ATE522546T1 - Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet - Google Patents

Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet

Info

Publication number
ATE522546T1
ATE522546T1 AT04732278T AT04732278T ATE522546T1 AT E522546 T1 ATE522546 T1 AT E522546T1 AT 04732278 T AT04732278 T AT 04732278T AT 04732278 T AT04732278 T AT 04732278T AT E522546 T1 ATE522546 T1 AT E522546T1
Authority
AT
Austria
Prior art keywords
amino acid
monoclonal antibodies
probnp
native probnp
binds amino
Prior art date
Application number
AT04732278T
Other languages
English (en)
Inventor
Volker Klemt
Anneliese Borgya
Andreas Gallusser
Michael Grol
Klaus Hallermayer
Christoph Seidel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33427054&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE522546(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE522546T1 publication Critical patent/ATE522546T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Cardiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04732278T 2003-05-12 2004-05-12 Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet ATE522546T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03010591 2003-05-12
PCT/EP2004/005091 WO2004099252A1 (en) 2003-05-12 2004-05-12 Method of detecting native probnp with amonoclonal antibody binding to the amino acids 38-44

Publications (1)

Publication Number Publication Date
ATE522546T1 true ATE522546T1 (de) 2011-09-15

Family

ID=33427054

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04732282T ATE517124T1 (de) 2003-05-12 2004-05-12 Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindet
AT04732278T ATE522546T1 (de) 2003-05-12 2004-05-12 Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT04732282T ATE517124T1 (de) 2003-05-12 2004-05-12 Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindet

Country Status (15)

Country Link
US (4) US7264938B2 (de)
EP (4) EP1625163B8 (de)
JP (4) JP4430066B2 (de)
KR (2) KR100857752B1 (de)
CN (3) CN101967190A (de)
AT (2) ATE517124T1 (de)
AU (1) AU2004235974B2 (de)
BR (1) BRPI0410261B8 (de)
CA (2) CA2522747C (de)
DK (3) DK1625163T3 (de)
ES (3) ES2369008T3 (de)
HU (1) HUE025169T2 (de)
MX (1) MXPA05011826A (de)
PL (3) PL2256132T3 (de)
WO (2) WO2004099253A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2843396B1 (fr) * 2002-08-07 2005-04-15 Bio Rad Pasteur Anticorps specifiques pour le diagnostic de l'insuffisance cardiaque
CA2522747C (en) * 2003-05-12 2012-08-14 F. Hoffmann-La Roche Ag Method of detecting native probnp with a monoclonal antibody binding to the amino acids 38-43
WO2004105575A2 (en) * 2003-05-29 2004-12-09 Trustee Of Darmouth College A method for detecting cardiac ischemia via changes in b-natriuretic peptide levels
DE10355731A1 (de) 2003-11-28 2005-06-30 Roche Diagnostics Gmbh Analytischer Sandwichtest zur Bestimmung von NT-proBNP
DE602005001299T2 (de) * 2004-07-07 2008-02-07 Roche Diagnostics Gmbh Kombinationen von Markern zum Nachweis von typ 1 und 2 Diabetes
