ES2625351T1 - Método para eliminar bacterias de la sangre utilizando caudal alto - Google Patents

Método para eliminar bacterias de la sangre utilizando caudal alto Download PDF

Info

Publication number
ES2625351T1
ES2625351T1 ES15782250.3T ES15782250T ES2625351T1 ES 2625351 T1 ES2625351 T1 ES 2625351T1 ES 15782250 T ES15782250 T ES 15782250T ES 2625351 T1 ES2625351 T1 ES 2625351T1
Authority
ES
Spain
Prior art keywords
bacteria
sample
adsorption
subject
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES15782250.3T
Other languages
English (en)
Other versions
ES2625351T3 (en
Inventor
Keith Mccrea
Robert Ward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exthera Medical Corp
Original Assignee
Exthera Medical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exthera Medical Corp filed Critical Exthera Medical Corp
Publication of ES2625351T1 publication Critical patent/ES2625351T1/es
Application granted granted Critical
Publication of ES2625351T3 publication Critical patent/ES2625351T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0057—Special media to be introduced, removed or treated retained by adsorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/20—Pathogenic agents
    • A61M2202/203—Bacteria
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/62—In a cartridge

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • External Artificial Organs (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Un método ex vivo para eliminar bacterias de una muestra extraída de un sujeto que se sospecha que está infectado con bacterias, comprendiendo el método: poner en contacto una muestra extraída del sujeto con un medio de adsorción para permitir la formación de un complejo adherente, en el que el complejo adherente comprende bacterias y medio de adsorción; y separar la muestra del complejo adherente para producir la muestra con una cantidad reducida de bacterias.

Claims (48)

