ATE522546T1 - Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet - Google Patents

Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet

Info

Publication number
ATE522546T1
ATE522546T1 AT04732278T AT04732278T ATE522546T1 AT E522546 T1 ATE522546 T1 AT E522546T1 AT 04732278 T AT04732278 T AT 04732278T AT 04732278 T AT04732278 T AT 04732278T AT E522546 T1 ATE522546 T1 AT E522546T1
Authority
AT
Austria
Prior art keywords
amino acid
monoclonal antibodies
probnp
native probnp
binds amino
Prior art date
Application number
AT04732278T
Other languages
English (en)
Inventor
Volker Klemt
Anneliese Borgya
Andreas Gallusser
Michael Grol
Klaus Hallermayer
Christoph Seidel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33427054&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE522546(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE522546T1 publication Critical patent/ATE522546T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04732278T 2003-05-12 2004-05-12 Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet ATE522546T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03010591 2003-05-12
PCT/EP2004/005091 WO2004099252A1 (en) 2003-05-12 2004-05-12 Method of detecting native probnp with amonoclonal antibody binding to the amino acids 38-44

Publications (1)

Publication Number Publication Date
ATE522546T1 true ATE522546T1 (de) 2011-09-15

Family

ID=33427054

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04732282T ATE517124T1 (de) 2003-05-12 2004-05-12 Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindet
AT04732278T ATE522546T1 (de) 2003-05-12 2004-05-12 Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38- 43 bindet

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT04732282T ATE517124T1 (de) 2003-05-12 2004-05-12 Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 42- 46 bindet

Country Status (15)

Country Link
US (4) US7264939B2 (de)
EP (4) EP1625164B1 (de)
JP (4) JP5128125B2 (de)
KR (2) KR100857752B1 (de)
CN (3) CN100497393C (de)
AT (2) ATE517124T1 (de)
AU (1) AU2004235974B2 (de)
BR (1) BRPI0410261B8 (de)
CA (2) CA2522747C (de)
DK (3) DK1625164T3 (de)
ES (3) ES2369008T3 (de)
HU (1) HUE025169T2 (de)
MX (1) MXPA05011826A (de)
PL (3) PL1625164T3 (de)
WO (2) WO2004099253A1 (de)

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AT500800B1 (de) * 2004-09-08 2008-07-15 Biomedica Medizinprodukte Gmbh Verfahren zur bestimmung von probnp
CN106908603B (zh) 2007-01-25 2019-04-02 霍夫曼-拉罗奇有限公司 Igfbp-7在心力衰竭评估中的用途
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CA2780301A1 (en) * 2009-11-13 2011-05-19 Bg Medicine, Inc. Risk factors and prediction of myocardial infarction
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AU2012262154B2 (en) 2011-05-31 2016-08-04 Idexx Laboratories, Inc. Detection of degradation products of feline NT-proBNP
JP6119607B2 (ja) * 2011-09-20 2017-04-26 コニカミノルタ株式会社 検体希釈用液、それを用いたキットおよび蛍光測定方法
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CN103304665A (zh) * 2013-05-21 2013-09-18 上海贝西生物科技有限公司 一种抗氨基末端脑利钠肽前体单克隆抗体及其应用
EP3206032B1 (de) * 2014-10-10 2019-02-27 Akira Matsumori Verfahren zur detektion eines patienten mit herzversagen, verfahren zur unterscheidung von herzkrankheiten, testreagens für herzversagen, testkit für herzversagen, vorrichtung zur detektion von herzversagen und programm zur detektion von herzversagen
EP3360570A1 (de) 2017-02-13 2018-08-15 Roche Diagnostics GmbH Monoklonale antikörper für nt-probnp punktmutationen
ES2948008T3 (es) 2017-10-02 2023-08-25 Otsuka Pharma Co Ltd Método para detectar analito
EP3779438A4 (de) * 2018-04-13 2022-01-26 Kyoritsu Seiyaku Corporation Verfahren zur erkennung von herzversagen, instrument zur erkennung von herzversagen, sandwich-immunoassay-verfahren und antikörperkombination
CN108752480B (zh) * 2018-05-30 2022-03-29 中元汇吉生物技术股份有限公司 一种免疫原组合物、其制备方法及其用途
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
CN111487222B (zh) * 2019-01-28 2023-11-14 上海乐合生物科技有限公司 一种检测bnp的spr芯片的制备方法
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US20230366894A1 (en) * 2020-09-30 2023-11-16 Roche Diagnostics Operations, Inc. Circulating total-nt-probnp (glycosylated and unglycosylated nt-probnp) and its ratio with nt-probnp (unglycosylated nt-probnp) in the assessment of atrial fibrillation
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CN112986586A (zh) * 2021-02-20 2021-06-18 广东菲鹏生物有限公司 一种氨基末端脑尿钠肽检测方法和试剂盒
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Also Published As

Publication number Publication date
JP4834136B2 (ja) 2011-12-14
ES2548327T3 (es) 2015-10-15
EP1625164B1 (de) 2011-07-20
US7811770B2 (en) 2010-10-12
BRPI0410261B8 (pt) 2021-07-27
CA2522378C (en) 2011-03-29
US7264938B2 (en) 2007-09-04
US20070117156A1 (en) 2007-05-24
DK2256132T3 (en) 2015-07-13
BRPI0410261B1 (pt) 2020-03-10
JP5128125B2 (ja) 2013-01-23
ATE517124T1 (de) 2011-08-15
ES2372282T3 (es) 2012-01-18
JP5649631B2 (ja) 2015-01-07
PL1625164T3 (pl) 2011-12-30
PL2256132T3 (pl) 2016-08-31
CN1784425A (zh) 2006-06-07
DK1625163T3 (da) 2011-12-05
DK1625164T3 (da) 2011-10-31
US7264939B2 (en) 2007-09-04
CA2522747C (en) 2012-08-14
JP2007525427A (ja) 2007-09-06
EP2256132A1 (de) 2010-12-01
JP2013018784A (ja) 2013-01-31
ES2369008T3 (es) 2011-11-24
CN101967190A (zh) 2011-02-09
US20070099241A1 (en) 2007-05-03
BRPI0410261A (pt) 2006-05-16
CN100497393C (zh) 2009-06-10
AU2004235974B2 (en) 2008-02-14
EP2949669A1 (de) 2015-12-02
CN1832964A (zh) 2006-09-13
EP2256132B1 (de) 2015-04-01
KR100857752B1 (ko) 2008-09-11
HK1097855A1 (zh) 2007-07-06
KR20080011467A (ko) 2008-02-04
US20060110775A1 (en) 2006-05-25
EP1625163B1 (de) 2011-08-31
JP2010011860A (ja) 2010-01-21
US7807380B2 (en) 2010-10-05
KR20060003905A (ko) 2006-01-11
WO2004099252A1 (en) 2004-11-18
AU2004235974A1 (en) 2004-11-18
EP1625164A1 (de) 2006-02-15
US20060110776A1 (en) 2006-05-25
MXPA05011826A (es) 2006-01-26
PL1625163T3 (pl) 2012-01-31
WO2004099253A1 (en) 2004-11-18
JP4430066B2 (ja) 2010-03-10
HUE025169T2 (en) 2016-02-29
JP2007535470A (ja) 2007-12-06
EP1625163A1 (de) 2006-02-15
CA2522378A1 (en) 2004-11-18
EP1625163B8 (de) 2011-11-02
CA2522747A1 (en) 2004-11-18

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