ES471732A1 - Procedimiento para la preparacion de nuevos derivados de la 9-cloroprednisolona - Google Patents
Procedimiento para la preparacion de nuevos derivados de la 9-cloroprednisolonaInfo
- Publication number
- ES471732A1 ES471732A1 ES471732A ES471732A ES471732A1 ES 471732 A1 ES471732 A1 ES 471732A1 ES 471732 A ES471732 A ES 471732A ES 471732 A ES471732 A ES 471732A ES 471732 A1 ES471732 A1 ES 471732A1
- Authority
- ES
- Spain
- Prior art keywords
- chloro
- alpha
- prednisolone
- topical
- antiinflammatory activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 229960005205 prednisolone Drugs 0.000 title 1
- 230000009885 systemic effect Effects 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
- BQFPCTXLBRVFJL-UHFFFAOYSA-N triethoxymethylbenzene Chemical compound CCOC(OCC)(OCC)C1=CC=CC=C1 BQFPCTXLBRVFJL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimiento para la preparación de nuevos derivados de la 9-cloroprednisolona de la fórmula general **(Fórmula)** en donde R1 significa un grupo alonoilo con 1 a 8 átomos de carbono o un grupo benzoilo, y X representa un átomo de fluor, un átomo de cloro o un grupo hidroxi, caracterizado porque se desdobla por hidrólisis o con halogenuro de trimatilsililo o con halogenuro de trifenilmetilo un ortoéster.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2645105A DE2645105C2 (de) | 1976-10-04 | 1976-10-04 | Derivate des 9-Chlorprednisolons, Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Präparat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES471732A1 true ES471732A1 (es) | 1979-02-01 |
Family
ID=5989829
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471733A Expired ES471733A1 (es) | 1976-10-04 | 1978-07-14 | Procedimiento para la preparacion de nuevos derivados de la 9-cloroprednisolona |
| ES471732A Expired ES471732A1 (es) | 1976-10-04 | 1978-07-14 | Procedimiento para la preparacion de nuevos derivados de la 9-cloroprednisolona |
| ES471734A Expired ES471734A1 (es) | 1976-10-04 | 1978-07-14 | Procedimiento para la preparacion de nuevos derivados de la 9-cloroprednisolona |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471733A Expired ES471733A1 (es) | 1976-10-04 | 1978-07-14 | Procedimiento para la preparacion de nuevos derivados de la 9-cloroprednisolona |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471734A Expired ES471734A1 (es) | 1976-10-04 | 1978-07-14 | Procedimiento para la preparacion de nuevos derivados de la 9-cloroprednisolona |
Country Status (9)
| Country | Link |
|---|---|
| AU (1) | AU518954B2 (es) |
| BE (1) | BE859345A (es) |
| CA (1) | CA1100943A (es) |
| DD (1) | DD132348A5 (es) |
| DE (1) | DE2645105C2 (es) |
| ES (3) | ES471733A1 (es) |
| PL (1) | PL112152B1 (es) |
| SU (1) | SU902668A3 (es) |
| ZA (1) | ZA775914B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2932165A1 (de) * | 1979-08-06 | 1981-02-26 | Schering Ag | Neue derivate des 9-chlorprednisolons, ihre herstellung und verwendung |
| DE3227312A1 (de) * | 1982-07-19 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung |
-
1976
- 1976-10-04 DE DE2645105A patent/DE2645105C2/de not_active Expired
-
1977
- 1977-09-30 PL PL1977214009A patent/PL112152B1/pl unknown
- 1977-10-04 BE BE181431A patent/BE859345A/xx not_active IP Right Cessation
- 1977-10-04 DD DD7700201347A patent/DD132348A5/xx unknown
- 1977-10-04 CA CA288,063A patent/CA1100943A/en not_active Expired
- 1977-10-04 AU AU29310/77A patent/AU518954B2/en not_active Expired
- 1977-10-04 ZA ZA00775914A patent/ZA775914B/xx unknown
-
1978
- 1978-07-14 ES ES471733A patent/ES471733A1/es not_active Expired
- 1978-07-14 ES ES471732A patent/ES471732A1/es not_active Expired
- 1978-07-14 ES ES471734A patent/ES471734A1/es not_active Expired
-
1979
- 1979-05-04 SU SU792764204A patent/SU902668A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| DD132348A5 (de) | 1978-09-20 |
| DE2645105C2 (de) | 1986-03-13 |
| CA1100943A (en) | 1981-05-12 |
| DE2645105A1 (de) | 1978-04-06 |
| ZA775914B (en) | 1978-05-30 |
| AU518954B2 (en) | 1981-10-29 |
| BE859345A (fr) | 1978-04-04 |
| PL112152B1 (en) | 1980-09-30 |
| ES471733A1 (es) | 1979-02-01 |
| ES471734A1 (es) | 1979-02-01 |
| SU902668A3 (ru) | 1982-01-30 |
| AU2931077A (en) | 1979-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971103 |