ES426336A1 - Naphthyridine derivatives - Google Patents
Naphthyridine derivativesInfo
- Publication number
- ES426336A1 ES426336A1 ES426336A ES426336A ES426336A1 ES 426336 A1 ES426336 A1 ES 426336A1 ES 426336 A ES426336 A ES 426336A ES 426336 A ES426336 A ES 426336A ES 426336 A1 ES426336 A1 ES 426336A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- atoms
- symbols
- part contains
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000005054 naphthyridines Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Abstract
Procedure for preparing naphthyridine derivatives, of general formula: ** (See formula) ** in which: one of the symbols = X - represents = N- and the other three each represent a group (see graph) in which Y represents a hydrogen or halogen atom or an alkyl radical containing from 1 to 4 carbon atoms, alkyloxy whose alkyl part contains from 1 to 4 carbon atoms, cyano or nitro; being able to be the symbols Y of the three groups (see graph) identical or different, the symbols = A - and = A1 - represent a group = OH - o = N, it being understood that when = A - represents = CH -, - A1- represents = CH - o = N - and when A represents = N -, = A1- represents = N-, the symbols Z represent atoms or radicals, identical or different, chosen from hydrogen and halogen atoms and the alkyl radicals contain from 1 to 4 carbon atoms, alkyloxyls whose alkyl part contains from 1 to 4 carbon and nitro atoms, and 1) n equals zero and R represents a hydrogen atom or an alkyl radical containing 1 to 4 carbon atoms, alkenyl with 2 to 4 carbon atoms, alkynyl with 2 to 4 carbon atoms, hydroxy alkyl whose alkyl part contains 1 to 4 carbon or phenyl atoms, or 2) n is equal to 1 and R represents an alkyl radical containing from 1 to 4 carbon atoms, hydroxyalkyl whose alkyl part contains from 1 to 4 carbon atoms or phenyl, as well as their addition salts with the acids; characterized in that a piperazine of general formula is reacted: ** (See formula) ** where n and R are defined as above, with a mixed carbonate of general formula: ** (See formula) ** where X, A, A1 and z are defined as above and Ar represents an optionally substituted phenyl radical; - and then the product obtained is eventually transformed into an addition salt with an acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7317516A FR2229400A1 (en) | 1973-05-15 | 1973-05-15 | 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants |
| FR7408728A FR2286642A2 (en) | 1974-03-14 | 1974-03-14 | 2-(Naphthyridin-2-yl)-isoindolin-1-one derivs - contg. 3-(piperazin-1-yl-carbonyloxy) gp., used as tranquillisers and antidepressants |
| FR7408730A FR2263752A1 (en) | 1974-03-14 | 1974-03-14 | 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES426336A1 true ES426336A1 (en) | 1976-07-01 |
Family
ID=27250114
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES426335A Expired ES426335A1 (en) | 1973-05-15 | 1974-05-14 | Naphthyridine derivatives |
| ES426336A Expired ES426336A1 (en) | 1973-05-15 | 1974-05-14 | Naphthyridine derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES426335A Expired ES426335A1 (en) | 1973-05-15 | 1974-05-14 | Naphthyridine derivatives |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5758345B2 (en) |
| AR (2) | AR209421A1 (en) |
| AT (1) | AT336030B (en) |
| CH (2) | CH592662A5 (en) |
| CS (1) | CS191881B2 (en) |
| DD (1) | DD111078A5 (en) |
| DE (1) | DE2423650A1 (en) |
| DK (1) | DK136819B (en) |
| ES (2) | ES426335A1 (en) |
| FI (1) | FI55659C (en) |
| GB (1) | GB1417935A (en) |
| HU (1) | HU169609B (en) |
| IE (1) | IE39263B1 (en) |
| IL (1) | IL44815A (en) |
| LU (1) | LU70071A1 (en) |
| NL (1) | NL7406194A (en) |
| NO (1) | NO140012C (en) |
| OA (1) | OA04700A (en) |
| PH (1) | PH11400A (en) |
| PL (1) | PL90061B1 (en) |
| SE (1) | SE410857B (en) |
| SU (2) | SU583757A3 (en) |
| YU (2) | YU133674A (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS537455B1 (en) * | 1971-02-01 | 1978-03-17 | ||
