ES2548327T3 - Método para detectar proBNP con un anticuerpo monoclonal - Google Patents

Método para detectar proBNP con un anticuerpo monoclonal Download PDF

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Publication number
ES2548327T3
ES2548327T3 ES10172014.2T ES10172014T ES2548327T3 ES 2548327 T3 ES2548327 T3 ES 2548327T3 ES 10172014 T ES10172014 T ES 10172014T ES 2548327 T3 ES2548327 T3 ES 2548327T3
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ES
Spain
Prior art keywords
probnp
monoclonal antibody
antibody
determined
binds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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ES10172014.2T
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English (en)
Inventor
Volker Klemt
Anneliese Borgya
Andreas Gallusser
Michael Grol
Christoph Seidel
Klaus Hallermayer
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
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Publication of ES2548327T3 publication Critical patent/ES2548327T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Un anticuerpo que se fija específicamente al proBNP nativo, en el cual dicho anticuerpo que se fija específicamente al proBNP nativo es un anticuerpo monoclonal el cual se fija a péptidos sintéticos que consisten en los aminoácidos 39 a 46, 40 a 47, 41 a 48 y 42 a 49, respectivamente, de NT-proBNP y en términos de los valores de proBNP, como se determinan en muestras de pacientes que usan dicho anticuerpo se correlacionan con un valor r de al menos r>=0,95 o superior a los valores de proBNP como se determina en dichas muestras usando el anticuerpo monoclonal MAB 1.21.3 producido por la línea celular de hibridoma depositada bajo DSM ACC2650 en la DSMZ, y en el cual dicho valor r se determina mediante análisis de regresión lineal.

Description

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Claims (1)

  1. imagen1
ES10172014.2T 2003-05-12 2004-05-12 Método para detectar proBNP con un anticuerpo monoclonal Expired - Lifetime ES2548327T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03010591 2003-05-12
EP03010591 2003-05-12

Publications (1)

Publication Number Publication Date
ES2548327T3 true ES2548327T3 (es) 2015-10-15

Family

ID=33427054

Family Applications (3)

Application Number Title Priority Date Filing Date
ES04732278T Expired - Lifetime ES2372282T3 (es) 2003-05-12 2004-05-12 Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 38-43.
ES10172014.2T Expired - Lifetime ES2548327T3 (es) 2003-05-12 2004-05-12 Método para detectar proBNP con un anticuerpo monoclonal
ES04732282T Expired - Lifetime ES2369008T3 (es) 2003-05-12 2004-05-12 Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 42-46.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES04732278T Expired - Lifetime ES2372282T3 (es) 2003-05-12 2004-05-12 Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 38-43.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES04732282T Expired - Lifetime ES2369008T3 (es) 2003-05-12 2004-05-12 Método para detectar probnp con un anticuerpo monoclonal que fija los aminoácidos 42-46.

Country Status (15)

Country Link
US (4) US7264938B2 (es)
EP (4) EP1625163B8 (es)
JP (4) JP5128125B2 (es)
KR (2) KR100857752B1 (es)
CN (3) CN1784425A (es)
AT (2) ATE517124T1 (es)
AU (1) AU2004235974B2 (es)
BR (1) BRPI0410261B8 (es)
CA (2) CA2522378C (es)
DK (3) DK1625163T3 (es)
ES (3) ES2372282T3 (es)
HU (1) HUE025169T2 (es)
MX (1) MXPA05011826A (es)
PL (3) PL1625163T3 (es)
WO (2) WO2004099253A1 (es)

