ES480894A1 - Procedimiento para la preparacion de derivados de tiadiazol. - Google Patents

Procedimiento para la preparacion de derivados de tiadiazol.

Info

Publication number
ES480894A1
ES480894A1 ES480894A ES480894A ES480894A1 ES 480894 A1 ES480894 A1 ES 480894A1 ES 480894 A ES480894 A ES 480894A ES 480894 A ES480894 A ES 480894A ES 480894 A1 ES480894 A1 ES 480894A1
Authority
ES
Spain
Prior art keywords
histamine
receptor
action
thiadiazole derivatives
antisecretory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480894A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Zeneca Inc
Original Assignee
Imperial Chemical Industries Ltd
ICI Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd, ICI Americas Inc filed Critical Imperial Chemical Industries Ltd
Publication of ES480894A1 publication Critical patent/ES480894A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Dental Preparations (AREA)

Abstract

Procedimiento para preparar derivados de tiadiazol que son antagónicos H-2 a la histamina y que exhiben la secreción de ácido gástrico. Se postula que la histamina compuesta fisiológicamente activa que ocurre naturalmente dentro del cuerpo de un animal puede combinarse, mientras ejerce su actividad, con ciertos receptores específicos, de los cuales existen por lo menos dos tipos diferentes y separados. El primero se ha llamado al receptor H-1, y la acción de la histamina en este receptor histamínico ha sido llamado al receptor H-2, y la acción de la histamina en este receptor es bloqueada por drogas tales como la cimetidina. Se sabe que uno de los resultados del bloqueo de la acción histamínica en el receptor H-2 es que inhibe la secreción de ácido gástrico y, por lo tanto, un compuesto que posee esta capacidad es útil en el tratamiento de úlceras pépticas y otras condiciones causadas o exacerbadas por la acidez gástrica.
ES480894A 1978-05-24 1979-05-24 Procedimiento para la preparacion de derivados de tiadiazol. Expired ES480894A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2173778 1978-05-24

Publications (1)

Publication Number Publication Date
ES480894A1 true ES480894A1 (es) 1980-02-01

Family

ID=10167957

Family Applications (3)

Application Number Title Priority Date Filing Date
ES480894A Expired ES480894A1 (es) 1978-05-24 1979-05-24 Procedimiento para la preparacion de derivados de tiadiazol.
ES484150A Expired ES484150A1 (es) 1978-05-24 1979-09-13 Procedimiento para la preparacion de derivados de tiadiazol
ES484149A Expired ES484149A1 (es) 1978-05-24 1979-09-13 Procedimiento para la preparacion de un derivado de tiadia- zol

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES484150A Expired ES484150A1 (es) 1978-05-24 1979-09-13 Procedimiento para la preparacion de derivados de tiadiazol
ES484149A Expired ES484149A1 (es) 1978-05-24 1979-09-13 Procedimiento para la preparacion de un derivado de tiadia- zol

Country Status (22)

