ES342556A1 - Procedimiento para la preparacion de los 3-(piperacinoal- quil)-pirazoles. - Google Patents

Procedimiento para la preparacion de los 3-(piperacinoal- quil)-pirazoles.

Info

Publication number: ES342556A1
Authority: ES; Spain
Prior art keywords: pyrazole; piperazino; methyl; phenyl; benzyl
Prior art date: 1966-07-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES342556A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck KGaA

Original Assignee

E Merck AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-07-02

Filing date

1967-07-01

Publication date

1968-10-16

1967-07-01 Application filed by E Merck AG filed Critical E Merck AG

1968-10-16 Publication of ES342556A1 publication Critical patent/ES342556A1/es

Status Expired legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 abstract 5
125000003226 pyrazolyl group Chemical group 0.000 abstract 3
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
208000010513 Stupor Diseases 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 2
150000003217 pyrazoles Chemical class 0.000 abstract 2
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
QVEQOOSUPOKDAZ-UHFFFAOYSA-N (1-benzylpyrazol-3-yl)methanol Chemical compound N1=C(CO)C=CN1CC1=CC=CC=C1 QVEQOOSUPOKDAZ-UHFFFAOYSA-N 0.000 abstract 1
PHVARKYTFXXCCT-UHFFFAOYSA-N (5-methyl-1H-pyrazole-3-carbonyl) 5-methyl-1H-pyrazole-3-carboxylate Chemical compound CC1=CC(=NN1)C(=O)OC(=O)C1=NNC(=C1)C PHVARKYTFXXCCT-UHFFFAOYSA-N 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
PWZDJIUQHUGFRJ-UHFFFAOYSA-N 1-(2-chlorophenyl)piperazine Chemical compound ClC1=CC=CC=C1N1CCNCC1 PWZDJIUQHUGFRJ-UHFFFAOYSA-N 0.000 abstract 1
YEUKJUMCLOIQKH-UHFFFAOYSA-N 1-benzylpyrazole-3-carbonyl chloride Chemical compound C(C1=CC=CC=C1)N1N=C(C=C1)C(=O)Cl YEUKJUMCLOIQKH-UHFFFAOYSA-N 0.000 abstract 1
208000001953 Hypotension Diseases 0.000 abstract 1
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
PVMDFYQUHLWHDM-UHFFFAOYSA-N [1-(2-chlorophenyl)piperazin-2-yl]-(5-methyl-1H-pyrazol-3-yl)methanone Chemical compound ClC1=C(C=CC=C1)N1C(CNCC1)C(=O)C1=NNC(=C1)C PVMDFYQUHLWHDM-UHFFFAOYSA-N 0.000 abstract 1
PUCOVUCZFUSOPZ-UHFFFAOYSA-N [1-(3-chlorophenyl)piperazin-2-yl]-(5-methyl-1H-pyrazol-3-yl)methanone Chemical compound ClC=1C=C(C=CC1)N1C(CNCC1)C(=O)C1=NNC(=C1)C PUCOVUCZFUSOPZ-UHFFFAOYSA-N 0.000 abstract 1
PEVWTIDSXAJNRG-UHFFFAOYSA-N [1-(4-methoxyphenyl)piperazin-2-yl]-(5-methyl-1H-pyrazol-3-yl)methanone Chemical compound COC1=CC=C(C=C1)N1C(CNCC1)C(=O)C1=NNC(=C1)C PEVWTIDSXAJNRG-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000001387 anti-histamine Effects 0.000 abstract 1
239000000739 antihistaminic agent Substances 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
230000000572 bronchospasmolytic effect Effects 0.000 abstract 1
CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 abstract 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
208000021822 hypotensive Diseases 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 1
239000003176 neuroleptic agent Substances 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 abstract 1
150000004885 piperazines Chemical group 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1
239000003204 tranquilizing agent Substances 0.000 abstract 1
230000002936 tranquilizing effect Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Catalysts (AREA)

ES342556A 1966-07-02 1967-07-01 Procedimiento para la preparacion de los 3-(piperacinoal- quil)-pirazoles. Expired ES342556A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE1620016A DE1620016C3 (de)	1966-07-02	1966-07-02	3-{Piperazinoalkyl)-pyrazole und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number	Publication Date
ES342556A1 true ES342556A1 (es)	1968-10-16

Family

ID=7313285

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES342556A Expired ES342556A1 (es)	1966-07-02	1967-07-01	Procedimiento para la preparacion de los 3-(piperacinoal- quil)-pirazoles.

