ES463783A1 - Un procedimiento para la preparacion de cis-4a-aril-octahi- dro-1h-2-pirindinas 2-sustituidas. - Google Patents

Un procedimiento para la preparacion de cis-4a-aril-octahi- dro-1h-2-pirindinas 2-sustituidas.

Info

Publication number: ES463783A1
Authority: ES; Spain
Prior art keywords: octahydro; formula; pyrindines; cis; phenyl
Prior art date: 1976-11-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES463783A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-11-02

Filing date

1977-11-02

Publication date

1979-07-16

1977-11-02 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1979-07-16 Publication of ES463783A1 publication Critical patent/ES463783A1/es

Status Expired legal-status Critical Current

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
229940100198 alkylating agent Drugs 0.000 abstract 1
239000002168 alkylating agent Substances 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

ES463783A 1976-11-02 1977-11-02 Un procedimiento para la preparacion de cis-4a-aril-octahi- dro-1h-2-pirindinas 2-sustituidas. Expired ES463783A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US73795876A	1976-11-02	1976-11-02

Publications (1)

Publication Number	Publication Date
ES463783A1 true ES463783A1 (es)	1979-07-16

Family

ID=24965981

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES463783A Expired ES463783A1 (es)	1976-11-02	1977-11-02	Un procedimiento para la preparacion de cis-4a-aril-octahi- dro-1h-2-pirindinas 2-sustituidas.
ES463784A Expired ES463784A1 (es)	1976-11-02	1977-11-02	Un procedimiento para la preparacion de un compuesto cis.
ES472276A Expired ES472276A1 (es)	1976-11-02	1978-08-01	Un procedimiento para la preparacion de un grupo de cis-4a- aril-octahidro-1h-2-pirindinas 2-sustituidas

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ES463784A Expired ES463784A1 (es)	1976-11-02	1977-11-02	Un procedimiento para la preparacion de un compuesto cis.
ES472276A Expired ES472276A1 (es)	1976-11-02	1978-08-01	Un procedimiento para la preparacion de un grupo de cis-4a- aril-octahidro-1h-2-pirindinas 2-sustituidas

Country Status (26)

Country	Link
JP (1)	JPS5356669A (fr)
AR (1)	AR223454A1 (fr)
AT (1)	ATA782177A (fr)
AU (1)	AU513679B2 (fr)
BE (1)	BE860314A (fr)
CA (1)	CA1100136A (fr)
CS (1)	CS211380B2 (fr)
DD (1)	DD133795A5 (fr)
DE (1)	DE2748466A1 (fr)
DK (1)	DK485277A (fr)
ES (3)	ES463783A1 (fr)
FR (1)	FR2369267A1 (fr)
GB (1)	GB1590155A (fr)
GR (1)	GR70053B (fr)
HU (1)	HU176231B (fr)
IE (1)	IE45901B1 (fr)
IL (1)	IL53236A0 (fr)
NL (1)	NL7712053A (fr)
NZ (1)	NZ185539A (fr)
PH (1)	PH12590A (fr)
PL (3)	PL108466B1 (fr)
PT (1)	PT67194B (fr)
RO (3)	RO72900A (fr)
SE (3)	SE7712218L (fr)
SU (3)	SU812174A3 (fr)
ZA (1)	ZA776497B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT68934A (en) *	1977-12-27	1979-01-01	Lilly Co Eli	Process for preparing 4a-aryl-octahydro-1h-2-pyrindines
US4277608A (en) *	1979-06-21	1981-07-07	Eli Lilly And Company	Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) *	1979-06-21	1980-11-25	Eli Lilly And Company	Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) *	1994-12-23	1996-07-03	Smithkline Beecham Corp	3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
US8598164B2 (en)	2010-05-06	2013-12-03	Vertex Pharmaceuticals Incorporated	Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
KR101923367B1 (ko)	2011-02-02	2018-12-04	버텍스 파마슈티칼스 인코포레이티드	이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드
WO2012112743A1 (fr)	2011-02-18	2012-08-23	Vertex Pharmaceuticals Incorporated	Amides de pipéridine spirocyclique chromanique en tant que modulateurs des canaux ioniques
US8828996B2 (en)	2011-03-14	2014-09-09	Vertex Pharmaceuticals Incorporated	Morpholine-spirocyclic piperidine amides as modulators of ion channels

