ES2741399T3 - Apilimod para el uso en el tratamiento de cáncer renal - Google Patents

Apilimod para el uso en el tratamiento de cáncer renal Download PDF

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Publication number
ES2741399T3
ES2741399T3 ES15795318T ES15795318T ES2741399T3 ES 2741399 T3 ES2741399 T3 ES 2741399T3 ES 15795318 T ES15795318 T ES 15795318T ES 15795318 T ES15795318 T ES 15795318T ES 2741399 T3 ES2741399 T3 ES 2741399T3
Authority
ES
Spain
Prior art keywords
apilimod
composition
inhibitor
therapeutic agent
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES15795318T
Other languages
English (en)
Spanish (es)
Inventor
Neil Beeharry
Sophia Gayle
Sean Landrette
Paul Beckett
Chris Conrad
Tian Xu
Jonathan Rothberg
Henri Lichenstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OrphAI Therapeutics Inc
Original Assignee
AI Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AI Therapeutics Inc filed Critical AI Therapeutics Inc
Application granted granted Critical
Publication of ES2741399T3 publication Critical patent/ES2741399T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
ES15795318T 2014-11-07 2015-11-06 Apilimod para el uso en el tratamiento de cáncer renal Active ES2741399T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462077127P 2014-11-07 2014-11-07
PCT/US2015/059512 WO2016073877A1 (en) 2014-11-07 2015-11-06 Apilimod for use in the treatment of renal cancer

Publications (1)

Publication Number Publication Date
ES2741399T3 true ES2741399T3 (es) 2020-02-10

Family

ID=54548302

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15795318T Active ES2741399T3 (es) 2014-11-07 2015-11-06 Apilimod para el uso en el tratamiento de cáncer renal

Country Status (16)

Country Link
US (3) US10206910B2 (2)
EP (2) EP3215158B1 (2)
JP (1) JP6705828B2 (2)
KR (1) KR20170098812A (2)
CN (1) CN107249638B (2)
AU (1) AU2015342869A1 (2)
BR (1) BR112017008799A2 (2)
CA (1) CA2966359A1 (2)
ES (1) ES2741399T3 (2)
HU (1) HUE044557T2 (2)
IL (1) IL251905B (2)
MX (1) MX377593B (2)
PL (1) PL3215158T3 (2)
PT (1) PT3215158T (2)
RU (1) RU2727802C2 (2)
WO (1) WO2016073877A1 (2)

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CA2966359A1 (en) 2014-11-07 2016-05-12 Lam Therapeutics, Inc. Apilimod for use in the treatment of renal cancer
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RU2019108279A (ru) * 2016-08-25 2020-09-25 ЭйАй ТЕРАПЬЮТИКС, ИНК. Композиции, содержащие ингибиторы pikfyve, и способы, связанные с ингибированием сигнального пути rank
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BR112022010113A2 (pt) 2019-11-25 2022-09-06 Univ California Inibidores de vegf de longa ação para neovascularização intraocular
TWI885039B (zh) 2020-01-13 2025-06-01 美商邊際分析公司 經取代吡唑并嘧啶及其用途
CN114306370A (zh) * 2021-12-31 2022-04-12 北京悦康科创医药科技股份有限公司 反义寡核苷酸在制备治疗肾癌药物中的应用

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Also Published As

Publication number Publication date
IL251905A0 (en) 2017-06-29
PT3215158T (pt) 2019-08-23
EP3215158A1 (en) 2017-09-13
CN107249638B (zh) 2021-05-14
HUE044557T2 (hu) 2019-11-28
JP2017535601A (ja) 2017-11-30
RU2017119065A3 (2) 2019-06-05
US20170333408A1 (en) 2017-11-23
MX2017006015A (es) 2017-11-17
US11166944B2 (en) 2021-11-09
US20200297706A1 (en) 2020-09-24
CN107249638A (zh) 2017-10-13
RU2017119065A (ru) 2018-12-07
BR112017008799A2 (pt) 2017-12-19
EP3215158B1 (en) 2019-05-08
US10206910B2 (en) 2019-02-19
KR20170098812A (ko) 2017-08-30
JP6705828B2 (ja) 2020-06-03
WO2016073877A1 (en) 2016-05-12
AU2015342869A1 (en) 2017-06-15
IL251905B (en) 2021-03-25
RU2727802C2 (ru) 2020-07-24
MX377593B (es) 2025-03-10
EP3581184A1 (en) 2019-12-18
US20190201385A1 (en) 2019-07-04
CA2966359A1 (en) 2016-05-12
PL3215158T3 (pl) 2019-11-29
EP3581184B1 (en) 2021-02-24

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