  1. 5
    10
    15
    20
    25
    30
    35
    40
    45
    50
    55
    60
    65
    REIVINDICACIONES
    1. Un metodo ex vivo para eliminar bacterias de una muestra extralda de un sujeto que se sospecha que esta infectado con bacterias, comprendiendo el metodo:
    poner en contacto una muestra extralda del sujeto con un medio de adsorcion para permitir la formacion de un complejo adherente, en el que el complejo adherente comprende bacterias y medio de adsorcion; y separar la muestra del complejo adherente para producir la muestra con una cantidad reducida de bacterias.
  2. 2. El metodo de la reivindicacion 1, en el que la muestra se selecciona del grupo que consiste en sangre entera, suero y plasma.
  3. 3. El metodo de la reivindicacion 2, en el que la muestra es sangre entera.
  4. 4. El metodo de la reivindicacion 1, en el que el medio de adsorcion es un sustrato solido de area superficial alta que tiene una superficie hidrofila desprovista de adsorbente polisacarldico.
  5. 5. El metodo de la reivindicacion 4, en el que el sustrato solido comprende una pluralidad de microesferas polimericas rlgidas.
  6. 6. El metodo de la reivindicacion 5, en el que la microesfera polimerica rlgida es un miembro seleccionado del grupo que consiste en poliuretano, polimetilmetacrilato, polietileno o copollmeros de etileno y otros monomeros, polietilen imina, polipropileno y poliisobutileno.
  7. 7. El metodo de la reivindicacion 4, en el que el sustrato solido comprende una o una pluralidad de fibras huecas.
  8. 8. El metodo de la reivindicacion 4, en el que el sustrato solido comprende fibras solidas o hilo tejido fabricado de fibras solidas.
  9. 9. El metodo de la reivindicacion 4, en el que la superficie hidrofila es una superficie cationica.
  10. 10. El metodo de la reivindicacion 1, en el que el medio de adsorcion tiene un area superficial alta como resultado de una superficie o topografla rugosa.
  11. 11. El metodo de la reivindicacion 4, en el que la superficie hidrofila es una superficie con carga neutra.
  12. 12. El metodo de la reivindicacion 1, en el que las bacterias en la muestra se reducen de aproximadamente aproximadamente 99,9 %.
  13. 13. El metodo de la reivindicacion 12, en el que las bacterias en la muestra se reducen de aproximadamente aproximadamente 40 %.
  14. 14. El metodo de la reivindicacion 1, en el que las bacterias son bacterias gram negativas.
  15. 15. El metodo de la reivindicacion 1, en el que las bacterias son bacterias gram positivas.
  16. 16. El metodo de la reivindicacion 1, en el que las bacterias se seleccionan del grupo que consiste en Escherichia coli, Klebsiella pneumoniae, Escherichia coli resistente a carbapenemo, Klebsiella pneumoniae resistente a carbapenemo y Klebsiella pneumoniae productora de betalactamasa de espectro ampliado, Enterococcus faecium, Acinetobacter baumannii y Staphylococcus aureus resistente a meticilina (SARM).
  17. 17. El metodo de la reivindicacion 1, en el que las bacterias se seleccionan del grupo que consiste en Staphylococcus aureus, Staphylococcus aureus resistente a meticilina (SARM) y Escherichia coli.
  18. 18. El metodo de la reivindicacion 1, en el que la muestra tiene un caudal lineal de aproximadamente 8 cm/min a aproximadamente 1000 cm/min.
  19. 19. El metodo de la reivindicacion 1, en el que la muestra tiene un caudal volumetrico de aproximadamente 50 ml/min a aproximadamente 5 l/min.
  20. 20. Un metodo ex vivo para eliminar bacterias de una muestra extralda de un sujeto que se sospecha que esta infectado con bacterias, en el que se sabe que las bacterias tienen una baja afinidad, o ninguna, por sulfato de heparan, comprendiendo el metodo:
    poner en contacto una muestra extralda del sujeto con un medio de adsorcion para permitir la formacion de un complejo adherente, en el que el medio de adsorcion es un sustrato solido de area superficial alta que tiene al
    20 % a 20 % a
    5
    10
    15
    20
    25
    30
    35
    40
    45
    50
    55
    60
    65
    menos un adsorbente polisacarldico en su superficie; y
    separar la muestra del complejo adherente para producir la muestra con una cantidad reducida de bacterias.
  21. 21. El metodo de la reivindicacion 20, en el que la muestra se selecciona del grupo que consiste en sangre entera, suero y plasma.
  22. 22. El metodo de la reivindicacion 21, en el que la muestra es sangre entera.
  23. 23. El metodo de la reivindicacion 20, en el que el sustrato solido comprende una pluralidad de microesferas polimericas rlgidas.
  24. 24. El metodo de la reivindicacion 20, en el que el complejo adherente comprende bacterias y el medio de adsorcion.
  25. 25. El metodo de la reivindicacion 23, en el que la microesfera polimerica rlgida es un miembro seleccionado del grupo que consiste en poliuretano, polimetilmetacrilato, polietileno o copollmeros de etileno y otros monomeros, polietilen imina, polipropileno y poliisobutileno.
  26. 26. El metodo de la reivindicacion 20, en el que el sustrato solido comprende una o una pluralidad de fibras huecas.
  27. 27. El metodo de la reivindicacion 20, en el que el al menos un absorbente polisacarldico es un miembro seleccionado del grupo que consiste en heparina, heparan sulfato, acido hialuronico, acido sialico, hidratos de carbono con secuencias de manosa y quitosano.
  28. 28. El metodo de la reivindicacion 27, en el que el al menos un absorbente polisacarldico es heparina o heparan sulfato.
  29. 29. El metodo de la reivindicacion 28, en el que el al menos un absorbente polisacarldico es heparina.
  30. 30. El metodo de la reivindicacion 29, en el que las microesferas se recubren con aproximadamente de 0,27 mg a aproximadamente 10 mg de heparina por gramo de microesfera.
  31. 31. El metodo de la reivindicacion 30, en el que la microesfera se recubre con 2+0,5 mg de heparina por gramo de microesfera.
  32. 32. El metodo de la reivindicacion 20, en el que las bacterias en la muestra se reducen de aproximadamente 20 % a aproximadamente 99,9 %.
  33. 33. El metodo de la reivindicacion 20, en el que las bacterias en la muestra se reducen de aproximadamente 20 % a aproximadamente 40 %.
  34. 34. El metodo de la reivindicacion 20, en el que las bacterias en la muestra fracasan en un ensayo de union a heparina in vitro.
  35. 35. El metodo de la reivindicacion 16, en el que las bacterias son bacterias gram negativas.
  36. 36. El metodo de la reivindicacion 16, en el que las bacterias son bacterias gram positivas.
  37. 37. El metodo de la reivindicacion 20, en el que las bacterias se seleccionan del grupo que consiste en Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Enterococcus faecium, Escherichia coli resistente a carbapenemo, Klebsiella pneumoniae resistente a carbapenemo y Klebsiella pneumoniae productora de betalactamasa de espectro ampliado.
  38. 38. El metodo de la reivindicacion 20, en el que la muestra tiene un caudal lineal de aproximadamente 8 cm/min a aproximadamente 1000 cm/min.
  39. 39. El metodo de la reivindicacion 20, en el que la muestra tiene un caudal volumetrico de aproximadamente 50 ml/min a aproximadamente 5 l/min.
  40. 40. Un metodo ex vivo para eliminar bacterias de una muestra extralda de un sujeto que se somete a dialisis, comprendiendo el metodo:
    poner en contacto una muestra extralda del sujeto con un cartucho de adsorcion que comprende medios de adsorcion, en el que el cartucho de adsorcion esta en serie con un cartucho de dialisis para permitir la formacion de un complejo adherente; y
    separar la muestra del complejo adherente para producir la muestra con una cantidad reducida de bacterias.
    5
    10
    15
    20
    25
    30
  41. 41. El metodo de la reivindicacion 40, en el que la muestra tiene un volumen de sangre total menor de 200 ml.
  42. 42. El metodo de la reivindicacion 40, en el que el cartucho de adsorcion tiene una altura de columna entre 1 cm-50 cm.
  43. 43. El metodo de la reivindicacion 40, en el que el cartucho de adsorcion tiene un diametro de columna entre 1 cm- 50 cm.
  44. 44. El metodo de la reivindicacion 40, en el que el cartucho de adsorcion es proximal al sujeto en comparacion con el cartucho de dialisis.
  45. 45. El metodo de la reivindicacion 40, en el que el cartucho de adsorcion es distal al sujeto en comparacion con el cartucho de dialisis.
  46. 46. El metodo de la reivindicacion 40, en el que el complejo adherente comprende bacterias y medios de adsorcion.
  47. 47. El metodo de la reivindicacion 40, en el que la muestra tiene un caudal lineal de aproximadamente 8 cm/min a aproximadamente 1000 cm/min.
  48. 48. El metodo de la reivindicacion 40, en el que la muestra tiene un caudal volumetrico de aproximadamente 50 ml/min a aproximadamente 5 l/min.
ES15782250T 2014-04-24 2015-04-17 Method for removing bacteria from blood using high flow rate Active ES2625351T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461984013P 2014-04-24 2014-04-24
US201461984013P 2014-04-24
PCT/US2015/026340 WO2015164198A1 (en) 2014-04-24 2015-04-17 Method for removing bacteria from blood using high flow rate

