ES340247A1 - Procedimiento para la produccion de derivados de fenotiaci-na. - Google Patents

Procedimiento para la produccion de derivados de fenotiaci-na.

Info

Publication number: ES340247A1
Authority: ES; Spain
Prior art keywords: formula; compound; piperidine; hydroxy; pyrrolidinyl
Prior art date: 1966-05-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES340247A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-05-10

Filing date

1967-05-08

Publication date

1968-09-01

1966-05-10 Priority claimed from CH679966A external-priority patent/CH480363A/de

1966-05-16 Priority claimed from CH708166A external-priority patent/CH476757A/de

1967-03-08 Priority claimed from CH337167A external-priority patent/CH504467A/de

1967-05-08 Application filed by Sandoz AG filed Critical Sandoz AG

1968-09-01 Publication of ES340247A1 publication Critical patent/ES340247A1/es

Status Expired legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 abstract 13
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004414 alkyl thio group Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
GEPUCQBKRNPVEV-UHFFFAOYSA-N 3-(4-hydroxypiperidin-4-yl)-1-methylpyrrolidin-2-one Chemical compound OC1(CCNCC1)C1C(N(CC1)C)=O GEPUCQBKRNPVEV-UHFFFAOYSA-N 0.000 abstract 2
229910052783 alkali metal Inorganic materials 0.000 abstract 2
-1 alkali metal amide Chemical class 0.000 abstract 2
239000011230 binding agent Substances 0.000 abstract 2
229910052794 bromium Inorganic materials 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
239000012442 inert solvent Substances 0.000 abstract 2
229910052740 iodine Inorganic materials 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 2
PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 abstract 1
XYZPXHOZGVUYPA-UHFFFAOYSA-N 2-(4-hydroxypiperidin-4-yl)-n,n-dimethylacetamide Chemical compound CN(C)C(=O)CC1(O)CCNCC1 XYZPXHOZGVUYPA-UHFFFAOYSA-N 0.000 abstract 1
QIKHFKKUHZUSAF-UHFFFAOYSA-N 2-[1-(3-chloropropyl)-4-hydroxypiperidin-4-yl]-N,N-dimethylacetamide Chemical compound ClCCCN1CCC(CC1)(O)CC(N(C)C)=O QIKHFKKUHZUSAF-UHFFFAOYSA-N 0.000 abstract 1
RQFUZUMFPRMVDX-UHFFFAOYSA-N 3-Bromo-1-propanol Chemical compound OCCCBr RQFUZUMFPRMVDX-UHFFFAOYSA-N 0.000 abstract 1
UKTLIHHWZIDFBC-UHFFFAOYSA-N 3-[1-(3-chloropropyl)-4-hydroxypiperidin-4-yl]-1-methylpyrrolidin-2-one Chemical compound ClCCCN1CCC(CC1)(C1C(N(CC1)C)=O)O UKTLIHHWZIDFBC-UHFFFAOYSA-N 0.000 abstract 1
URIDUTWNKLUVQO-UHFFFAOYSA-N 3-[4-hydroxy-1-(3-hydroxypropyl)piperidin-4-yl]-1-methylpyrrolidin-2-one Chemical compound OCCCN1CCC(CC1)(C1C(N(CC1)C)=O)O URIDUTWNKLUVQO-UHFFFAOYSA-N 0.000 abstract 1
GIQHURABUXXWSL-UHFFFAOYSA-N ClC1=CC=2N(C3=CC=CC=C3SC2C=C1)CCCOC(=O)OCC.BrCCCCl Chemical compound ClC1=CC=2N(C3=CC=CC=C3SC2C=C1)CCCOC(=O)OCC.BrCCCCl GIQHURABUXXWSL-UHFFFAOYSA-N 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
MFESCIUQSIBMSM-UHFFFAOYSA-N I-BCP Chemical compound ClCCCBr MFESCIUQSIBMSM-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
229940030600 antihypertensive agent Drugs 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
230000000911 decarboxylating effect Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
AHKJGIUKIBGOKH-UHFFFAOYSA-N morpholine;piperidine Chemical compound C1CCNCC1.C1COCCN1 AHKJGIUKIBGOKH-UHFFFAOYSA-N 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

