ES471985A1 - Procedimiento para preparar 6,7-dihidro-5h, 13h-quinazolino -3,2-a(1,4)-benzociazepin-5,13-dionas - Google Patents
Procedimiento para preparar 6,7-dihidro-5h, 13h-quinazolino -3,2-a(1,4)-benzociazepin-5,13-dionasInfo
- Publication number
- ES471985A1 ES471985A1 ES471985A ES471985A ES471985A1 ES 471985 A1 ES471985 A1 ES 471985A1 ES 471985 A ES471985 A ES 471985A ES 471985 A ES471985 A ES 471985A ES 471985 A1 ES471985 A1 ES 471985A1
- Authority
- ES
- Spain
- Prior art keywords
- aryl
- medicaments
- compounds
- alkyl
- quinazolino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title abstract 2
- NGYKOTTXJAPLPC-UHFFFAOYSA-N 6,7-dihydroquinazolino[3,2-a][1,4]benzodiazepine-5,13-dione Chemical class O=C1NCC2=NC3=CC=CC=C3C(=O)N2C2=CC=CC=C12 NGYKOTTXJAPLPC-UHFFFAOYSA-N 0.000 title 1
- -1 nitro, amino Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003496 anti-amnesic effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedimiento para preparar 6,7-dihidro-5H,13H-quinazolino[3,2-a][1,4]-benzodiazepin-5,13-dionas de fórmula general (I) **(Fórmula)** en la cual R1 y R5 representan 1,2,3 ó 4 sustituyentes de grupo formado por hidrógeno, alquilo, hidroxi, aciloxi, alcoxi, nitro, amino, alquilamino, dialquilamino, acilamino, acilalquilamino, alcoxicarbonilamino, halógeno, trifluorometilo, ciano, carboxi, alcoxicarbonilo, aminocarbonilo, alquilaminocarbonilo, dialquilaminocarbonilo, aminosulfonilo, alquilaminosulfonilo, dialquilaminosulfonilo, alquilaminocarbonilamino y dialquilaminocarbonilamino; R2 representa hidrógeno, alquilo eventualmente sustituido, aralquilo, arilo o heterocicloalquilo, acilo o alcoxicarbonilo, y R3 y R4 representan sustituyentes iguales o diferentes del grupo formado por hidrógeno, alquilo eventualmente sustituido, aralquilo eventualmente sustituido en la parte arilo, arilo eventualmente sustituido o heteroarilo, y sus sales inobjetables desde el punto de vista de ácidos inorgánicos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772733681 DE2733681A1 (de) | 1977-07-26 | 1977-07-26 | 6,7-dihydro-5h, 13h-chinazolino eckige klammer auf 3,2-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu benzodiazepin-5,13-dione, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE19772758875 DE2758875A1 (de) | 1977-12-30 | 1977-12-30 | 6,7-dihydro-5h,13h-chinazolino eckige klammer auf 3,2-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu benzodiazepin-5,13-dione, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES471985A1 true ES471985A1 (es) | 1979-10-01 |
Family
ID=25772398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471985A Expired ES471985A1 (es) | 1977-07-26 | 1978-07-24 | Procedimiento para preparar 6,7-dihidro-5h, 13h-quinazolino -3,2-a(1,4)-benzociazepin-5,13-dionas |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4187306A (es) |
| EP (1) | EP0000538A1 (es) |
| JP (1) | JPS5424896A (es) |
| AU (1) | AU3828478A (es) |
| DK (1) | DK330378A (es) |
| ES (1) | ES471985A1 (es) |
| FI (1) | FI782318A7 (es) |
| IL (1) | IL55207A0 (es) |
| IT (1) | IT7826042A0 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4530790A (en) * | 1982-12-27 | 1985-07-23 | Merck & Co., Inc. | Cholecystokinin antagonists |
| US4563451A (en) * | 1985-01-25 | 1986-01-07 | Merck & Co., Inc. | Quinazolino-1,4-benzodiazepin-5,13-diones |
| US4559338A (en) * | 1985-01-25 | 1985-12-17 | Merck & Co., Inc. | Soluble quinazolino-1,4-benzodiazepin-5,13-dione derivatives |
| US4554272A (en) * | 1985-01-25 | 1985-11-19 | Merck & Co., Inc. | Substituted quinazolino-1,4-benzodiazepin-6,9-diones and their preparation |
| US4735941A (en) * | 1986-12-23 | 1988-04-05 | Merck & Co., Inc. | 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents |
| EP0272868A1 (en) * | 1986-12-23 | 1988-06-29 | Merck & Co. Inc. | 1,4-Benzodiazepines with 6-membered heterocyclic rings |
| US5670640A (en) * | 1996-02-02 | 1997-09-23 | Hoffmann-La Roche Inc. | Process for the manufacture of imidazodiazepine derivatives |
| TWI707859B (zh) * | 2017-09-07 | 2020-10-21 | 日商衛材R&D企管股份有限公司 | 五環化合物 |
| MX2021009685A (es) * | 2019-03-05 | 2021-09-10 | Eisai R&D Man Co Ltd | Compuesto heterociclo pentaciclico. |
| TWI870286B (zh) * | 2019-03-05 | 2025-01-11 | 日商衛材R&D企管股份有限公司 | 五環化合物之鹽及其等之結晶 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3280117A (en) * | 1964-04-20 | 1966-10-18 | Sandoz Ag | Tricyclic quinazolinones |
| US3651046A (en) * | 1969-01-30 | 1972-03-21 | Hoffmann La Roche | Quinazolino-benzodiazepines and methods for the preparation thereof |
-
1978
- 1978-07-06 US US05/922,419 patent/US4187306A/en not_active Expired - Lifetime
- 1978-07-18 EP EP78100425A patent/EP0000538A1/de not_active Withdrawn
- 1978-07-24 FI FI782318A patent/FI782318A7/fi not_active Application Discontinuation
- 1978-07-24 IL IL55207A patent/IL55207A0/xx unknown
- 1978-07-24 JP JP8953778A patent/JPS5424896A/ja active Pending
- 1978-07-24 IT IT7826042A patent/IT7826042A0/it unknown
- 1978-07-24 ES ES471985A patent/ES471985A1/es not_active Expired
- 1978-07-24 AU AU38284/78A patent/AU3828478A/en active Pending
- 1978-07-25 DK DK330378A patent/DK330378A/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI782318A7 (fi) | 1979-01-27 |
| JPS5424896A (en) | 1979-02-24 |
| US4187306A (en) | 1980-02-05 |
| EP0000538A1 (de) | 1979-02-07 |
| IT7826042A0 (it) | 1978-07-24 |
| AU3828478A (en) | 1980-01-31 |
| DK330378A (da) | 1979-01-27 |
| IL55207A0 (en) | 1978-09-29 |
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