ES2550033T3 - Forma de dosificación farmacéutica sólida de ticagrelor - Google Patents

Forma de dosificación farmacéutica sólida de ticagrelor Download PDF

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Publication number
ES2550033T3
ES2550033T3 ES10795382.0T ES10795382T ES2550033T3 ES 2550033 T3 ES2550033 T3 ES 2550033T3 ES 10795382 T ES10795382 T ES 10795382T ES 2550033 T3 ES2550033 T3 ES 2550033T3
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Prior art keywords
ticagrelor
dosage form
pharmaceutical dosage
solid pharmaceutical
ticagrelor solid
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Sandra Brueck
Dominique Meergans
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Ratiopharm GmbH
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Ratiopharm GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Forma de dosificación farmacéutica oral sólida que comprende ticagrelor o una sal o un éster farmacéuticamente aceptables del mismo, caracterizada por que al menos el 90 % en volumen de las partículas de ticagrelor tienen un tamaño de partícula en el intervalo de 1 μm a 150 μm.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
E10795382
13-10-2015
Ejemplo 2
Ingredientes
Función mg/Comprimido % en peso
Ticagrelor
Ingrediente activo 90,0 52,0
Lactosa
Diluyente 72,0 41,6
Almidón de maíz
Disgregante 11,0 6,4
Peso total
173,0 100,0
Los comprimidos se prepararon usando un proceso similar al proceso descrito en el ejemplo 1.
Ejemplo 3
Ingredientes
Función mg/Comprimido % en peso
Ticagrelor
Ingrediente activo 90,0 54,9
Isomalt
Diluyente 72,0 43,9
Estearato de magnesio
Lubricante 2,0 1,2
Peso total
164,0 100,0
10 Las partículas de ticagrelor se prepararon usando un proceso de molienda en seco. El ticagrelor se molió usando un molino de chorro de aire. Posteriormente se añadió el diluyente al agente activo y se mezclaron en un mezclador de caída libre. El lubricante, estearato de magnesio se tamizó y se mezcló con la mezcla. Después la mezcla final se comprimió en comprimidos usando una prensa de comprimidos adecuada y después opcionalmente se recubrió con un material de recubrimiento, por ejemplo Opadry.
15
Ejemplo 4
Ingredientes
Función mg/Comprimido % en peso
Ticagrelor
Ingrediente activo 90,0 48,3
Hidroxipropilmetil celulosa (HPMC)
Aglomerante 18,0 9,7
SDS
Agente humectante 4,5 2,4
Manitol
Diluyente 64 34,3
Croscarmelosa
Disgregante 7,2 3,9
Sílice
Emoliente 0,9 0,5
Estearato de magnesio
Lubricante 1,8 1,0
Peso total
186,4 100,0
Las partículas de ticagrelor se prepararon usando un proceso de molienda en húmedo. La co-molienda se realizó
20 con ticagrelor junto con HPMC y SDS en un agente dispersante usando un molino húmedo. Posteriormente la suspensión se secó por atomización. La mitad de manitol, croscarmelosa y dióxido de sílice se añadieron a los intermedios secos, se mezclaron y se compactaron. Las partículas compactadas se tamizaron, posteriormente se añadieron los excipientes restantes y se mezclaron. Después la mezcla final se comprimió en comprimidos usando una prensa de comprimidos adecuada y después opcionalmente se recubrió con un material de recubrimiento, por
25 ejemplo Opadry.
Ejemplo 5
Ingredientes
Función mg/Comprimido % en peso
Ticagrelor
Ingrediente activo 90,0 46,7
Povidona
Aglutinante 45,0 23,4
SDS
Agente humectante 1,0 0,5
Celulosa microcristalina
Diluyente 45,0 23,4
Croscarmelosa
Disgregante 9,0 4,7
7
imagen6

Claims (1)

  1. imagen1
ES10795382.0T 2009-12-23 2010-12-20 Forma de dosificación farmacéutica sólida de ticagrelor Active ES2550033T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09180628 2009-12-23
EP09180628 2009-12-23
PCT/EP2010/070268 WO2011076749A2 (en) 2009-12-23 2010-12-20 Solid pharmaceutical dosage form

Publications (1)

Publication Number Publication Date
ES2550033T3 true ES2550033T3 (es) 2015-11-04

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ES10795382.0T Active ES2550033T3 (es) 2009-12-23 2010-12-20 Forma de dosificación farmacéutica sólida de ticagrelor
ES13169378.0T Active ES2548845T3 (es) 2009-12-23 2010-12-20 Forma de dosificación farmacéutica sólida de ticagrelor y ácido acetilsalicílico

