ES2564419T3 - Composiciones de poliuretano hidrófilo - Google Patents

Composiciones de poliuretano hidrófilo Download PDF

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Publication number
ES2564419T3
ES2564419T3 ES07733393.8T ES07733393T ES2564419T3 ES 2564419 T3 ES2564419 T3 ES 2564419T3 ES 07733393 T ES07733393 T ES 07733393T ES 2564419 T3 ES2564419 T3 ES 2564419T3
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Prior art keywords
polymer
swelling
polymers
fluconazole
respect
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Inventor
Jukka Tuominen
Amaia Zurutuza
Mark Livingston
Janet A. Halliday
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Ferring BV
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Ferring BV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/16—Catalysts
    • C08G18/18—Catalysts containing secondary or tertiary amines or salts thereof
    • C08G18/20—Heterocyclic amines; Salts thereof
    • C08G18/2045—Heterocyclic amines; Salts thereof containing condensed heterocyclic rings
    • C08G18/2063—Heterocyclic amines; Salts thereof containing condensed heterocyclic rings having two nitrogen atoms in the condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C08G18/4837—Polyethers containing oxyethylene units and other oxyalkylene units
    • C08G18/4841—Polyethers containing oxyethylene units and other oxyalkylene units containing oxyethylene end groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/74—Polyisocyanates or polyisothiocyanates cyclic
    • C08G18/75—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic
    • C08G18/758—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing two or more cycloaliphatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una composición farmacéutica de liberación controlada en forma de dosificación sólida que comprende (i) un polímero lineal apto para hinchamiento en agua que se puede obtener haciendo reaccionar juntos (a) un óxido de polietileno de peso molecular medio menor o igual a 4000; (b) un diol C5 a C20 alifático; y (c) un isocianato difuncional, en el que la relación de los componentes (a) con respecto a (b) con respecto a (c) está dentro del intervalo 0,01-0,1 a 1 a 1,01-1,1 en términos de pesos equivalentes; junto con (ii) un agente farmacéuticamente activo.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
Ejemplo 7. Capacidad de hinchamiento de polímeros en diferentes disolventes
Las determinaciones de hinchamiento para un número de polímeros seleccionados se llevaron a cabo en agua, etanol, alcohol isopropílico (IPA) y una mezcla al 50 % de IPA/agua con el fin de medir la cantidad de disolvente absorbido por el polímero. Los resultados se calcularon en base al hinchamiento medio de 5-10 muestras de ensayo y se muestran en la Tabla 3. La fórmula usada para los cálculos se muestra a continuación:
imagen7
Tabla 3. Porcentaje de hinchamiento de polímeros seleccionados en diferentes medios de hinchamiento (agua, etanol, IPA e IPA/agua al 50 %)
Nombre de
% de Hinchamiento en % de Hinchamiento % de Hinchamiento % de Hinchamiento
Polímero
Agua en Etanol en IPA en IPA/Agua al 50 %
Polímero A
81 190 15 300
Polímero E
41 80 18 115
Polímero J
10 - - -
Polímero K
5,6 - - -
Polímero P*3
1,5 - - -
10 Ejemplo 8. Ensayo de dureza Shore
Los polímeros fabricados se sometieron a ensayo en cuanto a la dureza Shore usando durómetros A y D. Estas mediciones se conocen bien por parte del experto en la técnica. Los resultados se presentan como la media de cuatro mediciones y se presentan en la Tabla 4.
Tabla 4. Valores de dureza Shore determinada para los polímeros fabricados
Nombre de Polímero
Durómetro A Durómetro D
Dureza Máxima Deformación permanente por fatiga(15 segundos)
Dureza Máxima Deformación permanente por fatiga(15 segundos)
Polímero A
95,3 0,8 59,3 5,3
Polímero B
98,0 0,0 60,6 4,1
Polímero C
97,5 0,5 53,1 2,1
Polímero D
96,0 0,0 50,5 4,3
Polímero E
98,0 0,0 67,0 6,5
Polímero F
94,5 0,0 53,5 3,3
Polímero G
97,5 0,0 65,8 6,0
Polímero H
N/A N/A N/A N/A
Polímero I
96,5 1,0 53,8 0,8
Polímero J
93,0 1,5 55,8 2,3
Polímero K
99,0 0,0 63,0 3,6
Polímero L
99,0 0,0 66,0 4,8
Polímero M
99,0 0,0 68,4 4,9
Polímero N
99,5 0,0 77,8 4,9
Polímero O
99,0 0,0 70,6 2,9
Polímero P
100,0 0,0 67,8 3,8
Condiciones experimentales: Temperatura 21 ºC Humedad relativa % HR 39
8 5
10
15
20
Ejemplo 9. Películas poliméricas fabricadas por medio de moldeo por compresión
Un número de polímeros seleccionados y una formulación polimérica cargada de fármaco de la Tabla 1 se secaron durante la noche a vacío antes del procesado. Las temperaturas de placa superior e inferior de la máquina de moldeo por compresión se ajustaron a la temperatura de procesado objetivo. Se colocaron dos láminas de Teflon entre el molde y las placas calientes. El tiempo de fusión fue de 3-5 minutos seguido de un tiempo de retención de 30-120 segundos a presión (170-200 bar). Se usó una cantidad predeterminada de polímero para llenar el molde. Tras el enfriamiento hasta temperatura ambiente las muestras (dispositivos de óvulo vaginal con dimensiones de 30 mm x 10 mm x 1 mm) se empujaron mecánicamente hacia afuera y se mantuvieron en el congelador para análisis posterior. Las condiciones de procesado se muestran en la Tabla 5.
Tabla 5. Procesado térmico de polímeros fabricados usando moldeo por compresión.
Polímero
Fluconazol (% Temperatura Presión de Tiempo de Tiempo de Espesor de
en peso)
(ºC) Cilindro (Bar) Fusión (s) Presión (s) Molde (mm)
Polímero
- 150 200 180 60 0,4
A
Polímero
- 160 170 180 30 1,0
B
Polímero
- 160 200 240 120 1,0
B
Polímero
- 190 200 180 20 0,4
C
Polímero
- 200 200 180 60 0,4
C
Polímero
- 180 200 300 60 0,4
D
Polímero
- 200 200 180 50 0,4
D
Polímero
- 165 200 270 60 0,4
E
Polímero
20 160 200 270 60 1,0
E
Polímero
- 170 200 210 60 0,4
E
Polímero
- 160 170 180 30 1,0
H
Polímero
- 200 200 180 50 0,4
P

Ejemplo 10. Carga de fármaco -extrusión
Los polímeros seleccionados se cargaron con el fluconazol de fármaco modelo. Se usó un extrusor de laboratorio de husillo gemelar en co-rotación de 16 mm para la carga de los polímeros. La Tabla 6 muestra las condiciones de carga de fármaco.
Tabla 6. Condiciones de carga por extrusión usadas en los dispositivos cargados con fluconazol
Polímero
Fármaco Fármaco (% enpeso) Velocidad de husillo (rpm) Perfil de temperatura desde la alimentación hasta la boquilla (ºC)
Polímero A
Fluconazol 20 30 96-150-150-150-155
Polímero E
Fluconazol 20 30 95-135-135-135-135
Ejemplo 11. Estudios de liberación de fármaco
La cantidad de fluconazol liberado a partir de los polímeros cargados por extrusión se investigó por medio de un procedimiento de solución basado en el procedimiento de paletas USP. Esta técnica está formada por un sistema de solución UV automatizado en el que se conecta una paleta de solución Distek (modelo 2100C) (velocidad de 50 rpm) a un espectrofotómetro Unicam UV 500 por medio de una bomba peristáltica Icalis. El sistema se opera usando un soporte lógico Dsolve.
