ES445659A1 - Procedimiento para la obtencion de derivados olefinicos de amino acidos. - Google Patents

Procedimiento para la obtencion de derivados olefinicos de amino acidos.

Info

Publication number: ES445659A1
Authority: ES; Spain
Prior art keywords: carbon atoms; hydrogen; straight; branched; lower alkyl
Prior art date: 1975-03-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES445659A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Richardson Vicks Inc

Original Assignee

Richardson Merrell Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-03-18

Filing date

1976-02-28

Publication date

1977-06-01

1976-02-28 Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc

1977-06-01 Publication of ES445659A1 publication Critical patent/ES445659A1/es

Status Expired legal-status Critical Current

Links

150000001413 amino acids Chemical class 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 9
125000000217 alkyl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
150000002431 hydrogen Chemical group 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229910052740 iodine Chemical group 0.000 abstract 1
239000011630 iodine Chemical group 0.000 abstract 1
150000003951 lactams Chemical class 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000002831 pharmacologic agent Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES445659A 1975-03-18 1976-02-28 Procedimiento para la obtencion de derivados olefinicos de amino acidos. Expired ES445659A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/559,544 US3960927A (en)	1975-03-18	1975-03-18	Olefinic derivatives of amino acids

Publications (1)

Publication Number	Publication Date
ES445659A1 true ES445659A1 (es)	1977-06-01

Family

ID=24233995

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES445659A Expired ES445659A1 (es)	1975-03-18	1976-02-28	Procedimiento para la obtencion de derivados olefinicos de amino acidos.

Country Status (20)

