ES396219A1 - Un metodo para preparar 2,4-diamino-5-bencilpirimidinas. - Google Patents
Un metodo para preparar 2,4-diamino-5-bencilpirimidinas.Info
- Publication number
- ES396219A1 ES396219A1 ES396219A ES396219A ES396219A1 ES 396219 A1 ES396219 A1 ES 396219A1 ES 396219 A ES396219 A ES 396219A ES 396219 A ES396219 A ES 396219A ES 396219 A1 ES396219 A1 ES 396219A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- compound
- represent
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000004982 aromatic amines Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB963871*[A GB1375162A (da) | 1970-10-22 | 1970-10-22 | |
| GB963871 | 1971-04-16 | ||
| GB4749171 | 1971-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES396219A1 true ES396219A1 (es) | 1975-09-16 |
Family
ID=27255400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES396219A Expired ES396219A1 (es) | 1970-10-22 | 1971-10-21 | Un metodo para preparar 2,4-diamino-5-bencilpirimidinas. |
Country Status (20)
| Country | Link |
|---|---|
| JP (2) | JPS5536662B1 (da) |
| AR (3) | AR192588A1 (da) |
| AT (1) | AT319948B (da) |
| BE (1) | BE774281A (da) |
| BG (4) | BG20365A3 (da) |
| CA (1) | CA967158A (da) |
| CH (3) | CH568301A5 (da) |
| DD (1) | DD100877A5 (da) |
| DK (1) | DK132174C (da) |
| ES (1) | ES396219A1 (da) |
| FI (1) | FI56175C (da) |
| FR (1) | FR2111769B1 (da) |
| GB (1) | GB1375162A (da) |
| IE (1) | IE37452B1 (da) |
| IL (2) | IL37984A (da) |
| LU (1) | LU64129A1 (da) |
| MC (1) | MC894A1 (da) |
| NL (1) | NL175178C (da) |
| SE (2) | SE384505B (da) |
| ZM (1) | ZM14971A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792096A (fr) * | 1971-12-01 | 1973-05-30 | Hoffmann La Roche | Nouvelles benzylpyrimidines |
| FR2397407A2 (fr) * | 1977-07-11 | 1979-02-09 | Dick Pierre | Derives de 2,4-diamino pyrimidines et leur mise en solution en association avec des sulfamides |
| ZW9979A1 (en) * | 1978-05-24 | 1980-12-24 | Wellcome Found | Benzylpyrimidine compositions |
| JPS61156909A (ja) * | 1984-12-27 | 1986-07-16 | Matsushita Electric Ind Co Ltd | カレント・ミラ−回路 |
| JPS62145907A (ja) * | 1985-12-20 | 1987-06-30 | Hitachi Ltd | トランジスタ回路 |
| BRPI0509258A8 (pt) | 2004-03-26 | 2019-01-22 | Astrazeneca Ab | composto de 8-oxoadenina 9-substituída |
| JP2009542645A (ja) | 2006-07-05 | 2009-12-03 | アストラゼネカ・アクチエボラーグ | Ｔｌｒ７のモジュレーターとして作用する８−オキソアデニン誘導体 |
| TW200831105A (en) | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| EP2132209B8 (en) | 2007-03-19 | 2014-04-16 | AstraZeneca AB | 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators |
| JP5329444B2 (ja) | 2007-03-19 | 2013-10-30 | アストラゼネカ・アクチエボラーグ | Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物 |
| EP2138497A4 (en) | 2007-03-20 | 2012-01-04 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
| PE20091236A1 (es) * | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | Derivados de pirimidina como immunomoduladores de tlr7 |
| UY31531A1 (es) | 2007-12-17 | 2009-08-03 | Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr) | |
| GB0908772D0 (en) | 2009-05-21 | 2009-07-01 | Astrazeneca Ab | New salts 756 |
| AU2010250923A1 (en) | 2009-05-21 | 2011-11-17 | Astrazeneca Ab | Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases |
| CN103370317B (zh) | 2010-12-16 | 2015-10-07 | 阿斯利康(瑞典)有限公司 | 可用于治疗的咪唑并[4,5-c]喹啉-1-基衍生物 |
| WO2012080730A1 (en) | 2010-12-17 | 2012-06-21 | Astrazeneca Ab | Purine derivatives |