9
Condiciones experimentales:
Temperatura 37 ºC
Medio de solución 500 ml de agua desgasificada y desionizada
Los perfiles de liberación de fármaco in vitro de los polímeros cargados por extrusión se compararon con los
5 polímeros lineales de hinchamiento elevado y los reticulados cargados por difusión, véase Figura 2. Los polímeros A y E cargados por extrusión se representaron con otro polímero lineal de hinchamiento elevado cargado por extrusión de la patente WO2004029125 (fluconazol al 20 % en peso de % SW elevado). El polímero reticulado cargado por difusión de la patente EP0016652/EP0016654 (fluconazol al 17 % en peso reticulado) también se muestra en el gráfico siguiente con otro polímero lineal de hinchamiento elevado cargado por difusión de la patente
10 WO2004029125 (fluconazol al 17 % en peso de % de SW elevado).
10

Claims (1)

  1. imagen1
ES07733393.8T 2006-07-05 2007-06-27 Composiciones de poliuretano hidrófilo Active ES2564419T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0613333 2006-07-05
GBGB0613333.4A GB0613333D0 (en) 2006-07-05 2006-07-05 Hydrophilic polyurethane compositions
PCT/GB2007/002401 WO2008003932A1 (en) 2006-07-05 2007-06-27 Hydrophilic polyurethane compositions

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ES2564419T3 true ES2564419T3 (es) 2016-03-22

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US (2) US8974813B2 (es)
EP (2) EP2966104B1 (es)
JP (1) JP5394237B2 (es)
CN (1) CN101484493B (es)
AU (1) AU2007271000B2 (es)
BR (1) BRPI0713630B1 (es)
CA (1) CA2656489C (es)
ES (2) ES2707749T3 (es)
GB (1) GB0613333D0 (es)
HK (1) HK1220220A1 (es)
PL (1) PL2966104T3 (es)
TR (1) TR201900597T4 (es)
WO (1) WO2008003932A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
CN101977651A (zh) 2008-01-25 2011-02-16 犹他大学研究基金会 线性级释放聚合物
EP2437684B1 (en) 2009-06-03 2022-06-15 ForSight Vision5, Inc. Anterior segment drug delivery
US8393979B2 (en) 2010-06-24 2013-03-12 Nike, Inc. Golf ball with hydrophilic coating layer
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
US8602915B2 (en) 2010-11-01 2013-12-10 Nike, Inc. Golf ball with changeable dimples
WO2012158779A1 (en) 2011-05-17 2012-11-22 Reprotect, Inc. Reusable intravaginal delivery device, system, and method
CA2848397C (en) 2011-09-14 2022-04-26 Forsight Vision5, Inc. Ocular insert apparatus and methods
WO2014066775A1 (en) 2012-10-26 2014-05-01 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
HUE049418T2 (hu) * 2013-12-10 2020-09-28 Lubrizol Advanced Mat Inc Nagyon rugalmas termoplasztikus poliuretánok
EP3283004A4 (en) 2015-04-13 2018-12-05 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
MY209023A (en) * 2016-06-28 2025-06-17 Lubrizol Advanced Mat Inc Articles made from hydrophilic thermoplastic polyurethane compositions
JP7185641B2 (ja) * 2017-12-04 2022-12-07 住友精化株式会社 揮発性物質放散用組成物
CN108283726A (zh) * 2018-03-05 2018-07-17 湖南科技大学 一种聚氨酯基创伤敷料的制备方法
CN108404192A (zh) * 2018-03-05 2018-08-17 湖南科技大学 一种止血创伤敷料的制备方法
AU2019345248B2 (en) 2018-09-17 2025-04-24 Dsm Ip Assets B.V. Polyurethane excipient
JP7736576B2 (ja) 2019-06-28 2025-09-09 ユーデモン テクノロジーズ プロプライアタリー リミティド 成形ポリウレタンヒドロゲル
GB201916808D0 (en) 2019-11-19 2020-01-01 Ferring Bv Pharmaceutical delivery device
FR3116715B1 (fr) * 2020-11-30 2025-02-28 Polymerexpert Sa Polymère apte à former un revêtement glissant pour injecteur ophtalmique

Family Cites Families (360)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE505703C2 (sv) 1995-12-15 1997-09-29 Polyrand Ab Linjär blockpolymer innefattande urea- och uretangrupper, förfarande för framställning av linjära blockpolymerer samt användning av blockpolymererna som implantat
US3916898A (en) 1964-05-20 1975-11-04 Searle & Co Administration of medicaments and the like
US3487068A (en) 1966-12-16 1969-12-30 Upjohn Co Lincomycin-2-phosphates,7-substituted compounds and salts thereof
US3860701A (en) 1968-04-22 1975-01-14 Searle & Co Method for use and compositions of 11-lower alkyl steroids and drug delivery system for the controlled elution of 11-lower alkyl steroids
US3830907A (en) 1968-04-22 1974-08-20 Searle & Co Compositions for the sustained release of 17alpha-ethyl-19-nortestosterone
US3565991A (en) 1968-04-22 1971-02-23 Searle & Co Methods for use and compositions of 17alpha-ethyl-19-nortestosterone and carriers for the sustained release of steroids
US3639157A (en) 1968-07-18 1972-02-01 Bayer Ag Process for finishing textile materials with a polymer of a vinyl compound and the reaction product of a polyol and an organic polyisocyanate
US3948262A (en) 1969-04-01 1976-04-06 Alza Corporation Novel drug delivery device
US3734097A (en) 1969-04-01 1973-05-22 Alza Corp Therapeutic adhesive tape
US3967618A (en) 1969-04-01 1976-07-06 Alza Corporation Drug delivery device
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3993073A (en) 1969-04-01 1976-11-23 Alza Corporation Novel drug delivery device
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3598122A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3797494A (en) 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3896819A (en) 1969-04-01 1975-07-29 Alejandro Zaffaroni IUD having a replenishing drug reservoir
US3845761A (en) 1970-06-02 1974-11-05 Alza Corp Intrauterine contraceptive anti-fertility device for the management of reproduction
US3737521A (en) 1970-12-09 1973-06-05 Goodrich Co B F Formulation for sustained release of a biological agent
US3995631A (en) 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3760805A (en) 1971-01-13 1973-09-25 Alza Corp Osmotic dispenser with collapsible supply container
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US3941880A (en) 1971-02-22 1976-03-02 G. D. Searle & Co. Method for use of 11-lower alkyl steroids
US3731683A (en) 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US4041208A (en) 1971-06-21 1977-08-09 Ppg Industries, Inc. Transparent, impact-resistant polyesterurethane laminates
US3931113A (en) 1971-06-21 1976-01-06 Ppg Industries, Inc. Impact-resistant thermoplastic polyester urethanes
US3881043A (en) 1971-06-21 1975-04-29 Ppg Industries Inc Laminated safety windshields
US3892842A (en) 1971-09-01 1975-07-01 Alza Corp Intrauterine contraceptive device for releasing steroid having double bond functionality
US3948254A (en) 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3921636A (en) 1973-01-15 1975-11-25 Alza Corp Novel drug delivery device
US3867933A (en) 1973-03-06 1975-02-25 Tecna Corp Intrauterine device and process of making the same
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4036227A (en) 1973-04-25 1977-07-19 Alza Corporation Osmotic releasing device having a plurality of release rate patterns
FR2250520B1 (es) 1973-11-09 1977-04-15 Cournut Rene
US3901852A (en) * 1974-07-29 1975-08-26 Upjohn Co Thermoplastic polyurethanes prepared from 4,4'-methylenebis (phenyl isocyanate)
US3993072A (en) 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
US4093708A (en) 1974-12-23 1978-06-06 Alza Corporation Osmotic releasing device having a plurality of release rate patterns