Publications (2)

Publication Number Publication Date
ES2625351T1 true ES2625351T1 (es) 2017-07-19
ES2625351T3 ES2625351T3 (en) 2025-04-07

Family

ID=54333028

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15782250T Active ES2625351T3 (en) 2014-04-24 2015-04-17 Method for removing bacteria from blood using high flow rate

Country Status (12)

Country Link
US (2) US20170035956A1 (es)
EP (1) EP3134146B1 (es)
JP (3) JP2017513636A (es)
KR (1) KR20170020749A (es)
CN (1) CN106255520B (es)
AU (2) AU2015250107A1 (es)
BR (1) BR112016024569B1 (es)
CA (1) CA2946294C (es)
DE (1) DE15782250T1 (es)
ES (1) ES2625351T3 (es)
MX (1) MX2016013873A (es)
WO (1) WO2015164198A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101397386B1 (ko) 2005-12-13 2014-05-26 엑스테라 메디컬 코퍼레이션 혈액으로부터 병원성 미생물, 염증 세포 또는 염증단백질의 체외 제거를 위한 방법
ES2861359T3 (es) 2009-12-01 2021-10-06 Exthera Medical Corp Dispositivo para eliminar citoquinas de la sangre con polisacáridos inmovilizados en superficie
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
EP2861273B1 (en) 2012-06-13 2017-08-23 ExThera Medical Corporation Use of heparin and carbohydrates to treat cancer
BR112015032134B1 (pt) 2013-06-24 2022-05-10 Exthera Medical Corporation Método de ligação em ponto de extremidade de uma manose não redutora a um substrato e esfera possuindo uma manose ligada em ponto de extremidade
BR112016009827B1 (pt) 2013-11-08 2021-10-26 Exthera Medical Corporation Método in vitro para concentrar patógenos infecciosos presentes em uma amostra biológica obtida a partir de um indivíduo sob suspeita de estar infectado com os ditos patógenos, concentrador e kit
EP3134146B1 (en) 2014-04-24 2024-12-25 ExThera Medical Corporation Method for removing bacteria from blood using high flow rate
US10857283B2 (en) 2014-09-22 2020-12-08 Exthera Medical Corporation Wearable hemoperfusion device
WO2017151797A1 (en) 2016-03-02 2017-09-08 Exthera Medical Corporation Method for treating drug intoxication
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
JP7033083B2 (ja) * 2016-05-26 2022-03-09 サイトソーベンツ・コーポレーション 内毒素血症誘発分子を除去するための血液適合性多孔質ポリマービーズ収着材の使用
EP3548164A1 (en) * 2016-11-29 2019-10-09 Gambro Lundia AB Membrane for the adsorption of bacteria
EP3388140A1 (en) * 2017-04-10 2018-10-17 Gambro Lundia AB Extracorporeal blood circuit
AU2018346535A1 (en) * 2017-10-05 2020-04-30 Minnetronix, Inc. Systems, catheters, and methods for treating along the central nervous system
JP7429343B2 (ja) 2018-01-05 2024-02-08 パス イーエックス，インク． 流体からの疾患材料の捕捉および除去のためのデバイス
WO2020231830A1 (en) 2019-05-16 2020-11-19 Exthera Medical Corporation Method for modulating endothelial glycocalyx structure
KR102419508B1 (ko) * 2020-10-14 2022-07-11 대전보건대학교 산학협력단 신규한 메티실린-내성 황색포도상구균 검출 방법 및 이의 용도
US20240001017A1 (en) * 2020-11-30 2024-01-04 Alteco Medical Ab Device for binding and separation of at least one component from a body fluid
CN114011389B (zh) * 2021-12-08 2023-10-31 广州康盛生物科技股份有限公司 一种用于脓毒血症的血液净化材料及其制备方法和应用
KR102863574B1 (ko) * 2022-12-16 2025-09-22 서울대학교산학협력단 병원 내 2차 감염을 감소시키기 위한 혈액관류장치
JPWO2024177096A1 (es) 2023-02-21 2024-08-29
WO2025117428A1 (en) * 2023-11-29 2025-06-05 Exthera Medical Corporation Fluidized bed extracorporeal treatment device
CN120437731B (zh) * 2025-07-09 2025-11-04 天津泰达洁净材料有限公司 一种熔喷pbt非织造布复合滤材及其制备方法与应用

