ES2551356T3 - Métodos y composiciones para modular la diferenciación de células pluripotenciales - Google Patents
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- ES2551356T3 ES2551356T3 ES08856546.0T ES08856546T ES2551356T3 ES 2551356 T3 ES2551356 T3 ES 2551356T3 ES 08856546 T ES08856546 T ES 08856546T ES 2551356 T3 ES2551356 T3 ES 2551356T3
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
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- C12N2510/00—Genetically modified cells
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US521107P | 2007-12-03 | 2007-12-03 | |
| US5211P | 2007-12-03 | ||
| US12594108P | 2008-04-30 | 2008-04-30 | |
| US125941P | 2008-04-30 | ||
| US13157708P | 2008-06-10 | 2008-06-10 | |
| US131577P | 2008-06-10 | ||
| PCT/US2008/013299 WO2009073180A2 (en) | 2007-12-03 | 2008-12-03 | Methods and compositions for modulating differentiation of pluripotential cells |
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| ES2551356T3 true ES2551356T3 (es) | 2015-11-18 |
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| ES08856546.0T Active ES2551356T3 (es) | 2007-12-03 | 2008-12-03 | Métodos y composiciones para modular la diferenciación de células pluripotenciales |
| ES15185035T Active ES2787513T3 (es) | 2007-12-03 | 2008-12-03 | Métodos y composiciones para modular la diferenciación de células pluripotenciales |
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| ES15185035T Active ES2787513T3 (es) | 2007-12-03 | 2008-12-03 | Métodos y composiciones para modular la diferenciación de células pluripotenciales |
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| US (1) | US20110306137A1 (pl) |
| EP (3) | EP2222839B1 (pl) |
| DK (1) | DK2222839T3 (pl) |
| ES (2) | ES2551356T3 (pl) |
| PL (1) | PL2222839T3 (pl) |
| PT (1) | PT2222839E (pl) |
| WO (1) | WO2009073180A2 (pl) |
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| AU2003207064B2 (en) | 2002-02-06 | 2006-07-13 | Sanbio, Inc. | Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferring Notch gene |
| US10316288B2 (en) * | 2008-04-30 | 2019-06-11 | Sanbio, Inc. | Neural regenerating cells with alterations in DNA methylation |
| EP2806881A1 (en) | 2012-01-27 | 2014-12-03 | SanBio, Inc. | Methods and compositions for modulating angiogenesis and vasculogenesis |
| CN104519891B (zh) | 2012-05-16 | 2019-03-22 | 桑比欧公司 | 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 |
| WO2014058464A1 (en) | 2012-10-09 | 2014-04-17 | Sanbio, Inc. | Methods and compositions for treatment of retinal degeneration |
| WO2016210256A1 (en) * | 2015-06-25 | 2016-12-29 | The University Of Florida Research Foundation, Inc. | Conductive nonwoven mat and method of using the conductive nonwoven mat |
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| JP2002513545A (ja) | 1998-05-07 | 2002-05-14 | ザ ユニヴァーシティー オブ サウス フロリダ | 脳および脊髄修復のためのニューロン源としての骨髄細胞 |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| EP1749884A1 (en) | 2000-02-11 | 2007-02-07 | Philadelphia, Health and Education Corporation | Differentiation of bone marrow cells into neuronal cells and uses therefor |
| US20030003090A1 (en) | 2001-05-31 | 2003-01-02 | Prockop Darwin J. | Directed in vitro differentiation of marrow stromal cells into neural cell progenitors |
| JP3886346B2 (ja) | 2001-06-22 | 2007-02-28 | サンバイオ，インコーポレイティド | 骨髄間質細胞由来Ｓｃｈｗａｎｎ細胞を含む神経再生用医薬組成物 |
| US7129034B2 (en) | 2001-10-25 | 2006-10-31 | Cedars-Sinai Medical Center | Differentiation of whole bone marrow |
| AU2003207064B2 (en) * | 2002-02-06 | 2006-07-13 | Sanbio, Inc. | Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferring Notch gene |
| US20030181380A1 (en) * | 2002-03-08 | 2003-09-25 | Pear Warren S. | Modulating lymphoid commitment and survival |
| US20040235165A1 (en) | 2003-05-19 | 2004-11-25 | Darwin Prockop | In vitro differentiation of adult stem cells |
| ATE523587T1 (de) * | 2004-04-12 | 2011-09-15 | Sanbio Inc | Eigenschaften neuronaler vorläuferzellen zeigende zellen |
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Also Published As
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| US20110306137A1 (en) | 2011-12-15 |
| EP2985341A2 (en) | 2016-02-17 |
| ES2787513T3 (es) | 2020-10-16 |
| DK2222839T3 (en) | 2015-12-21 |
| EP2222839A4 (en) | 2012-02-01 |
| EP2222839A2 (en) | 2010-09-01 |
| PT2222839E (pt) | 2015-11-30 |
| EP3696261A1 (en) | 2020-08-19 |
| EP2222839B1 (en) | 2015-09-16 |
| EP2985341A3 (en) | 2016-06-01 |
| PL2222839T3 (pl) | 2016-02-29 |
| EP2985341B1 (en) | 2020-04-01 |
| WO2009073180A2 (en) | 2009-06-11 |
| WO2009073180A3 (en) | 2009-10-15 |
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