US4018918A (en) 1975-05-20 1977-04-19 The Upjohn Company Topical clindamycin preparations
GB1479987A (en) 1975-06-20 1977-07-13 Interox Chemicals Ltd Polyurethanes
US4036360A (en) 1975-11-12 1977-07-19 Graham Magnetics Incorporated Package having dessicant composition
US4235988A (en) * 1976-12-13 1980-11-25 Imperial Chemical Industries Limited Delivery means for biologically active agents
GB1551620A (en) * 1976-12-13 1979-08-30 Ici Ltd Delivery means for biologically active agents
US4289757A (en) 1978-02-28 1981-09-15 The Upjohn Company Method for treating inflammation
US4205115A (en) 1978-04-19 1980-05-27 Ppg Industries, Inc. Polyester coating composition
US4215691A (en) 1978-10-11 1980-08-05 Alza Corporation Vaginal contraceptive system made from block copolymer
US4286587A (en) 1978-10-11 1981-09-01 Alza Corporation Vaginal drug delivery system made from polymer
US4237885A (en) 1978-10-23 1980-12-09 Alza Corporation Delivery system with mated members for storing and releasing a plurality of beneficial agents
US5017382A (en) 1979-03-21 1991-05-21 National Research Development Corporation Controlled release compositions (II)
GB2047093B (en) 1979-03-21 1983-12-07 Graham N B Controlled release compositions
US5079009A (en) 1979-03-21 1992-01-07 National Research Development Corporation Controlled release compositions including polyethylene oxide with urethane cross-linking
US4250611A (en) 1979-04-19 1981-02-17 Alza Corporation Process for making drug delivery device with reservoir
JPS56253A (en) 1979-06-11 1981-01-06 Sumitomo Metal Ind Ltd Cr-mo steel of excellent strength and tenacity to be hot- worked
US4264757A (en) 1979-06-26 1981-04-28 Union Carbide Corporation Radiation-curable allyl- or vinyl capped polycaprolactone compositions
US4402695A (en) 1980-01-21 1983-09-06 Alza Corporation Device for delivering agent in vagina
US4731289A (en) 1980-02-14 1988-03-15 Ppg Industries, Inc. Abrasion resistant polyurethane coatings for rigid plastics
US4276405A (en) 1980-03-28 1981-06-30 Union Carbide Corporation Low-energy-curable coatings compositions
DE3017989C2 (de) 1980-05-10 1982-05-19 IPOS Gesellschaft für integrierte Prothesen-Entwicklung und orthopädietechnischen Service mbH & Co KG, 2120 Lüneburg "Auffangbeutel für künstliche Darmausgänge"
US4466936A (en) 1981-02-03 1984-08-21 Bayer Aktiengesellschaft Production of molds using gel compositions with depot action based on a polyurethane matrix and relatively high molecular weight polyols
AU558611B2 (en) 1981-02-03 1987-02-05 Bayer Aktiengesellschaft Polyurethane gel
JPS57185313A (en) 1981-05-08 1982-11-15 Daicel Chem Ind Ltd Polyurethane and its preparation
JPS57155230A (en) 1981-02-27 1982-09-25 Daicel Chem Ind Ltd Lactone polymer having narrow molecular weight distribution and its preparation
US4426485A (en) 1982-06-14 1984-01-17 Union Carbide Corporation Polymers with hydrophobe bunches
JPS5948409A (ja) 1982-09-10 1984-03-19 Teikoku Seiyaku Kk 矯正的歯牙移動促進剤
US4438225A (en) 1983-04-12 1984-03-20 Henkel Corporation Polyester polyols from bishydroxymethyl tricyclo compounds and caprolactone and polyurethanes based thereon
GB8319766D0 (en) 1983-07-22 1983-08-24 Graham N B Controlled release device
FR2557576B1 (fr) 1984-01-03 1988-06-03 Gould Francis Composition d'acrylate de polyurethane hydrophile, son procede de preparation et son utilisation comme pansement pour brulures, implant, contraceptif, dispositif intra-uterin, canule, systeme d'application orale, membrane permeable aux gaz, prothese de la cornee, pansement chirurgical, membrane de dialyse, lentille de contact et enrobage de coques de bateau
US4694238A (en) 1984-01-10 1987-09-15 Peter Norton Dual voltage power supply system for vehicles
GB8403138D0 (en) 1984-02-07 1984-03-14 Graham N B Sustained release of active ingredient
US4503216A (en) 1984-02-21 1985-03-05 Eastman Kodak Company Hydroxyl-terminated polyether-esters
US4568741A (en) 1984-05-15 1986-02-04 The Upjohn Company Synthesis of 7-halo-7-deoxylincomycins
EP0180264A1 (en) 1984-10-12 1986-05-07 Akzo N.V. Release system for two or more active substances
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
JPS61250019A (ja) 1985-04-27 1986-11-07 Bridgestone Corp 微小気泡質状ポリウレタンエラストマ−の製造方法
JPS6257467A (ja) 1985-09-06 1987-03-13 Asahi Glass Co Ltd コ−テイング剤組成物
US4707495A (en) 1985-10-28 1987-11-17 Ortho Pharmaceutical Peptic ulcer treatment method
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5731303A (en) 1985-12-04 1998-03-24 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery compositions
US4917686A (en) 1985-12-16 1990-04-17 Colorado Biomedical, Inc. Antimicrobial device and method
IE59361B1 (en) 1986-01-24 1994-02-09 Akzo Nv Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension
US5219885A (en) 1987-02-16 1993-06-15 Froelich Juergen Prostaglandin E1 derivatives as pharmaceutically active agents, and pharmaceutical compositions containing these compounds, especially for transcutaneous administration
US4804691A (en) 1987-08-28 1989-02-14 Richards Medical Company Method for making a biodegradable adhesive for soft living tissue
EP0310037B1 (en) 1987-09-28 1993-07-14 Kuraray Co., Ltd. Leather-like sheet material and method of producing same
US5035891A (en) 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
JP2538953B2 (ja) 1987-11-17 1996-10-02 三菱重工業株式会社 工業用ロボットのバランス機構
AU2800489A (en) 1987-12-02 1989-07-05 Tyndale Plains-Hunter Ltd. Hydrophilic polyurethanes of improved strength
EP0401210A4 (en) 1988-02-01 1990-12-27 Tyndale Plains-Hunter, Ltd. Thermally reversible polyurethane hydrogels and cosmetic, biological and medical uses
US5064653A (en) 1988-03-29 1991-11-12 Ferris Mfg. Co. Hydrophilic foam compositions
IE60383B1 (en) 1988-05-27 1994-07-13 Elan Corp Plc Controlled release pharmaceutical formulation
US5219663A (en) 1988-06-22 1993-06-15 Hitachi Maxell, Ltd. Magnetic recording medium having a magnetic layer formed from an aromatic polycarbonate polyurethane resin
JPH024736A (ja) 1988-06-22 1990-01-09 Hitachi Maxell Ltd ポリカーボネートポリオール、芳香族ポリカーボネートポリウレタン樹脂、コーティング材、キャストフィルム、磁気記録媒体
JP2613441B2 (ja) 1988-07-18 1997-05-28 トヨタ自動車株式会社 発泡ポリウレタンの製法
US5000955A (en) 1988-07-29 1991-03-19 Tyndale Plains-Hunter Ltd. Thermally reversible polyurethane hydrogels and cosmetic, biological and medical uses
US4933418A (en) 1988-08-10 1990-06-12 Ormco Corporation Stain-resistant orthodontic device
US4895934A (en) 1988-08-22 1990-01-23 E. I. Du Pont De Nemours And Company Process for the preparation of clindamycin phosphate
SE463851B (sv) 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
US5470829A (en) 1988-11-17 1995-11-28 Prisell; Per Pharmaceutical preparation
FR2641786B1 (fr) 1989-01-19 1992-09-11 Sami Composition de polymere d'urethanne et preparation d'articles a partir de ces polymeres
DE3903538A1 (de) 1989-02-07 1990-08-16 Basf Ag Herstellung von emulgatorfreien, waessrigen polyurethandispersionen
ES2010145A6 (es) 1989-03-02 1989-10-16 Uriach & Cia Sa J Procedimiento para la obtencion de derivados de la 2-picolilamina.