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US (2) US8663661B2 (es)
EP (2) EP2515871B1 (es)
CA (1) CA2785487C (es)
EA (1) EA026094B1 (es)
ES (2) ES2550033T3 (es)
WO (1) WO2011076749A2 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102657629B (zh) * 2012-05-14 2014-04-02 深圳市华力康生物医药有限公司 替卡格雷缓释片系统及其制备方法
CZ2012705A3 (cs) * 2012-10-16 2014-04-23 Zentiva, K.S. Pevná orální farmaceutická formulace obsahující ticagrelor
WO2014118808A2 (en) * 2013-02-04 2014-08-07 Hetero Research Foundation Ticagrelor solid dispersion
EP2813216A1 (en) 2013-06-10 2014-12-17 Zentiva, a.s. Stabilized amorphous ticagrelor
WO2014170026A1 (en) 2013-04-18 2014-10-23 Zentiva, K.S. Stabilized amorphous ticagrelor
CA2913326A1 (en) * 2013-05-29 2014-12-04 Ratiopharm Gmbh Solid pharmaceutical dosage form
EP2813212A1 (en) * 2013-06-10 2014-12-17 Zentiva, a.s. Drug formulation using API in nanofibers
EP2816043A1 (en) * 2013-06-21 2014-12-24 LEK Pharmaceuticals d.d. Spherical ticagrelor particles
WO2015001489A1 (en) 2013-07-01 2015-01-08 Ranbaxy Laboratories Limited Pharmaceutical compositions of ticagrelor
CN104414989B (zh) * 2013-09-10 2019-02-22 四川海思科制药有限公司 一种替卡格雷药物组合物及其制备方法
CN104434805B (zh) * 2013-09-22 2017-09-29 成都盛迪医药有限公司 一种替格瑞洛固体分散体及其制备方法
CZ2013866A3 (cs) 2013-11-08 2015-05-20 Zentiva, K.S. Způsob výroby a nová krystalická forma intermediátu syntézy ticagreloru
CN104644604A (zh) * 2013-11-23 2015-05-27 天津市汉康医药生物技术有限公司 替格瑞洛倍半水合物胶囊及其制备方法
CN103751109A (zh) * 2013-12-31 2014-04-30 北京万全德众医药生物技术有限公司 替格瑞洛干混悬剂及其制备方法
WO2015110952A1 (en) * 2014-01-21 2015-07-30 Wockhardt Limited Solid oral pharmaceutical compositions comprising ticagrelor or salt thereof
CN104971042B (zh) * 2014-04-04 2018-01-05 中国医学科学院医药生物技术研究所 替格瑞洛口服自微乳组合物
KR20160012706A (ko) * 2014-07-25 2016-02-03 동아에스티 주식회사 서방성 제제
CN104523640B (zh) * 2014-12-19 2017-02-22 河南润弘制药股份有限公司 一种替格瑞洛片及其制备方法
JP6451310B2 (ja) * 2014-12-24 2019-01-16 ライオン株式会社 固形医薬組成物及びその製造方法
CN105832683A (zh) * 2015-01-15 2016-08-10 成都国弘医药有限公司 一种含有替格瑞洛的片剂
CN105998026B (zh) * 2015-03-26 2020-07-14 四川海思科制药有限公司 一种替卡格雷药物组合物及其制备方法
TR201601835A2 (tr) 2016-02-12 2017-08-21 Ali Raif Ilac Sanayi Ve Ticaret Anonim Sirketi Ti̇kagrelor i̇çeren formülasyonlar i̇çi̇n üreti̇m yöntemi̇
US20170296666A1 (en) 2016-04-18 2017-10-19 Amneal Pharmaceuticals Company Gmbh Stable Pharmaceutical Composition Of Amorphous Ticagrelor
CN105943515A (zh) * 2016-06-24 2016-09-21 山东鲁抗医药股份有限公司 一种替格瑞洛口腔崩解片及其制备方法
TR201617983A2 (tr) 2016-12-07 2018-06-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Ti̇cagrelorun kati oral farmasöti̇k bi̇leşi̇mleri̇
CN106727378A (zh) * 2016-12-28 2017-05-31 江苏飞马药业有限公司 一种含有替格瑞洛主药的片剂组合物及其制备方法
WO2019170244A1 (en) 2018-03-08 2019-09-12 Pharmaceutical Oriented Services Ltd. Ticagrelor—containing tablet formulation
EP3829547B1 (en) 2018-07-27 2025-09-03 KRKA, d.d., Novo mesto Pharmaceutical composition of ticagrelor
CN110327305A (zh) * 2019-06-26 2019-10-15 慧生医学科技(徐州)有限公司 一种替格瑞洛片及其制备方法
WO2021096444A1 (en) 2019-11-13 2021-05-20 Santa Farma İlaç Sanayi̇ A.Ş. Pharmaceutical compositions comprising ticagrelor
GR1010621B (el) * 2022-12-19 2024-01-30 Elpen Ανωνυμος Εταιρεια Φαρμακευτικη Βιομηχανια, Στερεες φαρμακοτεχνικες μορφες τικαγρελορης

