ES2742503T3 - Derivados de FGF21 y sus usos - Google Patents

Derivados de FGF21 y sus usos Download PDF

Info

Publication number: ES2742503T3
Authority: ES; Spain
Prior art keywords: ethoxy; amino; fgf21; oxo; ethylamino
Prior art date: 2014-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES15817847T

Other languages

English (en)

Spanish (es)

Inventor

Birgit Wieczorek

Tina Møller Tagmose

Kristian Sass-Ørum

Birgitte Andersen

Jørgen Olsen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

Original Assignee

Novo Nordisk AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-12-23

Filing date

2015-12-22

Publication date

2020-02-14

2015-12-22 Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS

2020-02-14 Application granted granted Critical

2020-02-14 Publication of ES2742503T3 publication Critical patent/ES2742503T3/es

Status Active legal-status Critical Current

2035-12-22 Anticipated expiration legal-status Critical

Links

108090000376 Fibroblast growth factor 21 Proteins 0.000 title claims abstract description 384
102000003973 Fibroblast growth factor 21 Human genes 0.000 title claims abstract description 384
101000846529 Homo sapiens Fibroblast growth factor 21 Proteins 0.000 claims abstract description 74
102000056713 human FGF21 Human genes 0.000 claims abstract description 74
239000000126 substance Substances 0.000 claims abstract description 59
108090000623 proteins and genes Proteins 0.000 claims abstract description 58
102000004169 proteins and genes Human genes 0.000 claims abstract description 57
239000004606 Fillers/Extenders Substances 0.000 claims abstract description 50
229910052717 sulfur Inorganic materials 0.000 claims abstract description 18
150000001408 amides Chemical class 0.000 claims abstract description 10
150000002148 esters Chemical class 0.000 claims abstract description 10
150000003839 salts Chemical class 0.000 claims abstract description 9
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 6
239000011593 sulfur Substances 0.000 claims abstract description 6
125000000896 monocarboxylic acid group Chemical group 0.000 claims abstract 7
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 363
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 291
-1 11-carboxyundecanoylamino Chemical group 0.000 claims description 140
125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 136
150000001875 compounds Chemical class 0.000 claims description 113
238000000034 method Methods 0.000 claims description 112
125000005647 linker group Chemical group 0.000 claims description 72
238000011282 treatment Methods 0.000 claims description 70
125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 60
150000001413 amino acids Chemical class 0.000 claims description 47
239000002253 acid Substances 0.000 claims description 46
230000002265 prevention Effects 0.000 claims description 26
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 20
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 19
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 19
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 18
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AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 claims description 6
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XRWSZZJLZRKHHD-WVWIJVSJSA-N asunaprevir Chemical compound O=C([C@@H]1C[C@H](CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)OC1=NC=C(C2=CC=C(Cl)C=C21)OC)N[C@]1(C(=O)NS(=O)(=O)C2CC2)C[C@H]1C=C XRWSZZJLZRKHHD-WVWIJVSJSA-N 0.000 claims description 5
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PYRKKGOKRMZEIT-UHFFFAOYSA-N 2-[6-(2-cyclopropylethoxy)-9-(2-hydroxy-2-methylpropyl)-1h-phenanthro[9,10-d]imidazol-2-yl]-5-fluorobenzene-1,3-dicarbonitrile Chemical compound C1=C2C3=CC(CC(C)(O)C)=CC=C3C=3NC(C=4C(=CC(F)=CC=4C#N)C#N)=NC=3C2=CC=C1OCCC1CC1 PYRKKGOKRMZEIT-UHFFFAOYSA-N 0.000 claims description 3
WYFCZWSWFGJODV-MIANJLSGSA-N 4-[[(1s)-2-[(e)-3-[3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl]prop-2-enoyl]-5-(4-methyl-2-oxopiperazin-1-yl)-3,4-dihydro-1h-isoquinoline-1-carbonyl]amino]benzoic acid Chemical compound O=C1CN(C)CCN1C1=CC=CC2=C1CCN(C(=O)\C=C\C=1C(=CC=C(Cl)C=1F)N1N=NN=C1)[C@@H]2C(=O)NC1=CC=C(C(O)=O)C=C1 WYFCZWSWFGJODV-MIANJLSGSA-N 0.000 claims description 3
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ES15817847T 2014-12-23 2015-12-22 Derivados de FGF21 y sus usos Active ES2742503T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP14199935		2014-12-23
PCT/EP2015/080969 WO2016102562A1 (en)	2014-12-23	2015-12-22	Fgf21 derivatives and uses thereof

Publications (1)

Publication Number	Publication Date
ES2742503T3 true ES2742503T3 (es)	2020-02-14

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ES15817847T Active ES2742503T3 (es)	2014-12-23	2015-12-22	Derivados de FGF21 y sus usos

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US (3)	US9744213B2 (2)
EP (1)	EP3236991B1 (2)
JP (1)	JP6727210B2 (2)
KR (1)	KR102427527B1 (2)
CN (1)	CN107108709B (2)
AR (1)	AR103246A1 (2)
AU (1)	AU2015371056B2 (2)
DK (1)	DK3236991T3 (2)
ES (1)	ES2742503T3 (2)
HK (1)	HK1246156B (2)
HR (1)	HRP20191292T1 (2)
HU (1)	HUE044783T2 (2)
IL (1)	IL252438B (2)
MX (1)	MX377044B (2)
MY (1)	MY181181A (2)
PL (1)	PL3236991T3 (2)
PT (1)	PT3236991T (2)
RS (1)	RS59154B1 (2)
RU (1)	RU2729011C2 (2)
SA (1)	SA517381673B1 (2)
SI (1)	SI3236991T1 (2)
TW (2)	TWI681966B (2)
WO (1)	WO2016102562A1 (2)
ZA (1)	ZA201703768B (2)