US5888930A (en) 1989-03-27 1999-03-30 Bend Research, Inc. Asymmetric microporous beads for controlled release
US5002540A (en) 1989-05-22 1991-03-26 Warren Kirschbaum Intravaginal device and method for delivering a medicament
US5034461A (en) 1989-06-07 1991-07-23 Bausch & Lomb Incorporated Novel prepolymers useful in biomedical devices
US5061254A (en) 1989-06-21 1991-10-29 Becton, Dickinson And Company Thermoplastic elastomeric hydrophilic polyetherurethane expandable catheter
US5178874A (en) 1989-06-30 1993-01-12 Smithkline Beechman Corporation Intermittent release dosage form
US5110598A (en) 1989-06-30 1992-05-05 Smithkline Beecham Corp. Intermittent release dosage form
JP2844474B2 (ja) 1989-07-19 1999-01-06 ダイセル化学工業株式会社 ポリウレタンの製造方法
GB8918589D0 (en) 1989-08-15 1989-09-27 Graham Neil B Polymeric compositions
US5118779A (en) 1989-10-10 1992-06-02 Polymedica Industries, Inc. Hydrophilic polyurethane elastomers
AU636668B2 (en) 1989-10-18 1993-05-06 Ferris Corp. Process for preparing a sheet of polymer-based foam
DE4006521A1 (de) 1990-03-02 1991-09-05 Bayer Ag Zuckerhaltige polymere zur umhuellung und einbettung von arzneistoffen
EP0456176A3 (en) 1990-05-09 1992-03-25 The Cloeren Company Extrusion apparatus
DE4019171A1 (de) 1990-06-15 1991-12-19 Henkel Kgaa Beschichtungsmittel
GB2244920B (en) 1990-06-16 1994-05-25 British Aerospace A contraceptive device
US5130126A (en) 1990-07-09 1992-07-14 Nippon Oil & Fats Co., Ltd. Polymer-drug conjugate and a method of producing it
ES2084825T3 (es) 1990-07-26 1996-05-16 Monsanto Co Procedimiento de preparacion de poliamidas entrecruzadas.
US5326632A (en) 1990-08-07 1994-07-05 Komatsu Seiren Co., Ltd. Moisture-permeable waterproof fabric and process for production thereof
US5114718A (en) 1990-09-20 1992-05-19 The Procter & Gamble Company Sustained release compositions for treating periodontol disease
JPH05239205A (ja) 1991-02-13 1993-09-17 Ajinomoto Co Inc ポリアミノ酸ウレタン樹脂
GB2254002B (en) 1991-01-16 1995-03-22 Controlled Therapeutics Retrievable pessary
US5652274A (en) 1991-03-01 1997-07-29 Martin; Alain Therapeutic-wound healing compositions and methods for preparing and using same
US5159047A (en) 1991-06-14 1992-10-27 E. I. Du Pont De Nemours And Company Coatings containing caprolactone oligomer polyols
CA2071137A1 (en) 1991-07-10 1993-01-11 Clarence C. Lee Composition and method for revitalizing scar tissue
US5176907A (en) 1991-08-13 1993-01-05 The Johns Hopkins University School Of Medicine Biocompatible and biodegradable poly (phosphoester-urethanes)
US5322063A (en) 1991-10-04 1994-06-21 Eli Lilly And Company Hydrophilic polyurethane membranes for electrochemical glucose sensors
US5252602A (en) 1991-10-11 1993-10-12 Rafeul Alam Effects of misoprostol on allergic responses
DE69224294T2 (de) 1991-10-16 1998-08-20 Richardson Vicks Inc Verbesserte hautpenetrationssysteme fuer erhoehte topische freisetzung von arzneimitteln
US6117843A (en) 1992-02-18 2000-09-12 Lloyd J. Baroody Compositions for the treatment of acne containing clindamycin and benzoyl peroxide
US5650171A (en) 1992-04-29 1997-07-22 Penederm, Inc. Retinoic acid-containing polyether-polyurethane compositions
US5578643A (en) 1992-05-20 1996-11-26 Loyola University Of Chicago Protective prostaglandins for use in conjunction with chemotherapeutic agents
JP3119533B2 (ja) 1992-05-27 2000-12-25 日本ペイント株式会社 耐チッピング性塗料組成物
US5710215A (en) 1992-06-15 1998-01-20 Ebnother Ag Method and material mixture for manufacture of reactive hotmelts
JP2909477B2 (ja) 1992-07-16 1999-06-23 ビーティージー・インターナショナル・リミテッド 回収可能なペッサリー
DE4225045A1 (de) 1992-07-29 1994-02-03 Basf Ag Verwendung von wasserlöslichen oder in Wasser dispergierbaren Polyurethanen als Hilfsmittel in kosmetischen und pharmazeutischen Zubereitungen und Polyurethane, die Polymilchsäurepolyole einpolymerisiert enthalten
US5310759A (en) 1992-08-12 1994-05-10 Bockman Richard S Methods of protecting and preserving connective and support tissues
US6328991B1 (en) 1992-10-21 2001-12-11 John Myhling Composition and method for prevention of sexually transmitted diseases, including aids
EP0665733B1 (en) 1992-10-21 2003-05-07 Gynetech Laboratories, Inc. Vaginal sponge delivery system
US5747582A (en) 1992-10-29 1998-05-05 Bayer Aktiengesellschaft Aqueous coating compositions and their use for the preparation of coatings that are permeable to water vapor
DE4241118A1 (de) 1992-12-07 1994-06-09 Basf Ag Verwendung von kationischen Polyurethanen und Polyharnstoffen als Hilfsmittel in kosmetischen und pharmazeutischen Zubereitungen
DE4242687B8 (de) 1992-12-17 2006-01-12 Henkel Kgaa Hydrophile Polyurethane
DE4315173A1 (de) 1992-12-23 1994-06-30 Bayer Ag Reine, insbesondere katalysatorfreie Polyurethane
US5324746A (en) 1993-02-12 1994-06-28 Mckee Rex N Method of treating damaged mucosal and epithelial tissues with misoprostol
GB9306887D0 (en) 1993-04-01 1993-05-26 Graham Neil B Random block copolymers
US5328954A (en) 1993-04-16 1994-07-12 Icet, Inc. Encrusting and bacterial resistant coatings for medical applications
FR2705567A1 (fr) 1993-05-25 1994-12-02 Smith & Nephew Laboratoires Fi Microparticules, procédé de préparation et application aux pansements.
