ES2653615T3 - Pluralidad de dosis de LAG-3 recombinante para su uso en la provocación de una respuesta inmunitaria de monocitos - Google Patents

Pluralidad de dosis de LAG-3 recombinante para su uso en la provocación de una respuesta inmunitaria de monocitos Download PDF

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ES2653615T3
ES2653615T3 ES12196313.6T ES12196313T ES2653615T3 ES 2653615 T3 ES2653615 T3 ES 2653615T3 ES 12196313 T ES12196313 T ES 12196313T ES 2653615 T3 ES2653615 T3 ES 2653615T3
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lag
immune response
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monocytes
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Frédéric Triebel
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Immutep SAS
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Abstract

Proteína LAG-3 recombinante LAG-3, o derivado de la misma que es un mutante o fragmento de LAG-3 que mantiene la capacidad de LAG-3 para unirse a moléculas MHC de clase II, que provoca una respuesta inmunitaria mediada por monocitos, y un agente de quimioterapia, para su uso en el tratamiento del cáncer mediante la administración de una pluralidad efectiva de dosis de la proteína LAG-3 recombinante o derivado de la misma, donde la proteína LAG-3 recombinante o derivado de la misma se debe administrar antes de, con, o posteriormente a la administración del agente de quimioterapia.

Description

imagen1
imagen2
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Se predice que el régimen posológico óptimo para IMP321 será de entre 6 y 30 mg/inyección.
Estas dosis han demostrado ser seguras y proporcionar una exposición sistémica aceptable en base a los resultados de los datos farmacocinéticos obtenidos en pacientes con cáncer de células renales metastásico (Figura 5). Podría 5 obtenerse una concentración en sangre de IMP321 superior a 1 ng/ml durante al menos 24 horas después de la inyección s.c. en pacientes inyectados con dosis de IMP321 de más de 6 mg (Figura 5).
Ejemplo 4: Tratamiento de pacientes con cáncer de páncreas avanzado que reciben dosis de gemcitabina y IMP321
10 Los pacientes, que reciben como una primera línea de quimioterapia para el cáncer de páncreas avanzado (o pacientes no elegibles para la extirpación quirúrgica del tumor) 6 ciclos de gemcitabina estándar (1 gm/m2 administrada por vía i.v. durante 30 min) en los días 1, 8 y 15 de un ciclo de 28 días, reciben además de 6 a 30 mg de IMP321 s.c. en los días 2 y 16 de cada ciclo de 28 días. O bien, IMP321 se administra en los días 3 o 17.
15 Por consiguiente, cada paciente recibe un ciclo estándar de 6 meses de gemcitabina con 12 inyecciones s.c. de IMP321, administrándose cada inyección uno a dos días después de la administración de gemcitabina en un esquema cada dos semanas.
20 El número de monocitos se analiza mediante clasificación de células activadas por fluorescencia (FACS) como en el ejemplo 1.
Lista de referencias
25 [1] TRIEBEL et al., J. Exp. Med., 171 : 1393-1405, 1990
[2] BRIGNONE et al., J. Immune Based Ther Immunotherapies, 5 : 5, 2007
[3] TRIEBEL et al., Trends Immunol., 24 : 619-622, 2003
[4] HUARD et al., Proc. Natl. Acad. Sci. USA, 94 : 5744-5749, 1997
[5] PRIGENT et al., Eur. J. Immunol., 29 : 3867-3876, 1999 30 [6] BRIGNONE et al., J. Immunol., 179: 4202-4211, 2007
7

Claims (1)

  1. imagen1
    imagen2
ES12196313.6T 2007-10-05 2008-10-03 Pluralidad de dosis de LAG-3 recombinante para su uso en la provocación de una respuesta inmunitaria de monocitos Active ES2653615T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07291214A EP2044949A1 (en) 2007-10-05 2007-10-05 Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
EP07291214 2007-10-05

Publications (1)

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ES2653615T3 true ES2653615T3 (es) 2018-02-08

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ID=38871960

Family Applications (4)

Application Number Title Priority Date Filing Date
ES12196316T Active ES2744700T3 (es) 2007-10-05 2008-10-03 Régimen de dosificación de LAG-3 para su uso en el tratamiento de cáncer
ES12196314T Active ES2705901T3 (es) 2007-10-05 2008-10-03 Composiciones que comprenden LAG-3 y anticuerpos terapéuticos y sus usos en el tratamiento de cáncer
ES08836333.8T Active ES2437333T3 (es) 2007-10-05 2008-10-03 Regímenes de dosificación de LAG-3Ig (IMP321) para uso en el tratamiento del cáncer
ES12196313.6T Active ES2653615T3 (es) 2007-10-05 2008-10-03 Pluralidad de dosis de LAG-3 recombinante para su uso en la provocación de una respuesta inmunitaria de monocitos

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES12196316T Active ES2744700T3 (es) 2007-10-05 2008-10-03 Régimen de dosificación de LAG-3 para su uso en el tratamiento de cáncer
ES12196314T Active ES2705901T3 (es) 2007-10-05 2008-10-03 Composiciones que comprenden LAG-3 y anticuerpos terapéuticos y sus usos en el tratamiento de cáncer
ES08836333.8T Active ES2437333T3 (es) 2007-10-05 2008-10-03 Regímenes de dosificación de LAG-3Ig (IMP321) para uso en el tratamiento del cáncer

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US (4) US9579382B2 (es)
EP (7) EP2044949A1 (es)
JP (3) JP5908210B2 (es)
CN (3) CN101873864A (es)
AU (1) AU2008306576B2 (es)
DK (4) DK2601962T3 (es)
ES (4) ES2744700T3 (es)
NO (1) NO2604275T3 (es)
PL (3) PL2601962T3 (es)
PT (3) PT2601961T (es)
TR (1) TR201900764T4 (es)
WO (1) WO2009044273A2 (es)

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