| FR2324305A2 (en) * | 1975-09-22 | 1977-04-15 | Rhone Poulenc Ind | NEW DERIVATIVES OF ISOINDOLINE, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM |
| AR208414A1 (en) * | 1974-11-07 | 1976-12-27 | Rhone Poulenc Ind | PROCEDURE TO OBTAIN NEW DERIVATIVES OF ((ACIL-4PIPERAZINIL-1) CARBONYLOXI-5 PYRROLINONE-2) |
| FR2322600A1 (en) * | 1975-09-04 | 1977-04-01 | Rhone Poulenc Ind | Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576) |
| OA05287A (en) * | 1975-04-07 | 1981-02-28 | Rhone Poulenc Ind | New heterocyclic compounds and their preparation. |
| JPS5546257A (en) * | 1978-09-27 | 1980-03-31 | Hitachi Cable | Flame retardant cable |
| JPS5546256A (en) * | 1978-09-27 | 1980-03-31 | Hitachi Cable | Flame retardant insulated wire |
| JPS63191981U (en) * | 1987-05-30 | 1988-12-09 | ||
| CN1128139C (en) * | 1995-01-11 | 2003-11-19 | 三进制药株式会社 | New piperazine derivatives and their production methods |
| SK27598A3 (en) * | 1996-06-29 | 1998-11-04 | Samjin Pharm Co Ltd | Piperazine derivatives and process for the preparation thereof |
-
1974
- 1974-04-29 OA OA55189A patent/OA04700A/en unknown
- 1974-04-30 PH PH15794A patent/PH11400A/en unknown
- 1974-05-08 NL NL7406194A patent/NL7406194A/xx not_active Application Discontinuation
- 1974-05-13 IE IE1012/74A patent/IE39263B1/en unknown
- 1974-05-13 GB GB2108174A patent/GB1417935A/en not_active Expired
- 1974-05-13 IL IL44815A patent/IL44815A/en unknown
- 1974-05-13 JP JP49052378A patent/JPS5758345B2/ja not_active Expired
- 1974-05-13 HU HURO780A patent/HU169609B/hu unknown
- 1974-05-14 CH CH659574A patent/CH592662A5/xx not_active IP Right Cessation
- 1974-05-14 SU SU7402026597A patent/SU583757A3/en active
- 1974-05-14 ES ES426335A patent/ES426335A1/en not_active Expired
- 1974-05-14 DK DK263374AA patent/DK136819B/en not_active IP Right Cessation
- 1974-05-14 ES ES426336A patent/ES426336A1/en not_active Expired
- 1974-05-14 SE SE7406452A patent/SE410857B/en not_active IP Right Cessation
- 1974-05-14 DD DD178499A patent/DD111078A5/xx unknown
- 1974-05-14 CH CH53477A patent/CH592663A5/xx not_active IP Right Cessation
- 1974-05-14 NO NO741744A patent/NO140012C/en unknown
- 1974-05-14 LU LU70071A patent/LU70071A1/xx unknown
- 1974-05-15 CS CS743472A patent/CS191881B2/en unknown
- 1974-05-15 DE DE2423650A patent/DE2423650A1/en not_active Withdrawn
- 1974-05-15 AT AT400874A patent/AT336030B/en not_active IP Right Cessation
- 1974-05-15 PL PL1974171103A patent/PL90061B1/en unknown
- 1974-05-15 YU YU01336/74A patent/YU133674A/en unknown
- 1974-05-15 FI FI1498/74A patent/FI55659C/en active
- 1974-05-15 AR AR253755A patent/AR209421A1/en active
-
1975
- 1975-01-29 AR AR257458A patent/AR210851A1/en active
- 1975-03-18 SU SU752112823A patent/SU589916A3/en active
-
1981
- 1981-12-08 YU YU02877/81A patent/YU287781A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS191881B2 (en) | 1979-07-31 |
| CH592663A5 (en) | 1977-10-31 |
| HU169609B (en) | 1976-12-28 |
| ES426335A1 (en) | 1976-09-01 |
| IE39263B1 (en) | 1978-08-30 |
| GB1417935A (en) | 1975-12-17 |
| FI55659C (en) | 1979-09-10 |
| JPS5040593A (en) | 1975-04-14 |
| JPS5758345B2 (en) | 1982-12-09 |
| PL90061B1 (en) | 1976-12-31 |
| LU70071A1 (en) | 1975-02-24 |
| CH592662A5 (en) | 1977-10-31 |
| DD111078A5 (en) | 1975-01-20 |
| ATA400874A (en) | 1976-08-15 |
| DK136819C (en) | 1978-05-16 |
| YU133674A (en) | 1983-01-21 |
| YU287781A (en) | 1983-01-21 |
| SU583757A3 (en) | 1977-12-05 |
| IL44815A (en) | 1977-12-30 |
| SE410857B (en) | 1979-11-12 |
| SU589916A3 (en) | 1978-01-25 |
| IE39263L (en) | 1974-11-15 |
| DE2423650A1 (en) | 1974-12-05 |
| NO741744L (en) | 1974-11-18 |
| OA04700A (en) | 1980-07-31 |
| NO140012B (en) | 1979-03-12 |
| NO140012C (en) | 1979-06-20 |
| FI55659B (en) | 1979-05-31 |
| DK136819B (en) | 1977-11-28 |
| AT336030B (en) | 1977-04-12 |
| AR209421A1 (en) | 1977-04-29 |
| PH11400A (en) | 1977-12-14 |
| IL44815A0 (en) | 1975-02-10 |
| AU6888074A (en) | 1975-11-13 |
| AR210851A1 (en) | 1977-09-30 |
| NL7406194A (en) | 1974-11-19 |
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