ES398079A1 - A procedure for preparing compounds of 1-substitute-2 - (1,1-difluoroalcohyl) -1H-imidazo (4,5-b) pyridine. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for preparing compounds of 1-substitute-2 - (1,1-difluoroalcohyl) -1H-imidazo (4,5-b) pyridine. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES398079A1 ES398079A1 ES398079A ES398079A ES398079A1 ES 398079 A1 ES398079 A1 ES 398079A1 ES 398079 A ES398079 A ES 398079A ES 398079 A ES398079 A ES 398079A ES 398079 A1 ES398079 A1 ES 398079A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- radical
- see formula
- difluoroalcohyl
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- -1 -CF2Cl Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- RVAUFHAJSOMPOZ-UHFFFAOYSA-N NCl[N+]([O-])=O Chemical compound NCl[N+]([O-])=O RVAUFHAJSOMPOZ-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
A process for preparing 1-substituted-2- (1,1-difluoroalcohyl) -1H-imidazo (4,5-b) pyridine compounds, characterized by formula I **(See formula)** wherein R1 represents hydrogen, chlorine, fluorine, C1-C6 perfluoroalkyl, or a radical of the formula: **(See formula)** where each Z independently represents hydrogen or halogen and n represents 0 or 1; R2 represents halogen, nitro, -CF3, -CF2Cl, -CF2H, or C1-C4 lower alcohol-sulfenyl; and R3 represents: (1) C2-C16 alkanoyl, (2) -C3-C16 alkenoyl; (3) a radical of formula (see formula) C1-C4 lower alcohol or (see formula), where X is, as above, oxygen or sulfur; (4) a radical of formula (see formula) where R5 represents methylene, ethylene, or vinylene, and n represents 0 or 1; (5) a radical of formulas (see formula) -substituted phenyl and (see formula) substituted phenyl, where substituted phenyl is a phenyl radical having 1 to 3 substituents, each of which, independently, is amino, nitro, chlorine, methyl, or methoxy, and R6 represents lower alcohol of both inclusive, characterized by reacting the hydroxy compound in which R3 is hydrogen with a carboxylic acid or carboxylic acid anhydride to provide R3 in the form of the desired ester. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10041070A | 1970-12-21 | 1970-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES398079A1 true ES398079A1 (en) | 1974-07-16 |
Family
ID=22279615
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES398079A Expired ES398079A1 (en) | 1970-12-21 | 1971-12-17 | A procedure for preparing compounds of 1-substitute-2 - (1,1-difluoroalcohyl) -1H-imidazo (4,5-b) pyridine. (Machine-translation by Google Translate, not legally binding) |
| ES398078A Expired ES398078A1 (en) | 1970-12-21 | 1971-12-17 | A procedure for preparing compounds of 1-substitute-2 - (1,1-difluoroalcohyl) -1H-imidazo (4,5-b) pyridine. (Machine-translation by Google Translate, not legally binding) |
| ES398077A Expired ES398077A1 (en) | 1970-12-21 | 1971-12-17 | A procedure for preparing compounds of 1.sustituide-2 - (1, 1-difluoroalcohil) -1H-imidazo (4,5-b) pyridine. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES398078A Expired ES398078A1 (en) | 1970-12-21 | 1971-12-17 | A procedure for preparing compounds of 1-substitute-2 - (1,1-difluoroalcohyl) -1H-imidazo (4,5-b) pyridine. (Machine-translation by Google Translate, not legally binding) |
| ES398077A Expired ES398077A1 (en) | 1970-12-21 | 1971-12-17 | A procedure for preparing compounds of 1.sustituide-2 - (1, 1-difluoroalcohil) -1H-imidazo (4,5-b) pyridine. (Machine-translation by Google Translate, not legally binding) |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | AT323166B (en) |
| CA (1) | CA924726A (en) |
| ES (3) | ES398079A1 (en) |
| PH (1) | PH10137A (en) |
| SU (1) | SU374785A3 (en) |
| TR (1) | TR16706A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108250196B (en) * | 2016-12-29 | 2022-12-30 | 上海汇伦医药股份有限公司 | Process for the preparation of (piperazin-1-yl) -1-hydro-imidazoheteroaromatic compounds |
-
1971
- 1971-03-04 CA CA106895A patent/CA924726A/en not_active Expired
- 1971-03-18 SU SU1633751A patent/SU374785A3/ru active
- 1971-03-18 AT AT371172A patent/AT323166B/en not_active IP Right Cessation
- 1971-03-18 TR TR1670671A patent/TR16706A/en unknown
- 1971-03-19 PH PH12304A patent/PH10137A/en unknown
- 1971-12-17 ES ES398079A patent/ES398079A1/en not_active Expired
- 1971-12-17 ES ES398078A patent/ES398078A1/en not_active Expired
- 1971-12-17 ES ES398077A patent/ES398077A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| TR16706A (en) | 1973-03-01 |
| SU374785A3 (en) | 1973-03-20 |
| CA924726A (en) | 1973-04-17 |
| PH10137A (en) | 1976-09-06 |
| ES398077A1 (en) | 1974-07-16 |
| ES398078A1 (en) | 1974-07-16 |
| AT323166B (en) | 1975-06-25 |
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