Family Cites Families (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3782382A (en) 1972-02-03 1974-01-01 K N Enterprises Inc Means for blood administration and the like
US4103685A (en) 1976-01-05 1978-08-01 Lupien Paul J Method and apparatus for extravascular treatment of blood
JPS54127493U (es) 1978-02-25 1979-09-05
US4430496A (en) 1980-01-17 1984-02-07 Varian Associates, Inc. Strong anion exchange composition and methods
US4415665A (en) 1980-12-12 1983-11-15 Pharmacia Fine Chemicals Ab Method of covalently binding biologically active organic substances to polymeric substances
JPS5853757A (ja) 1981-09-25 1983-03-30 Denki Kagaku Kogyo Kk 免疫アフイニテイクロマトグラフイ−用吸着体及びその製法
SE8200751L (sv) 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
JPS58146354A (ja) 1982-02-26 1983-08-31 日機装株式会社 体液浄化器の製造法
US4820302A (en) 1982-04-22 1989-04-11 Sterling Drug Inc. Bio compatible and blood compatible materials and methods
CA1221307A (en) 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent and process for preparing the same
JPS59227827A (ja) 1983-06-10 1984-12-21 Nippon Koutai Kenkyusho:Kk マラリア原虫由来糖鎖関連抗原及びその製造法
FR2558063B1 (fr) 1984-01-18 1987-02-20 Hospal Ind Rein artificiel a aiguille unique
DE3609021A1 (de) 1985-03-25 1986-09-25 Bio-Rad Laboratories, Inc., Richmond, Calif. Chromatographisches trennmedium fuer die schnelle analyse von kleinen proben
DE3519011A1 (de) 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
DE3880647T2 (de) 1987-11-20 1993-11-18 Kanegafuchi Chemical Ind Sorbentmittel für Serum-Amyloid-Proteine.
US4955870A (en) 1988-08-23 1990-09-11 Ridderheim Kristen A Hypodermic syringe with retractable needle
JPH0489500A (ja) 1990-07-31 1992-03-23 Kirin Brewery Co Ltd アフィニティクロマトグラフィーによる物質の精製法および精製装置
US5227049A (en) 1990-08-20 1993-07-13 Hospal Industrie Single-needle circuit for circulating blood outside the body in blood treatment apparatus
FR2672219B1 (fr) 1991-02-06 1998-09-11 Hospal Ind Procede de commande de la circulation du sang dans un circuit a aiguille unique.
SE469256B (sv) 1991-02-18 1993-06-14 Medscand Ab Rengoeringsprodukt
WO1992017502A1 (en) 1991-03-26 1992-10-15 Otsuka Pharmaceutical Factory, Inc. Adsorbed cellular fibronectin and process for separating and purifying fibronectins
US5211850A (en) 1991-07-26 1993-05-18 Research Medical, Inc. Plasma filter sorbent system for removal of components from blood
DE4217917A1 (de) 1992-05-30 1993-12-02 Job Prof Dr Med Harenberg Immobilisation von chemisch kovalent gebundenem Heparin an Polymere mit Arylresten im Polymer
DE4331358A1 (de) 1992-10-12 1994-04-14 Braun Melsungen Ag Verfahren zur quantitativen selektiven Entfernung oder präparativen Gewinnung von Tumor-Nekrose-Faktor (TNF) oder/und Lipopolysacchariden (LPS) aus wäßrigen Flüssigkeiten
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5437861A (en) 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
NO931809L (no) 1993-05-19 1994-11-21 Norsk Hydro As Hemofilter
US5447859A (en) 1993-07-16 1995-09-05 Viagene Method for the purification or removal of retroviruses using sulfated cellulose
US5753227A (en) 1993-07-23 1998-05-19 Strahilevitz; Meir Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases
WO1995005400A1 (en) 1993-08-19 1995-02-23 Minnesota Mining And Manufacturing Company Heparin functional affinity supports
JPH07178161A (ja) 1993-12-24 1995-07-18 Terumo Corp 医療器具
SE9501056D0 (sv) 1995-03-23 1995-03-23 Probi Ab Epithelial adherent lactobacilli
US6312907B1 (en) 1995-04-24 2001-11-06 The Texas A & M University System DbpA compositions and methods of use
DE19515554C2 (de) 1995-04-27 1999-06-17 Braun Melsungen Ag Verwendung eines Mittels und Vorrichtung zur simultanen extrakorporalen Elimination von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus Vollblut oder/und Blutplasma
DE69638094D1 (de) 1995-06-07 2010-01-21 Cerus Corp Verfahren und vorrichtungen zur entfernung von psoralenen aus blutprodukten.
US6544727B1 (en) 1995-06-07 2003-04-08 Cerus Corporation Methods and devices for the removal of psoralens from blood products
WO1997000969A1 (de) 1995-06-20 1997-01-09 Johannes Schumacher Verfahren und vorrichtung zur bestimmung der aktivität von enzymen in flüssigkeiten, beziehungsweise der konzentration und/oder aktivität von inhibitoren in flüssigkeiten
DE69722491T2 (de) 1996-03-18 2004-05-19 Kaneka Corp. Adsorbens und Verfahren zur Entfernung von Chemokinen des CC-Subtyps aus Körperflüssigkeiten
RU2089283C1 (ru) 1996-03-23 1997-09-10 Научно-исследовательская фирма "Ультрасан" Био-, гемосовместимые сорбенты на основе сверхсшитых полимеров стирола с модифицированной поверхностью, способ их получения (варианты) и способ получения матрицы сорбента
