 1997-03-27 1998-10-22 Advanced Bionics, Inc. System of implantable devices for monitoring and/or affecting body para meters
JP3274384B2 (ja) 1997-03-31 2002-04-15 株式会社パイオラックス 留置カテーテル及びその挿入装置
AU6112798A (en) 1997-03-31 1998-10-22 Biosense, Inc. Deflectable catheter
US5879295A (en) 1997-04-02 1999-03-09 Medtronic, Inc. Enhanced contact steerable bowing electrode catheter assembly
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5876373A (en) 1997-04-04 1999-03-02 Eclipse Surgical Technologies, Inc. Steerable catheter
US5972026A (en) 1997-04-07 1999-10-26 Broncus Technologies, Inc. Bronchial stenter having diametrically adjustable electrodes
US7027869B2 (en) 1998-01-07 2006-04-11 Asthmatx, Inc. Method for treating an asthma attack
US5865815A (en) 1997-04-25 1999-02-02 Contimed, Inc. Prostatic obstruction relief catheter
US5948007A (en) 1997-04-30 1999-09-07 Medtronic, Inc. Dual channel implantation neurostimulation techniques
US6078840A (en) 1997-04-30 2000-06-20 Medtronic, Inc. Medical electrical lead having improved fixation
US5971983A (en) 1997-05-09 1999-10-26 The Regents Of The University Of California Tissue ablation device and method of use
US6012457A (en) 1997-07-08 2000-01-11 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6024740A (en) 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US6326020B1 (en) 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations
US5827278A (en) 1997-05-20 1998-10-27 Cordis Webster, Inc. Deflectable tip electrode catheter with nylon stiffener and compression coil
US6128522A (en) 1997-05-23 2000-10-03 Transurgical, Inc. MRI-guided therapeutic unit and methods
US5951539A (en) 1997-06-10 1999-09-14 Target Therpeutics, Inc. Optimized high performance multiple coil spiral-wound vascular catheter
US6152912A (en) 1997-06-10 2000-11-28 Target Therapeutics, Inc. Optimized high performance spiral-wound vascular catheter
US20030109778A1 (en) 1997-06-20 2003-06-12 Cardiac Assist Devices, Inc. Electrophysiology/ablation catheter and remote actuator therefor
WO1999000060A1 (en) 1997-06-26 1999-01-07 Advanced Coronary Intervention Electrosurgical catheter for resolving obstructions by radio frequency ablation
USRE40279E1 (en) 1997-06-26 2008-04-29 Sherwood Services Ag Method and system for neural tissue modification
US6251109B1 (en) 1997-06-27 2001-06-26 Daig Corporation Process and device for the treatment of atrial arrhythmia
US6248345B1 (en) 1997-07-02 2001-06-19 Euro-Celtique, S.A. Prolonged anesthesia in joints and body spaces
US6652515B1 (en) 1997-07-08 2003-11-25 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6966908B2 (en) 1997-07-08 2005-11-22 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6500174B1 (en) 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US6869431B2 (en) 1997-07-08 2005-03-22 Atrionix, Inc. Medical device with sensor cooperating with expandable member
US6164283A (en) 1997-07-08 2000-12-26 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
CN1161081C (zh) 1997-07-08 2004-08-11 加利福尼亚大学董事会 周缘消融装置组件和方法
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
US6514249B1 (en) 1997-07-08 2003-02-04 Atrionix, Inc. Positioning system and method for orienting an ablation element within a pulmonary vein ostium
DE69739334D1 (de) 1997-07-16 2009-05-07 Metacure N V Einrichtung zur Steuerung eines glatten Muskels
US6080151A (en) 1997-07-21 2000-06-27 Daig Corporation Ablation catheter
US6014579A (en) * 1997-07-21 2000-01-11 Cardiac Pathways Corp. Endocardial mapping catheter with movable electrode
US6125302A (en) 1997-09-02 2000-09-26 Advanced Bionics Corporation Precurved modiolar-hugging cochlear electrode
WO1999011313A1 (en) 1997-09-04 1999-03-11 Alcon Laboratories, Inc. Flexible tube with circular grooves of varying width and depth
US6200312B1 (en) * 1997-09-11 2001-03-13 Vnus Medical Technologies, Inc. Expandable vein ligator catheter having multiple electrode leads
US6258084B1 (en) 1997-09-11 2001-07-10 Vnus Medical Technologies, Inc. Method for applying energy to biological tissue including the use of tumescent tissue compression
US5871531A (en) 1997-09-25 1999-02-16 Medtronic, Inc. Medical electrical lead having tapered spiral fixation
US5891114A (en) 1997-09-30 1999-04-06 Target Therapeutics, Inc. Soft-tip high performance braided catheter
US6048338A (en) 1997-10-15 2000-04-11 Scimed Life Systems, Inc. Catheter with spiral cut transition member
US6190356B1 (en) 1997-10-20 2001-02-20 Robert M. Bersin Helical spiral balloon catheter
US6156046A (en) 1997-11-07 2000-12-05 Prolifix Medical, Inc. Methods and systems for treating obstructions in a body lumen
WO1999023958A1 (en) 1997-11-07 1999-05-20 Prolifix Medical, Inc. Methods and systems for treating obstructions in a body lumen
US6120500A (en) 1997-11-12 2000-09-19 Daig Corporation Rail catheter ablation and mapping system
US6120476A (en) 1997-12-01 2000-09-19 Cordis Webster, Inc. Irrigated tip catheter
US6917834B2 (en) 1997-12-03 2005-07-12 Boston Scientific Scimed, Inc. Devices and methods for creating lesions in endocardial and surrounding tissue to isolate focal arrhythmia substrates
US6280441B1 (en) 1997-12-15 2001-08-28 Sherwood Services Ag Apparatus and method for RF lesioning
AU2022999A (en) 1997-12-31 1999-07-19 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
US6699231B1 (en) 1997-12-31 2004-03-02 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
US6146380A (en) 1998-01-09 2000-11-14 Radionics, Inc. Bent tip electrical surgical probe
EP0988091B1 (en) 1998-01-15 2009-10-21 Regenesis Biomedical, Inc. Improved pulsed electromagnetic energy treatment apparatus
US6251130B1 (en) 1998-03-24 2001-06-26 Innercool Therapies, Inc. Device for applications of selective organ cooling
US6522932B1 (en) 1998-02-10 2003-02-18 Advanced Bionics Corporation Implantable, expandable, multicontact electrodes and tools for use therewith
US6205361B1 (en) 1998-02-10 2001-03-20 Advanced Bionics Corporation Implantable expandable multicontact electrodes
US6415187B1 (en) 1998-02-10 2002-07-02 Advanced Bionics Corporation Implantable, expandable, multicontact electrodes and insertion needle for use therewith
US6645201B1 (en) * 1998-02-19 2003-11-11 Curon Medical, Inc. Systems and methods for treating dysfunctions in the intestines and rectum
DE69923291T2 (de) * 1998-02-19 2005-06-09 Curon Medical Inc., Sunnyvale Elektrochirurgische vorrichtung zur behandlung von schliessmuskeln
US6258087B1 (en) 1998-02-19 2001-07-10 Curon Medical, Inc. Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
KR19990072499A (ko) 1998-02-19 1999-09-27 리페르트 존 유연성이높은부위를가지는카테테르안내와이어장치
US6273886B1 (en) 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US7371210B2 (en) 1998-02-24 2008-05-13 Hansen Medical, Inc. Flexible instrument
US20020138082A1 (en) 1998-02-24 2002-09-26 Brock David L. Surgical instrument
US6142993A (en) 1998-02-27 2000-11-07 Ep Technologies, Inc. Collapsible spline structure using a balloon as an expanding actuator
US6308090B1 (en) 1998-03-09 2001-10-23 Irvine Biomedical, Inc. Devices and methods for coronary sinus mapping
US5951471A (en) 1998-03-09 1999-09-14 Irvine Biomedical, Inc. Catheter-based coronary sinus mapping and ablation
US6132456A (en) 1998-03-10 2000-10-17 Medtronic, Inc. Arrangement for implanting an endocardial cardiac lead
US6078841A (en) 1998-03-27 2000-06-20 Advanced Bionics Corporation Flexible positioner for use with implantable cochlear electrode array
US6071729A (en) 1998-04-02 2000-06-06 Jeffries; Thomas W. Disruption of the cytochrome C gene in xylose-fermenting yeast
US6086527A (en) 1998-04-02 2000-07-11 Scimed Life Systems, Inc. System for treating congestive heart failure
US6314325B1 (en) 1998-04-07 2001-11-06 William R. Fitz Nerve hyperpolarization method and apparatus for pain relief
US6106518A (en) 1998-04-09 2000-08-22 Cryocath Technologies, Inc. Variable geometry tip for a cryosurgical ablation device
WO1999052421A1 (en) 1998-04-13 1999-10-21 Prolifix Medical, Inc. Guidewire for precision catheter positioning
WO1999052424A1 (en) 1998-04-14 1999-10-21 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6219577B1 (en) * 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6064902A (en) 1998-04-16 2000-05-16 C.R. Bard, Inc. Pulmonary vein ablation catheter
US5968085A (en) 1998-04-20 1999-10-19 Medtronic, Inc. Pacing lead with integral guidance using ultrasound
US5916154A (en) 1998-04-22 1999-06-29 Nellcor Puritan Bennett Method of enhancing performance in pulse oximetry via electrical stimulation
US20020065542A1 (en) 1998-04-22 2002-05-30 Ronald G. Lax Method and apparatus for treating an aneurysm
EP0951920B1 (de) 1998-04-22 2004-10-20 BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin Gefässelektrodenleitung
US6269269B1 (en) 1998-04-23 2001-07-31 Medtronic Inc. Method and apparatus for synchronized treatment of obstructive sleep apnea
US6058331A (en) 1998-04-27 2000-05-02 Medtronic, Inc. Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control
US6511492B1 (en) 1998-05-01 2003-01-28 Microvention, Inc. Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
US5928272A (en) 1998-05-02 1999-07-27 Cyberonics, Inc. Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity
US6192889B1 (en) 1998-05-05 2001-02-27 Woodside Biomedical, Inc. Method of suppression and prevention of the gag reflex
US6146381A (en) 1998-05-05 2000-11-14 Cardiac Pacemakers, Inc. Catheter having distal region for deflecting axial forces
US6042580A (en) 1998-05-05 2000-03-28 Cardiac Pacemakers, Inc. Electrode having composition-matched, common-lead thermocouple wire for providing multiple temperature-sensitive junctions
US6049737A (en) 1998-05-05 2000-04-11 Cardiac Pacemakers, Inc. Catheter having common lead for electrode and sensor
US6312425B1 (en) 1998-05-05 2001-11-06 Cardiac Pacemakers, Inc. RF ablation catheter tip electrode with multiple thermal sensors
US6592581B2 (en) 1998-05-05 2003-07-15 Cardiac Pacemakers, Inc. Preformed steerable catheter with movable outer sleeve and method for use
US6074339A (en) 1998-05-07 2000-06-13 Medtronic Ave, Inc. Expandable braid device and method for radiation treatment
EP1079890A4 (en) 1998-05-08 2008-12-03 Genetronics Inc VASODILATION OF AN ELECTRICALLY INDUCED VESSEL
US6231572B1 (en) 1998-05-29 2001-05-15 Applied Medical Resources Corporation Electrosurgical catheter apparatus and method
US6623474B1 (en) 1998-06-04 2003-09-23 Biosense Webster, Inc. Injection catheter with needle stop
US7198635B2 (en) * 2000-10-17 2007-04-03 Asthmatx, Inc. Modification of airways by application of energy
US6368316B1 (en) 1998-06-11 2002-04-09 Target Therapeutics, Inc. Catheter with composite stiffener
US6292695B1 (en) 1998-06-19 2001-09-18 Wilton W. Webster, Jr. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US6094596A (en) 1998-06-19 2000-07-25 Angeron Corporation Transvenous defibrillation lead system for use in middle cardiac vein
US6287306B1 (en) 1998-06-22 2001-09-11 Daig Corporation Even temperature linear lesion ablation catheter
US6066132A (en) 1998-06-30 2000-05-23 Ethicon, Inc. Articulating endometrial ablation device
US6322559B1 (en) 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
US6302903B1 (en) 1998-07-07 2001-10-16 Medtronic, Inc. Straight needle apparatus for creating a virtual electrode used for the ablation of tissue
US6972013B1 (en) 1998-07-13 2005-12-06 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
WO2000002621A1 (en) 1998-07-13 2000-01-20 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US7599736B2 (en) 2001-07-23 2009-10-06 Dilorenzo Biomedical, Llc Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease
US6179860B1 (en) 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6610083B2 (en) 1998-08-24 2003-08-26 Radiant Medical, Inc. Multiple lumen heat exchange catheters