1977
- 1977-10-26 PT PT67194A patent/PT67194B/pt unknown
- 1977-10-27 GB GB44729/77A patent/GB1590155A/en not_active Expired
- 1977-10-27 NZ NZ185539A patent/NZ185539A/xx unknown
- 1977-10-27 CA CA289,687A patent/CA1100136A/fr not_active Expired
- 1977-10-27 IL IL53236A patent/IL53236A0/xx unknown
- 1977-10-28 IE IE2206/77A patent/IE45901B1/en unknown
- 1977-10-28 BE BE1008483A patent/BE860314A/fr unknown
- 1977-10-28 SE SE7712218A patent/SE7712218L/xx unknown
- 1977-10-28 PH PH20380A patent/PH12590A/en unknown
- 1977-10-28 DE DE19772748466 patent/DE2748466A1/de not_active Withdrawn
- 1977-10-28 FR FR7732776A patent/FR2369267A1/fr active Granted
- 1977-10-29 GR GR54664A patent/GR70053B/el unknown
- 1977-10-31 AR AR269797A patent/AR223454A1/es active
- 1977-11-01 ZA ZA00776497A patent/ZA776497B/xx unknown
- 1977-11-01 NL NL7712053A patent/NL7712053A/xx not_active Application Discontinuation
- 1977-11-01 HU HU77EI768A patent/HU176231B/hu unknown
- 1977-11-01 AU AU30235/77A patent/AU513679B2/en not_active Expired
- 1977-11-01 DK DK485277A patent/DK485277A/da unknown
- 1977-11-02 RO RO7792007A patent/RO72900A/fr unknown
- 1977-11-02 ES ES463783A patent/ES463783A1/es not_active Expired
- 1977-11-02 PL PL1977212226A patent/PL108466B1/pl unknown
- 1977-11-02 PL PL1977212225A patent/PL108610B1/pl unknown
- 1977-11-02 DD DD7700201831A patent/DD133795A5/xx unknown
- 1977-11-02 AT AT0782177A patent/ATA782177A/de not_active Application Discontinuation
- 1977-11-02 SU SU772539649A patent/SU812174A3/ru active
- 1977-11-02 ES ES463784A patent/ES463784A1/es not_active Expired
- 1977-11-02 RO RO7799434A patent/RO78300A/fr unknown
- 1977-11-02 JP JP13211177A patent/JPS5356669A/ja active Pending
- 1977-11-02 CS CS777150A patent/CS211380B2/cs unknown
- 1977-11-02 RO RO7799435A patent/RO77935A/fr unknown
- 1977-11-02 PL PL1977201885A patent/PL109690B1/pl unknown
1978
- 1978-08-01 ES ES472276A patent/ES472276A1/es not_active Expired
- 1978-10-03 SU SU782669355A patent/SU913941A3/ru active
- 1978-10-03 SU SU782669395A patent/SU845777A3/ru active
1981
- 1981-05-18 SE SE8103106A patent/SE8103106L/sv unknown
- 1981-05-18 SE SE8103107A patent/SE8103107L/sv unknown