SE507028C2 (sv) 1996-08-06 1998-03-16 Medicarb Ab Ny medicinsk användning
WO1998029727A2 (en) 1996-12-31 1998-07-09 Stephon, Robert, L. Microsphere-enhanced immunoassay for the detection of veterinary diseases
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
WO1998042392A1 (en) 1997-03-25 1998-10-01 Kaneka Corporation Adsorbent for eliminating hepatitis c virus, adsorber, and adsorption method
AU8211398A (en) 1997-05-27 1998-12-30 Akzo Nobel N.V. Use of oligosaccharide for preventing blood clotting in extracorporeal blood circuits
US6465170B2 (en) 1997-06-13 2002-10-15 Baxter Aktiengesellschaft Method for depleting viral and molecular pathogens in a biological material
US6197568B1 (en) 1997-07-29 2001-03-06 The Regents Of The University Of Michigan Method and compositions for isolation, diagnosis and treatment of polyanion-binding microorganisms
US20020197250A1 (en) 2001-04-10 2002-12-26 Renal Tech International Biocompatible devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood
US20020159995A1 (en) 1997-07-30 2002-10-31 Renal Tech International Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood, generated as a result of extracorporeal blood processing
US20020197249A1 (en) 2001-04-10 2002-12-26 Renal Tech International Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products
US6053894A (en) 1997-08-04 2000-04-25 Shadd, Jr.; Daniel L. Hypodermic syringe
US7611831B2 (en) 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US6136424A (en) 1998-02-06 2000-10-24 Renal Tech International, Llc Method of and material for purification of physiological liquids of organism, and method of producing the material
GB9804632D0 (en) 1998-03-05 1998-04-29 Cantab Pharma Res Virus preparations and methods
US8197430B1 (en) 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
JP2000086688A (ja) 1998-09-04 2000-03-28 Ngk Insulators Ltd パルボウイルス吸着糖鎖リガンドおよびこれを利用したパルボウイルス除去装置
NO984143L (no) 1998-09-09 2000-03-10 Norsk Hydro As Ny prosess for å fremstille overflatemodifiserende stoffer
CA2347004A1 (en) 1998-10-19 2000-04-27 Cbd Technologies Ltd. Methods of concentrating microorganisms using affinity separation
EP1066843B1 (en) 1998-12-24 2011-08-24 Toray Industries, Inc. Column for purifying blood
JP2000217575A (ja) 1999-02-01 2000-08-08 Masashi Funayama 生理活性物質、ヒト血球分化細胞およびヒト細胞の吸着体。
DE19916352A1 (de) 1999-04-12 2000-10-19 Braun Melsungen Ag Entfernung von hüllehaltigen Viren aus Blut, Plasma oder Serum
SE515295C2 (sv) 1999-11-23 2001-07-09 Medicarb Ab Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat
JP2001178817A (ja) 1999-12-24 2001-07-03 Terumo Corp 人工腎臓用装置およびこれを用いた品質評価装置ならびに流体回路
US7067060B2 (en) * 2000-01-11 2006-06-27 Nephros, Inc. Ionic enhanced dialysis/diafiltration system
JP2001190273A (ja) 2000-01-14 2001-07-17 Jsr Corp ウイルス濃縮用粒子、該粒子を使用するウイルス濃縮方法およびウイルス検出方法
GB0001450D0 (en) 2000-01-21 2000-03-08 Genpoint As Cell isolation method
US7179660B1 (en) 2000-03-06 2007-02-20 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use
EP1192963A4 (en) 2000-04-05 2004-08-25 Toray Industries ADSORBENTS FOR PROTEINS OF THE HIGH MOBILITY PROTEIN AND PILLAR GROUP FOR CLEANING BODY LIQUIDS
US7181261B2 (en) 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
DE10045434B4 (de) 2000-09-14 2005-07-14 Fresenius Hemocare Gmbh Adsorbens mit unterschiedlich modifizierten Oberflächenbereichen, Verfahren zu dessen Herstellung und Verwendung davon
JP4283430B2 (ja) 2000-09-26 2009-06-24 株式会社カネカ エンテロトキシンの吸着材、吸着除去方法および吸着器
US8153121B2 (en) 2000-10-06 2012-04-10 Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center Diagnosis and therapy of antibody-mediated inflammatory autoimmune disorders
US8178304B2 (en) 2000-10-06 2012-05-15 Smith Terry J Diagnostic methods relating to Graves' disease and other autoimmune disorders
US6509104B2 (en) 2000-12-05 2003-01-21 Michigan Biotechnology Institute Antithrombogenic polymer coating
EP1884274A1 (en) 2000-12-29 2008-02-06 Upfront Chromatography A/S Extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids
KR100804542B1 (ko) 2001-01-30 2008-02-20 가부시키가이샤 가네카 직접 혈액관류가 가능한 체액 처리기
DE10117043A1 (de) 2001-04-05 2002-11-07 Gerhard Puetz Verfahren zur Eliminierung von potentiell toxischen und/oder schädlichen Stoffen
US20020197252A1 (en) 2001-04-10 2002-12-26 Renal Tech International Selective adsorption devices and systems
US6773412B2 (en) 2001-04-13 2004-08-10 Chf Solutions, Inc. User interface for blood treatment device
JP2003128502A (ja) 2001-10-18 2003-05-08 Noritake Co Ltd 有害物質の処理材およびその製造方法
KR20040050912A (ko) 2001-10-10 2004-06-17 가부시키가이샤 노리타케 캄파니 리미티드 생물학적 유해 물질을 선택적으로 불활성화 하는 광촉매재료 및 그 이용