US6304787B1 (en) 1998-08-26 2001-10-16 Advanced Bionics Corporation Cochlear electrode array having current-focusing and tissue-treating features
US6228109B1 (en) 1998-08-31 2001-05-08 Lily Chen Tu Methods for treating atherosclerosis and vulnerable plaques
US6123702A (en) 1998-09-10 2000-09-26 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6385472B1 (en) 1999-09-10 2002-05-07 Stereotaxis, Inc. Magnetically navigable telescoping catheter and method of navigating telescoping catheter
US6319251B1 (en) * 1998-09-24 2001-11-20 Hosheng Tu Medical device and methods for treating intravascular restenosis
US6544215B1 (en) 1998-10-02 2003-04-08 Scimed Life Systems, Inc. Steerable device for introducing diagnostic and therapeutic apparatus into the body
US6123718A (en) 1998-11-02 2000-09-26 Polymerex Medical Corp. Balloon catheter
US6701176B1 (en) 1998-11-04 2004-03-02 Johns Hopkins University School Of Medicine Magnetic-resonance-guided imaging, electrophysiology, and ablation
US6083156A (en) * 1998-11-16 2000-07-04 Ronald S. Lisiecki Portable integrated physiological monitoring system
US7313444B2 (en) 1998-11-20 2007-12-25 Pacesetter, Inc. Self-anchoring coronary sinus lead
US6319250B1 (en) 1998-11-23 2001-11-20 C.R. Bard, Inc Tricuspid annular grasp catheter
US6638278B2 (en) 1998-11-23 2003-10-28 C. R. Bard, Inc. Intracardiac grasp catheter
WO2000035531A1 (en) 1998-12-14 2000-06-22 Tre Esse Progettazione Biomedica S.R.L. Catheter system for performing intramyocardiac therapeutic treatment
US20070066972A1 (en) 2001-11-29 2007-03-22 Medwaves, Inc. Ablation catheter apparatus with one or more electrodes
US6077227A (en) 1998-12-28 2000-06-20 Medtronic, Inc. Method for manufacture and implant of an implantable blood vessel cuff
US7122019B1 (en) 2000-11-28 2006-10-17 Flowmedica Inc. Intra-aortic renal drug delivery catheter
US6749598B1 (en) 1999-01-11 2004-06-15 Flowmedica, Inc. Apparatus and methods for treating congestive heart disease
US7481803B2 (en) 2000-11-28 2009-01-27 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US7329236B2 (en) 1999-01-11 2008-02-12 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US7780628B1 (en) 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
CA2368707C (en) 1999-02-02 2006-06-06 Transurgical, Inc. Intrabody hifu applicator
US6210408B1 (en) 1999-02-24 2001-04-03 Scimed Life Systems, Inc. Guide wire system for RF recanalization of vascular blockages
US6210339B1 (en) 1999-03-03 2001-04-03 Endosonics Corporation Flexible elongate member having one or more electrical contacts
ATE298536T1 (de) 1999-03-09 2005-07-15 Thermage Inc Vorichtung zur behandlung von gewebe
US6508774B1 (en) 1999-03-09 2003-01-21 Transurgical, Inc. Hifu applications with feedback control
US6464687B1 (en) 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system
US6136021A (en) * 1999-03-23 2000-10-24 Cardiac Pacemakers, Inc. Expandable electrode for coronary venous leads
US6129750A (en) 1999-03-23 2000-10-10 Cardiac Pacemakers, Inc. Fixation mechanism for a coronary venous pacing lead
US6678558B1 (en) 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US6161049A (en) 1999-03-26 2000-12-12 Urologix, Inc. Thermal therapy catheter
US20010007070A1 (en) 1999-04-05 2001-07-05 Medtronic, Inc. Ablation catheter assembly and method for isolating a pulmonary vein
US6325797B1 (en) 1999-04-05 2001-12-04 Medtronic, Inc. Ablation catheter and method for isolating a pulmonary vein
US20050010095A1 (en) 1999-04-05 2005-01-13 Medtronic, Inc. Multi-purpose catheter apparatus and method of use
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US6738663B2 (en) 1999-04-09 2004-05-18 Oncostim, A Minnesota Corporation Implantable device and method for the electrical treatment of cancer
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US6366808B1 (en) 2000-03-13 2002-04-02 Edward A. Schroeppel Implantable device and method for the electrical treatment of cancer
US6178349B1 (en) 1999-04-15 2001-01-23 Medtronic, Inc. Drug delivery neural stimulation device for treatment of cardiovascular disorders
US6317615B1 (en) 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US6939346B2 (en) 1999-04-21 2005-09-06 Oratec Interventions, Inc. Method and apparatus for controlling a temperature-controlled probe
US6923784B2 (en) 1999-04-30 2005-08-02 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
US6610046B1 (en) 1999-04-30 2003-08-26 Usaminanotechnology Inc. Catheter and guide wire
US6341236B1 (en) 1999-04-30 2002-01-22 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
WO2000066017A1 (en) 1999-05-04 2000-11-09 Curon Medical, Inc. Electrodes for creating lesions in tissue regions at or near a sphincter
US6178352B1 (en) 1999-05-07 2001-01-23 Woodside Biomedical, Inc. Method of blood pressure moderation
EP1179995B1 (en) 1999-05-11 2007-01-31 Atrionix, Inc. Balloon anchor wire
US6758830B1 (en) 1999-05-11 2004-07-06 Atrionix, Inc. Catheter positioning system
US7343195B2 (en) 1999-05-18 2008-03-11 Mediguide Ltd. Method and apparatus for real time quantitative three-dimensional image reconstruction of a moving organ and intra-body navigation
US6692490B1 (en) * 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
DE29909082U1 (de) 1999-05-25 1999-07-22 Starck, Bernd, Dipl.-Ing., 75443 Ötisheim Stimulations-, Sensing- und/oder Defibrillationselektrode sowie Ballon-Katheter zum Einbringen der Elektrode
US6304777B1 (en) 1999-05-26 2001-10-16 Impulse Dynamics N.V. Induction of cardioplegia applied electrical signals
US6442424B1 (en) 1999-05-26 2002-08-27 Impulse Dynamics N.V. Local cardiac motion control using applied electrical signals
US7171263B2 (en) * 1999-06-04 2007-01-30 Impulse Dynamics Nv Drug delivery device
US6890329B2 (en) 1999-06-15 2005-05-10 Cryocath Technologies Inc. Defined deflection structure
US6546272B1 (en) 1999-06-24 2003-04-08 Mackinnon Nicholas B. Apparatus for in vivo imaging of the respiratory tract and other internal organs
CA2376903A1 (en) * 1999-06-25 2001-01-04 Emory University Devices and methods for vagus nerve stimulation
US6272383B1 (en) 1999-06-28 2001-08-07 Woodside Biomedical, Inc. Electro-acupuncture method using an electrical stimulator
US6620172B1 (en) 1999-07-01 2003-09-16 Medsource Technologies, Inc. Entraining biological calculi
US6364904B1 (en) 1999-07-02 2002-04-02 Scimed Life Systems, Inc. Helically formed stent/graft assembly
US6605061B2 (en) 1999-07-14 2003-08-12 Tricardia, L.L.C. Catheter for drug injection in cardiovascular system
US6300108B1 (en) 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US7053063B2 (en) 1999-07-21 2006-05-30 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes in tissue
US6927049B2 (en) 1999-07-21 2005-08-09 The Regents Of The University Of California Cell viability detection using electrical measurements
US6508804B2 (en) 1999-07-28 2003-01-21 Scimed Life Systems, Inc. Catheter having continuous lattice and coil reinforcement
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
FR2797389B1 (fr) 1999-08-09 2001-11-30 Novatech Inc Prothese aortique bifurquee
US6767544B2 (en) 2002-04-01 2004-07-27 Allergan, Inc. Methods for treating cardiovascular diseases with botulinum toxin
US6246914B1 (en) 1999-08-12 2001-06-12 Irvine Biomedical, Inc. High torque catheter and methods thereof
US6442415B1 (en) 1999-08-12 2002-08-27 Magnetic Moments, L.L.C. Contrast-enhanced coronary artery and coronary artery bypass graft imaging using an aortic root catheter injection with either magnetic resonance angiography or computed tomographic angiography
US7171275B2 (en) 1999-08-12 2007-01-30 Irvine Biomedical Inc. High torque balloon catheter possessing multi-directional deflectability and methods thereof
US6611720B2 (en) 1999-08-12 2003-08-26 Irvine Biomedical Inc. High torque catheter possessing multi-directional deflectability and methods thereof
US6450942B1 (en) 1999-08-20 2002-09-17 Cardiorest International Ltd. Method for reducing heart loads in mammals
US6575966B2 (en) * 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
US6599256B1 (en) 1999-09-10 2003-07-29 Transurgical, Inc. Occlusion of tubular anatomical structures by energy application
US6607520B2 (en) 1999-09-15 2003-08-19 The General Hospital Corporation Coiled ablation catheter system
US6632223B1 (en) * 2000-03-30 2003-10-14 The General Hospital Corporation Pulmonary vein ablation stent and method
US7510536B2 (en) 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
US6454775B1 (en) 1999-12-06 2002-09-24 Bacchus Vascular Inc. Systems and methods for clot disruption and retrieval
CA2384866C (en) * 1999-09-28 2012-07-10 Stuart D. Edwards Treatment of tissue by application of energy and drugs
US6272377B1 (en) 1999-10-01 2001-08-07 Cardiac Pacemakers, Inc. Cardiac rhythm management system with arrhythmia prediction and prevention
US6473644B1 (en) 1999-10-13 2002-10-29 Cyberonics, Inc. Method to enhance cardiac capillary growth in heart failure patients
US6287304B1 (en) 1999-10-15 2001-09-11 Neothermia Corporation Interstitial cauterization of tissue volumes with electrosurgically deployed electrodes
US6669655B1 (en) 1999-10-20 2003-12-30 Transurgical, Inc. Sonic element and catheter incorporating same
AU1144601A (en) 1999-10-29 2001-05-14 Universitat Zurich Method of volumetric blood flow measurement
US6436091B1 (en) 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
CA2391488C (en) * 1999-11-22 2012-04-03 Boston Scientific Limited Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6745080B2 (en) 1999-11-22 2004-06-01 Scimed Life Systems, Inc. Helical and pre-oriented loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6542781B1 (en) 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6613046B1 (en) * 1999-11-22 2003-09-02 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6711444B2 (en) 1999-11-22 2004-03-23 Scimed Life Systems, Inc. Methods of deploying helical diagnostic and therapeutic element supporting structures within the body
US6529756B1 (en) 1999-11-22 2003-03-04 Scimed Life Systems, Inc. Apparatus for mapping and coagulating soft tissue in or around body orifices
US20020026228A1 (en) 1999-11-30 2002-02-28 Patrick Schauerte Electrode for intravascular stimulation, cardioversion and/or defibrillation
ATE365574T1 (de) 1999-11-30 2007-07-15 Biotronik Gmbh & Co Kg Gerät zur regelung der herzfrequenz und der herzpumpkraft
US6575932B1 (en) * 1999-12-02 2003-06-10 Ottawa Heart Institute Adjustable multi-balloon local delivery device
US6280466B1 (en) 1999-12-03 2001-08-28 Teramed Inc. Endovascular graft system
US6592567B1 (en) 1999-12-07 2003-07-15 Chf Solutions, Inc. Kidney perfusion catheter
US6415183B1 (en) 1999-12-09 2002-07-02 Cardiac Pacemakers, Inc. Method and apparatus for diaphragmatic pacing
US20030150464A1 (en) 1999-12-17 2003-08-14 Casscells S. Ward Inducing apoptosis of atrial myocytes to treat atrial fibrillation
EP1239787B1 (en) 1999-12-21 2010-12-15 Covidien AG Apparatus for thermal treatment of an intervertebral disc
DE10042330A1 (de) 1999-12-22 2002-03-14 Hans Sachse Dünndarmsonde, wandverstärkt
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
US6885888B2 (en) 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US20060085046A1 (en) 2000-01-20 2006-04-20 Ali Rezai Methods of treating medical conditions by transvascular neuromodulation of the autonomic nervous system
US6438423B1 (en) 2000-01-20 2002-08-20 Electrocore Technique, Llc Method of treating complex regional pain syndromes by electrical stimulation of the sympathetic nerve chain
US6356787B1 (en) 2000-02-24 2002-03-12 Electro Core Techniques, Llc Method of treating facial blushing by electrical stimulation of the sympathetic nerve chain
US6356786B1 (en) 2000-01-20 2002-03-12 Electrocore Techniques, Llc Method of treating palmar hyperhydrosis by electrical stimulation of the sympathetic nervous chain
US7184827B1 (en) 2000-01-24 2007-02-27 Stuart D. Edwards Shrinkage of dilatations in the body