Country Status (14)

Country	Link
US (1)	US3491097A (da)
BE (1)	BE700732A (da)
CH (1)	CH485751A (da)
CY (1)	CY622A (da)
DE (1)	DE1620016C3 (da)
DK (1)	DK117635B (da)
ES (1)	ES342556A1 (da)
FR (1)	FR6682M (da)
GB (1)	GB1124710A (da)
IL (1)	IL28144A (da)
MY (1)	MY7200042A (da)
NL (1)	NL154739B (da)
SE (1)	SE345456B (da)
YU (2)	YU32681B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2110568A1 (de) *	1971-03-05	1972-09-07	Merck Patent Gmbh	Neue N-Acyl-(piperazinoalkyl)-pyrazole
US3960863A (en) *	1974-06-25	1976-06-01	Sankyo Company Limited	Pyrido[1,2-a]pyrimidinone derivatives
US3941881A (en) *	1975-03-14	1976-03-02	American Cyanamid Company	Novel 3 or 5-aminopyrazolium salts and fungicidal use thereof
DE2835158A1 (de) *	1978-08-10	1980-02-21	Bayer Ag	Substituierte pyrazol-derivate sowie verfahren zu ihrer herstellung
DE4425146A1 (de) *	1994-07-15	1996-01-18	Basf Ag	Verwendung heterocyclischer Verbindungen
DE19728996A1 (de)	1997-07-07	1999-01-14	Basf Ag	Triazolverbindungen und deren Verwendung
CN100509790C (zh) *	2002-06-29	2009-07-08	赞塔里斯有限公司	芳基羰基哌嗪和杂芳基羰基哌嗪及其治疗良性和恶性肿瘤疾病的用途
KR100868353B1 (ko) *	2007-03-08	2008-11-12	한국화학연구원	도파민 ｄ4 수용체 길항제인 신규 피페라지닐프로필피라졸유도체, 이의 제조방법 및 이를 포함하는 약학적 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2329680A (en) *	1943-01-30	1943-09-14	American Cyanamid Co	Defoliation
NL72956C (da) *	1947-11-12
DE1595920B2 (de) *	1964-11-04	1978-08-10	Merck Patent Gmbh, 6100 Darmstadt	4-(co-Piperazinoalkyl)-pyrazole, ihre Salze und Verfahren zu ihrer Herstellung

1966
- 1966-07-02 DE DE1620016A patent/DE1620016C3/de not_active Expired
1967
- 1967-06-13 IL IL28144A patent/IL28144A/en unknown
- 1967-06-16 CH CH861467A patent/CH485751A/de not_active IP Right Cessation
- 1967-06-20 US US647311A patent/US3491097A/en not_active Expired - Lifetime
- 1967-06-22 GB GB28901/67A patent/GB1124710A/en not_active Expired
- 1967-06-26 DK DK329967AA patent/DK117635B/da unknown
- 1967-06-28 NL NL676709008A patent/NL154739B/xx not_active IP Right Cessation
- 1967-06-29 SE SE9735/67*A patent/SE345456B/xx unknown
- 1967-06-30 BE BE700732D patent/BE700732A/xx unknown
- 1967-06-30 FR FR112589A patent/FR6682M/fr not_active Expired
- 1967-07-01 ES ES342556A patent/ES342556A1/es not_active Expired
1971
- 1971-11-27 CY CY62271A patent/CY622A/xx unknown
1972
- 1972-10-19 YU YU2619/72A patent/YU32681B/xx unknown
- 1972-10-19 YU YU2617/72A patent/YU32679B/xx unknown
- 1972-12-31 MY MY197242A patent/MY7200042A/xx unknown