ES340247A 1966-05-10 1967-05-08 Procedimiento para la produccion de derivados de fenotiaci-na. Expired ES340247A1 (es)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
CH679966A CH480363A (de)	1966-05-10	1966-05-10	Verfahren zur Herstellung neuer Phenothiazin-Derivate
CH708166A CH476757A (de)	1966-05-16	1966-05-16	Verfahren zur Herstellung neuer Phenothiazin-Derivate
CH1301666		1966-09-08
CH1301466		1966-09-08
CH337067		1967-03-08
CH337167A CH504467A (de)	1967-03-08	1967-03-08	Verfahren zur Herstellung neuer Phenothiazin-Derivate
CH337267		1967-03-08

Publications (1)

Publication Number	Publication Date
ES340247A1 true ES340247A1 (es)	1968-09-01

Family

ID=27561076

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
ES340244A Expired ES340244A1 (es)	1966-05-10	1967-05-08	Procedimiento para la produccion de derivados de fenotiaci-na.
ES340247A Expired ES340247A1 (es)	1966-05-10	1967-05-08	Procedimiento para la produccion de derivados de fenotiaci-na.
ES340245A Expired ES340245A1 (es)	1966-05-10	1967-05-08	Procedimiento para la produccion de derivados de fenotiaci-na.
ES340246A Expired ES340246A1 (es)	1966-05-10	1967-05-08	Procedimiento para la produccion de derivados de fenotiaci-na.
ES340243A Expired ES340243A1 (es)	1966-05-10	1967-05-08	Procedimiento para la produccion de derivados de fenotiaci-na.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES340244A Expired ES340244A1 (es)	1966-05-10	1967-05-08	Procedimiento para la produccion de derivados de fenotiaci-na.

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
ES340245A Expired ES340245A1 (es)	1966-05-10	1967-05-08	Procedimiento para la produccion de derivados de fenotiaci-na.
ES340246A Expired ES340246A1 (es)	1966-05-10	1967-05-08	Procedimiento para la produccion de derivados de fenotiaci-na.
ES340243A Expired ES340243A1 (es)	1966-05-10	1967-05-08	Procedimiento para la produccion de derivados de fenotiaci-na.

Country Status (9)

Country	Link
US (1)	US3445464A (es)
BE (1)	BE698166A (es)
CA (1)	CA921473A (es)
DE (1)	DE1695720A1 (es)
ES (5)	ES340244A1 (es)
FR (2)	FR1522688A (es)
GB (1)	GB1178623A (es)
NL (1)	NL6706369A (es)
SE (1)	SE350264B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3857943A (en) *	1969-03-27	1974-12-31	May & Baker Ltd	New phenothiazine derivatives in the treatment of spasticity of muscles
US4812456A (en) *	1987-05-13	1989-03-14	Hoechst-Roussel Pharmaceuticals Inc.	1-(N-(2-alkylthio-10H-phenothiazin-10-yl)alkyl)-4-benzoylpiperidines and pharmaceutical use
US4822796A (en) *	1987-06-01	1989-04-18	Helsley Grover C	1-((Phenothiazin-10-yl)alkyl)-alpha-phenyl-4-piperidinemethanols and pharmaceutical use
US20040259866A1 (en) *	1998-06-30	2004-12-23	Snutch Terrance P.	Calcium channel blockers comprising two benzhydril moieties
US6310059B1 (en)	1998-06-30	2001-10-30	Neuromed Technologies, Inc.	Fused ring calcium channel blockers
WO2007133481A2 (en) *	2006-05-11	2007-11-22	Neuromed Pharmaceuticals Ltd.	Method for increasing the bioavailability of benzhydryl piperazine containing compounds
US8409560B2 (en)	2011-03-08	2013-04-02	Zalicus Pharmaceuticals Ltd.	Solid dispersion formulations and methods of use thereof
KR20140011366A (ko)	2011-03-08	2014-01-28	잘리커스 파마슈티컬즈 리미티드	고체 분산체 제형 및 그의 이용방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1213411B (de) *	1962-11-15	1966-03-31	Yoshitomi Pharmaceutical	Verfahren zur Herstellung von Phenthiazinderivaten und ihren Salzen

