ES443825A1 - Procedimiento para la preparacion de d-homoroceto-pregna- nos. - Google Patents

Procedimiento para la preparacion de d-homoroceto-pregna- nos.

Info

Publication number: ES443825A1
Authority: ES; Spain
Prior art keywords: hydrogen; ketopregnanes; homo; image; narcosis
Prior art date: 1974-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES443825A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Schering AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-12-23

Filing date

1975-12-23

Publication date

1977-05-01

1974-12-23 Priority claimed from DE19742461312 external-priority patent/DE2461312A1/de

1975-02-14 Priority claimed from DE19752506688 external-priority patent/DE2506688A1/de

1975-12-23 Application filed by Schering AG filed Critical Schering AG

1977-05-01 Publication of ES443825A1 publication Critical patent/ES443825A1/es

Status Expired legal-status Critical Current

Links

206010002091 Anaesthesia Diseases 0.000 title 1
208000010513 Stupor Diseases 0.000 title 1
230000037005 anaesthesia Effects 0.000 title 1
230000001939 inductive effect Effects 0.000 title 1
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
-1 azido, mercapto, thiocyano Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000000460 chlorine Chemical group 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES443825A 1974-12-23 1975-12-23 Procedimiento para la preparacion de d-homoroceto-pregna- nos. Expired ES443825A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19742461312 DE2461312A1 (de)	1974-12-23	1974-12-23	D-homo-20-keto-pregnane und verfahren zu ihrer herstellung
DE19752506688 DE2506688A1 (de)	1975-02-14	1975-02-14	D-homo-19-nor-20-ketopregnane und verfahren zu ihrer herstellung

Publications (1)

Publication Number	Publication Date
ES443825A1 true ES443825A1 (es)	1977-05-01

Family

ID=25768157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES443825A Expired ES443825A1 (es)	1974-12-23	1975-12-23	Procedimiento para la preparacion de d-homoroceto-pregna- nos.

Country Status (13)

Country	Link
US (1)	US4056633A (es)
JP (1)	JPS5188953A (es)
AU (1)	AU501685B2 (es)
CA (1)	CA1051868A (es)
DD (1)	DD123329A5 (es)
DK (1)	DK138501C (es)
ES (1)	ES443825A1 (es)
FR (1)	FR2295739A1 (es)
GB (1)	GB1538869A (es)
IL (1)	IL48628A0 (es)
LU (1)	LU74087A1 (es)
NL (1)	NL7514976A (es)
SE (1)	SE7514514L (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4104306A (en) *	1976-05-05	1978-08-01	Abbott Laboratories	12A-Deoxy chelocardin
US5439900A (en) *	1993-02-25	1995-08-08	Bukusoglu; Cuneyt	Methods and compositions for providing analgesia and enhanced anesthesia
DE60308388T2 (de) *	2002-08-16	2007-09-20	Pharmacia & Upjohn Co. Llc, Kalamazoo	5-Androsten-3beta-ol-Steroide und Verfahren für ihre Herstellung
US20070066579A1 (en) *	2002-08-16	2007-03-22	White Michael J	5-androsten-3beta-ol steroid intermediates and processs for their preparation
SMT202100509T1 (it)	2013-04-17	2021-11-12	Sage Therapeutics Inc	Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia
CN117304245A (zh)	2013-04-17	2023-12-29	萨奇治疗股份有限公司	刺激神经活性的19-去甲类固醇及其使用方法
WO2014169836A1 (en)	2013-04-17	2014-10-23	Sage Therapeutics, Inc.	19-nor neuroactive steroids and methods of use thereof
US9725481B2 (en)	2013-04-17	2017-08-08	Sage Therapeutics, Inc.	19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
CA2918735C (en)	2013-07-19	2023-08-01	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
CN105579043B (zh)	2013-08-23	2021-09-14	萨奇治疗股份有限公司	神经活性类固醇、组合物和其用途
US10246482B2 (en)	2014-06-18	2019-04-02	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
US20170233433A1 (en)	2014-10-16	2017-08-17	Sage Therapeutics, Inc.	Compositions and methods for treating cns disorders
MY190408A (en)	2014-10-16	2022-04-21	Sage Therapeutics Inc	Compositions and methods for treating cns disorders
WO2016082789A1 (en)	2014-11-27	2016-06-02	Sage Therapeutics, Inc.	Compositions and methods for treating cns disorders
LT3250210T (lt)	2015-01-26	2021-04-12	Sage Therapeutics, Inc.	Kompozicijos ir būdai, skirti gydyti cns sutrikimus
DK3258939T3 (da)	2015-02-20	2022-12-12	Sage Therapeutics Inc	Neuroaktive steroider, sammensætninger og anvendelser heraf
WO2018013613A1 (en)	2016-07-11	2018-01-18	Sage Therapeutics, Inc.	C17, c20, and c21 substituted neuroactive steroids and their methods of use
CA3030420C (en)	2016-07-11	2025-11-18	Sage Therapeutics, Inc.	C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND ASSOCIATED METHODS OF USE
EP3728285B1 (en) *	2017-12-22	2026-04-08	Sage Therapeutics, LLC	Compositions and methods for treating cns disorders
JP7538040B2 (ja) *	2018-01-12	2024-08-21	セージセラピューティクス，インコーポレイテッド	ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物
IL312610B2 (en)	2018-12-05	2026-05-01	Sage Therapeutics Llc	Neuroactive steroids and methods of using them
CN111410678B (zh) *	2019-01-08	2023-02-28	成都康弘药业集团股份有限公司	甾体类化合物、用途及其制备方法
JP7670626B2 (ja)	2019-05-31	2025-04-30	セージセラピューティクス，インコーポレイテッド	神経刺激性ステロイド及びその組成物
BR112021026447A2 (pt) *	2019-06-27	2022-04-12	Sage Therapeutics Inc	Composições e métodos para tratamento de distúrbios de cns
JP7787635B2 (ja)	2019-06-27	2025-12-17	セージセラピューティクス，エルエルシー	Ｃｎｓ障害を治療するための組成物及び方法
CA3143545A1 (en) *	2019-06-27	2020-12-30	Sage Therapeutics, Inc.	Compounds for treating cns disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3876705A (en) *	1972-06-12	1975-04-08	Univ New Brunswick	Steroid total synthesis and intermediates

