MX377593B - Composiciones para usar en el tratamiento de cáncer renal. - Google Patents

Composiciones para usar en el tratamiento de cáncer renal.

Info

Publication number
MX377593B
MX377593B MX2017006015A MX2017006015A MX377593B MX 377593 B MX377593 B MX 377593B MX 2017006015 A MX2017006015 A MX 2017006015A MX 2017006015 A MX2017006015 A MX 2017006015A MX 377593 B MX377593 B MX 377593B
Authority
MX
Mexico
Prior art keywords
apilimod
renal cancer
treatment
methods
present disclosure
Prior art date
Application number
MX2017006015A
Other languages
English (en)
Spanish (es)
Other versions
MX2017006015A (es
Inventor
Chris Conrad
Henri Lichenstein
Jonathan M Rothberg
Neil Beeharry
Paul Beckett
Sean Landrette
Sophia Gayle
Tian Xu
Original Assignee
Ai Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ai Therapeutics Inc filed Critical Ai Therapeutics Inc
Publication of MX2017006015A publication Critical patent/MX2017006015A/es
Publication of MX377593B publication Critical patent/MX377593B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
MX2017006015A 2014-11-07 2015-11-06 Composiciones para usar en el tratamiento de cáncer renal. MX377593B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462077127P 2014-11-07 2014-11-07
PCT/US2015/059512 WO2016073877A1 (en) 2014-11-07 2015-11-06 Apilimod for use in the treatment of renal cancer

Publications (2)

Publication Number Publication Date
MX2017006015A MX2017006015A (es) 2017-11-17
MX377593B true MX377593B (es) 2025-03-10

Family

ID=54548302

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017006015A MX377593B (es) 2014-11-07 2015-11-06 Composiciones para usar en el tratamiento de cáncer renal.

Country Status (16)

