ES2559062T3 - Método para la activación de linfocitos T colaboradores y composición para su uso en el método - Google Patents

Método para la activación de linfocitos T colaboradores y composición para su uso en el método Download PDF

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Publication number
ES2559062T3
ES2559062T3 ES08712039.0T ES08712039T ES2559062T3 ES 2559062 T3 ES2559062 T3 ES 2559062T3 ES 08712039 T ES08712039 T ES 08712039T ES 2559062 T3 ES2559062 T3 ES 2559062T3
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Prior art keywords
hla
helper
dpb1
lymphocyte
peptide
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ES08712039.0T
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English (en)
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Haruo Sugiyama
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International Institute of Cancer Immunology Inc
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International Institute of Cancer Immunology Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4242—Transcription factors, e.g. SOX or c-MYC
    • A61K40/4243—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)

Abstract

Un método para la activación in vitro de un linfocito T colaborador, que comprende la adición de un péptido WT1 a una célula presentadora de antígeno, y activando así el linfocito T colaborador, donde el péptido WT1 es un péptido que comprende una secuencia de aminoácidos: Lys Arg Tyr Phe Lys Leu Ser His Leu Gln Met His Ser Arg Lys His (SEC ID N.º: 2) y tiene una capacidad de unirse a uno cualquiera de una molécula HLA-DRB1*1501, molécula HLADPB1* 0901 y molécula HLA-DPB1*0501, donde dicho linfocito T colaborador es de un sujeto que es uno cualquiera de un sujeto positivo para HLA-DRB1*1501, positivo para HLA-DPB1*0901 y positivo para HLA-DPB1*0501.

Description

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Claims (1)

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ES08712039.0T 2007-02-27 2008-02-27 Método para la activación de linfocitos T colaboradores y composición para su uso en el método Active ES2559062T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007047317 2007-02-27
JP2007047317 2007-02-27
PCT/JP2008/053417 WO2008105462A1 (ja) 2007-02-27 2008-02-27 ヘルパーｔ細胞の活性化方法およびそのための組成物

Publications (1)

Publication Number Publication Date
ES2559062T3 true ES2559062T3 (es) 2016-02-10

Family

ID=39721287

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08712039.0T Active ES2559062T3 (es) 2007-02-27 2008-02-27 Método para la activación de linfocitos T colaboradores y composición para su uso en el método

Country Status (25)

Country Link
US (2) US10139395B2 (es)
EP (1) EP2119778B1 (es)
JP (2) JP5225262B2 (es)
KR (1) KR101598228B1 (es)
CN (6) CN103088103B (es)
AU (1) AU2008220031B2 (es)
BR (1) BRPI0808084A2 (es)
CA (1) CA2677075C (es)
CY (1) CY1117150T1 (es)
DK (1) DK2119778T3 (es)
ES (1) ES2559062T3 (es)
HR (1) HRP20160020T1 (es)
HU (1) HUE027472T2 (es)
IL (1) IL200161A (es)
MX (2) MX2009009168A (es)
MY (2) MY158219A (es)
NZ (3) NZ599160A (es)
PL (1) PL2119778T3 (es)
PT (1) PT2119778E (es)
RU (2) RU2009135802A (es)
SG (1) SG177998A1 (es)
SI (1) SI2119778T1 (es)
UA (1) UA101608C2 (es)
WO (1) WO2008105462A1 (es)
ZA (1) ZA200905467B (es)

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CN101580538B (zh) 2003-11-05 2013-06-19 株式会社国际癌症免疫研究所 Wt1衍生的hla-dr-结合抗原肽
ES2542141T3 (es) 2005-10-17 2015-07-31 Sloan Kettering Institute For Cancer Research Péptidos WT1 de unión a HLA de clase II, y composiciones y métodos que los comprenden
PL2010209T3 (pl) 2006-04-10 2017-04-28 Sloan Kettering Inst For Cancer Res Immunogeniczne peptydy WT-1 i sposoby ich użycia
MX2009009168A (es) 2007-02-27 2009-09-07 Int Inst Cancer Immunology Inc Metodo para activacion de celula t auxiliar y composicion para usarse en el metodo.
AR076349A1 (es) 2009-04-23 2011-06-01 Int Inst Cancer Immunology Inc Peptido auxiliar del antigeno del cancer
US8809050B2 (en) 2009-12-08 2014-08-19 Wilson Wolf Manufacturing Methods of cell culture for adoptive cell therapy
US8956860B2 (en) 2009-12-08 2015-02-17 Juan F. Vera Methods of cell culture for adoptive cell therapy
SG189287A1 (en) 2010-10-05 2013-05-31 Int Inst Cancer Immunology Inc Method for activating helper t cell
CA2846479A1 (en) 2011-09-14 2013-03-21 International Institute Of Cancer Immunology, Inc. Method for measuring anti-wt1 antibody
JP6218175B2 (ja) * 2011-12-14 2017-10-25 国立大学法人高知大学 ヘルパーｔ細胞誘導性ポリペプチドの改変
CA2861206C (en) 2012-01-13 2021-07-06 Richard J. O'reilly Immunogenic wt-1 peptides and methods of use thereof
EP2896693A4 (en) * 2012-09-12 2016-10-12 Int Inst Cancer Immunology Inc ANTIGEN SPECIFIC HELPER T CELL RECEPTOR GENES
WO2014098012A1 (ja) * 2012-12-17 2014-06-26 大塚製薬株式会社 ヘルパーt細胞の活性化方法
EP3769782A1 (en) 2013-01-15 2021-01-27 Memorial Sloan Kettering Cancer Center Immunogenic wt-1 peptides and methods of use thereof
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
EP3112378B1 (en) * 2014-02-26 2020-06-24 Tella, Inc. Wt1 antigenic polypeptide, and anti-tumor agent containing said polypeptide
CN108350411B (zh) 2015-06-25 2021-06-22 白川利朗 口服肿瘤疫苗
US11666646B2 (en) 2016-12-26 2023-06-06 National University Corporation Kobe University Cancer therapy utilizing combination of oral tumor vaccine and immunosuppression inhibitor
WO2021138447A1 (en) 2019-12-31 2021-07-08 Elixirgen Therapeutics, Inc. Temperature-based transient delivery of nucleic acids and proteins to cells and tissues
KR102647825B1 (ko) * 2021-07-22 2024-03-14 서울대학교산학협력단 항-hla-dp 단클론 항체 및 이의 용도
CN116559462A (zh) * 2023-04-12 2023-08-08 中国科学技术大学 用于肿瘤患者预后的生物标志物组及其用途