Country	Link
US (1)	US3960927A (es)
JP (1)	JPS593988B2 (es)
BE (1)	BE839657A (es)
CA (1)	CA1077487A (es)
CH (1)	CH631696A5 (es)
DE (1)	DE2607620C2 (es)
DK (1)	DK145339C (es)
ES (1)	ES445659A1 (es)
FR (1)	FR2304329A1 (es)
GB (1)	GB1472525A (es)
IE (1)	IE42410B1 (es)
IL (1)	IL48912A (es)
MX (1)	MX4654E (es)
NL (2)	NL187161C (es)
NO (1)	NO146428C (es)
NZ (1)	NZ179834A (es)
PH (1)	PH12100A (es)
PT (1)	PT64761B (es)
SE (1)	SE442295B (es)
ZA (1)	ZA76411B (es)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4039549A (en) *	1975-03-18	1977-08-02	Merrell Toraude Et Compagnie	Olefinic derivatives of amino acids
US4041041A (en) *	1975-03-18	1977-08-09	Merrell Toraude Et Compagnie	Acetylene derivatives of amino acids
CA1121375A (en) *	1977-07-01	1982-04-06	Brian W. Metcalf	Derivatives of amines and amino acids
CA1157030A (en) *	1977-07-01	1983-11-15	Brian W. Metcalf	.alpha.-VINYL AMINO ACIDS
US4147873A (en) *	1977-07-01	1979-04-03	Merrell Toraude Et Compagnie	α-Vinyl derivatives of α-amino acids
US4139563A (en) *	1977-07-01	1979-02-13	Merrell Toraude Et Compagnie	α-ACETYLENIC DERIVATIVES OF AMINES
US4326071A (en) *	1977-09-28	1982-04-20	Merrell Toraude Et Compagnie	Halomethyl derivatives of gamma-aminobutyric acid and related compounds
US4187316A (en) *	1978-01-12	1980-02-05	Merrell Toraude Et Compagnie	Substituted 1,5-cyclohexadiene carboxylic acid derivatives
US4178463A (en) *	1978-01-30	1979-12-11	Merrell Toraude Et Compagnie	Process for making 4-aminohex-5-enoic acid
US4254284A (en) *	1978-01-30	1981-03-03	Merrell Toraude Et Compagnie	Process for preparing 4-aminohex-5-ynoic acid
US5147868A (en) *	1978-07-24	1992-09-15	Merck & Co., Inc.	Thienamycin renal peptidase inhibitors
US4880793A (en) *	1978-07-24	1989-11-14	Merck & Co., Inc.	Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4323704A (en) *	1979-06-25	1982-04-06	Merrell Toraude Et Compagnie	αAcetylene and α-vinyl derivatives of amino acids
US4539208A (en) *	1980-09-17	1985-09-03	Merck & Co., Inc.	Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4372974A (en) *	1980-06-25	1983-02-08	New York University	Anticonvulsive compositions and method of treating convulsive disorders
GB2120244B (en) *	1982-05-17	1985-05-01	Merrell Toraude & Co	Aminoalkadiene derivative
GB2133002B (en) *	1982-12-30	1986-01-29	Merrell Toraude & Co	Process for preparing 4-amino-5-hexenoic acid
GB8311804D0 (en) *	1983-04-29	1983-06-02	Merrell Toraude & Co	Treatment of seizure disorders and pharmaceutical compositions
US4668703A (en) *	1983-07-07	1987-05-26	Syntex (U.S.A.) Inc.	γ-allenyl-γ-aminobutyric acids
JPS6036448A (ja) *	1983-07-07	1985-02-25	シンテツクス（ユー・エス・エイ）インコーポレイテツド	γ―アレル―γ―アミノ酪酸類
US4661510A (en) *	1983-08-17	1987-04-28	Syntex (U.S.A.) Inc.	α-allenic-α-amino acids as enzyme inhibitors
US4588825A (en) *	1983-10-11	1986-05-13	Merrell Dow Pharmaceuticals Inc.	Intermediates for the synthesis of 4-amino-4,5-dihydro-2-furancarboxylic acid
US4632994A (en) *	1983-11-04	1986-12-30	Gruppo Lepetit S.P.A.	Process for decomposing N-oxide derivatives producing 5-vinyl-2-pyrrolidones
JPS6137389U (ja) *	1984-08-09	1986-03-08	永大産業株式会社	家具用の戸
DE3536146A1 (de) *	1985-10-10	1987-04-16	Degussa	Verfahren zur enantioselektiven herstellung von (alpha)-vinyl-(alpha)-aminocarbonsaeuren
US4727062A (en) *	1986-03-17	1988-02-23	Merck & Co., Inc.	3-Halovinylglycine antibacterial agents
US4806680A (en) *	1986-03-17	1989-02-21	Merck & Co., Inc.	3-halovinylglycine antibacterial agents
CA2028782C (en) *	1989-11-07	2003-10-14	Christian T. Goralski	Process for the production of vinyl-gaba
US5208345A (en) *	1990-12-17	1993-05-04	Merrell Dow Pharmaceuticals Inc.	Process for the production of (S)-vinyl and allenyl gaba
AU644919B2 (en) *	1990-12-17	1993-12-23	Aventisub Ii Inc.	Process for the production of (S)-vinyl and allenyl gaba
EP0546230A1 (en) *	1991-12-10	1993-06-16	Merrell Dow Pharmaceuticals Inc.	Novel process for preparing 4-amino-5-hexenoic acid
US5705660A (en) *	1994-08-22	1998-01-06	Board Of Regents, University Of Nebraska-Lincoln	Method for the synthesis of α-oxiranyl amino acids
US7098206B2 (en) *	1998-01-21	2006-08-29	Smithkline Beecham Corporation	Pharmaceutically active morpholinol
US6998400B2 (en) *	1998-01-22	2006-02-14	Smithkline Beecham Corporation	Pharmaceutically active morpholinol
AU2483599A (en)	1998-01-29	1999-08-16	Sepracor, Inc.	Pharmaceutical uses of optically pure (-)-bupropion
WO1999038503A1 (en)	1998-01-29	1999-08-05	Sepracor Inc.	Pharmacological uses of optically pure (+)-bupropion
US6541520B1 (en)	1998-08-05	2003-04-01	Brookhaven Science Associates	Treatment of addiction and addiction-related behavior
US6734213B2 (en)	1999-01-20	2004-05-11	Smithkline Beecham Corporation	Pharmaceutically active morpholinol
US6855820B2 (en) *	1999-01-20	2005-02-15	Smithkline Beecham Corporation	Pharmaceutically active morpholinol
US6337328B1 (en) *	1999-03-01	2002-01-08	Sepracor, Inc.	Bupropion metabolites and methods of use
US6342496B1 (en) *	1999-03-01	2002-01-29	Sepracor Inc.	Bupropion metabolites and methods of use
KR20030059290A (ko)	2000-11-30	2003-07-07	화이자 프로덕츠 인코포레이티드	Ｇａｂａ 작용제 및 소르비톨 데하이드로게나제 억제제의혼합물
AP2001002359A0 (en)	2000-11-30	2001-12-31	Pfizer Prod Inc	Combination of gaba agonists and aldose reductase inhibitors.
CA2525366A1 (en) *	2003-05-16	2004-11-25	Pfizer Products Inc.	Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines
PT1691811E (pt)	2003-12-11	2014-10-30	Sunovion Pharmaceuticals Inc	Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
BRPI0507190A (pt) *	2004-01-29	2007-06-26	Pfizer Prod Inc	combinação de moduladores do ácido gama-aminobutìrico e antagonistas de 5-ht1b receptores
EP2275096A3 (en)	2005-08-26	2011-07-13	Braincells, Inc.	Neurogenesis via modulation of the muscarinic receptors
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
WO2007047978A2 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
EP2314289A1 (en)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2021000A2 (en)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenesis by modulating angiotensin
US7678808B2 (en)	2006-05-09	2010-03-16	Braincells, Inc.	5 HT receptor mediated neurogenesis
WO2008030651A1 (en)	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
EP2118052A4 (en) *	2007-03-15	2010-04-14	Sun Pharma Advanced Res Co Ltd	NEW PRODRUGS
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
EP2537827B1 (en)	2011-06-24	2014-06-11	Targeon SAS	Process for preparing 4-amino-5-hexenoic acid from succinimide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2460708A (en) *	1946-03-22	1949-02-01	Merck & Co Inc	Process for making acetamido dimethylacrylic acid
US2531595A (en) *	1949-06-09	1950-11-28	Sterling Drug Inc	Preparation of alpha-acylamino-alpha-substituted-acetic acids
US2588969A (en) *	1949-11-26	1952-03-11	Eastman Kodak Co	Certain acylamino-acrylates and-crotonates as insecticides
US3223729A (en) *	1962-06-06	1965-12-14	Sterling Drug Inc	3-allylhydantoic acid