Also Published As

Publication number	Publication date
DK117635B (da)	1970-05-19
YU32679B (en)	1975-04-30
CY622A (en)	1971-11-27
DE1620016A1 (de)	1970-02-12
US3491097A (en)	1970-01-20
CH485751A (de)	1970-02-15
YU261772A (en)	1974-10-31
FR6682M (da)	1969-02-03
YU261972A (en)	1974-10-31
MY7200042A (en)	1972-12-31
YU32681B (en)	1975-04-30
DE1620016C3 (de)	1979-08-30
BE700732A (da)	1968-01-02
DE1620016B2 (de)	1979-01-04
GB1124710A (en)	1968-08-21
NL6709008A (da)	1968-01-03
SE345456B (da)	1972-05-29
IL28144A (en)	1972-04-27
NL154739B (nl)	1977-10-17

Publication	Publication Date	Title
DE69613860D1 (de)	2001-08-16	Pyrazol-derivate, verfahren für ihre herstellung und sie enthaltende zusammensetzungen
DE3775427D1 (de)	1992-02-06	Quinonderivate, ihre herstellung und verwendung.
GB1167563A (en)	1969-10-15	Novel 3-(2-Substituted Ethyl) Indoles and Processes for Their Manufacture
ES342556A1 (es)	1968-10-16	Procedimiento para la preparacion de los 3-(piperacinoal- quil)-pirazoles.
KR900012929A (ko)	1990-09-03	신경안정적 및/또는 정신안정적 활성을 가진 피리미디닐-피페라지닐-알킬 아졸 유도체
WO2007142308A1 (ja)	2007-12-13	含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤
GB1086192A (en)	1967-10-04	Phenylcyclopropane derivatives
GB939901A (en)	1963-10-16	Improvements in or relating to amino pyrazoles
ES347749A1 (es)	1969-03-01	Procedimiento para la preparacion de derivados del indol.
GB1125112A (en)	1968-08-28	New derivatives of diazabicyclo-decane and process for preparing them
GB1033920A (en)	1966-06-22	Novel derivatives of triphenylethanols
AR009380A1 (es)	2000-04-12	Proceso de preparacion de un derivado de piridazin-3-ona, util como herbicida, acido carboxilico de utilizacion en el mismo, sal de este ultimo y proceso para preparar dicho acido carboxilico
AU685219B2 (en)	1998-01-15	Triazole derivatives
GB1453828A (en)	1976-10-27	Fluoro-substituted thiaxanthene derivatives
GB1304069A (da)	1973-01-24
GB1061571A (en)	1967-03-15	N,n'-disubstituted piperazines and process for their manufacture
IL56507A (en)	1984-01-31	(trihalomethyl)dimethyloxabicyclohexanone derivatives for the preparation of cis dihalovinyldimethylcyclopropanecarboxylic acids
CH644125A5 (de)	1984-07-13	Benzo-as-triazin-derivate und verfahren zur herstellung derselben.
US3657438A (en)	1972-04-18	Compositions and methods for treating inflammation
GB1307726A (en)	1973-02-21	Herbicide
GB843688A (en)	1960-08-10	Substituted 3,5-diketo-pyrazolidines
ES269692A1 (es)	1962-04-16	Procedimiento para la preparaciën de nuevos derivados de carbostirilo
GB1319493A (en)	1973-06-06	Isoquinolones and their manufacture
GB983608A (en)	1965-02-17	Novel des-a-steroid compounds, and processes for their preparation
GB1017696A (en)	1966-01-19	Substituted 5h-dibenzo[a, d]cycloheptenes and 10,11-dihydro-5h-dibenzo[a, d]cycloheptenes