ES471608A1 - Un procedimiento de preparacion de nuevos derivados de piri-midina - Google Patents

Un procedimiento de preparacion de nuevos derivados de piri-midina

Info

Publication number
ES471608A1
ES471608A1 ES471608A ES471608A ES471608A1 ES 471608 A1 ES471608 A1 ES 471608A1 ES 471608 A ES471608 A ES 471608A ES 471608 A ES471608 A ES 471608A ES 471608 A1 ES471608 A1 ES 471608A1
Authority
ES
Spain
Prior art keywords
methyl
methylpyrimidines
piperazinyl
pyridyl
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES471608A
Other languages
English (en)
Inventor
Alain Beguin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of ES471608A1 publication Critical patent/ES471608A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Un procedimiento de preparación de nuevos derivados de pirimidina de la fórmula general: **(Fórmula)** en la que R representa un radical piperidino o un radical 4-(2-metil-3-hidroxi-4-hidroximetil-5-piridil-metil)-1-piperazinilo y las sales terapéuticamente aceptables de los mismos, consistente en hacer reaccionar en un disolvente polar, a reflujo, la piperidina o la 4-(2-metil-3-hidroxi-4-hidroximetil-5-piridil-metil)-1-piperazina sobre el cloruro correspondiente.
ES471608A 1977-07-12 1978-07-11 Un procedimiento de preparacion de nuevos derivados de piri-midina Expired ES471608A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2928177 1977-07-12

Publications (1)

Publication Number Publication Date
ES471608A1 true ES471608A1 (es) 1979-01-16

Family

ID=10289056

Family Applications (1)

Application Number Title Priority Date Filing Date
ES471608A Expired ES471608A1 (es) 1977-07-12 1978-07-11 Un procedimiento de preparacion de nuevos derivados de piri-midina

Country Status (28)

Country Link
US (1) US4174395A (es)
JP (1) JPS5452088A (es)
AR (1) AR218072A1 (es)
AT (1) AT358198B (es)
AU (1) AU517046B2 (es)
BE (1) BE868539A (es)
CA (1) CA1097645A (es)
CH (1) CH632267A5 (es)
DE (1) DE2830670C2 (es)
DK (1) DK148685C (es)
EG (1) EG13550A (es)
ES (1) ES471608A1 (es)
FI (1) FI63026C (es)
FR (2) FR2397413A1 (es)
HK (1) HK18783A (es)
IE (1) IE47027B1 (es)
IN (1) IN148661B (es)
LU (1) LU79916A1 (es)
MX (1) MX5103E (es)
MY (1) MY8500031A (es)
NL (1) NL170855C (es)
NO (1) NO149846C (es)
NZ (1) NZ187655A (es)
OA (1) OA06120A (es)
PT (1) PT68268A (es)
SE (1) SE436875B (es)
SG (1) SG60982G (es)
ZA (1) ZA783521B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387221B (de) * 1980-09-08 1988-12-27 Bristol Myers Co Verfahren zur herstellung des neuen
US6854146B2 (en) 2000-06-12 2005-02-15 Milliken & Company Method for producing digitally designed carpet

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2459367A (en) * 1947-11-12 1949-01-18 American Cyanamid Co 1,4-di (heterocyclic substituted) piperazines
US2606906A (en) * 1948-10-14 1952-08-12 American Cyanamid Co 1-(2-pyridyl) piperazine and process of preparing same
US2748125A (en) * 1954-04-26 1956-05-29 American Cyanamid Co 1-substituted-4-sulfamylpiperazine and method of preparing the same
GB1433222A (es) * 1973-03-28 1976-04-22 Prod Ch8Mi Soc Et