1975
- 1975-12-09 IL IL48628A patent/IL48628A0/xx unknown
- 1975-12-17 AU AU87637/75A patent/AU501685B2/en not_active Expired
- 1975-12-17 US US05/641,602 patent/US4056633A/en not_active Expired - Lifetime
- 1975-12-19 DD DD190370A patent/DD123329A5/xx unknown
- 1975-12-22 GB GB52351/75A patent/GB1538869A/en not_active Expired
- 1975-12-22 LU LU74087A patent/LU74087A1/xx unknown
- 1975-12-22 SE SE7514514A patent/SE7514514L/xx unknown
- 1975-12-23 NL NL7514976A patent/NL7514976A/xx not_active Application Discontinuation
- 1975-12-23 DK DK588775A patent/DK138501C/da active
- 1975-12-23 ES ES443825A patent/ES443825A1/es not_active Expired
- 1975-12-23 CA CA242,439A patent/CA1051868A/en not_active Expired
- 1975-12-23 JP JP50153888A patent/JPS5188953A/ja active Pending
- 1975-12-23 FR FR7539458A patent/FR2295739A1/fr not_active Withdrawn

Also Published As

Publication number	Publication date
IL48628A0 (en)	1976-02-29
DK138501B (da)	1978-09-18
DD123329A5 (es)	1976-12-12
DK588775A (da)	1976-06-24
DK138501C (da)	1979-02-19
SE7514514L (sv)	1976-06-24
NL7514976A (nl)	1976-06-25
CA1051868A (en)	1979-04-03
JPS5188953A (en)	1976-08-04
FR2295739A1 (fr)	1976-07-23
AU8763775A (en)	1977-06-23
GB1538869A (en)	1979-01-24
LU74087A1 (es)	1976-07-20
AU501685B2 (en)	1979-06-28
US4056633A (en)	1977-11-01

Publication	Publication Date	Title
ES455804A1 (es)	1978-01-16	Un procedimiento de preparacion de nuevos derivados del aci-do 3-quinolein- carboxilico.
ES464193A1 (es)	1978-09-01	Procedimiento para la preparacion de espirolactonas.
ES455149A1 (es)	1978-01-01	Procedimiento para preparar n-fenil-n'-benzoil-ureas.
ES433145A1 (es)	1976-11-16	Procedimiento para preparar derivados de fenoxipropilamina.
ES467565A1 (es)	1978-10-16	Procedimiento para la preparacion de nuevas 4-acilamino-fe- nil-etanol-aminas.
GB2191196B (en)	1990-03-28	Imidazo pyrimidines
AU576199B2 (en)	1988-08-18	Beta-carboline derivatives
ES457385A1 (es)	1978-02-01	Procedimiento para preparar derivados de prostaglandinas.
IE800968L (en)	1980-11-11	Pyrazinobenzodiazepines
ES481551A1 (es)	1980-02-01	Procedimiento de preparacion de nuevos compuestos bis (ari- loxicarboxilicos).
ES474543A1 (es)	1979-04-16	Procedimiento para producir derivados del acido propionico.
ES476166A1 (es)	1979-06-01	Procedimiento para la preparacion de nuevas imidazo-isoqui- nolein-dionas
ES439038A1 (es)	1977-02-01	Procedimiento para la preparacion de nuevas isoquinoleinas.
ES435622A1 (es)	1976-12-16	Procedimiento para la preparacion de bencenosulfonifurcas.
ES8200648A2 (es)	1981-12-01	Procedimiento de preparacion de compuestos opacificantes para radiografia y similares
ES466815A1 (es)	1978-10-01	Procedimiento de preparacion de (2-tio)ureas disustituidas en las posiciones 1 y 3.
ES459197A1 (es)	1978-05-01	Procedimiento para preparar esteres oximicos de isonitroso- cianoacetamida.
CS572083A2 (en)	1984-12-14	Zpusob vyroby novych bazicky substituovanych 4 fenyl 4,5,6,7 tetrahydrothieno ( 2,3 c ) pyridinu
ES466682A1 (es)	1979-06-01	Procedimiento para la obtencion de derivados del acido inde-no - 2.1-b-tiopen-2-oxamico
ES448989A1 (es)	1977-07-01	Procedimiento para la obtencion de derivados alquinicos.
ES438513A1 (es)	1977-05-16	Procedimiento para la obtencion de derivados de hexahidro- diazepino-indol.
ES475780A1 (es)	1980-01-16	Un proceso para la produccion de nueva penicilina y deriva- dos cefalosporinicos
JPS5732274A (en)	1982-02-20	Substituted 3,5-diamino-1,2,4-oxadiazole and 3,5-diamino-1,2,4-thiadiazole, manufacture and use thereof
ES471267A1 (es)	1979-10-01	Procedimiento para la preparacion de alquilo inferior 2-tri-(inferior) alquilsililacetileno-n-carbetoxiglicinatos y ami-no acidos derivados de ellos
ES441436A1 (es)	1977-07-01	Procedimiento de preparacion de nuevas crotonanilidas susti-tuidas.