Country Link
US (3) US10206910B2 (2)
EP (2) EP3215158B1 (2)
JP (1) JP6705828B2 (2)
KR (1) KR20170098812A (2)
CN (1) CN107249638B (2)
AU (1) AU2015342869A1 (2)
BR (1) BR112017008799A2 (2)
CA (1) CA2966359A1 (2)
ES (1) ES2741399T3 (2)
HU (1) HUE044557T2 (2)
IL (1) IL251905B (2)
MX (1) MX377593B (2)
PL (1) PL3215158T3 (2)
PT (1) PT3215158T (2)
RU (1) RU2727802C2 (2)
WO (1) WO2016073877A1 (2)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102320190B1 (ko) 2014-01-24 2021-11-03 에이아이 테라퓨틱스, 인코포레이티드 아필리모드 조성물 및 이를 사용하기 위한 방법
RU2739992C2 (ru) * 2014-11-07 2020-12-30 ЭйАй ТЕРАПЬЮТИКС, ИНК. Композиции апилимода и способы их применения в лечении колоректального рака
CA2966359A1 (en) 2014-11-07 2016-05-12 Lam Therapeutics, Inc. Apilimod for use in the treatment of renal cancer
WO2017127661A1 (en) * 2016-01-21 2017-07-27 Lam Therapeutics, Inc. Biomarkers for treating cancer with apilimod
RU2019108279A (ru) * 2016-08-25 2020-09-25 ЭйАй ТЕРАПЬЮТИКС, ИНК. Композиции, содержащие ингибиторы pikfyve, и способы, связанные с ингибированием сигнального пути rank
BR112019007214A2 (pt) * 2016-10-12 2019-07-02 Ai Therapeutics Inc composições do apilimode e métodos para uso do mesmo no tratamento do mal de alzheimer
AU2018237598B2 (en) 2017-03-24 2023-12-14 Piksci Inc. Fused triazolo-pyrimidine compounds having useful pharmaceutical application
AU2019212622B2 (en) 2018-01-26 2024-05-23 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
US12589097B2 (en) 2018-02-21 2026-03-31 OrphAl Therapeutics Inc. Apilimod compositions and methods of use
TW202000205A (zh) 2018-02-21 2020-01-01 美商Ａｉ治療公司 使用阿吡莫德與麩胺酸性劑的組合治療
BR112022010113A2 (pt) 2019-11-25 2022-09-06 Univ California Inibidores de vegf de longa ação para neovascularização intraocular
TWI885039B (zh) 2020-01-13 2025-06-01 美商邊際分析公司 經取代吡唑并嘧啶及其用途
CN114306370A (zh) * 2021-12-31 2022-04-12 北京悦康科创医药科技股份有限公司 反义寡核苷酸在制备治疗肾癌药物中的应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
DK1921169T3 (da) 1993-11-12 2012-06-04 Phri Properties Inc Hybridiseringssonder til nukleinsyredetektion, universelle stamceller, fremgangsmåder og kits
US6693097B2 (en) 2001-11-30 2004-02-17 Synta Pharmaceuticals Corp. Pyrimidine compounds
NZ584288A (en) 2004-02-06 2011-10-28 Elan Pharm Inc Methods and compositions for treating tumors and metastatic disease
TWI380816B (zh) 2004-04-13 2013-01-01 Synta Pharmaceuticals Corp 抑制介白素-１２（ｉｌ-１２）生成之二鹽抑制劑
JP2008512490A (ja) 2004-09-08 2008-04-24 チェルシー・セラピューティクス，インコーポレイテッド 異常細胞増殖および炎症の障害を治療するための代謝的に不活性な葉酸拮抗剤
US7923557B2 (en) 2004-11-10 2011-04-12 Synta Pharmaceuticals Corporation Process for preparing trisubstituted pyrimidine compounds
WO2006124662A1 (en) 2005-05-13 2006-11-23 Synta Pharmaceuticals Corp. Il-12 modulatory compounds
WO2006128129A2 (en) * 2005-05-26 2006-11-30 Synta Pharmaceuticals Corp. Method for treating cancer
ES2365869T3 (es) 2005-11-17 2011-10-11 OSI Pharmaceuticals, LLC COMPUESTOS BICÍCLICOS FUSIONADOS INHIBIDORES DE LA mTOR.
AR057960A1 (es) 2005-12-02 2007-12-26 Osi Pharm Inc Inhibidores de proteina quinasa biciclicos
TW200738725A (en) 2006-01-25 2007-10-16 Osi Pharm Inc Unsaturated mTOR inhibitors
MX2009000385A (es) 2006-07-12 2009-04-06 Univ Tennessee Res Foundation Acil-anilidas sustituidas y metodos de uso de las mismas.
WO2008098058A1 (en) 2007-02-06 2008-08-14 Novartis Ag Pi 3-kinase inhibitors and methods of their use
RU2438664C2 (ru) 2007-05-15 2012-01-10 Пирамал Лайф Сайнсиз Лимитед Синергическая фармацевтическая комбинация для лечения рака
DE102007036076A1 (de) * 2007-08-01 2009-02-05 Bayer Healthcare Aktiengesellschaft Dipeptoid-Produgs und ihre Verwendung
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
JP5258331B2 (ja) 2008-03-03 2013-08-07 ロート製薬株式会社 光安定性が改善されたニューキノロン系抗菌剤含有医薬組成物
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
EP2318406B1 (en) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
AU2011224457B2 (en) 2010-03-08 2014-11-06 Sloan-Kettering Institute For Cancer Research Cdc7 kinase inhibitors and uses thereof
ES2768349T3 (es) * 2010-03-29 2020-06-22 Ea Pharma Co Ltd Preparación farmacéutica que comprende un derivado de fenilalanina
US8402515B2 (en) 2010-05-06 2013-03-19 Jonathan Weizman Apparatus and method for establishing a peer-to-peer communication session with a client device
WO2011146727A1 (en) 2010-05-19 2011-11-24 Philip Bosch Methods of treating interstitial cystitis
US8709419B2 (en) * 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
JP6061346B2 (ja) 2010-11-19 2017-01-18 エコール ポリテクニーク フェデラル ドゥ ローザンヌ （イーピーエフエル） ２−ピペラジン−１−イル−４ｈ−１，３−ベンゾチアジン−４−オン誘導体、および哺乳類の感染症治療へのその使用
WO2013152342A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Anti-cancer mtor inhibitor and anti-androgen combination
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
HK1203971A1 (en) 2012-05-15 2015-11-06 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
EP2903644A4 (en) 2012-10-05 2016-03-09 Cerulean Pharma Inc TREATMENT OF CANCER
US9295731B2 (en) 2013-04-01 2016-03-29 Mark Quang Nguyen Cleavable drug conjugates, compositions thereof and methods of use
KR102320190B1 (ko) 2014-01-24 2021-11-03 에이아이 테라퓨틱스, 인코포레이티드 아필리모드 조성물 및 이를 사용하기 위한 방법
CA2966359A1 (en) 2014-11-07 2016-05-12 Lam Therapeutics, Inc. Apilimod for use in the treatment of renal cancer
RU2739992C2 (ru) 2014-11-07 2020-12-30 ЭйАй ТЕРАПЬЮТИКС, ИНК. Композиции апилимода и способы их применения в лечении колоректального рака
KR101761573B1 (ko) 2014-12-29 2017-07-26 주식회사 인트론바이오테크놀로지 신규한 장출혈성 대장균 박테리오파지 Ｅｓｃ-ＣＨＰ-1 및 이의 장출혈성 대장균 증식 억제 용도
WO2016126707A1 (en) 2015-02-03 2016-08-11 Lam Therapeutics, Inc. Apilimod compositions and methods for using same
US20180078561A1 (en) 2015-03-31 2018-03-22 Lam Therapeutics, Inc. Active metabolites of apilimod and uses thereof
TWI746449B (zh) 2015-07-20 2021-11-21 美商Ａｉ治療公司 使用阿吡莫德治療癌症之方法
EP3817736A4 (en) 2018-07-05 2021-07-28 Mayo Foundation for Medical Education and Research PIKFYVE INHIBITORS
AR119934A1 (es) 2019-09-12 2022-01-19 Ai Therapeutics Inc Inhibidores de pikfyve para terapia contra el cáncer