Also Published As

Publication number Publication date
FI63026C (fi) 1983-04-11
IN148661B (es) 1981-05-02
DE2830670C2 (de) 1983-01-20
IE781383L (en) 1979-01-12
JPS5452088A (en) 1979-04-24
JPS5725554B2 (es) 1982-05-29
FR2397413A1 (fr) 1979-02-09
FR2400362B1 (es) 1980-06-06
AT358198B (de) 1980-08-25
DK148685C (da) 1986-02-17
EG13550A (en) 1982-03-31
NO782408L (no) 1979-01-15
CH632267A5 (fr) 1982-09-30
NL170855B (nl) 1982-08-02
NZ187655A (en) 1980-10-24
OA06120A (fr) 1981-06-30
SE7807721L (sv) 1979-01-13
MX5103E (es) 1983-03-16
NO149846B (no) 1984-03-26
DE2830670A1 (de) 1979-01-18
SG60982G (en) 1983-09-02
US4174395A (en) 1979-11-13
DK148685B (da) 1985-09-02
BE868539A (fr) 1978-10-16
ZA783521B (en) 1979-06-27
IE47027B1 (en) 1983-11-30
FR2400362A1 (fr) 1979-03-16
FR2397413B1 (es) 1980-07-18
FI63026B (fi) 1982-12-31
NO149846C (no) 1984-07-04
FI781982A7 (fi) 1979-01-13
NL170855C (nl) 1983-01-03
MY8500031A (en) 1985-12-31
DK310678A (da) 1979-01-13
SE436875B (sv) 1985-01-28
AU517046B2 (en) 1981-07-02
AR218072A1 (es) 1980-05-15
LU79916A1 (es) 1978-12-07
HK18783A (en) 1983-06-10
PT68268A (en) 1978-08-01
ATA474578A (de) 1980-01-15
NL7807228A (nl) 1979-01-16
CA1097645A (en) 1981-03-17
AU3793478A (en) 1980-01-17

Similar Documents

Publication Publication Date Title
MY108616A (en) Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines of piperazines, and compositions and methods of use thereof
DK0396083T3 (da) Heterocykliske N-oxidderivater af substituerede benzo(5,6)-cycloheptapyridiner, præparater og anvendelsesfremgangsmåder
DE69106237D1 (de) Antimigräne Alkoxypyrimidinderivate.
EP0276536A3 (en) Use of buspirone for the improvement of short term memory
NO163816C (no) Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive piperazinderivater.
ES456690A1 (es) Un procedimiento para la preparacion de nuevos derivados 1- sustituidos de 4-(diarilmetil) piperazina y de 4 (diarilme- toxi) piperidina.
NO900795L (no) Fremgangsmaate for fremstilling av nye 2-(1-piperazinyl)-4-fenylcykloalkanpyrimidinderivater.
PH14693A (en) 4-(3-or 4-substituted piperidino)quinazolines as cardiac stimulants
ATE75743T1 (de) Hydrazinderivate und ihre verwendung.
NZ183450A (en) Preparation of the crystalline -form of 2-(4-(2-foroyl)-piperazin-1-yl)-4-amino-6,7-dimethoxy-quinazdine hydrochloride
NO167204C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive diacylderivater av 4-(trialkylbenzyl)-piperazinylforbindelser.
IT7950921A0 (it) Derivati di 4-(naftilmetil)-piperi dine farmacologicamente attivi eprocedimento per la loro preparazione
NO172490C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,4-disubstituerte piperazinderivater
NO154054C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroksypyrimidinderivater.
EP0410114A3 (en) Use of 4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)-1-(4-fluorophenyl)-butanol in pharmaceutical compositions for the treatment of ischemia in brain
ES471608A1 (es) Un procedimiento de preparacion de nuevos derivados de piri-midina
AR223015A1 (es) Procedimiento para la preparacion de nuevos derivados de 4-amino-2-(4-(1,4(5)-benzodioxaciclohexil(heptil)-2-carbonil)-piperazin-1-il)quinazolina y sus sales de adicion de acidos farmaceuticamente aceptables
MX9205186A (es) Derivados de 4-[4-[4-(4-hidroxifenil)-1-piperazinil]-fenil]-5-metil-3h-1,2,4-triazo l-3-ona
JPS57149282A (en) 2-(4-(diphenylmethyl)-1-piperazinyl)acetic acid and their derivatives as medicine
IL60308A0 (en) 4-(substituted)thio-1-b-d-ribofuranosyl-pyrazolo(3,4-d)pyrimidine derivatives,their preparation and use in human and veterinary medicine
ATE8994T1 (de) Piperazinderivate des theophyllins.
NO152607C (no) Utgangsmaterialer for anvendelse ved fremstilling av terapeutisk aktive pyrimidinderivater
AU6960787A (en) 4-(2-pyrimidinyl)-1-piperazinyl heterocyclic carbonyl derivatives
AU522245B2 (en) & halomethyl derivatives of histamine and related compounds
CY1122A (en) 4-amino-6,7-dimethoxy-2-(4-(hetero-cyclo-carbonyl)piperazin-1-yl)quinazolines