AT500800B1 (de) * 2004-09-08 2008-07-15 Biomedica Medizinprodukte Gmbh Verfahren zur bestimmung von probnp
EP2498095A3 (de) 2007-01-25 2012-11-28 Roche Diagniostics GmbH Verwendung von IGFBP-7 bei der Beurteilung von Herzversagen
KR100836322B1 (ko) * 2007-08-31 2008-06-09 현대자동차주식회사 차량용 흡음재 제작장치 및 방법
US9482677B2 (en) 2008-02-27 2016-11-01 Scios Inc. Method, composition and device for sampling natriuretic peptides in a biological fluid
WO2009132815A1 (en) 2008-04-30 2009-11-05 Roche Diagnostics Gmbh Use of sfrp-3 in the assessment of heart failure
WO2011012268A1 (en) 2009-07-27 2011-02-03 Roche Diagnostics Gmbh Use of mimecan in the assessment of heart failure
EA201290311A1 (ru) * 2009-11-13 2012-12-28 БиДжи МЕДИСИН, ИНК. Факторы риска и прогнозирование инфаркта миокарда
EP2601531A1 (de) 2010-08-04 2013-06-12 IDEXX Laboratories, Inc. Nachweis von zersetzungsprodukten von hundespezifischem nt-probnp
US8481333B2 (en) 2011-05-31 2013-07-09 Idexx Laboratories, Inc. Detection of degradation products of feline NT-proBNP
JP6119607B2 (ja) * 2011-09-20 2017-04-26 コニカミノルタ株式会社 検体希釈用液、それを用いたキットおよび蛍光測定方法
US20140273273A1 (en) 2012-11-01 2014-09-18 Christie Mitchell Ballantyne Biomarkers to improve prediction of heart failure risk
CN103304665A (zh) * 2013-05-21 2013-09-18 上海贝西生物科技有限公司 一种抗氨基末端脑利钠肽前体单克隆抗体及其应用
CN106716135B (zh) 2014-10-10 2019-03-15 松森昭 用于检测心力衰竭的装置及储存介质
EP3360570A1 (de) * 2017-02-13 2018-08-15 Roche Diagnostics GmbH Monoklonale antikörper für nt-probnp punktmutationen
WO2019069885A1 (ja) * 2017-10-02 2019-04-11 コニカミノルタ株式会社 アナライトの検出方法
EP3779438A4 (de) * 2018-04-13 2022-01-26 Kyoritsu Seiyaku Corporation Verfahren zur erkennung von herzversagen, instrument zur erkennung von herzversagen, sandwich-immunoassay-verfahren und antikörperkombination
CN108752480B (zh) * 2018-05-30 2022-03-29 中元汇吉生物技术股份有限公司 一种免疫原组合物、其制备方法及其用途
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
CN111487222B (zh) * 2019-01-28 2023-11-14 上海乐合生物科技有限公司 一种检测bnp的spr芯片的制备方法
WO2021028520A1 (en) 2019-08-13 2021-02-18 Gentian As Highly sensitive particle enhanced assay for the quantification of nt-probnp
EP4222499A1 (de) * 2020-09-30 2023-08-09 F. Hoffmann-La Roche AG Zirkulierendes total-nt-probnp (glycosyliertes und unglycosyliertes nt-probnp) und sein verhältnis mit nt-probnp (unglycosyliertem nt-probnp) bei der beurteilung von vorhofflimmern
CN112986586A (zh) * 2021-02-20 2021-06-18 广东菲鹏生物有限公司 一种氨基末端脑尿钠肽检测方法和试剂盒
CN112964885B (zh) * 2021-02-20 2022-11-11 广东菲鹏生物有限公司 一种氨基末端脑尿钠肽检测方法和试剂盒
WO2023052642A1 (en) 2021-10-01 2023-04-06 Gentian As Novel method for determining a concentration of n-terminal pro-hormone bnp (nt-probnp) in a sample
WO2023175152A1 (en) 2022-03-18 2023-09-21 Roche Diagnostics Gmbh Troponin marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction
CN118922721A (zh) 2022-03-18 2024-11-08 豪夫迈·罗氏有限公司 用于2型与1型急性心肌梗死的早期辨别的cMyBPC标志物组合
JPWO2024219421A1 (de) * 2023-04-19 2024-10-24