Country Link
US (2) US4242350A (es)
EP (1) EP0006679B1 (es)
JP (1) JPS54160376A (es)
AT (1) ATE1353T1 (es)
AU (1) AU529253B2 (es)
CA (1) CA1124729A (es)
CS (2) CS207790B2 (es)
DD (1) DD143772A5 (es)
DE (1) DE2963363D1 (es)
DK (1) DK209079A (es)
ES (3) ES480894A1 (es)
FI (1) FI791656A7 (es)
GR (1) GR73611B (es)
HU (1) HU179492B (es)
IE (1) IE48221B1 (es)
IL (1) IL57388A0 (es)
NO (1) NO791710L (es)
NZ (1) NZ190448A (es)
PL (1) PL118387B1 (es)
PT (1) PT69651A (es)
SU (1) SU1037839A3 (es)
ZA (1) ZA792202B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2963363D1 (en) * 1978-05-24 1982-09-09 Ici Plc Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them
EP0014057B1 (en) * 1979-01-18 1985-01-02 Imperial Chemical Industries Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
GR71929B (es) * 1979-11-13 1983-08-19 Ici Ltd
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
EP0059597B1 (en) * 1981-02-27 1986-04-23 Imperial Chemical Industries Plc Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activity
CA1209998A (en) * 1981-03-09 1986-08-19 David J. Gilman Amide derivatives as histamine h-2 receptor antagonists
CA1233818A (en) * 1981-03-09 1988-03-08 David J. Gilman Guanidine derivatives as histamine h-2 receptor antagonists
US4460584A (en) * 1981-03-13 1984-07-17 Imperial Chemical Industries Plc Nitrogen heterocycles
US4463005A (en) * 1981-03-18 1984-07-31 Imperial Chemical Industries Plc Bicyclic guanidines
IN158869B (es) * 1981-03-18 1987-02-07 Ici Plc
US4451463A (en) * 1981-03-24 1984-05-29 Imperial Chemical Industries Plc Alcohol derivatives
EP0065823A1 (en) * 1981-05-13 1982-12-01 Imperial Chemical Industries Plc Heterocyclic guanidines as histamine H-2 antagonists
US4390701A (en) * 1981-05-18 1983-06-28 Bristol-Myers Company 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione
US4539316A (en) * 1981-05-18 1985-09-03 Bristol-Myers Company Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
US4546188A (en) * 1981-05-18 1985-10-08 Bristol-Myers Company Substituted 1,2-diaminocyclobutene-3,4-diones
US4607105A (en) * 1981-05-18 1986-08-19 Bristol-Myers Company 3-cyclobutene-1,2-dione intermediates
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
DE3267110D1 (de) * 1981-05-18 1985-12-05 Ici Plc Amidine derivatives
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
US4395553A (en) * 1981-05-18 1983-07-26 Bristol-Myers Company Chemical compounds
GB8419223D0 (en) * 1984-07-27 1984-08-30 Hoechst Uk Ltd Sulphamoylguanidine derivatives
JPS60255756A (ja) * 1984-06-01 1985-12-17 Ikeda Mohandou:Kk アミノアルキルフエノキシ誘導体
RU2348623C1 (ru) * 2007-05-21 2009-03-10 Государственное образовательное учреждение высшего профессионального образования "Ивановский государственный химико-технологический университет" (ИГХТУ) Способ получения 3,5-диамино-1,2,4-тиадиазола
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE842346C (de) * 1950-10-14 1952-06-26 Joachim Dipl-Chem Dr Goerdeler Verfahren zur Darstellung von 5-Amino-1, 2, 4-thiodiazolen
DE955684C (de) * 1953-10-14 1957-01-10 Bayer Ag Verfahren zur Herstellung von 5-Amino-1, 2, 4-thiodiazolen
NL266116A (es) 1960-06-22
BE758146A (fr) 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1305549A (es) 1969-10-29 1973-02-07
GB1338169A (en) 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1400319A (en) 1972-04-20 1975-07-16 Smith Kline French Lab Pharmaceutical compositions
GB1398426A (en) 1972-09-05 1975-06-18 Smith Kline French Lab Heterocyclic substituted guanidines
GB1397436A (en) 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1421999A (en) 1973-02-08 1976-01-21 Smith Kline French Lab Heterocyclic containing sulphoxides
GB1419994A (en) 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
GB1421792A (en) 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1497260A (en) 1974-06-28 1978-01-05 Smith Kline French Lab Guanidine derivatives
GB1533379A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted ureas
GB1531231A (en) 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
GB1533380A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1574214A (en) 1976-03-11 1980-09-03 Smith Kline French Lab Amidines
ZA782129B (en) * 1977-04-20 1979-03-28 Ici Ltd Hertocyclic derivatives
US4165378A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
DE2963363D1 (en) * 1978-05-24 1982-09-09 Ici Plc Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CS207791B2 (en) 1981-08-31
GR73611B (es) 1984-03-26
DD143772A5 (de) 1980-09-10
CA1124729A (en) 1982-06-01
ZA792202B (en) 1980-05-28
US4332949A (en) 1982-06-01
NZ190448A (en) 1980-12-19
US4242350A (en) 1980-12-30
PT69651A (en) 1979-06-01
ES484149A1 (es) 1980-04-16
AU4711479A (en) 1979-11-29
FI791656A7 (fi) 1981-01-01
EP0006679A1 (en) 1980-01-09
SU1037839A3 (ru) 1983-08-23
EP0006679B1 (en) 1982-07-21
ATE1353T1 (de) 1982-08-15
CS207790B2 (en) 1981-08-31
ES484150A1 (es) 1980-04-16
NO791710L (no) 1979-11-27
HU179492B (en) 1982-10-28
JPS54160376A (en) 1979-12-19
AU529253B2 (en) 1983-06-02
IE790902L (en) 1979-11-24
IL57388A0 (en) 1979-09-30
DK209079A (da) 1979-11-25
PL215764A1 (es) 1980-06-16
PL118387B1 (en) 1981-09-30
DE2963363D1 (en) 1982-09-09
IE48221B1 (en) 1984-10-31