WO2001055212A2 (en) 2000-01-27 2001-08-02 The General Hospital Corporation Delivery of therapeutic biological from implantable tissue matrices
US6628976B1 (en) 2000-01-27 2003-09-30 Biosense Webster, Inc. Catheter having mapping assembly
US6514226B1 (en) 2000-02-10 2003-02-04 Chf Solutions, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney
US7163504B1 (en) 2000-02-16 2007-01-16 Advanced Cardiovascular Systems, Inc. Multi-lumen fluted balloon radiation centering catheter
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US6536949B1 (en) 2000-03-07 2003-03-25 Richard R. Heuser Catheter for thermal evaluation of arteriosclerotic plaque
US6770070B1 (en) 2000-03-17 2004-08-03 Rita Medical Systems, Inc. Lung treatment apparatus and method
US6554774B1 (en) * 2000-03-23 2003-04-29 Tensys Medical, Inc. Method and apparatus for assessing hemodynamic properties within the circulatory system of a living subject
US6605084B2 (en) 2000-03-24 2003-08-12 Transurgical, Inc. Apparatus and methods for intrabody thermal treatment
US20010031981A1 (en) 2000-03-31 2001-10-18 Evans Michael A. Method and device for locating guidewire and treating chronic total occlusions
US6287608B1 (en) 2000-04-11 2001-09-11 Intellicardia, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney by infusion of a vasodilator
US6652517B1 (en) 2000-04-25 2003-11-25 Uab Research Foundation Ablation catheter, system, and method of use thereof
US20010044596A1 (en) 2000-05-10 2001-11-22 Ali Jaafar Apparatus and method for treatment of vascular restenosis by electroporation
AU2001261486A1 (en) 2000-05-12 2001-11-26 Cardima, Inc. Multi-channel rf energy delivery with coagulum reduction
US6306423B1 (en) 2000-06-02 2001-10-23 Allergan Sales, Inc. Neurotoxin implant
ATE290827T1 (de) 2000-06-13 2005-04-15 Atrionix Inc Chirurgische ablationssonde zum formen einer ringförmigen läsion
US6546270B1 (en) 2000-07-07 2003-04-08 Biosense, Inc. Multi-electrode catheter, system and method
US6405067B1 (en) 2000-07-07 2002-06-11 Biosense Webster, Inc. Catheter with tip electrode having a recessed ring electrode mounted thereon
US6635054B2 (en) 2000-07-13 2003-10-21 Transurgical, Inc. Thermal treatment methods and apparatus with focused energy application
ES2467916T3 (es) 2000-07-26 2014-06-13 Boston Scientific Neuromodulation Corporation Sistema estimulador recargable
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6584362B1 (en) * 2000-08-30 2003-06-24 Cardiac Pacemakers, Inc. Leads for pacing and/or sensing the heart from within the coronary veins
US6862479B1 (en) 2000-08-30 2005-03-01 Advanced Bionics Corporation Spinal cord stimulation as a therapy for sexual dysfunction
WO2002019933A1 (en) 2000-09-07 2002-03-14 Sherwood Services Ag Apparatus for and treatment of the intervertebral disc
US6405079B1 (en) 2000-09-22 2002-06-11 Mehdi M. Ansarinia Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions
US7840271B2 (en) 2000-09-27 2010-11-23 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US7499742B2 (en) 2001-09-26 2009-03-03 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US6985774B2 (en) 2000-09-27 2006-01-10 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US6522926B1 (en) 2000-09-27 2003-02-18 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US7616997B2 (en) 2000-09-27 2009-11-10 Kieval Robert S Devices and methods for cardiovascular reflex control via coupled electrodes
US7623926B2 (en) 2000-09-27 2009-11-24 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US6850801B2 (en) 2001-09-26 2005-02-01 Cvrx, Inc. Mapping methods for cardiovascular reflex control devices
US7158832B2 (en) 2000-09-27 2007-01-02 Cvrx, Inc. Electrode designs and methods of use for cardiovascular reflex control devices
US6845267B2 (en) 2000-09-28 2005-01-18 Advanced Bionics Corporation Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation
AU2002212996A1 (en) * 2000-09-28 2002-04-08 Non-Invasive Monitoring Systems, Inc. External addition of pulses to fluid channels of body to release or suppress endothelial mediators and to determine effectiveness of such intervention
US7306591B2 (en) 2000-10-02 2007-12-11 Novasys Medical, Inc. Apparatus and methods for treating female urinary incontinence
US6640120B1 (en) 2000-10-05 2003-10-28 Scimed Life Systems, Inc. Probe assembly for mapping and ablating pulmonary vein tissue and method of using same
US6926669B1 (en) 2000-10-10 2005-08-09 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US6802857B1 (en) 2000-10-11 2004-10-12 Uab Research Foundation MRI stent
US7104987B2 (en) 2000-10-17 2006-09-12 Asthmatx, Inc. Control system and process for application of energy to airway walls and other mediums
US7646544B2 (en) 2005-05-14 2010-01-12 Batchko Robert G Fluidic optical devices
WO2002034330A2 (en) 2000-10-26 2002-05-02 Medtronic, Inc. Method and apparatus to minimize the effects of a cardiac insult
WO2002045791A2 (en) 2000-10-26 2002-06-13 Medtronic, Inc. Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac comditions
EP1201198A1 (en) 2000-10-27 2002-05-02 MicroNet Medical, Inc. Catheter with thin film electrodes and method for making same
US6616624B1 (en) 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
US6942692B2 (en) 2000-11-16 2005-09-13 Cordis Corporation Supra-renal prosthesis and renal artery bypass
US6579308B1 (en) 2000-11-28 2003-06-17 Scimed Life Systems, Inc. Stent devices with detachable distal or proximal wires
US6728563B2 (en) 2000-11-29 2004-04-27 St. Jude Medical, Daig Division, Inc. Electrophysiology/ablation catheter having “halo” configuration
US7081114B2 (en) 2000-11-29 2006-07-25 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrophysiology/ablation catheter having lariat configuration of variable radius
US6681136B2 (en) 2000-12-04 2004-01-20 Science Medicus, Inc. Device and method to modulate blood pressure by electrical waveforms
US6676657B2 (en) 2000-12-07 2004-01-13 The United States Of America As Represented By The Department Of Health And Human Services Endoluminal radiofrequency cauterization system
US6527739B1 (en) 2000-12-29 2003-03-04 Advanced Cardiovascular Systems, Inc. Spiraled balloon arrangement for treatment of a tortuous vessel
US20020087151A1 (en) 2000-12-29 2002-07-04 Afx, Inc. Tissue ablation apparatus with a sliding ablation instrument and method
US6772015B2 (en) * 2000-12-29 2004-08-03 Medtronic, Inc Bifurcated lead system for a cardiac vein
US6666845B2 (en) 2001-01-04 2003-12-23 Advanced Neuromodulation Systems, Inc. Implantable infusion pump
WO2002053207A2 (en) 2001-01-04 2002-07-11 Advanced Neuromodulation Systems, Inc. Implantable infusion pump
US6622731B2 (en) 2001-01-11 2003-09-23 Rita Medical Systems, Inc. Bone-treatment instrument and method
US6480747B2 (en) 2001-01-16 2002-11-12 Quetzal Biomedical, Inc. Cardiac electrode catheter and method of manufacturing same
US6602241B2 (en) * 2001-01-17 2003-08-05 Transvascular, Inc. Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites
WO2002056799A2 (en) 2001-01-19 2002-07-25 Boston Scientific Limited Introducer for deployment of branched prosthesis
US6600954B2 (en) 2001-01-25 2003-07-29 Biocontrol Medical Bcm Ltd. Method and apparatus for selective control of nerve fibers
US6672312B2 (en) 2001-01-31 2004-01-06 Transurgical, Inc. Pulmonary vein ablation with myocardial tissue locating
US6451045B1 (en) 2001-02-22 2002-09-17 Alsius Corporation Heat exchange catheter having a helically wrapped heat exchanger
US6564096B2 (en) 2001-02-28 2003-05-13 Robert A. Mest Method and system for treatment of tachycardia and fibrillation
AU2002250250A1 (en) * 2001-03-01 2002-09-19 Three Arch Partners Intravascular device for treatment of hypertension
US6620151B2 (en) 2001-03-01 2003-09-16 Advanced Neuromodulation Systems, Inc. Non-constant pressure infusion pump
WO2002069821A1 (en) 2001-03-06 2002-09-12 Thermemed Corp. Vaporous delivery of thermal energy to tissue sites
US6786904B2 (en) 2002-01-10 2004-09-07 Triton Biosystems, Inc. Method and device to treat vulnerable plaque
DE10114725A1 (de) 2001-03-21 2002-09-26 Biotronik Mess & Therapieg Intravaskuläre Elektrodenleitung
WO2002076344A1 (en) 2001-03-23 2002-10-03 Durect Corporation Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space
CA2450376A1 (en) 2001-04-20 2002-10-31 The Board Of Regents Of The University Of Oklahoma Cardiac neuromodulation and methods of using same
WO2002085192A2 (en) 2001-04-23 2002-10-31 Transurgical, Inc. Improvements in ablation therapy
US6684105B2 (en) 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US7959626B2 (en) 2001-04-26 2011-06-14 Medtronic, Inc. Transmural ablation systems and methods
US6663627B2 (en) 2001-04-26 2003-12-16 Medtronic, Inc. Ablation system and method of use
DE60223794T2 (de) 2001-04-27 2008-10-30 C.R. Bard, Inc. Elektrophysiologie-katheter zur mapping und ablation
US6909920B2 (en) * 2001-04-27 2005-06-21 Medtronic, Inc. System and method for positioning an implantable medical device within a body
US6972016B2 (en) * 2001-05-01 2005-12-06 Cardima, Inc. Helically shaped electrophysiology catheter
US20020169444A1 (en) 2001-05-08 2002-11-14 Mest Robert A. Catheter having continuous braided electrode
CN100518685C (zh) 2001-05-10 2009-07-29 脉管动力股份有限公司 组织消融设备
WO2002089908A1 (en) 2001-05-10 2002-11-14 Super Dimension Ltd. Steerable multiple electrode catheter and method
US6716207B2 (en) 2001-05-22 2004-04-06 Scimed Life Systems, Inc. Torqueable and deflectable medical device shaft
US6771996B2 (en) 2001-05-24 2004-08-03 Cardiac Pacemakers, Inc. Ablation and high-resolution mapping catheter system for pulmonary vein foci elimination
WO2002096512A1 (en) 2001-05-29 2002-12-05 Medtronic, Inc. Closed-loop neuromodulation for prevention and treatment of cardiac conditions
US7674245B2 (en) 2001-06-07 2010-03-09 Cardiac Pacemakers, Inc. Method and apparatus for an adjustable shape guide catheter
US7127284B2 (en) 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
FR2827548A1 (fr) 2001-07-17 2003-01-24 Michelin Soc Tech Ensemble monte tubeless pour cycle, jante et pneumatique tubeless
US20060167498A1 (en) 2001-07-23 2006-07-27 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
EP1412022B1 (de) 2001-07-27 2005-04-13 Impella Cardiotechnik AG Neurostimulationseinheit zur immobilisation des herzens während kardiochirurgischer operationen
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US6622041B2 (en) 2001-08-21 2003-09-16 Cyberonics, Inc. Treatment of congestive heart failure and autonomic cardiovascular drive disorders
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US20030050635A1 (en) 2001-08-22 2003-03-13 Csaba Truckai Embolization systems and techniques for treating tumors
US7778703B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
DE60226501D1 (de) 2001-08-31 2008-06-19 Cyto Pulse Sciences Inc Dielektrophoresewellenform mit nichtlinearer amplitude zur zellfusion
WO2003020138A1 (en) 2001-08-31 2003-03-13 Scimed Life Systems, Inc. Percutaneous pringle occlusion device
US7252679B2 (en) 2001-09-13 2007-08-07 Cordis Corporation Stent with angulated struts
JP2005502417A (ja) 2001-09-19 2005-01-27 ウロロジックス， インコーポレイテッド マイクロ波アブレーションデバイス
US6547803B2 (en) 2001-09-20 2003-04-15 The Regents Of The University Of California Microfabricated surgical device for interventional procedures
US7547294B2 (en) 2001-09-20 2009-06-16 The Regents Of The University Of California Microfabricated surgical device for interventional procedures
JP3607231B2 (ja) 2001-09-28 2005-01-05 有限会社日本エレクテル 高周波加温バルーンカテーテル
EP1434621A2 (en) 2001-10-01 2004-07-07 AM Discovery, Incorporated Devices for treating atrial fibrilation
US8974446B2 (en) 2001-10-11 2015-03-10 St. Jude Medical, Inc. Ultrasound ablation apparatus with discrete staggered ablation zones
NL1019161C2 (nl) 2001-10-11 2003-04-14 Itsac Nv Kunststof spout.