1975
- 1975-03-18 US US05/559,544 patent/US3960927A/en not_active Expired - Lifetime
1976
- 1976-01-23 IE IE136/76A patent/IE42410B1/en unknown
- 1976-01-26 NZ NZ179834A patent/NZ179834A/en unknown
- 1976-01-26 GB GB285676A patent/GB1472525A/en not_active Expired
- 1976-01-26 NO NO760234A patent/NO146428C/no unknown
- 1976-01-26 ZA ZA411A patent/ZA76411B/xx unknown
- 1976-01-27 DK DK31476A patent/DK145339C/da not_active IP Right Cessation
- 1976-01-27 IL IL48912A patent/IL48912A/xx unknown
- 1976-02-02 PT PT64761A patent/PT64761B/pt unknown
- 1976-02-03 PH PH18044A patent/PH12100A/en unknown
- 1976-02-04 NL NLAANVRAGE7601116,A patent/NL187161C/xx active Protection Beyond IP Right Term
- 1976-02-04 SE SE7601205A patent/SE442295B/xx not_active IP Right Cessation
- 1976-02-17 CA CA245,927A patent/CA1077487A/en not_active Expired
- 1976-02-25 DE DE2607620A patent/DE2607620C2/de not_active Expired
- 1976-02-26 JP JP51019522A patent/JPS593988B2/ja not_active Expired
- 1976-02-27 CH CH245476A patent/CH631696A5/de active Protection Beyond IP Right Term
- 1976-02-28 ES ES445659A patent/ES445659A1/es not_active Expired
- 1976-03-02 MX MX7665U patent/MX4654E/es unknown
- 1976-03-16 FR FR7607547A patent/FR2304329A1/fr active Granted
- 1976-03-17 BE BE165245A patent/BE839657A/xx not_active IP Right Cessation
1993
- 1993-06-30 NL NL930125C patent/NL930125I2/nl unknown