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US20030148017A1 (en) 2001-12-07 2003-08-07 Olli Tuominen Copolymer coating for a hydrophobic membrane
WO2003078023A1 (en) 2002-03-14 2003-09-25 Baxter International Inc. Compound removal device
AU2003234194A1 (en) 2002-04-23 2003-11-10 Meir Strahilevitz Methods and devices for targeting a site in a mammal and for removing species from a mammal
US7488309B2 (en) 2002-07-03 2009-02-10 Bioanalytical Systems, Inc. Device and method for drug delivery to animals
EP1521624A2 (en) 2002-07-11 2005-04-13 Upfront Chromatography A/S An extracorporeal stabilised expanded bed adsorption method for the treatment of sepsis
ATE426808T1 (de) 2002-07-24 2009-04-15 Bio Rad Laboratories Proteininteraktionsdifferenzabbildung
US20040182783A1 (en) 2003-03-17 2004-09-23 Walker Kimberly A. Filter and concentrator device for treatment of blood
US7207964B2 (en) * 2003-03-17 2007-04-24 Hemavation, Llc Apparatus and method for down-regulating immune system mediators in blood
JP4662932B2 (ja) 2003-08-15 2011-03-30 ユニバーシティー オブ サウス フロリダ 試料からの病原体の捕獲およびアウリントリカルボン酸除去のための物質および方法
US7399400B2 (en) 2003-09-30 2008-07-15 Nano-Proprietary, Inc. Nanobiosensor and carbon nanotube thin film transistors
EP1689347A4 (en) 2003-11-19 2009-01-14 Novartis Vaccines & Diagnostic METHODS AND REAGENTS FOR THE TREATMENT, PREVENTION AND DIAGNOSIS OF BUNYAVIRUS INFECTION
US7540958B2 (en) 2004-03-08 2009-06-02 Gambro Lundia Ab Device for controlling blood circulation for a single needle circuit
US8273357B2 (en) 2004-07-16 2012-09-25 Massachusetts Institute Of Technology Antigen-carbohydrate conjugates
CN1988926B (zh) 2004-07-23 2010-05-05 株式会社钟化 填充有除去了水不溶性微粒的吸附材料的直接血液灌注用吸附器、与除去了水不溶性微粒的直接血液灌注用吸附材料的取得方法
DE102004037475A1 (de) 2004-07-30 2006-03-23 Heinrich, Hans-Werner, Prof. Dr. Filtersystem zur membrangetrennten, adsorptiven Behandlung partikelhaltiger Flüssigkeiten
DE112005001901T5 (de) 2004-08-04 2007-07-12 Aspira Biosystems Inc., Incline Village Einfangen und entfernen von Biomolekülen aus Körperflüssigkeiten unter Verwendung von partiellen molekularen Abdrücken
US7850858B2 (en) 2004-08-30 2010-12-14 Kaneka Corporation Granulocyte adsorbent
US8445293B2 (en) 2005-02-09 2013-05-21 Rapid Pathogen Screening, Inc. Method to increase specificity and/or accuracy of lateral flow immunoassays
GB0509433D0 (en) 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
EP1899450A4 (en) 2005-06-24 2010-03-24 Univ Texas SYSTEMS AND METHODS INCLUDING INCLUDED CASSETTES WITH DEFINITION SYSTEMS AND LIQUIDITY SUPPLY SYSTEMS
WO2008045021A2 (en) 2005-08-01 2008-04-17 Rensselaer Polytechnic Institute Blood compatible nanomaterials and methods of making and using the same
AU2006316039B2 (en) 2005-11-21 2011-08-18 Ge Healthcare Bio-Sciences Ab A method of chromatography using semi-synthetic heparin ligands
KR101397386B1 (ko) 2005-12-13 2014-05-26 엑스테라 메디컬 코퍼레이션 혈액으로부터 병원성 미생물, 염증 세포 또는 염증단백질의 체외 제거를 위한 방법
EP1963854B1 (en) 2005-12-21 2021-02-03 Meso Scale Technologies, LLC Assay apparatuses, methods and reagents
CA2643140C (en) 2006-02-22 2014-12-09 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits
US7763097B2 (en) 2006-06-08 2010-07-27 University of Pittsburgh—of the Commonwealth System of Higher Education Devices, systems and methods for reducing the concentration of a chemical entity in fluids
AU2007259677B2 (en) 2006-06-16 2012-07-26 Terumo Kabushiki Kaisha Blood treatment filter and blood treatment circuit
FR2902670B1 (fr) 2006-06-22 2009-04-24 Gambro Lundia Ab Utilisation d'une suspension pour traiter un support a usage medical, support a usage medical, echangeur et dispositif d'adsorption comprenant le support
WO2008147382A1 (en) 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
EP2097750A2 (en) 2006-10-26 2009-09-09 Abbott Laboratories Immunoassay of analytes in samples containing endogenous anti-analyte antibodies
GB0702183D0 (en) 2007-02-05 2007-03-14 Iti Scotland Ltd Pathogen binding
WO2008128251A1 (en) 2007-04-17 2008-10-23 The Children's Hospital Of Philadelphia Humanized viral vectors and methods of use thereof
US20100145317A1 (en) 2007-04-19 2010-06-10 Morris Laster Device system and method for monitoring and controlling blood analyte levels
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
AU2008265838A1 (en) 2007-06-18 2008-12-24 Exthera Medical Llc Device and method for restoration of the condition of blood
JP4226050B1 (ja) 2007-09-12 2009-02-18 株式会社Ｒｅｉメディカル 体液浄化処理用吸着カラム
WO2009086343A2 (en) 2007-12-31 2009-07-09 3M Innovative Properties Company Microorganism-capturing compositions and methods
US11051733B2 (en) 2008-01-18 2021-07-06 Wake Forest University Health Sciences Isolating and purifying cells for therapy