US6423788B1 (en) 1995-10-06 2002-07-23 Basf Corporation Curable coating composition
US5726244A (en) 1995-08-10 1998-03-10 Basf Corporation Aqueous coating compositions for environmental etch resistant coatings
US5777048A (en) 1996-06-20 1998-07-07 Basf Corporation Method for modified aminoplast compounds, aminoplasts obtained thereby and coatings containing the same
US5827930A (en) 1995-10-06 1998-10-27 Basf Corporation Curable coating composition
US5994479A (en) 1993-07-28 1999-11-30 Basf Corporation Curable coating compositions containing blends of carbamate-functional compounds
CA2128637C (en) 1993-07-28 2003-01-14 John W. Rehfuss Curable polyureas
US6080825A (en) 1993-07-28 2000-06-27 Basf Corporation Curable coating compositions containing blends of carbamate-functional compounds
US5792810A (en) 1995-10-06 1998-08-11 Basf Corporation Curable coating composition including compound having carbamate and hydroxyl functionality
US6084038A (en) 1993-07-28 2000-07-04 Basf Corporation Curable coating compositions containing blends of carbamate-functional compounds
US5744550A (en) 1994-11-03 1998-04-28 Basf Corporation Curable coating compositions containing carbamate additives
US5854385A (en) 1995-10-06 1998-12-29 Basf Corporation Coating compositions with low molecular weight carbamate or urea component
US5770650A (en) 1995-10-06 1998-06-23 Basf Corporation Curable compositions for coatings
US6160058A (en) 1993-07-28 2000-12-12 Basf Corporation Curable coating compositions containing blends of carbamate-functional compounds
JPH0753663A (ja) * 1993-07-30 1995-02-28 Takiron Co Ltd 経皮吸収製剤用基剤ポリマー
US5514698A (en) 1994-03-21 1996-05-07 Ortho Pharmaceutical Corporation Antifungal vaginal cream composition
US5472785A (en) 1994-04-12 1995-12-05 Minnesota Mining And Manufacturing Company Reactive wax-containing moisture curable hot melt composition
US5985859A (en) 1994-04-14 1999-11-16 The University Of Alabama Methods of inhibiting bacterial sialidase
IL109539A0 (en) 1994-05-03 1994-08-26 Yissum Res Dev Co Substained-release pharmaceutical system for the delivery of antioxidants
PL181729B1 (en) 1994-05-25 2001-09-28 Henkel Kgaa Fusible polyurethane glue hardenable by exposure to moisture
US5681278A (en) 1994-06-23 1997-10-28 Cormedics Corp. Coronary vasculature treatment method
DE4481181T1 (de) 1994-09-01 1997-07-17 Gore & Ass Hydrophiles Polyurethan
GB9419566D0 (en) 1994-09-27 1994-11-16 El Refaey Hazem Oral prostagladins for the routine management of the third stage of labour
US5563233A (en) 1994-11-16 1996-10-08 Tyndale Plains-Hunter, Ltd. Polyether polyurethane polymers and gels having improved absorption and slip properties
IL116433A (en) 1994-12-19 2002-02-10 Galen Chemicals Ltd INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS
US5659003A (en) 1994-12-21 1997-08-19 Basf Corporation Polyurethane polymer or oligomer having carbamate groups, method for its preparation, and coating composition
AU4652596A (en) 1995-01-09 1996-07-31 Atrix Laboratories, Inc. Liquid polymer delivery system
US20030158369A1 (en) 1995-02-02 2003-08-21 Slagel Edwin C. Impact resistant polyurethane and method of manufacture thereof
GB9506946D0 (en) * 1995-04-04 1995-05-24 Univ Strathclyde Microgels
US6093270A (en) 1995-05-26 2000-07-25 Henkel Kommanditgesellscahft Auf Aktien Bonding process
DK0828495T3 (da) 1995-06-01 2003-02-24 Searle & Co Misoprostolholdige faste stabiliserede dispersioner
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US5968542A (en) 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
US7833543B2 (en) 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US5733538A (en) 1995-06-07 1998-03-31 Thoratec Laboratories, Inc. Surface-modifying copolymers having cell adhesion properties
US5900433A (en) 1995-06-23 1999-05-04 Cormedics Corp. Vascular treatment method and apparatus
US5948416A (en) 1995-06-29 1999-09-07 The Procter & Gamble Company Stable topical compositions
WO1997005185A2 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
KR19990044445A (ko) 1995-09-13 1999-06-25 니뽄 신야쿠 가부시키가이샤 Ｐｇｅ1 함유 동결건조 제제 및 그 제법
DE19541326A1 (de) 1995-11-06 1997-05-07 Basf Ag Wasserlösliche oder wasserdispergierbare Polyurethane mit endständigen Säuregruppen, ihre Herstellung und ihre Verwendung
DE19541658A1 (de) 1995-11-08 1997-05-15 Basf Ag Wasserlösliche oder wasserdispergierbare Pfropfpolymere, ihre Herstellung und ihre Verwendung
US6008312A (en) 1995-12-01 1999-12-28 Hokushin Corp Method for producing millable polyurethanes and polyurethane elastomers
EP0776921A3 (en) 1995-12-01 1997-08-13 Hokushin Corp Process for the production of amorphous polymer chains in elastomers
JPH09157409A (ja) * 1995-12-01 1997-06-17 Nippon Miractran Kk 透湿フィルム又はシート、及びその製造方法
PT869772E (pt) 1995-12-27 2002-03-28 Janssen Pharmaceutica Nv Forma galenica solida bioadesiva
US6521164B1 (en) 1996-02-06 2003-02-18 Parker-Hannifin Corporation Injection-moldable thermoplastic polyurethane elastomer
US5627254A (en) 1996-05-03 1997-05-06 The Dow Chemical Company Rigid thermoplastic plyurethane comprising units of butane diol and a polyethylene glycol
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
EP0847428A1 (en) 1996-07-01 1998-06-17 Basf Corporation Curable coating compositions containing carbamate additives
US5972372A (en) 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
US5993972A (en) * 1996-08-26 1999-11-30 Tyndale Plains-Hunter, Ltd. Hydrophilic and hydrophobic polyether polyurethanes and uses therefor
CA2279651A1 (en) 1996-09-05 1998-03-12 Massachusetts Institute Of Technology Compositions and methods for treatment of neurological disorders and neurodegenerative diseases
US6184248B1 (en) 1996-09-05 2001-02-06 Robert K. K. Lee Compositions and methods for treatment of neurological disorders and neurodegenerative diseases
DE19638570A1 (de) 1996-09-20 1998-03-26 Bayer Ag Wirkstoffhaltige thermoplastische Polyurethane
US6130309A (en) 1996-09-20 2000-10-10 Tyndale Plains-Hunter, Ltd. Hydrophilic polyether polyurethanes containing carboxylic acid
WO1998020058A1 (en) 1996-11-04 1998-05-14 Imperial Chemical Industries Plc Rigid polyurethane foams
ATE318580T1 (de) 1996-12-20 2006-03-15 Alza Corp Gelzusammensetzungen und verfahren
US5853767A (en) 1997-01-02 1998-12-29 Melman; Steven A. Compositions for treating fungal, parasitic and/or bacterial infections, especially infections of organs such as the skin and vagina
US20050208152A1 (en) 1997-01-22 2005-09-22 Marton Milankovits Pharmaceutical compositions primarily for the treatment and prevention of genitourinary infections and their extragenital complications
WO1998044952A1 (en) 1997-04-04 1998-10-15 Monsanto Company pH-SELECTIVE DELIVERY SYSTEM USING CROSS-LINKED POLYMERIC RESINS AS VEHICLES
US20020115814A1 (en) 1997-04-28 2002-08-22 Woodhouse Kimberly Ann Incorporation by reference of co-pending application
US6221997B1 (en) 1997-04-28 2001-04-24 Kimberly Ann Woodhouse Biodegradable polyurethanes
GR1002847B (el) 1997-05-06 1998-01-27 Χρηση της μισοπροστολης ή/και της μισοπροστολης οξυ για την παρασκευη φαρμακευτικου προιοντος για τη θεραπευτικη αντιμετωπιση των δυσλειτουργιων της στυσεως
JPH10332902A (ja) 1997-05-27 1998-12-18 Nippon Ee R C Kk プラスチックレンズとその製造方法及びプライマー組成物
US6197327B1 (en) 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
ES2123466B1 (es) 1997-06-11 1999-11-16 Merquinsa Mercados Quimicos S Termoplastico de poliuretano y procedimiento para su obtencion.
