ES2535511T3 - Ésteres de bendamustina y compuestos relacionados, y uso médico de los mismos - Google Patents

Ésteres de bendamustina y compuestos relacionados, y uso médico de los mismos Download PDF

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Publication number
ES2535511T3
ES2535511T3 ES12165728.2T ES12165728T ES2535511T3 ES 2535511 T3 ES2535511 T3 ES 2535511T3 ES 12165728 T ES12165728 T ES 12165728T ES 2535511 T3 ES2535511 T3 ES 2535511T3
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ES
Spain
Prior art keywords
bendamustine
esters
related compounds
medical use
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12165728.2T
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English (en)
Inventor
Helmut Schickaneder
Armin Buschauer
Günther BERNHARDT
Christian Schickaneder
Michael Limmert
Stefan Huber
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Individual
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Individual
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Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2535511T3 publication Critical patent/ES2535511T3/es
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un compuesto de fórmula I **Fórmula** o una sal farmacéuticamente aceptable del mismo, en la que R1 es alquilo C1-C3, R2 y R3 independientemente entre sí representan alcanodiílo C1-C3, Y1 e Y2 representan oxígeno, y R4 y R5 forman una estructura anular junto con el nitrógeno situado entre R4 y R5, en la que la estructura anular se selecciona entre el grupo que consiste en pirrolidina, piperidina, piperazina y morfolino.
ES12165728.2T 2012-04-26 2012-04-26 Ésteres de bendamustina y compuestos relacionados, y uso médico de los mismos Active ES2535511T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12165728.2A EP2656843B1 (en) 2012-04-26 2012-04-26 Esters of bendamustine and related compounds, and medical use thereof

Publications (1)

Publication Number Publication Date
ES2535511T3 true ES2535511T3 (es) 2015-05-12

Family

ID=46045872

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12165728.2T Active ES2535511T3 (es) 2012-04-26 2012-04-26 Ésteres de bendamustina y compuestos relacionados, y uso médico de los mismos

Country Status (8)

Country Link
US (1) US8809549B2 (es)
EP (1) EP2656843B1 (es)
DK (1) DK2656843T3 (es)
ES (1) ES2535511T3 (es)
HR (1) HRP20150436T1 (es)
PL (1) PL2656843T3 (es)
PT (1) PT2656843E (es)
SI (1) SI2656843T1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101955065B1 (ko) * 2012-06-19 2019-03-06 헬무트 쉬카네더 벤다무스틴 유도체 및 관련 화합물, 및 이의 암 치료 의약 용도
KR20150086308A (ko) * 2012-11-12 2015-07-27 이그니타, 인코포레이티드 벤다무스틴 유도체 및 그의 사용 방법
RU2672722C2 (ru) 2014-04-10 2018-11-19 Хубэй Био-Фармасьютикал Индастриал Текнолоджикал Инститьют Инк. Аналоги соединений 4н-пиразоло[1,5-а]бензимидазола в качестве ингибиторов parp
EP3419973B1 (en) * 2016-02-24 2020-04-08 Acesion Pharma ApS Novel potassium channel inhibitors
RU2020115024A (ru) 2017-10-05 2021-11-08 Тьюб Фармасьютикалз Гмбх Препараты бендамустина для перорального введения

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
MX2011003751A (es) * 2008-10-08 2011-04-27 Cephalon Inc Procesos para preparar bendamustina.
MX2011005643A (es) 2008-12-03 2011-09-27 Astellas Deutschland Gmbh Formas de dosificacion oral de bendamustina.
CN101691359B (zh) 2009-09-30 2011-04-13 深圳万乐药业有限公司 一种高纯度的盐酸苯达莫司汀的合成方法
EP2516404A4 (en) * 2009-12-23 2013-04-17 Reddys Lab Ltd Dr PREPARATION OF BENDAMUSTINE AND ITS SALTS
JO3659B1 (ar) 2010-06-02 2020-08-27 Astellas Deutschland Gmbh أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية
DE102010055499A1 (de) * 2010-12-22 2011-06-16 W.C. Heraeus Gmbh Prozess zur Herstellung von Bendamustinalkylester, Bendarmustin sowie Derivaten davon

Also Published As

Publication number Publication date
US20130289032A1 (en) 2013-10-31
HRP20150436T1 (hr) 2015-05-22
EP2656843A1 (en) 2013-10-30
PL2656843T3 (pl) 2015-08-31
DK2656843T3 (en) 2015-04-20
US8809549B2 (en) 2014-08-19
SI2656843T1 (sl) 2015-06-30
EP2656843B1 (en) 2015-03-18
PT2656843E (pt) 2015-04-14

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