1967
- 1967-04-10 GB GB06325/67A patent/GB1178623A/en not_active Expired
- 1967-05-05 NL NL6706369A patent/NL6706369A/xx unknown
- 1967-05-06 DE DE19671695720 patent/DE1695720A1/de active Pending
- 1967-05-08 US US636596A patent/US3445464A/en not_active Expired - Lifetime
- 1967-05-08 BE BE698166D patent/BE698166A/xx unknown
- 1967-05-08 ES ES340244A patent/ES340244A1/es not_active Expired
- 1967-05-08 ES ES340247A patent/ES340247A1/es not_active Expired
- 1967-05-08 ES ES340245A patent/ES340245A1/es not_active Expired
- 1967-05-08 ES ES340246A patent/ES340246A1/es not_active Expired
- 1967-05-08 ES ES340243A patent/ES340243A1/es not_active Expired
- 1967-05-09 FR FR105718A patent/FR1522688A/fr not_active Expired
- 1967-05-09 SE SE06471/67A patent/SE350264B/xx unknown
- 1967-08-08 FR FR117185A patent/FR6647M/fr not_active Expired
1969
- 1969-09-30 CA CA063889A patent/CA921473A/en not_active Expired

Also Published As

Publication number	Publication date
ES340243A1 (es)	1968-09-01
ES340244A1 (es)	1968-09-01
NL6706369A (es)	1967-11-13
CA921473A (en)	1973-02-20
ES340245A1 (es)	1968-09-01
ES340246A1 (es)	1968-09-01
GB1178623A (en)	1970-01-21
FR6647M (es)	1969-01-20
US3445464A (en)	1969-05-20
BE698166A (es)	1967-11-08
SE350264B (es)	1972-10-23
FR1522688A (fr)	1968-04-26
DE1695720A1 (de)	1971-05-13

Publication	Publication Date	Title
GB745069A (en)	1956-02-22	Improvements in or relating to phenthiazine derivatives and to their production
ES340245A1 (es)	1968-09-01	Procedimiento para la produccion de derivados de fenotiaci-na.
GB1022033A (en)	1966-03-09	Basic esters
GB1167563A (en)	1969-10-15	Novel 3-(2-Substituted Ethyl) Indoles and Processes for Their Manufacture
SE7608265L (sv)	1977-01-22	1-(bensazolylalkyl)-piperidiner
GB963639A (en)	1964-07-15	New piperidine derivatives and processes for preparing the same
KR900016212A (ko)	1990-11-12	피리딜티아졸리딘 카복스아미드 유도체 및 이의 중간체, 및 이들의 제조방법
GB1029920A (en)	1966-05-18	Piperazine and piperidine compounds
US3509153A (en)	1970-04-28	5-phenyl (or 5-phenylalkyl)-2-(omega-(4-phenyl-1-piperazinyl)alkyl)tetrazoles
GB1539473A (en)	1979-01-31	N-aryl-n-(1-l-4-piperidinyl)-arylacetamides
GB727151A (en)	1955-03-30	Improvements in derivatives of pyrimidine and methods of making the same
US3337551A (en)	1967-08-22	Heterocyclic amides of 2, 6-dioxo-4-piperidineacetic acid
ES264077A1 (es)	1961-07-16	Un procedimiento de obtenciën de derivados de piperidina y pirrolidina y de sus sales acidas de adiciën
GB1114692A (en)	1968-05-22	Improvements in or relating to phenthiazine derivatives
ES336531A1 (es)	1968-04-01	Procedimiento para preparar derivados del acido d-lisergi- co.
SE8005493L (sv)	1981-02-07	4-(haftalenyloxi)piperidin-derivat
GB1021950A (en)	1966-03-09	Quinoline derivatives
ES338242A1 (es)	1968-06-16	Procedimiento para la produccion de derivados de la pipe- ridina.
GB1080880A (en)	1967-08-23	New thioamides
GB1120735A (en)	1968-07-24	Improvements in or relating to thieno-benzothiazine derivatives
GB1085066A (en)	1967-09-27	Substituted alkylpiperidines and methods of preparation thereof
ES327879A1 (es)	1967-08-01	Un procedimiento para la obtencion de nuevas i-cicloalcohiledenetil-4-fenil-piperidinas.
US3320264A (en)	1967-05-16	Amino alkyl esters of alpha-(4-chlorobutoxy)-benzilic acid
GB873777A (en)	1961-07-26	5-hydroxy-ª--alkyltryptophans
GB862127A (en)	1961-03-01	Derivatives of 2-hydroxy-3-naphthanilide