ES276073A1 - Procedure for the preparation of new derivatives of oxazolidinone (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new derivatives of oxazolidinone (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES276073A1 ES276073A1 ES276073A ES276073A ES276073A1 ES 276073 A1 ES276073 A1 ES 276073A1 ES 276073 A ES276073 A ES 276073A ES 276073 A ES276073 A ES 276073A ES 276073 A1 ES276073 A1 ES 276073A1
- Authority
- ES
- Spain
- Prior art keywords
- represent
- group
- radicals
- see formula
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title 1
- -1 polymethylene chain Polymers 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical group OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Preparation procedure of the new oxaxolidinone-2 derivatives, of general formula: **(See formula)** in which: a) each one of R1, R2, R3, R4 can represent, respectively, a hydrogen atom, a lower alcoholic residue, such as methyl, ethyl, propyl, butyl, being able to constitute especially two radicals R1, R2 or R3, R4 a polymethylene chain - (CH2) n-, comprising from 2 to 6 carbon atoms; an aralcohyl moiety, such as benzyl, phenethyl, phenyl isopropyl; a cycloalkyl residue, such as cyclopropyl, cyclopentyl, diclohexyl, cycloheptyl, optionally substituted by a lower alcohol group up to C4; a phenyl or thionyl group, optionally substituted by halogen atoms, such as F, Cl, Br, with radicals such as CF3, OH, NO2, NH2, lower alkoxy or methylene dioxy; b) X can represent an oxygen atom, a sulfur atom or a -NH- group; c) A can represent a straight or branched alkane chain, having from 2 to 5 carbon atoms, such as: **(See formula)** d) Z can represent an aliphatic amine moiety such as: **(See formula)** or heterocyclic such as: piperidino, morpholino, pyrrolidino, N-methyl-piperazino, N-piperonil-piperazino, or the like, said procedures being characterized in that an acid chloride is reacted, eventually under the cis or trans configuration, racemic or optically active, of general formula: **(See formula)** on a basic compound of the general formula Y-AZ (in which Y represents an OH or NH2 group, the radicals R, Z and A having the aforementioned meanings), in solution in an organic solvent, at a low temperature . (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR857672A FR1301267A (en) | 1961-04-04 | 1961-04-04 | New derivatives of oxazolidinone-2 and their preparation methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES276073A1 true ES276073A1 (en) | 1962-07-01 |
Family
ID=8752294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES276073A Expired ES276073A1 (en) | 1961-04-04 | 1962-04-02 | Procedure for the preparation of new derivatives of oxazolidinone (Machine-translation by Google Translate, not legally binding) |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH401059A (en) |
| DE (1) | DE1289846B (en) |
| DK (1) | DK102862C (en) |
| ES (1) | ES276073A1 (en) |
| FR (1) | FR1301267A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2125175A2 (en) * | 1971-02-17 | 1972-09-29 | Delalande Sa | 3-1 substd-amino-carbonyl)-5-phenyl-oxa-zoli |
| FR2081582A1 (en) * | 1970-03-24 | 1971-12-10 | Delalande Sa | 3-1 substd-amino-carbonyl)-5-phenyl-oxa-zoli |
| FR2191889A1 (en) * | 1972-07-13 | 1974-02-08 | Delalande Sa | 4,4,5-Triphenyl-oxazolidin-2-one derivs - analgesics, antiinflammatories and sedatives from triphenyl-amino-ethanols with ethyl carbonate |
| JPS6183170A (en) * | 1984-09-28 | 1986-04-26 | Nippon Chemiphar Co Ltd | Novel 1,3-oxazolidin-2-one derivative and its preparation |
-
1961
- 1961-04-04 FR FR857672A patent/FR1301267A/en not_active Expired
-
1962
- 1962-03-22 CH CH342662A patent/CH401059A/en unknown
- 1962-03-30 DE DE1962S0078763 patent/DE1289846B/en active Pending
- 1962-04-02 ES ES276073A patent/ES276073A1/en not_active Expired
- 1962-04-03 DK DK151762A patent/DK102862C/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DK102862C (en) | 1965-10-18 |
| CH401059A (en) | 1965-10-31 |
| FR1301267A (en) | 1962-08-17 |
| DE1289846B (en) | 1969-02-27 |
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