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445816C1 (de) 1984-12-15 1986-06-12 Behringwerke Ag, 3550 Marburg Flaechenfoermiges diagnostisches Mittel
JP2665850B2 (ja) 1991-11-14 1997-10-22 塩野義製薬株式会社 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体
GB9211686D0 (en) 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
WO1999013331A1 (en) * 1997-09-11 1999-03-18 Shionogi & Co., Ltd. Immunoassay method for bnp
GB9827348D0 (en) * 1998-12-12 1999-02-03 Univ Leicester Natriuretic peptide
AU758562B2 (en) * 1999-01-29 2003-03-27 Roche Diagnostics Gmbh Method of identifying N-terminal proBNP
US20030219734A1 (en) 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US20040096919A1 (en) * 2002-11-18 2004-05-20 Michelle Davey Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP
CA2522747C (en) * 2003-05-12 2012-08-14 F. Hoffmann-La Roche Ag Method of detecting native probnp with a monoclonal antibody binding to the amino acids 38-43

Also Published As

Publication number Publication date
DK1625163T3 (da) 2011-12-05
JP4430066B2 (ja) 2010-03-10
WO2004099253A1 (en) 2004-11-18
JP5128125B2 (ja) 2013-01-23
ES2369008T3 (es) 2011-11-24
CN1832964A (zh) 2006-09-13
JP2013018784A (ja) 2013-01-31
KR100857752B1 (ko) 2008-09-11
MXPA05011826A (es) 2006-01-26
EP1625164B1 (de) 2011-07-20
EP1625164A1 (de) 2006-02-15
AU2004235974B2 (en) 2008-02-14
BRPI0410261B8 (pt) 2021-07-27
CA2522747C (en) 2012-08-14
CA2522378A1 (en) 2004-11-18
EP2949669A1 (de) 2015-12-02
CN101967190A (zh) 2011-02-09
DK1625164T3 (da) 2011-10-31
KR20080011467A (ko) 2008-02-04
US20070117156A1 (en) 2007-05-24
EP1625163A1 (de) 2006-02-15
EP1625163B1 (de) 2011-08-31
US7811770B2 (en) 2010-10-12
ATE517124T1 (de) 2011-08-15
CN100497393C (zh) 2009-06-10
PL2256132T3 (pl) 2016-08-31
JP2010011860A (ja) 2010-01-21
ES2372282T3 (es) 2012-01-18
JP4834136B2 (ja) 2011-12-14
ES2548327T3 (es) 2015-10-15
CA2522747A1 (en) 2004-11-18
PL1625164T3 (pl) 2011-12-30
HUE025169T2 (en) 2016-02-29
US20060110776A1 (en) 2006-05-25
EP2256132B1 (de) 2015-04-01
DK2256132T3 (en) 2015-07-13
US7264939B2 (en) 2007-09-04
AU2004235974A1 (en) 2004-11-18
US7807380B2 (en) 2010-10-05
BRPI0410261A (pt) 2006-05-16
HK1097855A1 (zh) 2007-07-06
US7264938B2 (en) 2007-09-04
EP2256132A1 (de) 2010-12-01
JP2007525427A (ja) 2007-09-06
KR20060003905A (ko) 2006-01-11
WO2004099252A1 (en) 2004-11-18
JP2007535470A (ja) 2007-12-06
JP5649631B2 (ja) 2015-01-07
US20070099241A1 (en) 2007-05-03
EP1625163B8 (de) 2011-11-02
BRPI0410261B1 (pt) 2020-03-10
PL1625163T3 (pl) 2012-01-31
CA2522378C (en) 2011-03-29
CN1784425A (zh) 2006-06-07
US20060110775A1 (en) 2006-05-25

Similar Documents

Publication Publication Date Title
ATE517124T1 (de) Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindet
PE20090722A1 (es) Hepcidina, antagonistas de la hepcidina y metodos de uso
ATE480562T1 (de) Veränderung von fcrn-bindungsaffinitäten oder von serumhalbwertszeiten von antikörpern mittels mutagenese
ATE440868T1 (de) Monoklonaler antikírper gegen ein prion protein und dessen verwendung zum nachweis von prionen
DE60334696D1 (de) Antikörper, die spezifische für probnp(1-108) sind, und ihre verwendung zur diagnose von herzinfarkt
DE50014666D1 (de) VERFAHREN ZUM NACHWEIS VON N-TERMINALEM proBNP
RU2010133547A (ru) Анти-cldn антитела
ATE474852T1 (de) Nukleinsäuren, die für einen an ein g-protein gekoppelten, an der sensorischen transduktion beteiligten rezeptor kodieren
UA94576C2 (ru) Выделенное антитело, которое связывается с igf-1r, композиция, которая его содержит, и способы, которые касаются антител
ATE554390T1 (de) Verfahren zur gewinnung von antikörpern
JP2007525427A5 (de)
ATE335763T1 (de) Sandwich-immunoassay zur bestimmung von proanp- teilpeptiden
ATE445642T1 (de) Trennung von polypeptiden mit einer racemisierten aminosäure
DE60014124D1 (de) Antikörper, die spezifisch für fullerene sind
ATE523523T1 (de) Monoklonale anti minichomosome maintenance 2 protein antikörper und verfahren zu deren verwendung beim nachweis einer zervikalen erkrankung
RU2019132201A (ru) Антитела к человеческому эритроферрону и их применение
JP2004323508A (ja) 抗重金属モノクローナル抗体およびその使用方法
ATE513215T1 (de) Monoklonale antikörper, hybridomzellinien, verfahren und kits zum nachweis von phytase
WO2008081331A3 (en) Enhancing the level of antibody expression by framework re-engineering
ATE482398T1 (de) Verfahren zur stratifizierung von herzinsuffizienz
ATE535546T1 (de) Humane monoklonale antikörper, die spezifisch an ifg-ii binden
WO2009044561A1 (ja) 抗ｐｒｏＮＴ／ＮＭＮモノクローナル抗体
DE69919859D1 (de) Verfahren zum bestimmen eines überschäumfaktors für ein getränk
SE0202702L (sv) Immunotest för specifik bestämning av SCCA isoformer
PE20191840A1 (es) Kit diagnostico diferencial y rapido para deteccion de la coriza infecciosa y el sindrome de cabeza hinchada en la industria avicola

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1625163

Country of ref document: EP