ES2539272T3 - Uso terapéutico de precursor de óxido nítrico - Google Patents

Uso terapéutico de precursor de óxido nítrico Download PDF

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Publication number
ES2539272T3
ES2539272T3 ES06005642.1T ES06005642T ES2539272T3 ES 2539272 T3 ES2539272 T3 ES 2539272T3 ES 06005642 T ES06005642 T ES 06005642T ES 2539272 T3 ES2539272 T3 ES 2539272T3
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Prior art keywords
nitric oxide
therapeutic use
oxide precursor
citrulline
disorder
Prior art date
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Expired - Lifetime
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ES06005642.1T
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English (en)
Inventor
Marshall L. Summar
Brian W. Christman
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Vanderbilt University
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Vanderbilt University
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Application filed by Vanderbilt University filed Critical Vanderbilt University
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Publication of ES2539272T3 publication Critical patent/ES2539272T3/es
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04016—Carbamoyl-phosphate synthase (ammonia) (6.3.4.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
    • C12Y603/05005—Carbamoyl-phosphate synthase (glutamine-hydrolysing) (6.3.5.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Citrulina para usar en un procedimiento de tratamiento o prevención de una afección o trastorno en un sujeto que se somete a cirugía cardiaca, que está asociado con la función subóptima del ciclo de la urea.

Description

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Claims (1)

  1. imagen1
ES06005642.1T 1999-06-01 2000-06-01 Uso terapéutico de precursor de óxido nítrico Expired - Lifetime ES2539272T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/323,472 US6346382B1 (en) 1999-06-01 1999-06-01 Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto
US323472 1999-06-01

Publications (1)

Publication Number Publication Date
ES2539272T3 true ES2539272T3 (es) 2015-06-29

Family

ID=23259343

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06005642.1T Expired - Lifetime ES2539272T3 (es) 1999-06-01 2000-06-01 Uso terapéutico de precursor de óxido nítrico

Country Status (7)

Country Link
US (4) US6346382B1 (es)
EP (4) EP2361621B1 (es)
AU (1) AU5455600A (es)
DK (1) DK1690535T3 (es)
ES (1) ES2539272T3 (es)
PT (1) PT1690535E (es)
WO (1) WO2000073322A1 (es)

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Publication number Publication date
EP2335693A2 (en) 2011-06-22
HK1097437A1 (en) 2007-06-29
EP2361621A1 (en) 2011-08-31
EP2335693A3 (en) 2011-09-28
EP1187844A1 (en) 2002-03-20
US6743823B1 (en) 2004-06-01
DK1690535T3 (en) 2015-06-29
WO2000073322A1 (en) 2000-12-07
EP1690535A3 (en) 2007-07-18
EP1187844A4 (en) 2003-09-03
EP2361621B1 (en) 2017-08-09
US20120252895A1 (en) 2012-10-04
EP1690535A2 (en) 2006-08-16
US20080234379A1 (en) 2008-09-25
AU5455600A (en) 2000-12-18
US6346382B1 (en) 2002-02-12
EP1690535B1 (en) 2015-04-29
US8188147B2 (en) 2012-05-29
PT1690535E (pt) 2015-07-30
US8536225B2 (en) 2013-09-17

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