US20030082225A1 (en) 2001-10-19 2003-05-01 Mason Paul Arthur Sterile, breathable patch for treating wound pain
US20030078618A1 (en) * 2001-10-19 2003-04-24 Fey Kate E. System and method for removing implanted devices
US6829508B2 (en) * 2001-10-19 2004-12-07 Alfred E. Mann Foundation For Scientific Research Electrically sensing and stimulating system for placement of a nerve stimulator or sensor
US6926716B2 (en) 2001-11-09 2005-08-09 Surgrx Inc. Electrosurgical instrument
US7517349B2 (en) 2001-10-22 2009-04-14 Vnus Medical Technologies, Inc. Electrosurgical instrument and method
AUPR847201A0 (en) 2001-10-26 2001-11-15 Cook Incorporated Endoluminal graft
CA2468531C (en) 2001-11-29 2010-06-01 Medwaves, Inc. Radio-frequency-based catheter system with improved deflection and steering mechanisms
US7488313B2 (en) 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
WO2003047439A2 (en) 2001-12-03 2003-06-12 Ekos Corporation Catheter with multiple ultrasound radiating members
US6748255B2 (en) 2001-12-14 2004-06-08 Biosense Webster, Inc. Basket catheter with multiple location sensors
US20030125790A1 (en) 2001-12-27 2003-07-03 Vitaly Fastovsky Deployment device, system and method for medical implantation
US6980858B2 (en) * 2001-12-31 2005-12-27 Biosense Webster, Inc. Method and system for atrial defibrillation
US6893436B2 (en) 2002-01-03 2005-05-17 Afx, Inc. Ablation instrument having a flexible distal portion
US6817999B2 (en) 2002-01-03 2004-11-16 Afx, Inc. Flexible device for ablation of biological tissue
US7211055B2 (en) * 2002-01-15 2007-05-01 The Regents Of The University Of California System and method providing directional ultrasound therapy to skeletal joints
US20060189941A1 (en) 2002-01-22 2006-08-24 Mercator Medsystems, Inc. Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
EP1503685B1 (en) * 2002-01-23 2012-10-31 The Regents of The University of California Implantable thermal treatment apparatus
US7155284B1 (en) 2002-01-24 2006-12-26 Advanced Bionics Corporation Treatment of hypertension
US7967816B2 (en) 2002-01-25 2011-06-28 Medtronic, Inc. Fluid-assisted electrosurgical instrument with shapeable electrode
US6814733B2 (en) 2002-01-31 2004-11-09 Biosense, Inc. Radio frequency pulmonary vein isolation
AU2003212870A1 (en) 2002-02-01 2003-09-02 The Cleveland Clinic Foundation Methods of affecting hypothalamic-related conditions
EP1476222A2 (en) 2002-02-01 2004-11-17 The Cleveland Clinic Foundation Neural stimulation delivery device with independently moveable delivery structures
US7477945B2 (en) 2002-02-01 2009-01-13 The Cleveland Clinic Foundation Delivery device for stimulating the sympathetic nerve chain
US7311705B2 (en) 2002-02-05 2007-12-25 Medtronic, Inc. Catheter apparatus for treatment of heart arrhythmia
US6949121B1 (en) 2002-02-07 2005-09-27 Sentient Engineering & Technology, Llc Apparatus and methods for conduits and materials
US8133501B2 (en) 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
US20040073117A1 (en) * 2002-02-14 2004-04-15 Schwarz Karl Q. Method and system for delivering contrast agent
US7236821B2 (en) * 2002-02-19 2007-06-26 Cardiac Pacemakers, Inc. Chronically-implanted device for sensing and therapy
US6733499B2 (en) 2002-02-28 2004-05-11 Biosense Webster, Inc. Catheter having circular ablation assembly
CN1652841A (zh) 2002-03-14 2005-08-10 布雷恩斯盖特有限公司 血压调节技术
US6882885B2 (en) 2002-03-19 2005-04-19 Solarant Medical, Inc. Heating method for tissue contraction
ITBS20020039U1 (it) 2002-03-20 2003-09-22 Fogazzi Di Venturelli Andrea & Catetere con elettrodo flessibile raffreddato
US6736835B2 (en) * 2002-03-21 2004-05-18 Depuy Acromed, Inc. Early intervention spinal treatment methods and devices for use therein
WO2008088766A1 (en) 2002-03-22 2008-07-24 Cordis Corporation Rapid-exchange balloon catheter shaft and method
JP4295627B2 (ja) 2002-03-27 2009-07-15 シーブイアールエックス， インコーポレイテッド 電極構造体および循環系反射の制御におけるその使用方法
US20070135875A1 (en) * 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20080213331A1 (en) * 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US7620451B2 (en) * 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US7756583B2 (en) * 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US9636174B2 (en) * 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US7617005B2 (en) * 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8774913B2 (en) * 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US6978174B2 (en) * 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US20060206150A1 (en) * 2002-04-08 2006-09-14 Ardian, Inc. Methods and apparatus for treating acute myocardial infarction
US20070129761A1 (en) * 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8145317B2 (en) * 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
DE60336643D1 (de) 2002-04-11 2011-05-19 Medtronic Vascular Inc Vorrichtungen für die transluminale oder transthorakale interstitielle Elektrodenplatzierung
WO2003089046A1 (en) 2002-04-16 2003-10-30 Cyto Pulse Sciences, Inc. Method of treating biological materials with translating electrical fields and electrode polarity reversal
US20030199768A1 (en) 2002-04-19 2003-10-23 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030199767A1 (en) 2002-04-19 2003-10-23 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030199747A1 (en) 2002-04-19 2003-10-23 Michlitsch Kenneth J. Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030236443A1 (en) 2002-04-19 2003-12-25 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US20040147828A1 (en) 2002-04-22 2004-07-29 Gibson Charles A. Telescoping tip electrode catheter
DE10218427A1 (de) 2002-04-24 2003-11-06 Biotronik Mess & Therapieg Ablationsvorrichtung für Herzgewebe, insbesondere zur Erzeugung einer zirkulären Läsion um eine Gefäßmündung im Herzen
DE10218426A1 (de) 2002-04-24 2003-11-06 Biotronik Mess & Therapieg Ablationsvorrichtung für Herzgewebe, insbesondere zur Erzeugung linearer Läsionen zwischen zwei Gefäßmündungen im Herzen
US20030204161A1 (en) 2002-04-25 2003-10-30 Bozidar Ferek-Petric Implantable electroporation therapy device and method for using same
US6746474B2 (en) 2002-05-31 2004-06-08 Vahid Saadat Apparatus and methods for cooling a region within the body
US6748953B2 (en) 2002-06-11 2004-06-15 Scimed Life Systems, Inc. Method for thermal treatment of type II endoleaks in arterial aneurysms
JP2004016333A (ja) 2002-06-13 2004-01-22 Unique Medical Co Ltd 硬膜外麻酔用カテーテルおよび該硬膜外麻酔用カテーテルを用いる電気刺激装置
JP3813112B2 (ja) 2002-06-26 2006-08-23 テルモ株式会社 カテーテルおよび医療用チューブ
US6717384B2 (en) 2002-07-10 2004-04-06 Kentfa Electric Motorbike Corporation Frequency changer protection circuit for controlling the acceleration of an electric vehicle
US7115134B2 (en) 2002-07-22 2006-10-03 Chambers Technology, Llc. Catheter with flexible tip and shape retention
JP4602080B2 (ja) 2002-07-25 2010-12-22 ボストン サイエンティフィック リミテッド 人体構造内を進行する医療用具
US7914467B2 (en) 2002-07-25 2011-03-29 Boston Scientific Scimed, Inc. Tubular member having tapered transition for use in a medical device
US20040024392A1 (en) * 2002-08-05 2004-02-05 Lewis James D. Apparatus and method for cryosurgery
US7058456B2 (en) 2002-08-09 2006-06-06 Concentric Medical, Inc. Methods and devices for changing the shape of a medical device
US6893414B2 (en) 2002-08-12 2005-05-17 Breg, Inc. Integrated infusion and aspiration system and method
US20040193228A1 (en) 2003-03-31 2004-09-30 Gerber Martin T. Method, system and device for treating various disorders of the pelvic floor by electrical stimulation of the left and right pudendal nerves
US6780183B2 (en) 2002-09-16 2004-08-24 Biosense Webster, Inc. Ablation catheter having shape-changing balloon
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
JP2006508776A (ja) 2002-09-20 2006-03-16 フローメディカ，インコーポレイテッド 腎臓内カテーテルを介する選択的物質送達のための方法および装置
US7150741B2 (en) 2002-09-20 2006-12-19 Advanced Neuromodulation Systems, Inc. Programmable dose control module
JP2006513809A (ja) 2002-09-20 2006-04-27 フローメディカ，インコーポレイテッド 送達シースを通して大動脈内カテーテルを挿入するための装置および方法
WO2004107965A2 (en) 2002-09-20 2004-12-16 Flowmedica, Inc. Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens
US20050197624A1 (en) 2004-03-04 2005-09-08 Flowmedica, Inc. Sheath for use in peripheral interventions
EP1585572A4 (en) 2002-09-20 2010-02-24 Flowmedica Inc METHOD AND APPARATUS FOR ADMINISTERING INTRA-AORTIC SUBSTANCE TO A BRANCHED VESSEL
AU2003278858A1 (en) 2002-09-20 2004-04-08 Flowmedica, Inc. Method and apparatus for selective drug infusion via an intraaortic flow diverter delivery catheter
US7993325B2 (en) 2002-09-20 2011-08-09 Angio Dynamics, Inc. Renal infusion systems and methods
EP1542739B1 (en) 2002-09-26 2008-12-10 Angiotech International Ag Perivascular wraps
US7282213B2 (en) 2002-09-30 2007-10-16 Medtronic, Inc. Method for applying a drug coating to a medical device
EP1551505B1 (en) 2002-10-04 2010-02-24 Microchips, Inc. Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
AU2003284018A1 (en) 2002-10-04 2004-05-04 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
US20050033137A1 (en) 2002-10-25 2005-02-10 The Regents Of The University Of Michigan Ablation catheters and methods for their use
EP3097882A1 (en) 2002-10-31 2016-11-30 Boston Scientific Scimed, Inc. Improved electrophysiology loop catheter
US20030229380A1 (en) * 2002-10-31 2003-12-11 Adams John M. Heart failure therapy device and method
DE10252325B4 (de) 2002-11-11 2012-10-25 Admedes Schuessler Gmbh Sonde zur Hochfrequenz-Thermoablation sowie Verfahren zu deren Herstellung
DE10257146A1 (de) * 2002-12-06 2004-06-24 Admedes Schuessler Gmbh Metallelektrode
AU2002952663A0 (en) * 2002-11-14 2002-11-28 Western Sydney Area Health Service An intramural needle-tipped surgical device
US20040106954A1 (en) * 2002-11-15 2004-06-03 Whitehurst Todd K. Treatment of congestive heart failure
US7404824B1 (en) 2002-11-15 2008-07-29 Advanced Cardiovascular Systems, Inc. Valve aptation assist device
US20050004515A1 (en) 2002-11-15 2005-01-06 Hart Charles C. Steerable kink resistant sheath
US7317950B2 (en) * 2002-11-16 2008-01-08 The Regents Of The University Of California Cardiac stimulation system with delivery of conductive agent
ITBS20020107A1 (it) 2002-11-25 2004-05-26 Invatec Srl Tubo metallico con almeno una parte di lunghezza a flessibilita' variabile.