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US118410A (en) 1871-08-22 Improvement in combined hay and manure-forks
US4721709A (en) 1984-07-26 1988-01-26 Pyare Seth Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions
AR017014A1 (es) 1997-07-22 2001-08-22 Astrazeneca Ab Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
UA74141C2 (uk) 1998-12-09 2005-11-15 Дж.Д. Сірл Енд Ко. Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
GB0013407D0 (en) 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
CA2420597C (en) * 2000-08-31 2011-05-17 Rtp Pharma Inc. Milled particles
SE0101932D0 (sv) 2001-05-31 2001-05-31 Astrazeneca Ab Pharmaceutical combinations
UA80991C2 (en) 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
JP5122144B2 (ja) 2004-01-20 2013-01-16 ノバルティス アーゲー 直接圧縮製剤および方法
EP1898911A1 (en) * 2005-06-13 2008-03-19 Elan Pharma International Limited Nanoparticulate clopidogrel and aspirin combination formulations
JP2009504737A (ja) 2005-08-19 2009-02-05 イーライ リリー アンド カンパニー 脈管疾患の治療又は予防のためのｐａｒ−１／ｐａｒ−４阻害剤の使用
EP2035005A4 (en) * 2006-06-09 2011-07-06 Kemia Inc THERAPY BASED ON CYTOKINE INHIBITORS
US20080045548A1 (en) 2006-08-21 2008-02-21 Astrazeneca Ab Pharmaceutical Compositions
TWI482772B (zh) 2006-08-21 2015-05-01 Astrazeneca Ab 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物
EP2155195B1 (en) * 2007-04-13 2014-07-16 Millennium Pharmaceuticals, Inc. Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor
US20090048216A1 (en) * 2007-05-02 2009-02-19 Portola Pharmaceuticals, Inc. Intravenous and oral dosing of a direct-acting and reversible p2y12 inhibitor
KR101509829B1 (ko) * 2007-05-02 2015-04-06 포톨라 파마슈티컬스, 인코포레이티드 혈소판 ａｄｐ 수용체 억제제로 작용하는 화합물을 이용한 병용요법
WO2009007675A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and a p2 gamma 12 antagonist
AP2010005341A0 (en) * 2008-01-11 2010-08-31 Cipla Ltd Solid pharmaceutical dosage form
EP2240173A4 (en) 2008-01-25 2013-07-17 Alphapharm Pty Ltd PHARMACEUTICAL COMPOSITION OF DULOXETINE WITH DELAYED RELEASE
TR200801178A2 (tr) 2008-02-22 2009-09-23 Bi̇li̇m İlaç Sanayi̇ Ti̇caret A.Ş. Nateglinid ve surfaktan-ph ayarlayıcı sistemi içeren oral tablet kompozisyonları
DE102008037324A1 (de) 2008-08-11 2010-02-18 Ratiopharm Gmbh Pharmazeutische Formulierung zur pulmonalen Blutdrucksenkung
US20100183598A1 (en) * 2008-11-12 2010-07-22 Carolus Therapeutics, Inc. Methods of treating cardiovascular disorders
EP2585161A1 (en) * 2010-06-23 2013-05-01 Stefan Kralev Medical device for self-administration of patients with acute coronary events
CN102657629B (zh) * 2012-05-14 2014-04-02 深圳市华力康生物医药有限公司 替卡格雷缓释片系统及其制备方法

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EP2515871B1 (en) 2015-09-23
EA026094B1 (ru) 2017-03-31
EA201200937A1 (ru) 2013-02-28
US20140147505A1 (en) 2014-05-29
EP2633857A1 (en) 2013-09-04
US20130028938A1 (en) 2013-01-31
US8663661B2 (en) 2014-03-04
ES2548845T3 (es) 2015-10-21
EP2515871A2 (en) 2012-10-31
WO2011076749A3 (en) 2011-08-18
WO2011076749A2 (en) 2011-06-30
CA2785487C (en) 2017-11-28
CA2785487A1 (en) 2011-06-30
EP2633857B1 (en) 2015-08-12

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