| CA2871589C (en) | 2012-05-18 | 2020-12-22 | Seiji Hori | Pyrimidine carboxylic acid derivatives and their use as tlr7 agonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE710100A (da) * | 1967-02-02 | 1968-07-30 | ||
| JPS511716A (ja) * | 1974-06-25 | 1976-01-08 | Toray Industries | Horiesuterumaruchifuiramentono seiho |
-
1970
- 1970-10-22 GB GB963871*[A patent/GB1375162A/en not_active Expired
-
1971
- 1971-10-21 MC MC951A patent/MC894A1/fr unknown
- 1971-10-21 CA CA125,807A patent/CA967158A/en not_active Expired
- 1971-10-21 AT AT909371A patent/AT319948B/de not_active IP Right Cessation
- 1971-10-21 CH CH1532171A patent/CH568301A5/xx not_active IP Right Cessation
- 1971-10-21 CH CH1027775A patent/CH582681A5/xx not_active IP Right Cessation
- 1971-10-21 ES ES396219A patent/ES396219A1/es not_active Expired
- 1971-10-21 FI FI2975/71A patent/FI56175C/fi active
- 1971-10-21 SE SE7113328A patent/SE384505B/xx unknown
- 1971-10-21 LU LU64129A patent/LU64129A1/xx unknown
- 1971-10-21 BG BG021452A patent/BG20365A3/xx unknown
- 1971-10-21 CH CH1027675A patent/CH568302A5/xx not_active IP Right Cessation
- 1971-10-21 IL IL37984A patent/IL37984A/en unknown
- 1971-10-21 AR AR238596A patent/AR192588A1/es active
- 1971-10-21 NL NLAANVRAGE7114494,A patent/NL175178C/xx not_active IP Right Cessation
- 1971-10-21 BG BG018828A patent/BG20797A3/xx unknown
- 1971-10-21 DD DD167435A patent/DD100877A5/xx unknown
- 1971-10-21 BG BG021451A patent/BG20364A3/xx unknown
- 1971-10-21 FR FR7137870A patent/FR2111769B1/fr not_active Expired
- 1971-10-21 IE IE1329/71A patent/IE37452B1/xx unknown
- 1971-10-21 DK DK513771A patent/DK132174C/da not_active IP Right Cessation
- 1971-10-21 ZM ZM149/71A patent/ZM14971A1/xx unknown
- 1971-10-21 JP JP8365271A patent/JPS5536662B1/ja active Pending
- 1971-10-21 BE BE774281A patent/BE774281A/xx not_active IP Right Cessation
- 1971-10-21 IL IL45422A patent/IL45422A/en unknown
-
1972
- 1972-06-27 AR AR242772A patent/AR192802A1/es active
- 1972-06-27 AR AR242773A patent/AR192803A1/es active
- 1972-10-21 BG BG021466A patent/BG21406A3/xx unknown
-
1974
- 1974-05-20 SE SE7406661A patent/SE409705B/sv not_active IP Right Cessation
-
1977
- 1977-12-22 JP JP15499477A patent/JPS53135991A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5536662B1 (da) | 1980-09-22 |
| AR192802A1 (es) | 1973-03-14 |
| NL7114494A (da) | 1972-04-25 |
| LU64129A1 (da) | 1972-06-28 |
| FI56175C (fi) | 1979-12-10 |
| SE409705B (sv) | 1979-09-03 |
| DD100877A5 (da) | 1973-10-12 |
| IE37452B1 (en) | 1977-08-03 |
| DK132174B (da) | 1975-11-03 |
| CA967158A (en) | 1975-05-06 |
| CH568302A5 (da) | 1975-10-31 |
| BG20365A3 (bg) | 1975-11-05 |
| FR2111769B1 (da) | 1974-10-18 |
| AR192803A1 (es) | 1973-03-14 |
| NL175178B (nl) | 1984-05-01 |
| AT319948B (de) | 1975-01-10 |
| DK132174C (da) | 1976-03-29 |
| JPS53135991A (en) | 1978-11-28 |
| FR2111769A1 (da) | 1972-06-09 |
| SE384505B (sv) | 1976-05-10 |
| IE37452L (en) | 1972-04-22 |
| BG20364A3 (bg) | 1975-11-05 |
| MC894A1 (fr) | 1972-06-22 |
| AR192588A1 (es) | 1973-02-28 |
| GB1375162A (da) | 1974-11-27 |
| CH568301A5 (da) | 1975-10-31 |
| IL45422A (en) | 1976-03-31 |
| IL37984A0 (en) | 1971-12-29 |
| BG21406A3 (bg) | 1976-05-20 |
| CH582681A5 (da) | 1976-12-15 |
| BE774281A (fr) | 1972-04-21 |
| FI56175B (fi) | 1979-08-31 |
| NL175178C (nl) | 1984-10-01 |
| ZM14971A1 (en) | 1972-07-21 |
| BG20797A3 (bg) | 1975-12-20 |
| IL37984A (en) | 1976-03-31 |
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