US8509916B2 (en) * 2002-12-16 2013-08-13 Medtronic, Inc. Bilumen guide catheters for accessing cardiac sites
US7890188B2 (en) 2002-12-19 2011-02-15 Cardiac Pacemakers, Inc. Implantable lead for septal placement of electrode with fixation mechanism in the pulmonary artery
US20040162590A1 (en) 2002-12-19 2004-08-19 Whitehurst Todd K. Fully implantable miniature neurostimulator for intercostal nerve stimulation as a therapy for angina pectoris
WO2004062470A2 (en) 2003-01-03 2004-07-29 Advanced Neuromodulation Systems, Inc. System and method for stimulation of a person’s brain stem
US6847848B2 (en) 2003-01-07 2005-01-25 Mmtc, Inc Inflatable balloon catheter structural designs and methods for treating diseased tissue of a patient
US6960207B2 (en) 2003-01-21 2005-11-01 St Jude Medical, Daig Division, Inc. Ablation catheter having a virtual electrode comprising portholes and a porous conductor
US7013169B2 (en) 2003-01-27 2006-03-14 Cardiac Pacemakers, Inc. Dual steer preshaped catheter
WO2006020920A2 (en) 2003-01-29 2006-02-23 Medtronic, Inc. Catheter apparatus for treatment of heart arrhythmia
US8066700B2 (en) 2003-01-31 2011-11-29 Smith & Nephew, Inc. Cartilage treatment probe
US7167750B2 (en) 2003-02-03 2007-01-23 Enteromedics, Inc. Obesity treatment with electrically induced vagal down regulation
WO2004073505A2 (en) 2003-02-20 2004-09-02 Prorhythm, Inc. Cardiac ablation devices
US6941953B2 (en) 2003-02-20 2005-09-13 Medwaves, Inc. Preformed catheter set for use with a linear ablation system to produce ablation lines in the left and right atrium for treatment of atrial fibrillation
US6923808B2 (en) 2003-02-24 2005-08-02 Boston Scientific Scimed, Inc. Probes having helical and loop shaped inflatable therapeutic elements
US7004911B1 (en) 2003-02-24 2006-02-28 Hosheng Tu Optical thermal mapping for detecting vulnerable plaque
WO2004075948A2 (en) 2003-02-24 2004-09-10 Plc Systems, Inc. A method and catheter system applicable to acute renal failure
US20040176699A1 (en) 2003-03-03 2004-09-09 Volcano Therapeutics, Inc. Thermography catheter with improved wall contact
WO2004078066A2 (en) 2003-03-03 2004-09-16 Sinus Rhythm Technologies, Inc. Primary examiner
US7250041B2 (en) 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US7186251B2 (en) 2003-03-27 2007-03-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US7938828B2 (en) 2003-03-28 2011-05-10 Boston Scientific Scimed, Inc. Cooled ablation catheter
WO2004086992A1 (en) 2003-03-28 2004-10-14 C.R. Bard, Inc. Junction of catheter tip and electrode
US7597704B2 (en) 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
US7517342B2 (en) 2003-04-29 2009-04-14 Boston Scientific Scimed, Inc. Polymer coated device for electrically medicated drug delivery
US7221979B2 (en) 2003-04-30 2007-05-22 Medtronic, Inc. Methods and apparatus for the regulation of hormone release
CA2777958C (en) 2003-05-06 2015-01-20 Enpath Medical, Inc. Rotatable lead introducer
DE10323566B4 (de) 2003-05-26 2006-03-23 Fehling Ag Instrument zur unipolaren Ablation von Herzgewebe
EP1635736A2 (en) 2003-06-05 2006-03-22 FlowMedica, Inc. Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens
US7149574B2 (en) 2003-06-09 2006-12-12 Palo Alto Investors Treatment of conditions through electrical modulation of the autonomic nervous system
US7738952B2 (en) 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
US20060167437A1 (en) 2003-06-17 2006-07-27 Flowmedica, Inc. Method and apparatus for intra aortic substance delivery to a branch vessel
US7789877B2 (en) 2003-07-02 2010-09-07 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter electrode arrangement
CA2533116C (en) 2003-07-18 2016-06-07 Eastern Virginia Medical School Apparatus for generating electrical pulses and methods of using the same
US7670335B2 (en) 2003-07-21 2010-03-02 Biosense Webster, Inc. Ablation device with spiral array ultrasound transducer
JP2007521233A (ja) 2003-08-05 2007-08-02 フロウメディカ， インコーポレイテッド 放射線造影剤誘発性腎症の予防のためのシステムおよび方法
US7742809B2 (en) 2003-08-25 2010-06-22 Medtronic, Inc. Electroporation catheter with sensing capabilities
US7766868B2 (en) 2003-09-05 2010-08-03 Medtronic, Inc. Deflectable medical therapy delivery device having common lumen profile
US7156843B2 (en) * 2003-09-08 2007-01-02 Medtronic, Inc. Irrigated focal ablation tip
DE202004021946U1 (de) 2003-09-12 2013-05-29 Vessix Vascular, Inc. Auswählbare exzentrische Remodellierung und/oder Ablation von atherosklerotischem Material
US7502650B2 (en) 2003-09-22 2009-03-10 Cvrx, Inc. Baroreceptor activation for epilepsy control
US7435248B2 (en) 2003-09-26 2008-10-14 Boston Scientific Scimed, Inc. Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel
US7998112B2 (en) 2003-09-30 2011-08-16 Abbott Cardiovascular Systems Inc. Deflectable catheter assembly and method of making same
US7591813B2 (en) 2003-10-01 2009-09-22 Micrus Endovascular Corporation Long nose manipulatable catheter
US20050153885A1 (en) 2003-10-08 2005-07-14 Yun Anthony J. Treatment of conditions through modulation of the autonomic nervous system
US7186209B2 (en) 2003-10-09 2007-03-06 Jacobson Jerry I Cardioelectromagnetic treatment
US7416549B2 (en) 2003-10-10 2008-08-26 Boston Scientific Scimed, Inc. Multi-zone bipolar ablation probe assembly
WO2005037070A2 (en) 2003-10-11 2005-04-28 The Regents Of The University Of California Method and system for nerve repair, nanoknife, mems platform and uses thereof
US7480532B2 (en) 2003-10-22 2009-01-20 Cvrx, Inc. Baroreflex activation for pain control, sedation and sleep
US7220374B2 (en) * 2003-10-22 2007-05-22 Cadillac Products Automotive Company Molded foam vehicle energy absorbing device and method of manufacture
US7254451B2 (en) 2003-11-20 2007-08-07 Medtronic, Inc. Implantable lead including sensor
EP2599458B1 (en) 2003-11-25 2018-08-08 Cathrx Ltd A modular catheter
US7783353B2 (en) 2003-12-24 2010-08-24 Cardiac Pacemakers, Inc. Automatic neural stimulation modulation based on activity and circadian rhythm
US8396560B2 (en) 2004-11-18 2013-03-12 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
US20080015659A1 (en) 2003-12-24 2008-01-17 Yi Zhang Neurostimulation systems and methods for cardiac conditions
PL1696812T3 (pl) 2003-12-24 2015-12-31 Univ California Ablacja tkanki nieodwracalną elektroporacją
JP4707678B2 (ja) 2004-01-26 2011-06-22 カソリック リミテッド 調整可能なループを備えたカテーテルアセンブリ
US7637903B2 (en) 2004-02-09 2009-12-29 Cryocor, Inc. Catheter articulation segment with alternating cuts
US7245955B2 (en) 2004-02-23 2007-07-17 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrophysiology/ablation catheter having deflection assembly
US7499747B2 (en) 2004-03-02 2009-03-03 Cvrx, Inc. External baroreflex activation
US7976539B2 (en) 2004-03-05 2011-07-12 Hansen Medical, Inc. System and method for denaturing and fixing collagenous tissue
US20050209548A1 (en) 2004-03-19 2005-09-22 Dev Sukhendu B Electroporation-mediated intravascular delivery
CN1976738B (zh) 2004-04-23 2010-09-01 诺沃库勒有限公司 使用不同频率的电场治疗肿瘤等
EP1750799A2 (en) 2004-05-04 2007-02-14 The Cleveland Clinic Foundation Methods of treating medical conditions by neuromodulation of the sympathetic nervous system
US7231260B2 (en) 2004-05-06 2007-06-12 Boston Scientific Scimed, Inc. Intravascular self-anchoring electrode body with arcuate springs, spring loops, or arms
JP2008516638A (ja) 2004-05-14 2008-05-22 カーディマ・インコーポレイテッド 補強部材を備えた除去プローブ
US7758564B2 (en) 2004-05-14 2010-07-20 Ethicon Endo-Surgery, Inc. Medical instrument having a catheter and a medical guidewire
EP1750506A4 (en) 2004-05-14 2010-03-17 Flowmedica Inc BILATERAL LOCAL RENAL DELIVERY FOR THE TREATMENT OF CONGESTIVE HEART FAILURE AND BNP THERAPY
US20050261672A1 (en) 2004-05-18 2005-11-24 Mark Deem Systems and methods for selective denervation of heart dysrhythmias
US7632265B2 (en) 2004-05-28 2009-12-15 St. Jude Medical, Atrial Fibrillation Division, Inc. Radio frequency ablation servo catheter and method
US7294119B2 (en) 2004-06-10 2007-11-13 Safety Syringes, Inc. Passive delivery system diluents mixing and delivery
US20050277868A1 (en) 2004-06-11 2005-12-15 University Of South Florida Electroporation Device and Method for Delivery to Ocular Tissue
US20060004346A1 (en) 2004-06-17 2006-01-05 Begg John D Bend relief
US20060067972A1 (en) 2004-06-23 2006-03-30 Flowmedica, Inc. Devices for renal-based heart failure treatment
CA2572290A1 (en) 2004-06-24 2006-02-02 Ksn Energies, Llc Electrical impedance tomography to characterize tissue
US20060004417A1 (en) 2004-06-30 2006-01-05 Cvrx, Inc. Baroreflex activation for arrhythmia treatment
WO2006012050A2 (en) 2004-06-30 2006-02-02 Cvrx, Inc. Connection structures for extra-vascular electrode lead body
US7850675B2 (en) 2004-07-20 2010-12-14 Boston Scientific Scimed, Inc. Reinforced venous access catheter
FR2873385B1 (fr) 2004-07-23 2006-10-27 Centre Nat Rech Scient Cnrse Surveillance et controle d'une electroporation
JP2008508024A (ja) 2004-07-28 2008-03-21 アーディアン インコーポレイテッド 腎神経ブロッキング方法及び装置
US7373204B2 (en) 2004-08-19 2008-05-13 Lifestim, Inc. Implantable device and method for treatment of hypertension
WO2006031541A1 (en) 2004-09-09 2006-03-23 Vnus Medical Technologies, Inc. Methods and apparatus for treatment of hollow anatomical structures
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
EP1804902A4 (en) 2004-09-10 2008-04-16 Cleveland Clinic Foundation INTRALUMINAL ELECTRODE ASSEMBLY
US7753906B2 (en) 2004-09-14 2010-07-13 Richard Esposito Catheter having anchoring and stabilizing devices
US7542808B1 (en) 2004-09-17 2009-06-02 Cardiac Pacemakers, Inc. Lead and catheter assembly
US20060069323A1 (en) 2004-09-24 2006-03-30 Flowmedica, Inc. Systems and methods for bi-lateral guidewire cannulation of branched body lumens
US20060074403A1 (en) 2004-09-29 2006-04-06 Nasser Rafiee Curved catheter comprising a solid-walled metal tube with varying stiffness
US20060074453A1 (en) 2004-10-04 2006-04-06 Cvrx, Inc. Baroreflex activation and cardiac resychronization for heart failure treatment
US9101386B2 (en) 2004-10-15 2015-08-11 Amendia, Inc. Devices and methods for treating tissue
EP1809272A4 (en) 2004-10-18 2008-01-02 Maroon Biotech Corp METHOD AND COMPOSITIONS FOR TREATING DAMAGES THROUGH FREE RADICALS
US7524318B2 (en) 2004-10-28 2009-04-28 Boston Scientific Scimed, Inc. Ablation probe with flared electrodes
US20070083239A1 (en) * 2005-09-23 2007-04-12 Denise Demarais Methods and apparatus for inducing, monitoring and controlling renal neuromodulation
US7937143B2 (en) * 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US8409191B2 (en) 2004-11-04 2013-04-02 Boston Scientific Scimed, Inc. Preshaped ablation catheter for ablating pulmonary vein ostia within the heart
WO2006052940A2 (en) 2004-11-05 2006-05-18 Asthmatx, Inc. Medical device with procedure improvement features
WO2006052905A2 (en) 2004-11-08 2006-05-18 Cardima, Inc. System and method for performing ablation and other medical procedures using an electrode array with flex circuit
CA2587619C (en) 2004-11-15 2017-02-28 Biosense Webster, Inc. Catheter with micro-fabricated temperature sensing
US8332047B2 (en) 2004-11-18 2012-12-11 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
US20060116720A1 (en) 2004-12-01 2006-06-01 Penny Knoblich Method and apparatus for improving renal function
US7937160B2 (en) 2004-12-10 2011-05-03 Boston Scientific Neuromodulation Corporation Methods for delivering cortical electrode leads into patient's head
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
US8983582B2 (en) 2004-12-20 2015-03-17 Advanced Cardiovascular Systems, Inc. Methods and apparatuses for positioning within an internal channel
WO2006069215A2 (en) 2004-12-21 2006-06-29 Ebr Systems, Inc. Leadless cardiac system for pacing and arrhythmia treatment
US20060135953A1 (en) 2004-12-22 2006-06-22 Wlodzimierz Kania Tissue ablation system including guidewire with sensing element
CN102488967B (zh) 2004-12-27 2016-03-30 诺沃库勒有限公司 利用电场从不同方向治疗肿瘤等
US9833618B2 (en) 2005-02-04 2017-12-05 Palo Alto Investors Methods and compositions for treating a disease condition in a subject
US7828837B2 (en) 2005-02-17 2010-11-09 Khoury Medical Devices, LLC. Vascular endograft
US20060182873A1 (en) 2005-02-17 2006-08-17 Klisch Leo M Medical devices
US7548780B2 (en) 2005-02-22 2009-06-16 Cardiac Pacemakers, Inc. Cell therapy and neural stimulation for cardiac repair
EP1853186A4 (en) 2005-03-02 2009-10-21 Cathrx Ltd CATHETER FOR THERMAL TREATMENT
ES2380487T3 (es) 2005-03-28 2012-05-14 Vessix Vascular, Inc. Caracterización de tejido eléctrico intraluminal y energía RF ajustada para el tratamiento selectivo de ateroma y de otros tejidos diana
US7727187B2 (en) 2005-04-04 2010-06-01 Cook Incorporated Scored catheter device
US7499748B2 (en) 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
EP1877123A4 (en) 2005-05-02 2010-06-09 Resqmedical Ltd SELF-RETAINING CATHETER FOR INJECTING BODY THROUGHOUT AND THIS KIT CONTAINING