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ES2542141T3 (es) 2005-10-17 2015-07-31 Sloan Kettering Institute For Cancer Research Péptidos WT1 de unión a HLA de clase II, y composiciones y métodos que los comprenden
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ES2587980T3 (es) 2006-02-22 2016-10-28 International Institute Of Cancer Immunology, Inc Péptido WT1 con restricción HLA-A*3303 y composición farmacéutica que lo contiene
PL2010209T3 (pl) 2006-04-10 2017-04-28 Sloan Kettering Inst For Cancer Res Immunogeniczne peptydy WT-1 i sposoby ich użycia
CA2670658A1 (en) 2006-12-28 2008-07-10 International Institute Of Cancer Immunology, Inc. Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same
MX2009009168A (es) 2007-02-27 2009-09-07 Int Inst Cancer Immunology Inc Metodo para activacion de celula t auxiliar y composicion para usarse en el metodo.
EP3173480A3 (en) 2007-03-05 2017-08-16 International Institute of Cancer Immunology, Inc. Cancer antigen-specific t-cell receptor gene, peptide encoded by the gene, and use of them
AR076349A1 (es) * 2009-04-23 2011-06-01 Int Inst Cancer Immunology Inc Peptido auxiliar del antigeno del cancer
SG189287A1 (en) 2010-10-05 2013-05-31 Int Inst Cancer Immunology Inc Method for activating helper t cell
WO2014098012A1 (ja) 2012-12-17 2014-06-26 大塚製薬株式会社 ヘルパーt細胞の活性化方法

Also Published As

Publication number Publication date
BRPI0808084A2 (pt) 2014-07-22
CN103103246B (zh) 2018-05-01
JP5225262B2 (ja) 2013-07-03
JP2013139448A (ja) 2013-07-18
WO2008105462A1 (ja) 2008-09-04
RU2680539C2 (ru) 2019-02-22
EP2119778B1 (en) 2015-11-04
CA2677075C (en) 2018-07-10
PL2119778T3 (pl) 2016-04-29
MY164867A (en) 2018-01-30
CN103088103A (zh) 2013-05-08
EP2119778A1 (en) 2009-11-18
CN103149366B (zh) 2018-06-15
EP2119778A4 (en) 2010-08-18
RU2014104572A (ru) 2015-08-20
JPWO2008105462A1 (ja) 2010-06-03
CN103149366A (zh) 2013-06-12
CN103103246A (zh) 2013-05-15
CN104774910B (zh) 2018-04-10
US11555814B2 (en) 2023-01-17
JP5714619B2 (ja) 2015-05-07
NZ599161A (en) 2012-07-27
KR101598228B1 (ko) 2016-02-26
MX352947B (es) 2017-12-14
HK1138321A1 (en) 2010-08-20
UA101608C2 (uk) 2013-04-25
CN101622344A (zh) 2010-01-06
PT2119778E (pt) 2016-02-15
IL200161A0 (en) 2011-08-01
US20100247556A1 (en) 2010-09-30
ZA200905467B (en) 2010-05-26
US20200064332A1 (en) 2020-02-27
RU2009135802A (ru) 2011-04-10
CN103088103B (zh) 2015-09-30
IL200161A (en) 2015-11-30
AU2008220031B2 (en) 2013-06-13
CN104774910A (zh) 2015-07-15
CY1117150T1 (el) 2017-04-05
US10139395B2 (en) 2018-11-27
MX2009009168A (es) 2009-09-07
AU2008220031A1 (en) 2008-09-04
HUE027472T2 (en) 2016-09-28
MY158219A (en) 2016-09-15
CN104312974A (zh) 2015-01-28
CA2677075A1 (en) 2008-09-04
DK2119778T3 (en) 2016-01-25
NZ599160A (en) 2012-07-27
SI2119778T1 (sl) 2016-03-31
KR20090125067A (ko) 2009-12-03
CN104312974B (zh) 2018-09-04
NZ578721A (en) 2012-04-27
SG177998A1 (en) 2012-02-28
HRP20160020T1 (hr) 2016-02-12

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