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2015
- 2015-12-22 AR ARP150104256A patent/AR103246A1/es active IP Right Grant
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- 2015-12-22 ES ES15817847T patent/ES2742503T3/es active Active
- 2015-12-22 WO PCT/EP2015/080969 patent/WO2016102562A1/en not_active Ceased
- 2015-12-22 EP EP15817847.5A patent/EP3236991B1/en active Active
- 2015-12-22 RS RSP20191106 patent/RS59154B1/sr unknown
- 2015-12-22 PT PT15817847T patent/PT3236991T/pt unknown
- 2015-12-22 MY MYPI2017701848A patent/MY181181A/en unknown
- 2015-12-22 DK DK15817847.5T patent/DK3236991T3/da active
- 2015-12-22 CN CN201580069436.9A patent/CN107108709B/zh active Active
- 2015-12-22 HK HK18105587.8A patent/HK1246156B/en unknown
- 2015-12-22 AU AU2015371056A patent/AU2015371056B2/en active Active
- 2015-12-22 PL PL15817847T patent/PL3236991T3/pl unknown
- 2015-12-22 HR HRP20191292TT patent/HRP20191292T1/hr unknown
- 2015-12-22 JP JP2017533789A patent/JP6727210B2/ja active Active
- 2015-12-22 MX MX2017007458A patent/MX377044B/es active IP Right Grant
- 2015-12-22 SI SI201530859T patent/SI3236991T1/sl unknown
- 2015-12-22 KR KR1020177017682A patent/KR102427527B1/ko active Active
- 2015-12-22 RU RU2017125050A patent/RU2729011C2/ru active
- 2015-12-22 HU HUE15817847 patent/HUE044783T2/hu unknown
- 2015-12-22 TW TW108144310A patent/TWI708781B/zh active
2017
- 2017-03-08 US US15/453,617 patent/US9744213B2/en active Active
- 2017-05-22 IL IL252438A patent/IL252438B/en unknown
- 2017-06-01 ZA ZA2017/03768A patent/ZA201703768B/en unknown
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- 2017-12-21 US US15/849,920 patent/US10124039B2/en active Active

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Publication number	Publication date
AU2015371056A1 (en)	2017-06-15
CN107108709B (zh)	2021-12-14
US9744213B2 (en)	2017-08-29
KR20170095256A (ko)	2017-08-22
HRP20191292T1 (hr)	2019-10-18
TW202012431A (zh)	2020-04-01
TWI681966B (zh)	2020-01-11
US20180140673A1 (en)	2018-05-24
MX2017007458A (es)	2017-08-10
MY181181A (en)	2020-12-21
RU2017125050A3 (2)	2019-06-06
WO2016102562A1 (en)	2016-06-30
EP3236991B1 (en)	2019-06-19
JP2018505146A (ja)	2018-02-22
BR112017011552A2 (pt)	2018-02-14
CN107108709A (zh)	2017-08-29
JP6727210B2 (ja)	2020-07-22
ZA201703768B (en)	2020-05-27
TW201632545A (zh)	2016-09-16
AR103246A1 (es)	2017-04-26
IL252438B (en)	2021-09-30
US9895417B2 (en)	2018-02-20
RU2017125050A (ru)	2019-01-25
HK1246156B (en)	2020-03-27
HUE044783T2 (hu)	2019-11-28
US20170354713A1 (en)	2017-12-14
RU2729011C2 (ru)	2020-08-03
TWI708781B (zh)	2020-11-01
AU2015371056B2 (en)	2020-06-25
US20170182124A1 (en)	2017-06-29
US10124039B2 (en)	2018-11-13
RS59154B1 (sr)	2019-10-31
KR102427527B1 (ko)	2022-08-01
IL252438A0 (en)	2017-07-31
EP3236991A1 (en)	2017-11-01
DK3236991T3 (da)	2019-08-26
MX377044B (es)	2025-03-07
SI3236991T1 (sl)	2019-09-30
PT3236991T (pt)	2019-09-06
SA517381673B1 (ar)	2020-10-29
CA2972128A1 (en)	2016-06-30
PL3236991T3 (pl)	2019-12-31

Publication	Publication Date	Title
ES2742503T3 (es)	2020-02-14	Derivados de FGF21 y sus usos
HK1246156A1 (en)	2018-09-07	Fgf21 derivatives and uses thereof
ES2692495T3 (es)	2018-12-03	Derivados del FGF21 con aglutinante de albúmina A-B-C-D-E- y sus usos
ES2369895T3 (es)	2011-12-07	Insulina monocatenaria.
ES2985999T3 (es)	2024-11-08	Conjugados de proteínas
BRPI0607248A2 (pt)	2010-10-19	conjugado de um polipeptìdeo e um oligossacarìdeo, composição farmacêutica, uso do conjugado, e, processo para a preparação de um conjugado
JP2013533227A (ja)	2013-08-22	Ｆｇｆ２１類似体および誘導体
US20140315797A1 (en)	2014-10-23	Novel N-Terminally Modified Insulin Derivatives
KR20250017252A (ko)	2025-02-04	인간 아밀린 유사체 및 이의 유도체 및 이의 용도
US20140357838A1 (en)	2014-12-04	N-Terminally Modified Insulin Derivatives
WO2017220706A1 (en)	2017-12-28	Pharmaceutical compositions of fgf21 derivatives and uses thereof
CA2972128C (en)	2025-09-09	Fgf21 derivatives and uses thereof
BR112017011552B1 (pt)	2024-09-17	Derivados de uma proteína do fgf21 e uso terapêutico e/ou profilático dos mesmos
KR102936886B1 (ko)	2026-03-11	지속성 성장 호르몬 수용체 길항제 및 이의 용도