US9320564B2 (en) 2005-05-05 2016-04-26 Boston Scientific Scimed Inc. Steerable catheter and method for performing medical procedure adjacent pulmonary vein ostia
US7806871B2 (en) 2005-05-09 2010-10-05 Boston Scientific Scimed, Inc. Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent
DE102005023303A1 (de) 2005-05-13 2006-11-16 Celon Ag Medical Instruments Biegeweiche Applikationsvorrichtung zur Hochfrequenztherapie von biologischem Gewebe
US7857810B2 (en) 2006-05-16 2010-12-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation electrode assembly and methods for improved control of temperature and minimization of coagulation and tissue damage
US7850685B2 (en) 2005-06-20 2010-12-14 Medtronic Ablation Frontiers Llc Ablation catheter
WO2007002304A2 (en) 2005-06-22 2007-01-04 Vnus Medical Technologies, Inc. Methods and apparatus for introducing tumescent fluid to body tissue
US7717853B2 (en) 2005-06-24 2010-05-18 Henry Nita Methods and apparatus for intracranial ultrasound delivery
EP3434232A1 (en) 2005-06-29 2019-01-30 ZOLL Circulation, Inc. Devices, systems and methods for rapid endovascular cooling
AU2006268238A1 (en) 2005-07-11 2007-01-18 Medtronic Ablation Frontiers Llc Low power tissue ablation system
US20070021803A1 (en) * 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
DE102005047073A1 (de) 2005-09-30 2007-04-05 BSH Bosch und Siemens Hausgeräte GmbH Staubsauger mit Fliehkraftabscheider
US8712522B1 (en) 2005-10-18 2014-04-29 Cvrx, Inc. System for setting programmable parameters for an implantable hypertension treatment device
KR100778142B1 (ko) 2005-11-09 2007-11-29 황창모 신체조직의 선택적 제거를 위한 방사주파수 전극체
US7647124B2 (en) 2005-11-15 2010-01-12 Medtronic, Inc. Delivery catheter
US7729782B2 (en) 2005-11-15 2010-06-01 Medtronic, Inc. Delivery catheter
US20080045890A1 (en) 2005-12-16 2008-02-21 Mercator Medsystems, Inc. Methods and systems for ablating tissue
US20070156200A1 (en) 2005-12-29 2007-07-05 Lilian Kornet System and method for regulating blood pressure and electrolyte balance
US7993334B2 (en) 2005-12-29 2011-08-09 Boston Scientific Scimed, Inc. Low-profile, expanding single needle ablation probe
US20070162109A1 (en) 2006-01-11 2007-07-12 Luis Davila Intraluminal stent graft
CN101374465B (zh) 2006-01-27 2013-06-12 麦德托尼克公司 消融装置与将消融装置引导至体内的系统
US7662151B2 (en) 2006-02-15 2010-02-16 Boston Scientific Scimed, Inc. Contact sensitive probes
US20070208256A1 (en) 2006-03-03 2007-09-06 Medtronic Vascular, Inc. Multiple Branch Tubular Prosthesis and Methods
US8571650B2 (en) 2006-03-03 2013-10-29 Palo Alto Investors Methods and compositions for treating a renal associated condition in a subject
US20070225781A1 (en) 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
US7747334B2 (en) 2006-03-23 2010-06-29 Cardiac Pacemakers, Inc. Left ventricular lead shapes
US7579550B2 (en) 2006-03-31 2009-08-25 Boston Scientific Scimed, Inc. Flexible device shaft with angled spiral wrap
US20080004673A1 (en) 2006-04-03 2008-01-03 Cvrx, Inc. Implantable extravascular electrostimulation system having a resilient cuff
US20070255270A1 (en) 2006-04-27 2007-11-01 Medtronic Vascular, Inc. Intraluminal guidance system using bioelectric impedance
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
CN101437567A (zh) 2006-05-08 2009-05-20 导管治疗有限公司 形状赋予机构插入物
US20080004596A1 (en) 2006-05-25 2008-01-03 Palo Alto Institute Delivery of agents by microneedle catheter
US7615067B2 (en) 2006-06-05 2009-11-10 Cambridge Endoscopic Devices, Inc. Surgical instrument
US20070282376A1 (en) 2006-06-06 2007-12-06 Shuros Allan C Method and apparatus for neural stimulation via the lymphatic system
US7647101B2 (en) 2006-06-09 2010-01-12 Cardiac Pacemakers, Inc. Physical conditioning system, device and method
CN105056408B (zh) 2006-06-28 2018-09-25 美敦力Af卢森堡公司 用于热诱导的肾神经调制的系统
WO2008013441A1 (en) 2006-07-26 2008-01-31 Johan Willem Pieter Marsman Facilitation of antegrade insertion of a guidewire into the superficial femoral artery
US7708704B2 (en) 2006-07-31 2010-05-04 Codman & Shurtleff, Pc Interventional medical device component having an interrupted spiral section and method of making the same
US20080039904A1 (en) 2006-08-08 2008-02-14 Cherik Bulkes Intravascular implant system
US7674253B2 (en) 2006-08-18 2010-03-09 Kensey Nash Corporation Catheter for conducting a procedure within a lumen, duct or organ of a living being
US20080051704A1 (en) 2006-08-28 2008-02-28 Patel Rajnikant V Catheter and system for using same
US20080064957A1 (en) 2006-09-07 2008-03-13 Spence Paul A Ultrasonic implant, systems and methods related to diverting material in blood flow away from the head
US20080091255A1 (en) 2006-10-11 2008-04-17 Cardiac Pacemakers Implantable neurostimulator for modulating cardiovascular function
JP5312337B2 (ja) 2006-10-18 2013-10-09 べシックス・バスキュラー・インコーポレイテッド 標的組織の選択的な処置のための調節されたｒｆエネルギーおよび電気的な組織の特徴付け
US8317773B2 (en) 2006-11-07 2012-11-27 Angio Dynamics, Inc. Catheter with open faced sloped end portion
US8915926B2 (en) 2006-11-08 2014-12-23 Advanced Bionics Ag Pre-curved electrode array loading tools
CA2670149A1 (en) 2006-11-28 2008-06-05 Cathrx Ltd Catheter steering/insertion mechanism
US7955326B2 (en) 2006-12-29 2011-06-07 St. Jude Medical, Atrial Fibrillation Division, Inc. Pressure-sensitive conductive composite electrode and method for ablation
US20080183187A1 (en) 2007-01-30 2008-07-31 Cardiac Pacemakers, Inc. Direct delivery system for transvascular lead
WO2008101244A2 (en) 2007-02-18 2008-08-21 Via Biomedical, Inc. Guiding catheter support devices and methods
WO2008112870A2 (en) 2007-03-13 2008-09-18 University Of Virginia Patent Foundation Epicardial ablation catheter and method of use
US8187267B2 (en) 2007-05-23 2012-05-29 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter with flexible tip and methods of making the same
DE102007018277A1 (de) 2007-04-18 2008-10-30 Medical Service Gmbh Katheter-Set
US8103359B2 (en) 2007-05-17 2012-01-24 Cardiac Pacemakers, Inc. Systems and methods for fixating transvenously implanted medical devices
US8630704B2 (en) 2007-06-25 2014-01-14 Cardiac Pacemakers, Inc. Neural stimulation with respiratory rhythm management
US8864675B2 (en) 2007-06-28 2014-10-21 W. L. Gore & Associates, Inc. Catheter
US7863897B2 (en) 2007-09-07 2011-01-04 The General Hospital Corporation Method and apparatus for characterizing the temporal resolution of an imaging device
WO2009054802A1 (en) 2007-10-26 2009-04-30 Radi Medical Systems Ab Sensor guide wire with micro-cable winding
WO2009086007A1 (en) 2007-12-21 2009-07-09 St. Jude Medical, Atrial Fibrillation Division, Inc. Longitudinally incompressible, laterally flexible interior shaft for catheter
US8118809B2 (en) 2007-12-21 2012-02-21 St. Jude Medical, Atrial Fibrillation Division, Inc. Flexible conductive polymer electrode and method for ablation
US7949398B1 (en) 2007-12-27 2011-05-24 Pacesetter, Inc. Acquiring nerve activity from carotid body and/or sinus
US7848816B1 (en) 2007-12-27 2010-12-07 Pacesetter, Inc. Acquiring nerve activity from carotid body and/or sinus
US9204927B2 (en) 2009-05-13 2015-12-08 St. Jude Medical, Atrial Fibrillation Division, Inc. System and method for presenting information representative of lesion formation in tissue during an ablation procedure
US7985215B2 (en) 2007-12-28 2011-07-26 St. Jude Medical, Atrial Fibrillation Division, Inc. Deflectable catheter with distal deflectable segment
US20120239004A1 (en) 2008-03-03 2012-09-20 Mk International Pty Ltd Catheter with friction reducing surface shaping
US20090247933A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California; Angiodynamics, Inc. Balloon catheter method for reducing restenosis via irreversible electroporation
EP2106821B1 (en) 2008-03-31 2019-04-17 Dentsply IH AB Catheter assembly comprising a tubular member having pleated regions, and methods of activating and manufacturing the same
JP4362536B2 (ja) 2008-04-11 2009-11-11 日本ライフライン株式会社 カテーテル
DE102008019827A1 (de) 2008-04-19 2009-10-29 Biotronik Crm Patent Ag Steuerbare Elektrode zur tiefen Hirnstimulation
JP2011519699A (ja) 2008-05-09 2011-07-14 インノブアトイブエ プルモナルイ ソルウトイオンス，インコーポレイティッド 気管支樹の治療のためのシステム、アセンブリ、及び方法
WO2009140067A1 (en) 2008-05-15 2009-11-19 Boston Scientific Scimed, Inc. Apparatus for cryogenically ablating tissue and adjusting cryogenic ablation regions
US8437832B2 (en) 2008-06-06 2013-05-07 Biosense Webster, Inc. Catheter with bendable tip
US20090306651A1 (en) 2008-06-09 2009-12-10 Clint Schneider Catheter assembly with front-loaded tip
JP2010021134A (ja) 2008-06-11 2010-01-28 Sumitomo Chemical Co Ltd リチウム複合金属酸化物の製造方法
US9138559B2 (en) 2008-06-16 2015-09-22 Twin Star Medical, Inc Flexible catheter
US8100859B2 (en) 2008-06-24 2012-01-24 Cook Medical Technologies Llc Bent obturator
US20100004632A1 (en) 2008-07-03 2010-01-07 Kirk Kochin Wu Magnetic guided ablation catheter
US20100022989A1 (en) 2008-07-25 2010-01-28 Parasmo Ronald S Steerable catheter and method of making the same
US8123739B2 (en) 2008-08-19 2012-02-28 Cook Medical Technologies Llc Drainage catheter and method for catheterizing a patient
US8172831B2 (en) 2008-09-02 2012-05-08 Abbott Cardiovascular Systems Inc. Catheter configured for incremental rotation
US20100069882A1 (en) 2008-09-18 2010-03-18 Boston Scientific Scimed, Inc. Medical device with preferential bending
US20100099952A1 (en) 2008-10-22 2010-04-22 Boston Scientific Scimed, Inc. Steerable Shaft Having Micromachined Tube
WO2010048676A1 (en) 2008-10-31 2010-05-06 Cathrx Ltd A catheter assembly
AU2009314159B2 (en) 2008-11-11 2016-04-14 Shifamed Holdings, Llc Low profile electrode assembly
US11376061B2 (en) 2008-11-11 2022-07-05 Covidien Lp Energy delivery device and methods of use
US20150105659A1 (en) 2008-11-11 2015-04-16 Covidien Lp Energy delivery device and methods of use
US8317810B2 (en) 2008-12-29 2012-11-27 St. Jude Medical, Atrial Fibrillation Division, Inc. Tissue puncture assemblies and methods for puncturing tissue
US8808345B2 (en) * 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
US8123721B2 (en) 2008-12-31 2012-02-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Catheter having independently-deflectable segments and method of its manufacture
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US20100168739A1 (en) 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US20110276034A1 (en) 2009-01-15 2011-11-10 Cathrx Ltd Steerable stylet
JP2012517306A (ja) 2009-02-12 2012-08-02 イューエムセー ユトレヒト ホールディング ベースローテン フェンノートシャップ アブレーションカテーテル及び心臓組織を電気的に絶縁するための方法
US8725228B2 (en) 2009-02-20 2014-05-13 Boston Scientific Scimed, Inc. Steerable catheter having intermediate stiffness transition zone
WO2010096347A1 (en) 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Asymmetric dual directional steerable catheter sheath
CN201356648Y (zh) 2009-03-04 2009-12-09 微创医疗器械(上海)有限公司 盐水灌注射频消融导管
US8929969B2 (en) 2009-04-14 2015-01-06 Medtronic Ablation Frontiers Llc Catheter assembly and associated method
CN102573466A (zh) 2009-04-22 2012-07-11 墨卡托医疗系统公司 局部血管递送胍乙啶在治疗高血压中的用途
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US20120035615A1 (en) 2009-05-22 2012-02-09 Advanced Bionics, Llc Composite Stylet
US8282633B2 (en) 2009-06-15 2012-10-09 Olympus Medical Systems Corp. High-frequency surgical apparatus and high-frequency surgical method for closure of patent foramen ovale
AU2010266027B2 (en) 2009-06-24 2015-05-07 Shifamed Holdings, Llc Steerable medical delivery devices and methods of use
WO2011015218A1 (en) 2009-08-06 2011-02-10 Ls Medcap Gmbh Catheter with two fenestrations
US8435228B2 (en) 2009-08-12 2013-05-07 Medrad, Inc. Interventional catheter assemblies incorporating guide wire brake and management systems
US8380275B2 (en) 2009-08-14 2013-02-19 Boston Scientific Scimed, Inc. Systems and methods for making and using medical ablation systems and having mapping catheters with improved anchoring ability
CN201469401U (zh) 2009-08-21 2010-05-19 刘小青 螺旋状环肾动脉肾交感神经射频消融电极导管
US9439721B2 (en) 2009-08-25 2016-09-13 Medtronic Ablation Frontiers Llc Bi-modal linear and loop ablation catheter, and method
US8568401B2 (en) 2009-10-27 2013-10-29 Covidien Lp System for monitoring ablation size
WO2011055143A2 (en) 2009-11-04 2011-05-12 Emcision Limited Lumenal remodelling device and methods
US20110112400A1 (en) 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
EP2842510B1 (en) 2009-11-11 2022-08-24 Nuvaira, Inc. Device for treating tissue and controlling stenosis
EP2332607A1 (en) 2009-12-14 2011-06-15 The Royal College of Surgeons in Ireland A urethral catheter
US8920415B2 (en) 2009-12-16 2014-12-30 Biosense Webster (Israel) Ltd. Catheter with helical electrode
US8608735B2 (en) 2009-12-30 2013-12-17 Biosense Webster (Israel) Ltd. Catheter with arcuate end section
US20110263921A1 (en) 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
US20110200171A1 (en) 2010-01-19 2011-08-18 Ardian, Inc. Methods and apparatus for renal neuromodulation via stereotactic radiotherapy
