ES2573253T3 - Métodos para el suministro de anestésicos volátiles para anestesia regional y/o alivio del dolor - Google Patents

Métodos para el suministro de anestésicos volátiles para anestesia regional y/o alivio del dolor Download PDF

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Publication number
ES2573253T3
ES2573253T3 ES07842927.1T ES07842927T ES2573253T3 ES 2573253 T3 ES2573253 T3 ES 2573253T3 ES 07842927 T ES07842927 T ES 07842927T ES 2573253 T3 ES2573253 T3 ES 2573253T3
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supply
methods
pain relief
regional anesthesia
isoflurane
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English (en)
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Phillip C. Phan
Allen W. Burton
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University of Texas System
University of Texas at Austin
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University of Texas System
University of Texas at Austin
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Un anestésico de éter halogenado disuelto en una preparación farmacéutica para uso en un método para reducir el dolor en un sujeto en necesidad de dicha reducción del dolor, el método comprende administrar dicha preparación farmacéutica tópicamente en una cantidad efectiva para reducir el dolor, en donde dicho anestésico es isoflurano, y en donde dicho sujeto es un humano o en donde dicho sujeto es un ratón o una rata.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8
imagen9
imagen10
CONTROL
5 MIN 10 MIN 15 MIN 30 MIN 60 MIN
RATA 1
4.8 11 5.4 7.6 6.8 6.1
4.4
15 9 7.3 7.2 5.8.
4.8
19.5 9 8.8 4.9 5.1
20
6.8 7 5.2 4.9
RATA 2
3.4 10.9 9.9 10.4 8.2 3.8
4.3
12.6 8.7 9.4 6.9 4.7
3.6
18.1 12 5.4 8.1 7
17.3
9 13.4 6.4 4.1
RATA 3
3.6 14.2 12.2 6.1 5.2 4.2
3.8
20 12 7.1 6.1 3.5
4.7
20 9.1 4.8 5.8 3.3
16
8.9 5.2 6.5 3.8
RATA 5
3.9 9.8 8.8 7.9 4.9 4.2
2.6
11.8 7.8 6.4 4.3 3.5
2.6
9.1 10.2 6.9 4.7 3.8
11.8
8.1 4.3 3.8 3.5
media
3.875 14.81875 9.18125 7.375 5.9375 4.45625
DE
0.767671 3.809235 1.77067 2.231171 1.266331 1.073293
Ejemplo III (ejemplo de referencia)
Inhibición intratecal del dolor utilizando isoflurano disuelto en fluido cerebroespinal artificial
Se mide la sensibilidad al dolor después de la administración intratecal de isoflurano en fluido cerebroespinal artificial
5 (ACSF). Adicionalmente, como se detalla adelante, el isoflurano primero se disuelve en ACSF y luego se somete a sonicación antes de la administración. La relación de respuesta de dosis luego se evalúa al generar una gráfica de estímulo-respuesta (SR) con el propósito de determinar concentraciones relevantes de isoflurano que se pueden administrar intratecalmente para lograr analgesia o anestesia. La caracterización del perfil farmacológico de la administración intratecal de isoflurano in ACSF se realiza en este ejemplo utilizando ratas; adicionalmente, como lo
10 apreciaría un experto en la técnica, se pueden utilizar métodos análogos para determinar el perfil farmacológico preciso en humanos.
Se prepara isoflurano disuelto en ACSF mediante el siguiente método. Se mezcla isoflurano en un recipiente vacío cerrado en una relación v/v de 10-50% con solución de sal regulada que aproxima fluido cerebroespinal (pH 7.4) con la siguiente composición (en mM): NaCl, 120; KCl, 3; NaHCO3. 25; CaCl2, 2.5; MgCl2, 0.5; glucosa, 12. Las
15 soluciones combinadas se agitan mecánicamente durante 3-5 min y luego se mantienen en un sonicador termoneutro hasta uso.
12
imagen11
Sorkin et al., Anesthesiology, 95:965-973, 2001. Takenoshita et al., Progress in Anesthetic Mechanism, 3(1994): 326-329,1995 Yaksh et al., J. Appl. Physiol., 90:2386-2402, 2001.
14

Claims (1)

  1. imagen1
    imagen2
ES07842927.1T 2006-09-20 2007-09-20 Métodos para el suministro de anestésicos volátiles para anestesia regional y/o alivio del dolor Active ES2573253T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US84629306P 2006-09-20 2006-09-20
US846293P 2006-09-20
US94721907P 2007-06-29 2007-06-29
US947219P 2007-06-29
PCT/US2007/079097 WO2008036858A2 (en) 2006-09-20 2007-09-20 Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief

Publications (1)

Publication Number Publication Date
ES2573253T3 true ES2573253T3 (es) 2016-06-06

Family

ID=39092912

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ES07842927.1T Active ES2573253T3 (es) 2006-09-20 2007-09-20 Métodos para el suministro de anestésicos volátiles para anestesia regional y/o alivio del dolor

Country Status (9)

Country Link
US (3) US20080119820A1 (es)
EP (1) EP2081562B1 (es)
JP (4) JP2010504359A (es)
AU (1) AU2007299738B2 (es)
CA (1) CA2663857C (es)
DK (1) DK2081562T3 (es)
ES (1) ES2573253T3 (es)
PL (1) PL2081562T3 (es)
WO (1) WO2008036858A2 (es)

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CA2663857A1 (en) 2008-03-27
CA2663857C (en) 2017-10-31
JP2016041721A (ja) 2016-03-31
DK2081562T3 (en) 2016-05-30
US10357464B2 (en) 2019-07-23
WO2008036858A3 (en) 2008-08-07
JP2014074028A (ja) 2014-04-24
EP2081562A2 (en) 2009-07-29
JP2017218450A (ja) 2017-12-14
AU2007299738A1 (en) 2008-03-27
US20190358173A1 (en) 2019-11-28
AU2007299738B2 (en) 2013-03-28
US20110269843A1 (en) 2011-11-03
JP5827658B2 (ja) 2015-12-02
JP6312146B2 (ja) 2018-04-18
US10799466B2 (en) 2020-10-13
EP2081562B1 (en) 2016-02-24
JP2010504359A (ja) 2010-02-12
US20080119820A1 (en) 2008-05-22
WO2008036858A2 (en) 2008-03-27
PL2081562T3 (pl) 2017-05-31

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