EP2087916A1 (en) 2008-02-11 2009-08-12 ICinnovation BV Electrosorption device for the purification of blood and other fluids
CN101632686A (zh) 2008-04-04 2010-01-27 马斯特里赫特大学 糖胺聚糖用于修复糖萼的用途
BRPI0915397B8 (pt) 2008-06-23 2021-06-22 Temasek Polytechnic sorvente para um dispositivo de díalise
US20100021622A1 (en) 2008-07-24 2010-01-28 National Chiao Tung University Apparatus and method for forming multilayer polymer thin film
US20100040546A1 (en) 2008-08-13 2010-02-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Biological targeting compositions and methods of using the same
CN102186880A (zh) 2008-09-10 2011-09-14 Ith免疫治疗控股股份公司 炎症的治疗
US8310415B2 (en) 2008-09-30 2012-11-13 Animas Corporation Medical devices using bistable displays
US8454547B2 (en) 2009-02-25 2013-06-04 The Invention Science Fund I, Llc Device, system, and method for controllably reducing inflammatory mediators in a subject
US8801922B2 (en) 2009-06-24 2014-08-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Dialysis system
US20120219561A1 (en) 2009-07-31 2012-08-30 Ingeneron, Inc. Prophylaxis Against Cancer Metastasis
ES2861359T3 (es) 2009-12-01 2021-10-06 Exthera Medical Corp Dispositivo para eliminar citoquinas de la sangre con polisacáridos inmovilizados en superficie
US8366649B2 (en) 2009-12-09 2013-02-05 Araz Ibragimov Manually operated disposable single-needle circuit for extracorporeal treatment of blood
CA2786550C (en) 2010-02-09 2018-03-13 Exthera Medical, Llc Removal of virulence factors through extracorporeal therapy
WO2011133287A1 (en) 2010-04-19 2011-10-27 The Trustees Of Columbia University In The City Of New York Portable blood filtration devices, systems, and methods
ES2909788T3 (es) * 2010-10-15 2022-05-10 Seastar Medical Inc Cartucho de citaféresis y uso del mismo
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
US20130131423A1 (en) * 2011-04-12 2013-05-23 Tianxin Wang Methods to detect and treat diseases
ES2800316T3 (es) 2011-06-13 2020-12-29 Tla Targeted Immunotherapies Ab Tratamiento del cáncer
AU2012284097B2 (en) 2011-07-18 2017-08-03 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
EP2556849A1 (en) 2011-08-08 2013-02-13 Gambro Lundia AB Separation material
EP2861273B1 (en) 2012-06-13 2017-08-23 ExThera Medical Corporation Use of heparin and carbohydrates to treat cancer
US9717841B2 (en) 2012-09-11 2017-08-01 Gary L. McNeil Closed-circuit device and methods for isolation, modification, and re-administration of specific constituents from a biological fluid source
WO2014085713A1 (en) 2012-11-30 2014-06-05 The Methodist Hospital Research Institute Methods and compositions for detecting tuberculosis
BR112015032134B1 (pt) 2013-06-24 2022-05-10 Exthera Medical Corporation Método de ligação em ponto de extremidade de uma manose não redutora a um substrato e esfera possuindo uma manose ligada em ponto de extremidade
EP3049405A4 (en) 2013-09-26 2017-03-08 Pharmakea Inc. Autotaxin inhibitor compounds
BR112016009827B1 (pt) 2013-11-08 2021-10-26 Exthera Medical Corporation Método in vitro para concentrar patógenos infecciosos presentes em uma amostra biológica obtida a partir de um indivíduo sob suspeita de estar infectado com os ditos patógenos, concentrador e kit
EP3134146B1 (en) 2014-04-24 2024-12-25 ExThera Medical Corporation Method for removing bacteria from blood using high flow rate
US10857283B2 (en) 2014-09-22 2020-12-08 Exthera Medical Corporation Wearable hemoperfusion device
WO2016164643A1 (en) 2015-04-07 2016-10-13 Nxstage Medical, Inc. Blood treatment device priming devices, methods, and systems
WO2017001357A1 (en) 2015-06-29 2017-01-05 Gambro Lundia Ab Extracorporeal blood treatment apparatus for single-needle treatments
WO2017151797A1 (en) 2016-03-02 2017-09-08 Exthera Medical Corporation Method for treating drug intoxication
US9694344B2 (en) 2016-05-02 2017-07-04 LiSo Plastics, L.L.C. Multilayer polymeric membrane and process
CN206345699U (zh) 2016-09-13 2017-07-21 南京佳乐净膜科技有限公司 一种具有长效反冲洗功能的多级复合超微滤膜滤芯
US20200023001A1 (en) 2018-07-20 2020-01-23 Northeastern University GlycoFix (Structurally And Functionally Repaired Endothelial Glycocalyx)
WO2020231830A1 (en) 2019-05-16 2020-11-19 Exthera Medical Corporation Method for modulating endothelial glycocalyx structure
EP4072613A4 (en) 2019-12-12 2024-06-05 Stavro Medical, Inc. SYRINGE-BASED SYSTEMS FOR MANUAL EXTRACORPOREAL BLOOD TREATMENT AND BATCH PROCESSING METHODS
EP4073254B1 (en) 2019-12-12 2025-05-21 Stavro Medical, Inc. Extracorporeal blood treatment systems and methods employing batch processing
MX2023010736A (es) 2021-04-06 2023-09-20 Exthera Medical Corp Medios de filtracion.