EP2528649A1 (en) 2010-01-26 2012-12-05 Michael A. Evans Methods, devices, and agents for denervation
WO2013169741A1 (en) 2012-05-08 2013-11-14 Stein Emily A Agents and devices for affecting nerve function
US8571665B2 (en) 2010-03-23 2013-10-29 Boston Scientific Neuromodulation Corporation Helical radial spacing of contacts on a cylindrical lead
US8840601B2 (en) 2010-03-24 2014-09-23 Shifamed Holdings, Llc Intravascular tissue disruption
JP2013523282A (ja) 2010-03-31 2013-06-17 ボストン サイエンティフィック サイムド，インコーポレイテッド 曲げ剛性プロファイルを有するガイドワイヤ
CA2795933A1 (en) 2010-04-14 2011-10-20 Boston Scientific Scimed, Inc. Renal artery denervation apparatus employing helical shaping arrangement
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
EP2563255B1 (en) 2010-04-26 2017-03-22 Medtronic Ardian Luxembourg S.à.r.l. Catheter apparatuses and systems for renal neuromodulation
US10631912B2 (en) 2010-04-30 2020-04-28 Medtronic Xomed, Inc. Interface module for use with nerve monitoring and electrosurgery
US20120123400A1 (en) 2010-05-10 2012-05-17 David Francischelli Methods and devices for controlling energy during ablation
JP5886274B2 (ja) 2010-05-11 2016-03-16 キャスアールエックス リミテッドＣａｔｈｒｘ Ｌｔｄ カテーテル形状解放機構
US20130109987A1 (en) 2011-05-12 2013-05-02 Medical Device Innovations Inc. Method and device for treatment of arrhythmias and other maladies
CA2797130A1 (en) 2010-05-12 2011-11-17 Shifamed Holdings, Llc Low profile electrode assembly
CN102266245B (zh) 2010-06-04 2015-08-26 心诺普医疗技术（北京）有限公司 灌注式射频消融导管
US8753352B2 (en) 2010-06-25 2014-06-17 Advanced Bionics Ag Tools, systems, and methods for inserting a pre-curved electrode array portion of a lead into a bodily orifice
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US20120029505A1 (en) 2010-07-30 2012-02-02 Jenson Mark L Self-Leveling Electrode Sets for Renal Nerve Ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US20120029512A1 (en) 2010-07-30 2012-02-02 Willard Martin R Balloon with surface electrodes and integral cooling for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US20120065506A1 (en) 2010-09-10 2012-03-15 Scott Smith Mechanical, Electromechanical, and/or Elastographic Assessment for Renal Nerve Ablation
US9084610B2 (en) 2010-10-21 2015-07-21 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
JP2013544131A (ja) 2010-10-25 2013-12-12 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ 腎ニューロモジュレーションのためのマルチ電極アレイを有するカテーテル装置ならびに関連のシステムおよび方法
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
AU2011329669B2 (en) 2010-11-19 2016-07-28 Boston Scientific Scimed, Inc. Renal nerve detection and ablation apparatus and method
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
EP2645955B1 (en) 2010-12-01 2016-10-26 Boston Scientific Scimed, Inc. Expandable angular vascular electrode for renal nerve ablation
US20120157992A1 (en) 2010-12-15 2012-06-21 Scott Smith Off-wall electrode device for renal nerve ablation
US10016233B2 (en) 2010-12-06 2018-07-10 Biosense Webster (Israel) Ltd. Treatment of atrial fibrillation using high-frequency pacing and ablation of renal nerves
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
EP2656807A4 (en) 2010-12-21 2016-08-31 Terumo Corp BALLOON CATHETER AND POWER SUPPLY SYSTEM FOR IT
US20120184952A1 (en) 2011-01-19 2012-07-19 Jenson Mark L Low-profile off-wall electrode device for renal nerve ablation
WO2012100211A2 (en) 2011-01-20 2012-07-26 Hansen Medical, Inc. System and method for endoluminal and transluminal therapy
EP2667812A1 (en) 2011-01-28 2013-12-04 Medtronic Ardian Luxembourg S.à.r.l. Ablation catheter equipped with a shape memory material
JP2014505737A (ja) 2011-02-18 2014-03-06 メディベイション テクノロジーズ， インコーポレイテッド 糖尿病を処置する化合物および方法
WO2012134911A1 (en) 2011-03-25 2012-10-04 Medtronic Ablation Frontiers Llc Cooling systems for electrode arrays
WO2012130337A1 (en) 2011-04-01 2012-10-04 Flux Medical N.V. System, device and method for ablation of a vessel's wall from the inside
CN103841913B (zh) 2011-04-08 2016-02-24 柯惠有限合伙公司 用于天然或人造管腔的柔性微波导管
CN103517731B (zh) 2011-04-08 2016-08-31 柯惠有限合伙公司 用于去除肾交感神经和离子电渗式药物传递的离子电渗式药物传递系统和方法
US9237925B2 (en) 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
WO2012149167A2 (en) 2011-04-26 2012-11-01 Christopher Gerard Kunis Method and device for treatment of hypertension and other maladies
CN102274075A (zh) 2011-05-03 2011-12-14 上海微创电生理医疗科技有限公司 用于热致肾神经调节的多极点状电极导管
CN102198015B (zh) 2011-05-03 2013-11-06 上海微创电生理医疗科技有限公司 可伸缩螺旋叠环式电极导管
US20120323233A1 (en) 2011-05-09 2012-12-20 Cyberheart, Inc. Renovascular treatment device, system, and method for radiosurgically alleviating hypertension
US20120290053A1 (en) 2011-05-11 2012-11-15 St. Jude Medical, Inc. Renal nerve stimulation lead, delivery system, and method
US8909316B2 (en) 2011-05-18 2014-12-09 St. Jude Medical, Cardiology Division, Inc. Apparatus and method of assessing transvascular denervation
WO2012158864A1 (en) 2011-05-18 2012-11-22 St. Jude Medical, Inc. Apparatus and method of assessing transvascular denervation
US20120296232A1 (en) 2011-05-18 2012-11-22 St. Jude Medical, Inc. Method and apparatus of assessing transvascular denervation
WO2013009977A1 (en) 2011-07-12 2013-01-17 David Lambert Device for reducing renal sympathetic nerve activity
WO2013013156A2 (en) 2011-07-20 2013-01-24 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
WO2013016203A1 (en) 2011-07-22 2013-01-31 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
US20130035681A1 (en) 2011-08-04 2013-02-07 Boston Scientific Scimed, Inc. Novel catheter for contiguous rf ablation
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
EP2747690B1 (en) 2011-08-24 2019-01-23 Boston Scientific Scimed, Inc. Device and methods for nerve modulation
US9056185B2 (en) 2011-08-24 2015-06-16 Ablative Solutions, Inc. Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
US20130274674A1 (en) 2011-08-24 2013-10-17 Ablative Solutions, Inc. Intravascular ablation catheter with precision depth of penetration calibration
US9278196B2 (en) 2011-08-24 2016-03-08 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
ES2972941T3 (es) 2011-08-26 2024-06-17 Symap Medical Suzhou Ltd Sistema para localizar e identificar nervios funcionales que inervan la pared de las arterias
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
CN103271766B (zh) 2012-08-24 2015-08-26 苏州信迈医疗器械有限公司 一种用于标测和消融位于肾动脉上所分布的肾神经的装置
EP2750764A4 (en) 2011-09-01 2015-08-12 Perseus Biomed Inc METHOD AND SYSTEM FOR MODULATING TISSUE
EP2755587B1 (en) 2011-09-14 2018-11-21 Boston Scientific Scimed, Inc. Ablation device with multiple ablation modes
US9427579B2 (en) 2011-09-29 2016-08-30 Pacesetter, Inc. System and method for performing renal denervation verification
KR20150143881A (ko) 2011-09-30 2015-12-23 코비디엔 엘피 에너지 전달 장치 및 그 이용 방법
US8498686B2 (en) 2011-10-04 2013-07-30 Biosense Webster (Israel), Ltd. Mapping catheter with spiral electrode assembly
US20130090637A1 (en) 2011-10-05 2013-04-11 St. Jude Medical, Inc. Catheter device and method for denervation
US20130090647A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Ablation catheter with insulated tip
US20130090649A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
WO2013059735A1 (en) 2011-10-19 2013-04-25 Mercator Medsystems, Inc. Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation
CN102551874B (zh) 2011-10-20 2015-07-22 上海微创电生理医疗科技有限公司 肾动脉射频消融导管
US20150202220A1 (en) 2011-10-26 2015-07-23 Northwind Medical, Inc. Agents, methods, and devices for affecting nerve function
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
JP5729660B2 (ja) 2011-11-21 2015-06-03 株式会社ディナーヴ 腎動脈アブレーション用のカテーテルおよびシステム
CN202386778U (zh) 2011-11-29 2012-08-22 北京天助畅运医疗技术股份有限公司 射频消融装置
CA2856732A1 (en) 2011-12-09 2013-06-13 Metavention, Inc. Therapeutic neuromodulation of the hepatic system
CN102488552B (zh) 2011-12-15 2015-04-15 四川锦江电子科技有限公司 可操控螺旋形电生理导管
US9844405B2 (en) 2011-12-20 2017-12-19 Cardiac Pacemakers, Inc. Method and apparatus for monitoring and ablating nerves
CN202426649U (zh) 2011-12-22 2012-09-12 王涛 环形多点射频消融电极
US9433760B2 (en) 2011-12-28 2016-09-06 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US20130172880A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods for renal nerve modulation
US20130172879A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation medical devices
WO2013101485A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US8571654B2 (en) 2012-01-17 2013-10-29 Cyberonics, Inc. Vagus nerve neurostimulator with multiple patient-selectable modes for treating chronic cardiac dysfunction
CN104159535A (zh) 2012-01-17 2014-11-19 波士顿科学西美德公司 肾神经调节装置以及用于制造和使用该装置的方法
CA3239581A1 (en) 2012-01-26 2013-08-01 Autonomix Medical, Inc. Controlled sympathectomy and micro-ablation systems and methods
CN202538132U (zh) 2012-02-06 2012-11-21 北京中孵友信医药科技股份有限公司 蛇形腔内导管
US20130218029A1 (en) 2012-02-16 2013-08-22 Pacesetter, Inc. System and method for assessing renal artery nerve density
CN104271062B (zh) 2012-03-08 2017-07-07 美敦力Af卢森堡有限责任公司 采用神经调节装置的生物标志物取样和相关系统及方法
US20130253628A1 (en) 2012-03-22 2013-09-26 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
CN202537649U (zh) 2012-04-10 2012-11-21 北京中孵友信医药科技股份有限公司 全域定位腔内导管
US20130274730A1 (en) 2012-04-12 2013-10-17 Boston Scientific Scimed, Inc. Ablation catheter and methods for nerve modulation
US9439598B2 (en) 2012-04-12 2016-09-13 NeuroMedic, Inc. Mapping and ablation of nerves within arteries and tissues
EP3135237B1 (en) 2012-04-13 2019-07-24 Covidien LP Energy delivery device
CN102631240A (zh) 2012-04-13 2012-08-15 上海微创电生理医疗科技有限公司 冷盐水灌注型射频消融导管
US20130274737A1 (en) 2012-04-16 2013-10-17 Boston Scientific Scimed, Inc. Renal nerve modulation catheter design
WO2013158678A1 (en) 2012-04-16 2013-10-24 Boston Scientific Scimed, Inc. Helical tubing devices for fluid renal nerve modulation
US9113929B2 (en) 2012-04-19 2015-08-25 St. Jude Medical, Cardiology Division, Inc. Non-electric field renal denervation electrode
WO2013165920A1 (en) 2012-04-29 2013-11-07 Synecor Llc Intravascular electrode arrays for neuromodulation
WO2013169927A1 (en) 2012-05-08 2013-11-14 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US9717555B2 (en) 2012-05-14 2017-08-01 Biosense Webster (Israel), Ltd. Catheter with helical end section for vessel ablation
US9439722B2 (en) 2012-05-09 2016-09-13 Biosense Webster (Israel) Ltd. Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
US20150151077A1 (en) 2012-06-13 2015-06-04 Douglas C. Harrington Devices And Methods For Renal Denervation
CN102772249B (zh) 2012-06-19 2015-01-21 深圳市惠泰医疗器械有限公司 肾动脉轨道射频消融电极导管
CN102688093B (zh) 2012-06-20 2014-08-27 深圳市惠泰医疗器械有限公司 肾动脉冷盐水射频消融可控电极导管
US9295842B2 (en) 2012-07-05 2016-03-29 Mc10, Inc. Catheter or guidewire device including flow sensing and use thereof
JP2015521894A (ja) 2012-07-05 2015-08-03 エムシー１０ インコーポレイテッドＭｃ１０，Ｉｎｃ． 流量センシングを含むカテーテルデバイス
CN102743225B (zh) 2012-07-18 2014-04-02 深圳市惠泰医疗器械有限公司 肾动脉射频消融可控电极导管
US20150315188A1 (en) 2012-08-22 2015-11-05 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
US10321946B2 (en) 2012-08-24 2019-06-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices with weeping RF ablation balloons
WO2014036160A2 (en) 2012-08-28 2014-03-06 Boston Scientific Scimed, Inc. Renal nerve modulation and ablation catheter electrode design
EP3123973A1 (en) 2012-08-28 2017-02-01 Boston Scientific Scimed, Inc. Renal rf ablation system with a movable virtual electrode and related methods of use
CN202761434U (zh) 2012-08-29 2013-03-06 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经多功能消融导管系统
CN102908189B (zh) 2012-08-29 2015-04-08 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经多功能消融导管系统
CN102908188B (zh) 2012-08-29 2015-04-08 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经射频消融导管系统
CN202843784U (zh) 2012-08-29 2013-04-03 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经消融导管系统
CN102885648B (zh) 2012-08-29 2015-03-18 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经消融导管系统
CN102885649B (zh) 2012-08-29 2015-01-21 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经射频线控消融导管系统
WO2014056460A1 (zh) 2012-08-29 2014-04-17 第三军医大学第一附属医院 肾脏去交感神经多功能消融导管系统
TWI498101B (zh) 2012-08-30 2015-09-01 Univ Nat Chiao Tung 神經纖維分佈之分析方法及標準化誘發復合動作電位之量測方法
JP2014054430A (ja) 2012-09-13 2014-03-27 Nippon Koden Corp カテーテル
CN104869930B (zh) 2012-10-10 2020-12-25 波士顿科学国际有限公司 肾神经调制装置和方法
US9770593B2 (en) 2012-11-05 2017-09-26 Pythagoras Medical Ltd. Patient selection using a transluminally-applied electric current
US10004557B2 (en) 2012-11-05 2018-06-26 Pythagoras Medical Ltd. Controlled tissue ablation
US20140316496A1 (en) 2012-11-21 2014-10-23 NeuroTronik IP Holding (Jersey) Limited Intravascular Electrode Arrays for Neuromodulation
US20140163360A1 (en) 2012-12-07 2014-06-12 Boston Scientific Scimed, Inc. Irrigated catheter
EP2928404A1 (en) 2012-12-10 2015-10-14 Koninklijke Philips N.V. Digital ruler and reticule for renal denervation.