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FR2843396B1 (fr) * 2002-08-07 2005-04-15 Bio Rad Pasteur Anticorps specifiques pour le diagnostic de l'insuffisance cardiaque
EP1625163B8 (en) * 2003-05-12 2011-11-02 Roche Diagnostics GmbH Method of detecting probnp with a monoclonal antibody binding to the amino acids 38-43
WO2004105575A2 (en) * 2003-05-29 2004-12-09 Trustee Of Darmouth College A method for detecting cardiac ischemia via changes in b-natriuretic peptide levels
DE10355731A1 (de) 2003-11-28 2005-06-30 Roche Diagnostics Gmbh Analytischer Sandwichtest zur Bestimmung von NT-proBNP
DE602005001299T2 (de) * 2004-07-07 2008-02-07 Roche Diagnostics Gmbh Kombinationen von Markern zum Nachweis von typ 1 und 2 Diabetes
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WO2009132815A1 (en) 2008-04-30 2009-11-05 Roche Diagnostics Gmbh Use of sfrp-3 in the assessment of heart failure
ES2512018T3 (es) 2009-07-27 2014-10-23 F. Hoffmann-La Roche Ag Utilización de mimecán en la evaluación de la insuficiencia cardiaca
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JP6119607B2 (ja) * 2011-09-20 2017-04-26 コニカミノルタ株式会社 検体希釈用液、それを用いたキットおよび蛍光測定方法
US20140273273A1 (en) 2012-11-01 2014-09-18 Christie Mitchell Ballantyne Biomarkers to improve prediction of heart failure risk
CN103304665A (zh) * 2013-05-21 2013-09-18 上海贝西生物科技有限公司 一种抗氨基末端脑利钠肽前体单克隆抗体及其应用
SG11201702490PA (en) 2014-10-10 2017-04-27 Akira Matsumori Method for detecting cardiac failure patient, method for discrimination of cardiac disease, test reagent for cardiac failure, test kit for cardiac failure, device for detecting cardiac failure, and program for detecting cardiac failure
EP3360570A1 (en) 2017-02-13 2018-08-15 Roche Diagnostics GmbH Antibodies recognizing genetic variants
EP3657169B1 (en) * 2017-10-02 2023-05-03 Otsuka Pharmaceutical Co., Ltd. Method for detecting analyte
CN112074738B (zh) * 2018-04-13 2024-08-16 共立制药股份有限公司 心力衰竭检测方法、心力衰竭检测用器具、夹心免疫检测法以及抗体的组合
CN108752480B (zh) * 2018-05-30 2022-03-29 中元汇吉生物技术股份有限公司 一种免疫原组合物、其制备方法及其用途
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
CN111487222B (zh) * 2019-01-28 2023-11-14 上海乐合生物科技有限公司 一种检测bnp的spr芯片的制备方法
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CN112986586A (zh) * 2021-02-20 2021-06-18 广东菲鹏生物有限公司 一种氨基末端脑尿钠肽检测方法和试剂盒
JP2024538607A (ja) 2021-10-01 2024-10-23 ゲンティアン アクティーゼルスカブ サンプル中のｎ末端プロホルモンｂｎｐ（ｎｔ－プロｂｎｐ）の濃度を測定するための新規方法
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Also Published As

Publication number Publication date
JP2007535470A (ja) 2007-12-06
CA2522747C (en) 2012-08-14
EP1625164A1 (en) 2006-02-15
DK2256132T3 (en) 2015-07-13
EP1625163B1 (en) 2011-08-31
DK1625163T3 (da) 2011-12-05
US7264939B2 (en) 2007-09-04
CA2522747A1 (en) 2004-11-18
US20060110776A1 (en) 2006-05-25
EP1625163A1 (en) 2006-02-15
CN100497393C (zh) 2009-06-10
PL2256132T3 (pl) 2016-08-31
CN101967190A (zh) 2011-02-09
MXPA05011826A (es) 2006-01-26
JP2010011860A (ja) 2010-01-21
PL1625164T3 (pl) 2011-12-30
KR20080011467A (ko) 2008-02-04
HUE025169T2 (en) 2016-02-29
HK1097855A1 (zh) 2007-07-06
AU2004235974A1 (en) 2004-11-18
CN1784425A (zh) 2006-06-07
JP2013018784A (ja) 2013-01-31
US20070117156A1 (en) 2007-05-24
WO2004099252A1 (en) 2004-11-18
BRPI0410261B8 (pt) 2021-07-27
ATE522546T1 (de) 2011-09-15
US20070099241A1 (en) 2007-05-03
AU2004235974B2 (en) 2008-02-14
US7264938B2 (en) 2007-09-04
KR20060003905A (ko) 2006-01-11
ATE517124T1 (de) 2011-08-15
CA2522378C (en) 2011-03-29
WO2004099253A1 (en) 2004-11-18
CA2522378A1 (en) 2004-11-18
JP4834136B2 (ja) 2011-12-14
US7807380B2 (en) 2010-10-05
JP4430066B2 (ja) 2010-03-10
BRPI0410261A (pt) 2006-05-16
EP1625164B1 (en) 2011-07-20
JP5128125B2 (ja) 2013-01-23
PL1625163T3 (pl) 2012-01-31
EP2256132A1 (en) 2010-12-01
KR100857752B1 (ko) 2008-09-11
US7811770B2 (en) 2010-10-12
EP1625163B8 (en) 2011-11-02
ES2372282T3 (es) 2012-01-18
JP2007525427A (ja) 2007-09-06
DK1625164T3 (da) 2011-10-31
BRPI0410261B1 (pt) 2020-03-10
EP2949669A1 (en) 2015-12-02
CN1832964A (zh) 2006-09-13
US20060110775A1 (en) 2006-05-25
JP5649631B2 (ja) 2015-01-07
EP2256132B1 (en) 2015-04-01
ES2369008T3 (es) 2011-11-24

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