Also Published As

Publication number	Publication date
ZA776497B (en)	1979-06-27
PL109690B1 (en)	1980-06-30
RO72900A (fr)	1981-11-04
SE7712218L (sv)	1978-05-03
AR223454A1 (es)	1981-08-31
DD133795A5 (de)	1979-01-24
PT67194B (en)	1979-03-23
PH12590A (en)	1979-06-27
SE8103107L (sv)	1981-05-18
GR70053B (fr)	1982-07-26
CA1100136A (fr)	1981-04-28
GB1590155A (en)	1981-05-28
PL108466B1 (en)	1980-04-30
JPS5356669A (en)	1978-05-23
FR2369267B1 (fr)	1980-05-16
IE45901B1 (en)	1982-12-29
SU913941A3 (en)	1982-03-15
ES463784A1 (es)	1978-06-16
NL7712053A (nl)	1978-05-05
ES472276A1 (es)	1979-10-01
SE8103106L (sv)	1981-05-18
PL201885A1 (pl)	1978-12-04
SU845777A3 (ru)	1981-07-07
SU812174A3 (ru)	1981-03-07
PT67194A (en)	1977-11-01
AU513679B2 (en)	1980-12-18
HU176231B (en)	1981-01-28
RO78300A (fr)	1982-04-12
IE45901L (en)	1978-05-02
CS211380B2 (en)	1982-02-26
DK485277A (da)	1978-05-03
IL53236A0 (en)	1977-12-30
PL108610B1 (en)	1980-04-30
ATA782177A (de)	1981-10-15
DE2748466A1 (de)	1978-05-03
FR2369267A1 (fr)	1978-05-26
AU3023577A (en)	1979-05-10
BE860314A (fr)	1978-04-28
NZ185539A (en)	1979-12-11
RO77935A (fr)	1981-12-25

Publication	Publication Date	Title
JPS5513278A (en)	1980-01-30	Benzomorphane compound and medical compound containing it
ES413639A1 (es)	1976-01-16	Un procedimiento para la preparacion de un compuesto deri- vado de dopamina.
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ES8802039A1 (es)	1988-03-16	Procedimiento par preparar derivados de 1-piperazinacarboxamida
ES8200643A1 (es)	1981-10-16	Derivador del acido ciclohexano carboxilico
ES8106289A1 (es)	1981-02-16	Procedimiento de preparacion de nuevos derivados del a-fe- nil-2-pirrolidin-metanol
ES463784A1 (es)	1978-06-16	Un procedimiento para la preparacion de un compuesto cis.
ES8500953A1 (es)	1984-11-01	Procedimiento para preparar derivados de tieno-tiazol
ES421067A1 (es)	1976-04-01	Procedimiento para la preparacion de nuevas 2-fenilamino- imidazolinas sustituidas.
ES418827A1 (es)	1977-02-01	Un procedimiento para preparar nuevos derivados 2-aminoinda-no.
ES466127A1 (es)	1978-10-16	Un procedimiento para la preparacion de l-formil-indol-dihi-droindol dimero.
SE7909367L (sv)	1980-06-23	Sett att framstella piperidyl-indol-derivat, ny framstelld forening och dess salter samt anvendning derav sasom lekemedel och farmaceutiska kompositioner innehallande dessa foreningar
ES419019A1 (es)	1976-06-16	Procedimiento para la preparacion de compuestos polici- clicos.
ES8304086A1 (es)	1983-02-16	"un procedimiento para preparar derivados heterociclicos de amidoximas".
ES401342A1 (es)	1975-02-16	Procedimiento para la preparacion de nuevos derivados de lapiridina y de sus sales.
ES8401957A1 (es)	1984-01-01	Procedimiento de preparacion de derivados del acido 2-tiofen-acetico.
ES446132A1 (es)	1977-06-16	Un procedimiento para la preparacion de nuevos derivados de acido 2-alquil (inferior)-2 o 3-cefem-4-carboxilico.
ES270561A1 (es)	1962-02-16	Procedimiento para la preparación de nuevos derivados del ácido alquilbenzoico
GB2001062A (en)	1979-01-24	Preparation of Pyridinecarboxylic acid piperazides
IE43121L (en)	1976-12-19	Alkynes.
ES435351A1 (es)	1976-12-01	Procedimiento para preparar 1-(3-fenil-propil)-4-furoilpi- perazinas.
ES428442A1 (es)	1977-01-01	Un procedimiento para la preparacion de derivados de 1, 2, 3, 4-tetrahidroisoquinoleina.
ES413742A1 (es)	1976-01-16	Un procedimiento para la preparacion de compuestos de acidol-alfa-hidrazino-betaf-fenilpropionico.
ES459705A1 (es)	1978-03-16	Procedimiento para la preparacion de derivados de hidracina-piridacina.
ES447349A1 (es)	1977-11-01	Un procedimiento para la preparacion de nuevos derivados delacido 8-azaprostanoico.