RO78300A - Procede pour la preparation des cis-4a-aryloctahydro-1h-2-pyrimidines - Google Patents

Procede pour la preparation des cis-4a-aryloctahydro-1h-2-pyrimidines

Info

Publication number: RO78300A
Authority: RO; Romania
Prior art keywords: aryloctahydro; pyrimidines; cis; preparation
Prior art date: 1976-11-02

Application number

RO7799434A

Other languages

English (en)

Romanian (ro)

Inventor

Dennis M Zimmermen

Original Assignee

Eli Lilly And Co.,Us

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-11-02

Filing date

1977-11-02

Publication date

1982-04-12

1977-11-02 Application filed by Eli Lilly And Co.,Us filed Critical Eli Lilly And Co.,Us

1982-04-12 Publication of RO78300A publication Critical patent/RO78300A/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

RO7799434A 1976-11-02 1977-11-02 Procede pour la preparation des cis-4a-aryloctahydro-1h-2-pyrimidines RO78300A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US73795876A	1976-11-02	1976-11-02

Publications (1)

Publication Number	Publication Date
RO78300A true RO78300A (fr)	1982-04-12

Family

ID=24965981

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
RO7792007A RO72900A (fr)	1976-11-02	1977-11-02	Procede pour la preparation des cis-4a-phenyloctahydro-1h-2-pyrindines
RO7799434A RO78300A (fr)	1976-11-02	1977-11-02	Procede pour la preparation des cis-4a-aryloctahydro-1h-2-pyrimidines
RO7799435A RO77935A (fr)	1976-11-02	1977-11-02	Procede pour la preparation des cis-4a-arylo tahydro-1h-2-pyrinidine s

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
RO7792007A RO72900A (fr)	1976-11-02	1977-11-02	Procede pour la preparation des cis-4a-phenyloctahydro-1h-2-pyrindines

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
RO7799435A RO77935A (fr)	1976-11-02	1977-11-02	Procede pour la preparation des cis-4a-arylo tahydro-1h-2-pyrinidine s

Country Status (26)

Country	Link
JP (1)	JPS5356669A (fr)
AR (1)	AR223454A1 (fr)
AT (1)	ATA782177A (fr)
AU (1)	AU513679B2 (fr)
BE (1)	BE860314A (fr)
CA (1)	CA1100136A (fr)
CS (1)	CS211380B2 (fr)
DD (1)	DD133795A5 (fr)
DE (1)	DE2748466A1 (fr)
DK (1)	DK485277A (fr)
ES (3)	ES463783A1 (fr)
FR (1)	FR2369267A1 (fr)
GB (1)	GB1590155A (fr)
GR (1)	GR70053B (fr)
HU (1)	HU176231B (fr)
IE (1)	IE45901B1 (fr)
IL (1)	IL53236A0 (fr)
NL (1)	NL7712053A (fr)
NZ (1)	NZ185539A (fr)
PH (1)	PH12590A (fr)
PL (3)	PL108466B1 (fr)
PT (1)	PT67194B (fr)
RO (3)	RO72900A (fr)
SE (3)	SE7712218L (fr)
SU (3)	SU812174A3 (fr)
ZA (1)	ZA776497B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT68934A (en) *	1977-12-27	1979-01-01	Lilly Co Eli	Process for preparing 4a-aryl-octahydro-1h-2-pyrindines
US4277608A (en) *	1979-06-21	1981-07-07	Eli Lilly And Company	Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) *	1979-06-21	1980-11-25	Eli Lilly And Company	Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) *	1994-12-23	1996-07-03	Smithkline Beecham Corp	3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
US8598164B2 (en)	2010-05-06	2013-12-03	Vertex Pharmaceuticals Incorporated	Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
KR101923367B1 (ko)	2011-02-02	2018-12-04	버텍스 파마슈티칼스 인코포레이티드	이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드
WO2012112743A1 (fr)	2011-02-18	2012-08-23	Vertex Pharmaceuticals Incorporated	Amides de pipéridine spirocyclique chromanique en tant que modulateurs des canaux ioniques
US8828996B2 (en)	2011-03-14	2014-09-09	Vertex Pharmaceuticals Incorporated	Morpholine-spirocyclic piperidine amides as modulators of ion channels