WO2014091401A2 (en) 2012-12-10 2014-06-19 Perseus-Biomed Inc. Dynamic denervation procedures and systems for the implementation thereof
US10195467B2 (en) 2013-02-21 2019-02-05 Boston Scientific Scimed, Inc. Ablation catheter system with wireless radio frequency temperature sensor
US10028764B2 (en) 2013-02-21 2018-07-24 Boston Scientific Scimed, Inc. Ablation catheter with wireless temperature sensor
US20140249524A1 (en) 2013-03-01 2014-09-04 Boston Scientific Scimed, Inc. System and method for performing renal nerve modulation
US20140246465A1 (en) 2013-03-03 2014-09-04 Joan Darnell Peterson Fish n stow
US20140303617A1 (en) 2013-03-05 2014-10-09 Neuro Ablation, Inc. Intravascular nerve ablation devices & methods
US9956033B2 (en) 2013-03-11 2018-05-01 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
WO2014143571A1 (en) 2013-03-11 2014-09-18 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
AU2014249776B2 (en) 2013-03-12 2017-04-20 Boston Scientific Scimed, Inc. Medical systems and methods for modulating nerves
US9510902B2 (en) 2013-03-13 2016-12-06 St. Jude Medical, Cardiology Division, Inc. Ablation catheters and systems including rotational monitoring means
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US8876813B2 (en) 2013-03-14 2014-11-04 St. Jude Medical, Inc. Methods, systems, and apparatus for neural signal detection
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations
US9333113B2 (en) 2013-03-15 2016-05-10 Abbott Cardiovascular Systems Inc. System and method for denervation
US9186212B2 (en) 2013-03-15 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods utilizing two or more sites along denervation catheter
US9974477B2 (en) 2013-03-15 2018-05-22 St. Jude Medical, Cardiology Division, Inc. Quantification of renal denervation via alterations in renal blood flow pre/post ablation
US9713490B2 (en) 2013-03-15 2017-07-25 St. Jude Medical, Cardiology Division, Inc. Ablation system, methods, and controllers
WO2014150553A1 (en) 2013-03-15 2014-09-25 Boston Scientific Scimed, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
US9179973B2 (en) 2013-03-15 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods for renal denervation utilizing balloon catheter
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
WO2014150425A1 (en) 2013-03-15 2014-09-25 St. Jude Medical, Cardiology Division, Inc. Multi-electrode ablation system with a controller for determining a thermal gain of each electrode
AU2014237950B2 (en) 2013-03-15 2017-04-13 Boston Scientific Scimed, Inc. Control unit for use with electrode pads and a method for estimating an electrical leakage
WO2014162660A1 (ja) 2013-04-01 2014-10-09 テルモ株式会社 モニタリングデバイス及びモニタリングデバイスキット
CN105392519A (zh) 2013-05-02 2016-03-09 道格拉斯·C·哈灵顿 用于检测和治疗主动脉肾神经节的设备以及方法
WO2014176785A1 (zh) 2013-05-03 2014-11-06 上海安通医疗科技有限公司 一种用于调节神经的装置
US20140336637A1 (en) 2013-05-08 2014-11-13 Boston Scientific Scimed, Inc. Systems and methods for temperature monitoring and control during an ablation procedure
CA2913346A1 (en) 2013-06-05 2014-12-11 Metavention, Inc. Modulation of targeted nerve fibers
WO2015002787A1 (en) 2013-07-01 2015-01-08 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US20150025524A1 (en) 2013-07-18 2015-01-22 St. Jude Medical, Cardiology Division, Inc. Renal denervation monitoring and feedback apparatus, system and method
WO2015010074A1 (en) 2013-07-19 2015-01-22 Boston Scientific Scimed, Inc. Spiral bipolar electrode renal denervation balloon
US9913684B2 (en) 2013-08-23 2018-03-13 Oscor Inc. Steerable ablation catheter for renal denervation
US20150126992A1 (en) 2013-11-05 2015-05-07 Mogul Enterprises, Inc Helical DeNervation Ablation Catheter Apparatus
JP2015119831A (ja) 2013-12-24 2015-07-02 テルモ株式会社 アブレーションカテーテル
WO2015120340A1 (en) 2014-02-07 2015-08-13 Verve Medical, Inc. Methods and systems for ablation of the renal pelvis
US20150223877A1 (en) 2014-02-12 2015-08-13 Perseus-Biomed Inc. Methods and systems for treating nerve structures
WO2015170281A1 (en) 2014-05-07 2015-11-12 Rainbow Medical Ltd Controlled tissue ablation techniques
CN105167840A (zh) 2014-06-20 2015-12-23 上海安通医疗科技有限公司 一种多电极肾动脉射频消融导管
CN105326562A (zh) 2014-06-24 2016-02-17 上海安通医疗科技有限公司 一种用于调节肾神经的导管装置
JP2016086999A (ja) 2014-10-31 2016-05-23 テルモ株式会社 アブレーションカテーテル
WO2016094938A1 (en) 2014-12-17 2016-06-23 Cathrx Ltd An improved catheter and method of manufacture thereof
US9737361B2 (en) 2014-12-18 2017-08-22 Abbott Cardiovascular Systems Inc. System and method for a catheter
US9795780B2 (en) 2014-12-18 2017-10-24 Abbott Cardiovascular Systems Inc. System for denervation
CN205433879U (zh) 2015-12-08 2016-08-10 上海安通医疗科技有限公司 一种肾动脉射频消融导管
CN205433878U (zh) 2015-12-08 2016-08-10 上海安通医疗科技有限公司 一种肾动脉射频消融导管

Also Published As

Publication number Publication date
EP2329859A1 (en) 2011-06-08
ES2570927T3 (es) 2016-05-23
EP2457615B1 (en) 2014-12-17
DE602005025789D1 (de) 2011-02-17
US7653438B2 (en) 2010-01-26
US20210298826A1 (en) 2021-09-30
EP2495012A1 (en) 2012-09-05
EP2457614B1 (en) 2017-04-12
US20100222851A1 (en) 2010-09-02
EP2570154A3 (en) 2013-04-03
DE202005022096U1 (de) 2013-07-18
DE202005022057U1 (de) 2012-11-13
DE202005022060U1 (de) 2012-11-28
EP2561904A1 (en) 2013-02-27
EP2457614A1 (en) 2012-05-30
JP2008515544A (ja) 2008-05-15
CN101084038A (zh) 2007-12-05
ES2538708T3 (es) 2015-06-23
EP2561903A1 (en) 2013-02-27
US8852163B2 (en) 2014-10-07
EP2561903B1 (en) 2018-05-23
DE202005022061U1 (de) 2012-11-28
CN101940816A (zh) 2011-01-12
EP2572753B1 (en) 2015-01-28
US20180229033A1 (en) 2018-08-16
JP2012135630A (ja) 2012-07-19
US9289255B2 (en) 2016-03-22
US8548600B2 (en) 2013-10-01
ATE494039T1 (de) 2011-01-15
ES2743974T3 (es) 2020-02-21
EP2561905A1 (en) 2013-02-27
DE202005022083U1 (de) 2013-03-26
EP2561905B1 (en) 2014-06-04
EP3056242B1 (en) 2018-07-04
WO2006041881A3 (en) 2007-03-29
ES2531888T3 (es) 2015-03-20
US20130012866A1 (en) 2013-01-10
EP2457615A1 (en) 2012-05-30
CN101972513B (zh) 2017-06-23
JP2012110748A (ja) 2012-06-14
CA2583463C (en) 2013-04-30
US20150238252A1 (en) 2015-08-27
EP3446747A1 (en) 2019-02-27
US20140081259A1 (en) 2014-03-20
EP3108930A1 (en) 2016-12-28
US20070265687A1 (en) 2007-11-15
EP2570154B1 (en) 2015-03-04
US11963714B2 (en) 2024-04-23
EP2868344A1 (en) 2015-05-06
EP2572753A2 (en) 2013-03-27
EP3132825B1 (en) 2019-05-15
US20140018723A1 (en) 2014-01-16
US10245429B2 (en) 2019-04-02
EP1802370B1 (en) 2011-01-05
ES2691040T3 (es) 2018-11-23
CN101084038B (zh) 2010-11-17
EP1802370A2 (en) 2007-07-04
EP3159037A1 (en) 2017-04-26
WO2006041881B1 (en) 2007-05-10
JP2012106081A (ja) 2012-06-07
CA2583463A1 (en) 2006-04-20
JP2012143573A (ja) 2012-08-02
EP2561903A8 (en) 2013-04-03
CN101940815A (zh) 2011-01-12
CN101972513A (zh) 2011-02-16
US8934978B2 (en) 2015-01-13
DE202005022123U1 (de) 2014-03-27
WO2006041881A2 (en) 2006-04-20
JP2015013185A (ja) 2015-01-22
EP2572753A3 (en) 2013-05-22
US11033328B2 (en) 2021-06-15
EP3446747B1 (en) 2021-12-01
MX2007004238A (es) 2007-08-03
US20130116685A1 (en) 2013-05-09
US9675413B2 (en) 2017-06-13
EP2570154A2 (en) 2013-03-20
US20050288730A1 (en) 2005-12-29
ES2684499T3 (es) 2018-10-03
EP3939531B1 (en) 2024-03-13
DE202005022058U1 (de) 2012-11-13
EP2868344B1 (en) 2017-08-09
EP3939531A1 (en) 2022-01-19
EP3056242A1 (en) 2016-08-17
DE202005022059U1 (de) 2012-11-28
ES2740836T3 (es) 2020-02-06
EP2561902A8 (en) 2013-04-03
US20170326363A1 (en) 2017-11-16
US20160220305A1 (en) 2016-08-04
EP3132825A1 (en) 2017-02-22
JP2012110738A (ja) 2012-06-14
PL2561905T3 (pl) 2015-01-30
US9125661B2 (en) 2015-09-08
US20140058377A1 (en) 2014-02-27
JP5646135B2 (ja) 2014-12-24
US8768470B2 (en) 2014-07-01
ES2494119T3 (es) 2014-09-15
EP3108930B1 (en) 2019-05-15
US20160296279A1 (en) 2016-10-13
ES2534535T3 (es) 2015-04-23
US20140228739A1 (en) 2014-08-14
EP2561904B1 (en) 2016-02-10
EP2561902B1 (en) 2014-12-03
JP5952356B2 (ja) 2016-07-13
EP2561902A1 (en) 2013-02-27
US20190232055A1 (en) 2019-08-01
EP2561904A8 (en) 2013-04-03
EP2561905A8 (en) 2013-04-03
CN101940816B (zh) 2012-12-26
EP1802370A4 (en) 2009-10-21

Similar Documents

Publication Publication Date Title
ES2532077T3 (es) Aparato para la neuromodulación renal
ES2960299T3 (es) Dispositivos para la ablación endovascular de un nervio esplácnico
US10441356B2 (en) Methods for renal neuromodulation via neuromodulatory agents
ES2585215T3 (es) Aparato para realizar un tratamiento circunferencial no continuo a un paso interno del cuerpo
US20190175243A1 (en) Medical device and method for the denervation of renal perivascular nerves
JP2014516608A (ja) 高周波アブレーション・カテーテル装置
ES2361460T3 (es) Aparato para neuromodulación renal.