US6572874B1 (en) 1998-05-15 2003-06-03 Umd, Inc. Vaginal delivery of bisphosphonates
US6416779B1 (en) 1997-06-11 2002-07-09 Umd, Inc. Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections
US6039968A (en) 1997-06-24 2000-03-21 Hoechst Marion Roussel Intravaginal drug delivery device
US6103765A (en) 1997-07-09 2000-08-15 Androsolutions, Inc. Methods for treating male erectile dysfunction
CA2295595A1 (en) 1997-07-09 1999-01-21 Androsolutions, Inc. Improved methods and compositions for treating male erectile dysfunction
JP3130273B2 (ja) 1997-08-05 2001-01-31 三菱樹脂株式会社 雨どい
AU752603B2 (en) 1997-08-25 2002-09-26 Union Carbide Chemicals & Plastics Technology Corporation Condensation copolymers having surpressed crystallinity
DE19737348C2 (de) 1997-08-27 2002-07-25 Dan-Gabriel Vulpescu Neue Clindamycin und Clotrimazol enthaltende pharmazeutische Zusammensetzung
DE59807989D1 (de) * 1997-09-24 2003-05-22 Henkel Kgaa Polyurethan-klebstoff
DE19742217A1 (de) 1997-09-24 1999-04-01 Henkel Kgaa Hydrophiles, hochmolekulares Polyurethan, Klebstoffzusammensetzungen, die dieses enthalten sowie Verwendung dieses Polyurethans
DE19744473A1 (de) 1997-10-09 1999-04-15 Basf Ag Verwendung von wasserlöslichen oder wasserdispergierbaren Polyurethanen als Überzugsmittel oder Bindemittel für pharmazeutische Darreichungsformen
US20020004529A1 (en) 1997-10-20 2002-01-10 Gary W. Neal Methods, compositions, and kits for enhancing female sexual desire and responsiveness
US6593369B2 (en) 1997-10-20 2003-07-15 Vivus, Inc. Methods, compositions, and kits for enhancing female sexual desire and responsiveness
US20040044080A1 (en) 1997-10-28 2004-03-04 Place Virgil A. Treatment of dyspareunia with topically administered nitroglycerin formulations
US20040014761A1 (en) 1997-10-28 2004-01-22 Place Virgil A. Treatment of female sexual dysfunction with phosphodiesterase inhibitors
US20020013304A1 (en) 1997-10-28 2002-01-31 Wilson Leland F. As-needed administration of an androgenic agent to enhance female sexual desire and responsiveness
AU740758B2 (en) 1997-10-28 2001-11-15 Vivus, Inc. Treatment of female sexual dysfunction
US20020099003A1 (en) 1997-10-28 2002-07-25 Wilson Leland F. Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof
US20050070516A1 (en) 1997-10-28 2005-03-31 Vivus Inc. As-needed administration of an androgenic agent to enhance female desire and responsiveness
US5877216A (en) 1997-10-28 1999-03-02 Vivus, Incorporated Treatment of female sexual dysfunction
US6046244A (en) 1997-11-05 2000-04-04 Nexmed Holdings, Inc. Topical compositions for prostaglandin E1 delivery
US6414028B1 (en) 1997-11-05 2002-07-02 Nexmed Holdings, Inc. Topical compositions containing prostaglandin E1
AU1137899A (en) 1997-11-17 1999-06-07 Cosma International Inc. Projection welded panel spacer and method of making the same
ES2138918B1 (es) 1997-11-20 2000-09-16 Merquinsa Mercados Quimicos S Termoplastico de poliuretano cristalino y metodo para su obtencion.
US20020031513A1 (en) 1997-11-24 2002-03-14 Shamir Leibovitz Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals
GB2331924A (en) 1997-12-08 1999-06-09 Phares Pharm Res Nv Lipid compositions and their use
US6022554A (en) 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
DE19757569A1 (de) 1997-12-23 1999-06-24 Bayer Ag Aliphatische, emissionsarme, sinterfähige thermoplastische Polyurethanformmassen
US5959775A (en) 1997-12-23 1999-09-28 3M Innovative Properties Company Urethane/acrylate bead bond for retroreflective articles
AU751848B2 (en) 1998-01-28 2002-08-29 Bristol-Myers Squibb Company Methods of preparing polyurethane adhesives, adhesives produced thereby and medical devices employing the same
US6028057A (en) 1998-02-19 2000-02-22 Thorn Bioscience, Llc Regulation of estrus and ovulation in gilts
KR100684055B1 (ko) 1998-03-19 2007-02-16 머크 앤드 캄파니 인코포레이티드 생물활성 물질의 방출 조절용 액체 중합체성 조성물
US6423345B2 (en) 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6031002A (en) 1998-05-01 2000-02-29 Michael Ebert Method for enhancing female sexual response and a composition therefor
US5891915A (en) 1998-05-01 1999-04-06 Wysor; Michael S. Method for enhancing female sexual response and an ointment therefor
US6013637A (en) 1998-06-12 2000-01-11 Dermik Laboratories Inc. Anti-acne method and composition
US5942545A (en) 1998-06-15 1999-08-24 Macrochem Corporation Composition and method for treating penile erectile dysfunction
CN1321092A (zh) 1998-06-30 2001-11-07 安姆根有限公司 用于生物活性剂的延缓给药的热敏生物可降解水凝胶
DE19847791A1 (de) 1998-10-16 2000-04-20 Bayer Ag Wäßrige Polyurethandispersionen
NL1010367C2 (nl) 1998-10-21 2000-04-25 Akzo Nobel Nv Waterdampdoorlatende thermoplastische polyurethaanfilm.