1977
- 1977-10-26 PT PT67194A patent/PT67194B/pt unknown
- 1977-10-27 GB GB44729/77A patent/GB1590155A/en not_active Expired
- 1977-10-27 NZ NZ185539A patent/NZ185539A/xx unknown
- 1977-10-27 CA CA289,687A patent/CA1100136A/fr not_active Expired
- 1977-10-27 IL IL53236A patent/IL53236A0/xx unknown
- 1977-10-28 IE IE2206/77A patent/IE45901B1/en unknown
- 1977-10-28 BE BE1008483A patent/BE860314A/fr unknown
- 1977-10-28 SE SE7712218A patent/SE7712218L/xx unknown
- 1977-10-28 PH PH20380A patent/PH12590A/en unknown
- 1977-10-28 DE DE19772748466 patent/DE2748466A1/de not_active Withdrawn
- 1977-10-28 FR FR7732776A patent/FR2369267A1/fr active Granted
- 1977-10-29 GR GR54664A patent/GR70053B/el unknown
- 1977-10-31 AR AR269797A patent/AR223454A1/es active
- 1977-11-01 ZA ZA00776497A patent/ZA776497B/xx unknown
- 1977-11-01 NL NL7712053A patent/NL7712053A/xx not_active Application Discontinuation
- 1977-11-01 HU HU77EI768A patent/HU176231B/hu unknown
- 1977-11-01 AU AU30235/77A patent/AU513679B2/en not_active Expired
- 1977-11-01 DK DK485277A patent/DK485277A/da unknown
- 1977-11-02 RO RO7792007A patent/RO72900A/fr unknown
- 1977-11-02 ES ES463783A patent/ES463783A1/es not_active Expired
- 1977-11-02 PL PL1977212226A patent/PL108466B1/pl unknown
- 1977-11-02 PL PL1977212225A patent/PL108610B1/pl unknown
- 1977-11-02 DD DD7700201831A patent/DD133795A5/xx unknown
- 1977-11-02 AT AT0782177A patent/ATA782177A/de not_active Application Discontinuation
- 1977-11-02 SU SU772539649A patent/SU812174A3/ru active
- 1977-11-02 ES ES463784A patent/ES463784A1/es not_active Expired
- 1977-11-02 RO RO7799434A patent/RO78300A/fr unknown
- 1977-11-02 JP JP13211177A patent/JPS5356669A/ja active Pending
- 1977-11-02 CS CS777150A patent/CS211380B2/cs unknown
- 1977-11-02 RO RO7799435A patent/RO77935A/fr unknown
- 1977-11-02 PL PL1977201885A patent/PL109690B1/pl unknown
1978
- 1978-08-01 ES ES472276A patent/ES472276A1/es not_active Expired
- 1978-10-03 SU SU782669355A patent/SU913941A3/ru active
- 1978-10-03 SU SU782669395A patent/SU845777A3/ru active
1981
- 1981-05-18 SE SE8103106A patent/SE8103106L/sv unknown
- 1981-05-18 SE SE8103107A patent/SE8103107L/sv unknown

Also Published As

Publication number	Publication date
ZA776497B (en)	1979-06-27
PL109690B1 (en)	1980-06-30
RO72900A (fr)	1981-11-04
SE7712218L (sv)	1978-05-03
AR223454A1 (es)	1981-08-31
DD133795A5 (de)	1979-01-24
PT67194B (en)	1979-03-23
PH12590A (en)	1979-06-27
SE8103107L (sv)	1981-05-18
GR70053B (fr)	1982-07-26
CA1100136A (fr)	1981-04-28
GB1590155A (en)	1981-05-28
PL108466B1 (en)	1980-04-30
JPS5356669A (en)	1978-05-23
FR2369267B1 (fr)	1980-05-16
IE45901B1 (en)	1982-12-29
SU913941A3 (en)	1982-03-15
ES463784A1 (es)	1978-06-16
NL7712053A (nl)	1978-05-05
ES472276A1 (es)	1979-10-01
SE8103106L (sv)	1981-05-18
ES463783A1 (es)	1979-07-16
PL201885A1 (pl)	1978-12-04
SU845777A3 (ru)	1981-07-07
SU812174A3 (ru)	1981-03-07
PT67194A (en)	1977-11-01
AU513679B2 (en)	1980-12-18
HU176231B (en)	1981-01-28
IE45901L (en)	1978-05-02
CS211380B2 (en)	1982-02-26
DK485277A (da)	1978-05-03
IL53236A0 (en)	1977-12-30
PL108610B1 (en)	1980-04-30
ATA782177A (de)	1981-10-15
DE2748466A1 (de)	1978-05-03
FR2369267A1 (fr)	1978-05-26
AU3023577A (en)	1979-05-10
BE860314A (fr)	1978-04-28
NZ185539A (en)	1979-12-11
RO77935A (fr)	1981-12-25

Publication	Publication Date	Title
RO74936A (fr)	1980-10-30	Procede pour la preparation des mercaptoazetidiones
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RO70854A (fr)	1981-06-26	Procede pour la preparation des metha-aryloxybenzaldehydes
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RO70462A (fr)	1981-01-30	Procede pour la preparation des 3-halomethylcephem
RO73006A (fr)	1982-04-12	Procede de preparation des thioderives
RO71572A (fr)	1982-07-06	Procede pour la preparation des oxycarbamates n-sulphenyles
BE842584A (fr)	1976-12-06	Procede pour la preparation de dihalogenures gemines
RO83446A (fr)	1984-02-21	Procede pour la preparation des cyclopropylmethoxyanilides
RO71066A (fr)	1982-10-26	Procede pour la preparation des 2-chlorsulfinylazetidin-4-ones
RO72900A (fr)	1981-11-04	Procede pour la preparation des cis-4a-phenyloctahydro-1h-2-pyrindines
PT64718B (fr)	1977-06-03	Procede pour la preparation de phenyalcoylamines
RO71763A (fr)	1980-12-30	Procede pour la preparation des hydrures de dialkyle-aluminium
PT66890A (fr)	1977-09-01	Procede pour la preparation des aryloxy-1 amino-3 propanols-2
RO72558A (fr)	1982-09-09	Procede pour la preparation des cycloalcanpyrazoles
RO83713A (fr)	1984-05-23	Procede pour la preparation des haloacylamides
FR2296628A1 (fr)	1976-07-30	Procede pour la preparation de chloroamino-s-triazines
RO71742A (fr)	1982-02-26	Procede pour la preparation des 1-oxadethiacephalosporines
RO70052A (fr)	1980-07-15	Procede pour la preparation des 7-alcoxy-3-chloremethylecephemes
FR2348174A1 (fr)	1977-11-10	Procede pour la preparation de dihalogenures gemines
PT66065B (fr)	1978-06-23	Procede pour la preparation de hydrocarbonetes
RO75074A (fr)	1980-10-30	Procede pour la preparation des thiophenoles
RO81525A (fr)	1983-04-29	Procede pour la preparation des 9-fluor-prednisolones
FR2338277A1 (fr)	1977-08-12	Procede pour la preparation de la 6-methylpterine
RO74550A (fr)	1980-10-30	Procede pour la preparation des complexes de malonyluree