KR20170098812A - 신장암의 치료에 사용하기 위한 아필리모드 - Google Patents

신장암의 치료에 사용하기 위한 아필리모드 Download PDF

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Publication number
KR20170098812A
KR20170098812A KR1020177015388A KR20177015388A KR20170098812A KR 20170098812 A KR20170098812 A KR 20170098812A KR 1020177015388 A KR1020177015388 A KR 1020177015388A KR 20177015388 A KR20177015388 A KR 20177015388A KR 20170098812 A KR20170098812 A KR 20170098812A
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South Korea
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mode
composition
agent
cells
inhibitor
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Ceased
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KR1020177015388A
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Korean (ko)
Inventor
닐 비해리
소피아 게일
션 란드레테
폴 베케트
크리스 콘래드
티안 수
조나단 엠. 로스버그
헨리 리히텐슈타인
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램 테라퓨틱스, 인코포레이티드
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Publication of KR20170098812A publication Critical patent/KR20170098812A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
KR1020177015388A 2014-11-07 2015-11-06 신장암의 치료에 사용하기 위한 아필리모드 Ceased KR20170098812A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077127P 2014-11-07 2014-11-07
US62/077,127 2014-11-07
PCT/US2015/059512 WO2016073877A1 (en) 2014-11-07 2015-11-06 Apilimod for use in the treatment of renal cancer

Publications (1)

Publication Number Publication Date
KR20170098812A true KR20170098812A (ko) 2017-08-30

Family

ID=54548302

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177015388A Ceased KR20170098812A (ko) 2014-11-07 2015-11-06 신장암의 치료에 사용하기 위한 아필리모드

Country Status (16)

Country Link
US (3) US10206910B2 (2)
EP (2) EP3215158B1 (2)
JP (1) JP6705828B2 (2)
KR (1) KR20170098812A (2)
CN (1) CN107249638B (2)
AU (1) AU2015342869A1 (2)
BR (1) BR112017008799A2 (2)
CA (1) CA2966359A1 (2)
ES (1) ES2741399T3 (2)
HU (1) HUE044557T2 (2)
IL (1) IL251905B (2)
MX (1) MX377593B (2)
PL (1) PL3215158T3 (2)
PT (1) PT3215158T (2)
RU (1) RU2727802C2 (2)
WO (1) WO2016073877A1 (2)

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KR102320190B1 (ko) 2014-01-24 2021-11-03 에이아이 테라퓨틱스, 인코포레이티드 아필리모드 조성물 및 이를 사용하기 위한 방법
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CA2966359A1 (en) 2014-11-07 2016-05-12 Lam Therapeutics, Inc. Apilimod for use in the treatment of renal cancer
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RU2019108279A (ru) * 2016-08-25 2020-09-25 ЭйАй ТЕРАПЬЮТИКС, ИНК. Композиции, содержащие ингибиторы pikfyve, и способы, связанные с ингибированием сигнального пути rank
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AU2018237598B2 (en) 2017-03-24 2023-12-14 Piksci Inc. Fused triazolo-pyrimidine compounds having useful pharmaceutical application
AU2019212622B2 (en) 2018-01-26 2024-05-23 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
US12589097B2 (en) 2018-02-21 2026-03-31 OrphAl Therapeutics Inc. Apilimod compositions and methods of use
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BR112022010113A2 (pt) 2019-11-25 2022-09-06 Univ California Inibidores de vegf de longa ação para neovascularização intraocular
TWI885039B (zh) 2020-01-13 2025-06-01 美商邊際分析公司 經取代吡唑并嘧啶及其用途
CN114306370A (zh) * 2021-12-31 2022-04-12 北京悦康科创医药科技股份有限公司 反义寡核苷酸在制备治疗肾癌药物中的应用

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Also Published As

Publication number Publication date
IL251905A0 (en) 2017-06-29
ES2741399T3 (es) 2020-02-10
PT3215158T (pt) 2019-08-23
EP3215158A1 (en) 2017-09-13
CN107249638B (zh) 2021-05-14
HUE044557T2 (hu) 2019-11-28
JP2017535601A (ja) 2017-11-30
RU2017119065A3 (2) 2019-06-05
US20170333408A1 (en) 2017-11-23
MX2017006015A (es) 2017-11-17
US11166944B2 (en) 2021-11-09
US20200297706A1 (en) 2020-09-24
CN107249638A (zh) 2017-10-13
RU2017119065A (ru) 2018-12-07
BR112017008799A2 (pt) 2017-12-19
EP3215158B1 (en) 2019-05-08
US10206910B2 (en) 2019-02-19
JP6705828B2 (ja) 2020-06-03
WO2016073877A1 (en) 2016-05-12
AU2015342869A1 (en) 2017-06-15
IL251905B (en) 2021-03-25
RU2727802C2 (ru) 2020-07-24
MX377593B (es) 2025-03-10
EP3581184A1 (en) 2019-12-18
US20190201385A1 (en) 2019-07-04
CA2966359A1 (en) 2016-05-12
PL3215158T3 (pl) 2019-11-29
EP3581184B1 (en) 2021-02-24

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