DE19849499A1 (de) 1998-10-27 2000-05-04 Basf Ag Verfahren zur vollständigen Trocknung von Hydrogelen
GB9826192D0 (en) 1998-12-01 1999-01-20 Controlled Theraputics Scotlan Oral transmucosal delivery
US6486207B2 (en) 1998-12-10 2002-11-26 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
US20050004226A1 (en) 1998-12-10 2005-01-06 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
US6825234B2 (en) 1998-12-10 2004-11-30 Nexmed (Holdings) , Inc. Compositions and methods for amelioration of human female sexual dysfunction
DE19900457A1 (de) 1999-01-08 2000-07-13 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen
DE10004723A1 (de) 2000-02-03 2001-08-09 Bayer Ag Wässrige Sperrschicht auf Basis von Polyurethan-Disperionen
EP1035145A3 (en) 1999-03-08 2000-12-20 Toyo Boseki Kabushiki Kaisha Magnetic recording media and thermoplastic polyurethane resins therefor
ES2244422T3 (es) 1999-04-01 2005-12-16 Alza Corporation Dispositivos para la administracion transdermica de farmacos que comprenden un deposito de poliuretano para farmacos.
DE19915932A1 (de) 1999-04-09 2000-10-19 Freudenberg Carl Fa Thermoplastisch verarbeitbare Polyurethan-Formmasse
US6607686B2 (en) 1999-04-20 2003-08-19 Callaway Golf Company Thermosetting polyurethane material for a golf ball
US6117024A (en) 1999-04-20 2000-09-12 Callaway Golf Company Golf ball with polyurethane cover
US6592472B2 (en) 1999-04-20 2003-07-15 Callaway Golf Company Golf ball having a non-yellowing cover
IT1312310B1 (it) 1999-05-07 2002-04-15 Recordati Ind Chimica E Farma Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale
TWI232111B (en) 1999-08-06 2005-05-11 Upjohn Co Intravaginal clindamycin ovule composition
US6642274B1 (en) 1999-09-09 2003-11-04 Gary W. Neal Methods and compositions for preventing and treating prostate disorders
US6323241B1 (en) 2000-01-10 2001-11-27 Nexmed (Holdings) Inc. Prostaglandin compositions and methods of treatment for male erectile dysfunction
US7105571B2 (en) 2000-01-10 2006-09-12 Nexmed Holdings, Inc. Prostaglandin compositions and methods of treatment for male erectile dysfunction
US6693135B2 (en) 2000-01-10 2004-02-17 Nexmed (Holdings) Incorporated Prostaglandin compositions and methods of treatment for male erectile dysfunction
US20040110843A1 (en) 2000-01-10 2004-06-10 Nexmed (Holdings), Inc. Methods of treatment of male erectile dysfunction
IT1317735B1 (it) 2000-01-26 2003-07-15 Nicox Sa Sali di agenti antimicrobici.
DE10028810A1 (de) 2000-06-10 2001-12-20 Henkel Kgaa Polyurethan-Zusammensetzungen auf der Basis von Polyester-Block-Copolymeren
US6803495B2 (en) 2000-06-28 2004-10-12 World Properties, Inc. Polyurethane foam composition and method of manufacture thereof
US6740333B2 (en) 2000-07-07 2004-05-25 Anestic Aps Suppository and composition comprising at least one polyethylene glycol
JP4378667B2 (ja) * 2000-09-11 2009-12-09 東レ・オペロンテックス株式会社 ポリウレタン繊維の製造方法
DE10050137A1 (de) 2000-10-11 2002-04-18 Bayer Ag Stabilisierte Mono- und Polyasparaginsäureester
DE10051392A1 (de) 2000-10-17 2002-04-18 Bayer Ag Elektroisolierlackbindemittel mit Harnstoff- und/oder Hydantoinstruktur
JP5027962B2 (ja) 2000-10-19 2012-09-19 Ｄｉｃ株式会社 液状ウレタンプレポリマーの製造方法および樹脂組成物
US6811549B2 (en) 2001-02-16 2004-11-02 William H. Fleming Administration of therapeutic or diagnostic agents using interlabial pad
DE10112366B4 (de) 2001-03-15 2006-06-08 Bayer Materialscience Ag Aliphatische thermoplastische Polyurethane und ihre Verwendung
JP5025857B2 (ja) * 2001-06-12 2012-09-12 日清紡ホールディングス株式会社 分離膜モジュールの洗浄用ゲル粒子、製法及び洗浄方法
US6881788B2 (en) 2001-08-21 2005-04-19 Mitsui Takeda Chemicals, Inc. Polyurethane resin water dispersion and aqueous polyurethane adhesive
WO2003059373A2 (en) 2002-01-16 2003-07-24 Ramot At Tel Aviv University Ltd. Compositions and their use for enhancing and inhibiting fertilization
CH697081A5 (de) 2002-01-22 2008-04-30 Andreas F Dr Schaub Zusammensetzung für die Unterstützung der Geburt eines menschlichen Föten.
WO2003065924A1 (en) 2002-02-08 2003-08-14 Advanced Animal Technology Limited Control of a biological function
NZ517094A (en) 2002-02-08 2005-03-24 Advanced Animal Technology Ltd Improvements in and relating to substance delivery device
US6861503B2 (en) 2002-02-27 2005-03-01 Poly-Med, Inc. Interlinked solid polyethylene glycols and copolymers thereof
US6897281B2 (en) 2002-04-05 2005-05-24 Noveon Ip Holdings Corp. Breathable polyurethanes, blends, and articles
US7358295B2 (en) 2002-04-05 2008-04-15 Lubrizol Advanced Materials, Inc. Hybrid polymer composition, and article therefrom
US7179481B2 (en) 2002-09-19 2007-02-20 Kimberly-Clark Worldwide, Inc. Vaginal health products
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US6894140B2 (en) 2002-10-28 2005-05-17 Tyco Healthecare Gropu Lp Fast curing compositions
US20040142847A1 (en) 2002-11-21 2004-07-22 Rolf Bayersdoerfer Detergent tablets with polyurethane coating
US20050181030A1 (en) 2003-01-03 2005-08-18 Mo Y. J. Topical stabilized prostaglandin E compound dosage forms
US6841574B2 (en) 2003-01-03 2005-01-11 Nexmed Holdings, Inc. Topical stabilized prostaglandin E compound dosage forms
WO2004065450A2 (en) 2003-01-16 2004-08-05 Carnegie Mellon University Biodegradable polyurethanes and use thereof
GB0301577D0 (en) 2003-01-23 2003-02-26 Edko Pazarlama Tanitim Ltd Sti Topical pharmaceutical and/or cosmetic dispense systems
CN1292038C (zh) * 2003-03-14 2006-12-27 天津大学 亲水性聚氨酯压敏胶及其制备方法
GB0306977D0 (en) 2003-03-26 2003-04-30 Metris Therapeutics Ltd Device
WO2004091579A1 (en) 2003-04-16 2004-10-28 Pharmacia Corporation Stabilized prostaglandin formulation
JP4898431B2 (ja) 2003-04-29 2012-03-14 ザ ジェネラル ホスピタル コーポレイション 複数薬物の持続放出のための方法およびデバイス
US20040266688A1 (en) 2003-05-14 2004-12-30 Nayak Nihar R Methods for modulating endometrium
JP2005002691A (ja) 2003-06-13 2005-01-06 Nippon Yusoki Co Ltd 埋設用磁気マーカー、その製造方法、及び車両誘導設備
US8399013B2 (en) 2003-06-26 2013-03-19 Poly-Med, Inc. Partially absorbable fiber-reinforced composites for controlled drug delivery
US8404272B2 (en) 2003-06-26 2013-03-26 Poly-Med, Inc. Fiber-reinforced composite rings for intravaginal controlled drug delivery
CN1822815B (zh) 2003-07-10 2012-04-11 沃纳奇尔科特(爱尔兰)有限公司 阴道内药物传递装置
WO2005013906A2 (en) 2003-08-08 2005-02-17 Sri International pH-RESPONSIVE FILM FOR INTRAVAGINAL DELIVERY OF A BENEFICIAL AGENT
WO2005027807A1 (en) 2003-09-19 2005-03-31 Drugtech Corporation Pharmaceutical delivery system
ATE289514T1 (de) 2003-11-03 2005-03-15 Peter-Hansen Volkmann Vaginalpflegezusammensetzung
ES2235654B1 (es) 2003-12-26 2006-08-01 Instituto Nacional De Investigacion Y Tecnologia Agraria Y Alimentaria (Inia) Metodo de induccion y sincronizacion de la ovulacion para la inseminacion artificial sistematica en ganado caprino.
