ES2664975T3 - Películas hidrosolubles que comprenden alginatos de baja viscosidad - Google Patents

Películas hidrosolubles que comprenden alginatos de baja viscosidad Download PDF

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Publication number
ES2664975T3
ES2664975T3 ES06844046T ES06844046T ES2664975T3 ES 2664975 T3 ES2664975 T3 ES 2664975T3 ES 06844046 T ES06844046 T ES 06844046T ES 06844046 T ES06844046 T ES 06844046T ES 2664975 T3 ES2664975 T3 ES 2664975T3
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ES
Spain
Prior art keywords
film
solution
active substance
forming agent
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06844046T
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English (en)
Inventor
Kjell Stenberg
Fredrik Hübinette
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Uppsalagruppen Medical AB
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Uppsalagruppen Medical AB
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Application filed by Uppsalagruppen Medical AB filed Critical Uppsalagruppen Medical AB
Application granted granted Critical
Publication of ES2664975T3 publication Critical patent/ES2664975T3/es
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Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Psychiatry (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)

Abstract

Una película bioadhesiva que comprende al menos una sustancia biológicamente activa y/o al menos una sustancia terapéuticamente activa y un agente formador de película, consistiendo dicho agente formador de película en una sal de alginato de catión monovalente o una mezcla de sales de alginato de catión monovalente y teniendo dicho agente formador de película un contenido de guluronato (G) del 50 al 85 % en peso, un contenido de manurato (M) promedio del 15 al 50 % en peso, un peso molecular promedio de 30.000 g/mol a 90.000 g/mol y siendo tal que una solución acuosa al 10 % de la misma a una temperatura de 20 °C tiene una viscosidad de 10-1000mPas, de acuerdo con lo medido a una velocidad de cizallamiento de 20 rpm mediante el uso de un viscosímetro de Brookfield con un husillo N.º 2; siendo obtenible dicha película preparando una solución de dicho agente formador de película, cuya solución también contiene la al menos una sustancia biológicamente activa y/o la al menos una sustancia terapéuticamente activa, distribuyendo la solución sobre una superficie sólida y permitiendo que la solución se seque en dicha superficie.
ES06844046T 2005-12-23 2006-12-22 Películas hidrosolubles que comprenden alginatos de baja viscosidad Active ES2664975T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0502900A SE530184C2 (sv) 2005-12-23 2005-12-23 Bioadhesiv farmaceutisk filmkomposition innehållande lågviskösa alginater
PCT/SE2006/050626 WO2007073346A1 (en) 2005-12-23 2006-12-22 Water-soluble films comprising low-viscosity alginates

Publications (1)

Publication Number Publication Date
ES2664975T3 true ES2664975T3 (es) 2018-04-24

Family

ID=38188958

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06844046T Active ES2664975T3 (es) 2005-12-23 2006-12-22 Películas hidrosolubles que comprenden alginatos de baja viscosidad

Country Status (25)

Country Link
US (1) US8759282B2 (es)
EP (2) EP3335732B1 (es)
JP (1) JP5425471B2 (es)
KR (2) KR20080080405A (es)
CN (1) CN101346154B (es)
AU (1) AU2006327277B2 (es)
BR (1) BRPI0620403B8 (es)
CA (1) CA2633878C (es)
CY (1) CY1120100T1 (es)
DK (1) DK1976562T3 (es)
ES (1) ES2664975T3 (es)
HR (1) HRP20180420T1 (es)
HU (1) HUE038619T2 (es)
IL (1) IL191994A (es)
LT (1) LT1976562T (es)
NO (1) NO343482B1 (es)
NZ (1) NZ569261A (es)
PL (1) PL1976562T3 (es)
PT (1) PT1976562T (es)
RS (1) RS57034B1 (es)
RU (1) RU2445977C2 (es)
SE (1) SE530184C2 (es)
SI (1) SI1976562T1 (es)
WO (1) WO2007073346A1 (es)
ZA (1) ZA200805287B (es)

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US10799451B2 (en) 2012-03-27 2020-10-13 Nicoccino Ab Nicotine formulation
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Also Published As

Publication number Publication date
US20090221489A1 (en) 2009-09-03
CY1120100T1 (el) 2018-12-12
IL191994A (en) 2013-09-30
WO2007073346A1 (en) 2007-06-28
JP2009521433A (ja) 2009-06-04
BRPI0620403A2 (pt) 2012-12-11
RU2008130391A (ru) 2010-01-27
SE530184C2 (sv) 2008-03-18
US8759282B2 (en) 2014-06-24
SE0502900L (sv) 2007-06-24
HRP20180420T1 (hr) 2018-06-01
NO20083226L (no) 2008-09-18
KR20140046488A (ko) 2014-04-18
EP3335732B1 (en) 2020-10-14
LT1976562T (lt) 2018-05-25
PT1976562T (pt) 2018-04-09
ZA200805287B (en) 2009-11-25
JP5425471B2 (ja) 2014-02-26
NO343482B1 (no) 2019-03-25
EP1976562A4 (en) 2012-02-01
EP1976562B1 (en) 2018-02-21
NZ569261A (en) 2012-08-31
HUE038619T2 (hu) 2018-10-29
SI1976562T1 (en) 2018-06-29
DK1976562T3 (en) 2018-04-16
BRPI0620403B8 (pt) 2021-05-25
CN101346154A (zh) 2009-01-14
EP1976562A1 (en) 2008-10-08
CA2633878C (en) 2015-02-10
IL191994A0 (en) 2008-12-29
AU2006327277A1 (en) 2007-06-28
CA2633878A1 (en) 2007-06-28
RU2445977C2 (ru) 2012-03-27
KR101484530B1 (ko) 2015-01-20
EP3335732A1 (en) 2018-06-20
AU2006327277B2 (en) 2012-12-13
CN101346154B (zh) 2013-03-27
RS57034B1 (sr) 2018-05-31
PL1976562T3 (pl) 2018-06-29
BRPI0620403B1 (pt) 2020-11-10
KR20080080405A (ko) 2008-09-03

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