Also Published As

Publication number Publication date
WO2015164198A1 (en) 2015-10-29
JP2022125040A (ja) 2022-08-26
JP2021045573A (ja) 2021-03-25
CA2946294C (en) 2023-03-21
AU2015250107A1 (en) 2016-11-17
CN106255520B (zh) 2022-08-12
US20170035956A1 (en) 2017-02-09
BR112016024569A8 (pt) 2021-06-01
US11844895B2 (en) 2023-12-19
MX2016013873A (es) 2017-03-09
EP3134146A1 (en) 2017-03-01
US20200171233A1 (en) 2020-06-04
CA2946294A1 (en) 2015-10-29
EP3134146B1 (en) 2024-12-25
BR112016024569A2 (pt) 2017-08-15
EP3134146A4 (en) 2018-01-10
JP2017513636A (ja) 2017-06-01
BR112016024569B1 (pt) 2023-01-03
JP7184864B2 (ja) 2022-12-06
CN106255520A (zh) 2016-12-21
DE15782250T1 (de) 2017-08-10
AU2020200029B2 (en) 2022-07-28
KR20170020749A (ko) 2017-02-24
ES2625351T3 (en) 2025-04-07
AU2020200029A1 (en) 2020-01-30

Similar Documents

Publication Publication Date Title
ES2625351T1 (es) Método para eliminar bacterias de la sangre utilizando caudal alto
JP2017513636A5 (es)
Kolewe et al. Antifouling electrospun nanofiber mats functionalized with polymer zwitterions
Ren et al. Highly stable, protein-resistant surfaces via the layer-by-layer assembly of poly (sulfobetaine methacrylate) and tannic acid
AU2014302884B2 (en) Blood filtration system containing mannose coated substrate
da Camara et al. Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins
Kara et al. Enhancement of antibacterial properties of polyurethanes by chitosan and heparin immobilization
KR101851960B1 (ko) 항혈전성 재료
Chen et al. Platelet adhesion to human umbilical vein endothelial cells cultured on anionic hydrogel scaffolds
Tu et al. Surface hemocompatible modification of polysulfone membrane via covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan
Chi et al. Anticoagulant polyurethane substrates modified with poly (2-methacryloyloxyethyl phosphorylcholine) via SI-RATRP
JP2022534191A (ja) 内皮糖衣構造を調節するための方法
Li et al. Controllable modification of polymer membranes by LDDLT plasma flow: Antibacterial layer onto PE hollow fiber membrane module
Hwang et al. Monocyte activation on polyelectrolyte multilayers
KR20170134571A (ko) 항혈전성 재료
Veregue et al. Chitosan/heparin and tanfloc (polyphenolic tannin)/heparin multilayers deposited on superhydrophilic poly (ε-caprolactone) fibers to enhance hemocompatibility
JP2017112910A (ja) 細胞分離材及びその用途
HK1231791B (en) Method for removing bacteria from blood using high flow rate
Sauer-Budge et al. Materials and surface properties optimization to prevent biofouling of a novel bacterial concentrator
HK1231791A1 (en) Method for removing bacteria from blood using high flow rate
Chen Self-Driven 3D Filtration Enabled by Porous Superabsorbent Polymer Beads for Environmental Applications