EP1555278A1 (en) 2004-01-15 2005-07-20 Innocore Technologies B.V. Biodegradable multi-block co-polymers
RU2350763C2 (ru) 2004-01-28 2009-03-27 Нью Конденсейтор, Инк. Сепаратор для отделения жидкостей из потока текучей среды (варианты)
US20050169975A1 (en) 2004-02-03 2005-08-04 Nitto Denko Corporation Film base material for adhesive skin patch and adhesive skin patch
DE102004008015A1 (de) 2004-02-19 2005-09-08 Cognis Deutschland Gmbh & Co. Kg Verdickungsmittel für Polyurethanbasis
TW200604249A (en) 2004-03-24 2006-02-01 Commw Scient Ind Res Org Biodegradable polyurethane and polyurethane ureas
WO2005097210A1 (en) 2004-03-26 2005-10-20 The University Of Utah Research Foundation Bioresponsive polymer system for delivery of microbicides
CN100448488C (zh) 2004-03-29 2009-01-07 三洋化成工业株式会社 医疗用粘接剂和止血用密封剂
WO2005100429A1 (en) 2004-04-15 2005-10-27 The University Of Utah Research Foundation Bioresponsive polymer system for delivery of microbicides
US7485666B2 (en) 2004-06-17 2009-02-03 Kimberly-Clark Worldwide, Inc. Vaginal health products
US20060003950A1 (en) 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
DE102004031786A1 (de) 2004-07-01 2006-01-26 Cognis Deutschland Gmbh & Co. Kg Verdickungsmittel auf Polyurethanbasis
JP5017109B2 (ja) 2004-07-09 2012-09-05 ザ・ポピュレイション・カウンシル，インコーポレイテッド プロゲステロン受容体モジュレーターを含有する徐放性組成物
US8460378B2 (en) 2004-07-26 2013-06-11 DePuy Sythes Products, LLC Biocompatible, biodegradable polyurethane materials with controlled hydrophobic to hydrophilic ratio
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
WO2006024138A1 (en) 2004-08-30 2006-03-09 Taro Pharmaceutical Industries Ltd. A thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol
US20060093675A1 (en) 2004-10-29 2006-05-04 Mathew Ebmeier Intravaginal treatment of vaginal infections with metronidazole compositions
GB0424526D0 (en) 2004-11-05 2004-12-08 Controlled Therapeutics Sct Hydrogel delivery vehicle
WO2006084082A1 (en) 2005-02-03 2006-08-10 Duramed Pharmaceuticals, Inc. Compositions of unconjugated estrogens and methods for their use
WO2006089561A1 (en) 2005-02-23 2006-08-31 Abbas Abdelsalam Ghazi Pharmaceutical compositions containing organic acids useful for softening and ripening uterine cervix.
US7795467B1 (en) 2005-04-26 2010-09-14 Advanced Cardiovascular Systems, Inc. Bioabsorbable, biobeneficial polyurethanes for use in medical devices
TW200744610A (en) 2005-06-21 2007-12-16 Organon Nv New regimens for controlled drug delivery devices for contraception
TW200727920A (en) 2005-06-21 2007-08-01 Organon Nv New regimens for oral monophasic contraceptives
WO2007012006A1 (en) 2005-07-19 2007-01-25 The Population Council, Inc. Methods and compositions for emergency contraception using endothelin receptor antagonists
EP2633834A1 (en) 2005-12-06 2013-09-04 Covidien LP Bioabsorbable Surgical Composition
CA2630327C (en) 2005-12-08 2015-05-26 Tyco Healthcare Group Lp Biocompatible surgical compositons
US20070148105A1 (en) 2005-12-22 2007-06-28 Donald Spector Compositions and methods comprising magnetic particles for health use
WO2007086128A1 (ja) 2006-01-26 2007-08-02 Komatsu Seiren Co., Ltd. 耐久性のある透湿性防水シート用ポリウレタン樹脂組成物、透湿性防水シートおよびその製造方法
US20090011209A1 (en) 2006-03-06 2009-01-08 Basf Se Nonwoven based on thermoplastic polyurethane
AU2007240613B2 (en) 2006-04-20 2013-11-28 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
US8177706B2 (en) 2006-07-10 2012-05-15 Mcneil-Ppc, Inc. Method of treating urinary incontinence
MX2009000053A (es) 2006-07-12 2009-02-23 Controlled Therapeutics Sct Polimero para el suministro de medicamentos con sal clorhidrato de clindamicina.
WO2008037258A1 (en) 2006-09-28 2008-04-03 H. Lundbeck A/S [2-(6-flouro-1h-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
US20100104619A1 (en) 2006-11-22 2010-04-29 N.V. Organon Delivery system for a non-steroidal non-ionized hydrophilic drug
US7781651B2 (en) 2007-04-30 2010-08-24 Monsanto Technology Llc Plants and seeds of corn variety CV715590
ES2696999T3 (es) 2007-06-26 2019-01-21 Allergan Pharmaceuticals Int Ltd Dispositivos de administración intravaginal de medicamentos para la administración de macromoléculas y medicamentos solubles en agua
EP2173362A2 (en) 2007-06-27 2010-04-14 University Of Utah Compositions and methods for inhibiting viral and bacterial activity
AR066166A1 (es) 2007-09-21 2009-07-29 Organon Nv Sistema de suministro de droga
US8660175B2 (en) 2007-12-10 2014-02-25 Qualcomm Incorporated Selective display of interpolated or extrapolated video units
CN101977651A (zh) 2008-01-25 2011-02-16 犹他大学研究基金会 线性级释放聚合物
FI20085277A0 (fi) 2008-04-02 2008-04-02 Bayer Schering Pharma Oy Kohdunsisäinen järjestelmä
US20090269480A1 (en) 2008-04-24 2009-10-29 Medtronic Vascular, Inc. Supercritical Fluid Loading of Porous Medical Devices With Bioactive Agents
WO2010036878A1 (en) 2008-09-26 2010-04-01 The Trustees Of Columbia University In The City Of New York Use of trpv1 receptor agonists in cervical pain and labor
BRPI0919388B1 (pt) 2008-09-29 2019-02-19 Mitsubishi Chemical Corporation Método para produzir ácido succínico derivado de recursos de biomassa
WO2010119029A1 (en) 2009-04-14 2010-10-21 Laboratoire Hra-Pharma Method for on-demand contraception
AU2010274946B2 (en) 2009-07-21 2013-09-12 The Population Council, Inc. Multi-layered gradient vaginal ring
FI123146B (fi) 2009-10-01 2012-11-30 Bayer Schering Pharma Oy Kohdunsisäinen järjestelmä
US20110150955A1 (en) 2009-12-23 2011-06-23 Shannon Elizabeth Klingman Products and Methods for Reducing Malodor from the Pudendum

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