Similar Documents

Publication Publication Date Title
ES480894A1 (es) Procedimiento para la preparacion de derivados de tiadiazol.
ES2063734T3 (es) Imidazoles bloqueantes de receptores de angiotensina ii.
EP0313002A3 (en) Phenyl glycines for use in reducing neurotoxic injury
AR217850A1 (es) Derivados del acido 1,2,3-tiadiazol-5-carboxilico,composiciones de accion herbicida y reguladora del crecimiento que contienen estos compuestos,asi como procedimientos para la produccion de estos
NZ222104A (en) Benzimidazoles and anti gastric ulcer compositions
NO151282C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive para-substituerte 3-fenoksy-1-alkylamino-propanol-2-s som har beta-receptor blokkerende egenskaper
MX5137E (es) Procedimiento para la preparacion del acido tio-metil-delta3-cefem-carboxilico,7 alfa metoxi-7 beta(metilen-1,3-ditietan-2-il-carboxamido-4-substituido)-3-heterociclico
ES8700232A1 (es) Un procedimiento para producir 1a,25-dihidroxi-26,27-dime- tilcolecalciferol
ES2043891T3 (es) Procedimiento para preparar nuevos agentes antiarritmicos ii.
ATE12223T1 (de) Substituierte 3-phenoxy-1alkoxycarbonylalkylamino-propan-2-ole mit betarezeptor blockierenden eigenschaften.
SE8802805D0 (sv) Pharmaceutical compositions promoting the wound healing and process for preparing same
MX6834E (es) Procedimiento para preparar compuestos analogos de la prostaciclina
ES8504790A1 (es) Un procedimiento para producir derivados de tiazol
ES2094718T3 (es) Antagonistas de la serotonine para el tratamiento de heridas.
ES2074257T3 (es) Derivados de aminoacidos.
ES483087A1 (es) Procedimiento para la obtencion de bencimidazolcarbamatos
ES369816A1 (es) Procedimiento para la preparacion de 1 - ciano - o - 1 - carbamoil-formoximas sustituidas basicamente.
DE1695507C3 (de) Antik okzidiosemittel für Geflügel
US3475444A (en) Complexes of 2-substituted benzimidazoles and bis-halogenated phenols
FR2237631A1 (en) Ethyl benzthiazole-2-carbamates - for use as anthelmintics in man and animals
SU472489A3 (ru) Гербицидный состав
SU1053798A1 (ru) Средство дл повышени продуктивности тутового шелкопр да
FR2449680A1 (fr) Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant
SU655281A3 (ru) Способ борьбы с насекомыми
GB955522A (en) A sulphamoyl-benzothiadiazine derivative and preparation thereof