Also Published As

Publication number	Publication date
AU1071676A (en)	1977-08-11
PH12100A (en)	1978-11-02
NO760234L (es)	1976-09-21
PT64761A (en)	1976-03-01
NL930125I2 (nl)	1997-08-01
NO146428B (no)	1982-06-21
JPS51125320A (en)	1976-11-01
DK145339B (da)	1982-11-01
NO146428C (no)	1982-09-29
ZA76411B (en)	1977-01-26
IL48912A (en)	1980-09-16
SE442295B (sv)	1985-12-16
CA1077487A (en)	1980-05-13
GB1472525A (en)	1977-05-04
SE7601205L (sv)	1976-09-19
NL187161B (nl)	1991-01-16
CH631696A5 (de)	1982-08-31
IL48912A0 (en)	1976-03-31
DK31476A (da)	1976-09-19
FR2304329A1 (fr)	1976-10-15
IE42410B1 (en)	1980-07-30
NL7601116A (nl)	1976-09-21
JPS593988B2 (ja)	1984-01-27
PT64761B (en)	1977-06-06
NZ179834A (en)	1978-06-20
NL187161C (nl)	1991-06-17
US3960927A (en)	1976-06-01
DE2607620C2 (de)	1984-09-13
IE42410L (en)	1976-09-18
BE839657A (fr)	1976-07-16
NL930125I1 (nl)	1993-11-01
DK145339C (da)	1983-03-21
MX4654E (es)	1982-07-19
DE2607620A1 (de)	1976-09-30
FR2304329B1 (es)	1980-07-18

Legal Events

Date	Code	Title	Description
2007-11-16	FD1A	Patent lapsed	Effective date: 19970211

Publication	Publication Date	Title
IE42410L (en)	1976-09-18	Olefinic derivatives of aminoacids.
ES445660A1 (es)	1977-10-01	Procedimiento para preparar acidos w-acetileno-w-amino-alca-noicos y 2-alquenoicos.
ATE184000T1 (de)	1999-09-15	2-oxindolderivate als tyrosinekinaseinhibitoren
LU91587I2 (fr)	2009-09-22	Agomélatine et ses dérivés pharmaceutiquement acceptables (VALDOXAN)
ATE94061T1 (de)	1993-09-15	Arylsubstituierte aminderivate verwendbar in der krebstherapie.
ES8203845A1 (es)	1982-04-01	Procedimiento para preparar derivados de piridoxina
BR1101136A (pt)	1999-12-07	Derivado da pristinamicina iib, (dietilamino-2 metil-1 etil) sulfinil-26 pristinamicina iib, (dietilamino-2 propil) sulfonil-26 pristinamicina iib, (diisopropilamino-2 etil) sulfonil-26 pristinamicina iib, processo de preparação de novo derivado da pristinamicina iib e composição farmacêutica
ES2012648A6 (es)	1990-04-01	Procedimiento para la preparacion de nuevos derivados de 1,4-benzoxazina y 1,4-benzotiazina.
ATE96446T1 (de)	1993-11-15	Estramustin-ester.
ES478508A1 (es)	1979-07-16	Procedimiento para la preparacion de derivados alfa-acetile-nicos de alfa-animo acidos.
ES484616A1 (es)	1980-05-16	Un procedimiento para preparar nuevos derivados de pirrolil-piridazin-amina
ES445661A1 (es)	1977-06-01	Procedimiento para la preparacion de derivados de acetileno.
EP0683788A1 (en)	1995-11-29	3'-AZIRIDINO-ANTHRACYCLINE DERIVATIVES.
PT89082A (pt)	1988-12-01	Processo para a preparacao de novos derivados n-(23-vinblastinoilicos)do acido 1-amino-metilfosfonico
UA43338C2 (uk)	2001-12-17	Похідні бензолу
ES2118343T3 (es)	1998-09-16	Nuevos derivados de 2-(1h)-quinoleinona, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES475596A1 (es)	1979-12-01	Procedimiento para la preparacion de derivados de fenoxial- canolaminas
ES8103077A1 (es)	1981-02-16	Procedimiento de preparacion de nuevos derivados fenotiazi- nos o de sus sales de adicion acidas
ES475120A1 (es)	1979-05-16	Un procedimiento para la preparacion de imidazo (1,5-b)piri-dazinas.
ES8201525A1 (es)	1981-12-16	Un procedimiento para la preparacion de nuevos derivados de 1,1'-bifenil-2-il-alquilamina
ES454421A1 (es)	1978-10-16	Procedimiento para preparar derivados de acetamidoxina.
ES8800206A1 (es)	1987-10-16	Un procedimiento para preparar derivados de 2-aminopirimidinona
ES445339A1 (es)	1977-06-01	Un procedimiento para la preparacion de derivados pirrolidi-nicos.
MY102002A (en)	1992-02-29	Phenethylamine derivatives
ES8506313A1 (es)	1984-11-16	Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo(3.2.0)hepteno.