Also Published As

Publication number Publication date
IL251905A0 (en) 2017-06-29
ES2741399T3 (es) 2020-02-10
PT3215158T (pt) 2019-08-23
EP3215158A1 (en) 2017-09-13
CN107249638B (zh) 2021-05-14
HUE044557T2 (hu) 2019-11-28
JP2017535601A (ja) 2017-11-30
RU2017119065A3 (2) 2019-06-05
US20170333408A1 (en) 2017-11-23
MX2017006015A (es) 2017-11-17
US11166944B2 (en) 2021-11-09
US20200297706A1 (en) 2020-09-24
CN107249638A (zh) 2017-10-13
RU2017119065A (ru) 2018-12-07
BR112017008799A2 (pt) 2017-12-19
EP3215158B1 (en) 2019-05-08
US10206910B2 (en) 2019-02-19
KR20170098812A (ko) 2017-08-30
JP6705828B2 (ja) 2020-06-03
WO2016073877A1 (en) 2016-05-12
AU2015342869A1 (en) 2017-06-15
IL251905B (en) 2021-03-25
RU2727802C2 (ru) 2020-07-24
EP3581184A1 (en) 2019-12-18
US20190201385A1 (en) 2019-07-04
CA2966359A1 (en) 2016-05-12
PL3215158T3 (pl) 2019-11-29
EP3581184B1 (en) 2021-02-24

Similar Documents

Publication Publication Date Title
MX377593B (es) Composiciones para usar en el tratamiento de cáncer renal.
NZ731467A (en) Anti-tim3 antibodies and methods of use
TW201611847A (en) Compounds and compositions for treating EGFR expressing tumors
IL276733A (en) Use of Aribolin in cancer treatment
MX369691B (es) Inhibidores de glutaminasa y métodos de empleo.
MX2018000715A (es) Metodos para tratar cancer usando apilimod.
IL251371A0 (en) Cortexolone 17alpha-benzoate for use in the treatment of tumors
MX2017006026A (es) Apilimod para uso en el tratamiento de cancer colorrectal.
HUE045615T2 (hu) Rák kezelésére szolgáló eljárások és készítmények
SI3200815T1 (sl) Postopki in sestavki za zdravljenje raka
IL248767B (en) Trimethoxyphenyl-benzaimidazole compounds for cancer treatment
PH12016501422B1 (en) Functionalised benzopyran compounds and use thereof
GB201420533D0 (en) Use of Nanomaterials in treating cancer
MX2017000306A (es) Metodos para tratar hipotension.
PH12016501838A1 (en) Compounds and their methods of use
MX2015013021A (es) 5-bromo-indirrubinas.
EA201691907A1 (ru) Комбинированная терапия кураксинами
HK1242965A1 (en) Apilimod for use in the treatment of colorectal cancer
ZA201403006B (en) Composition for use in treatment of cancer
GB201410695D0 (en) Uses of oligouronates in cancer treatment
GB201411111D0 (en) bis-Pyridazine compounds and their use in treating cancer
PH12014000104A1 (en) Therapeutic methods and compositions for treating diabetes

Legal Events

Date Code Title Description
HC Change of company name or juridical status

Owner name: COVESTRO (NETHERLANDS) B.V.

FG Grant or registration