ES484149A1 - Procedimiento para la preparacion de un derivado de tiadia- zol - Google Patents
Procedimiento para la preparacion de un derivado de tiadia- zolInfo
- Publication number
- ES484149A1 ES484149A1 ES484149A ES484149A ES484149A1 ES 484149 A1 ES484149 A1 ES 484149A1 ES 484149 A ES484149 A ES 484149A ES 484149 A ES484149 A ES 484149A ES 484149 A1 ES484149 A1 ES 484149A1
- Authority
- ES
- Spain
- Prior art keywords
- methylamine
- antisecretory
- manufacture
- processes
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Dental Preparations (AREA)
Abstract
Procedimiento para la preparación de un derivado de tiadiazol. El procedimiento de la invención puede efectuarse empleando un exceso de metilamina, preferentemente en presencia de un diluyente o un disolvente tal como agua, metanol o etanol o una mezcla de cualquiera de dos de ellos. Un procedimiento preferido emplea una solución al 33% p/v de metilamina en etanol o una solución al 40% p/p de metilamina en agua. Alternativamente puede hacerse pasar una corriente de metilamina gaseosa a través de la suspensión agitada del compuesto de fórmula II en etanol. R1 es preferentemente un radical alcoxi o alquiltio, por ejemplo, un radical metoxi, etoxi o metilito. El radical metoxi es particularmente preferido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2173778 | 1978-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES484149A1 true ES484149A1 (es) | 1980-04-16 |
Family
ID=10167957
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES480894A Expired ES480894A1 (es) | 1978-05-24 | 1979-05-24 | Procedimiento para la preparacion de derivados de tiadiazol. |
| ES484149A Expired ES484149A1 (es) | 1978-05-24 | 1979-09-13 | Procedimiento para la preparacion de un derivado de tiadia- zol |
| ES484150A Expired ES484150A1 (es) | 1978-05-24 | 1979-09-13 | Procedimiento para la preparacion de derivados de tiadiazol |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES480894A Expired ES480894A1 (es) | 1978-05-24 | 1979-05-24 | Procedimiento para la preparacion de derivados de tiadiazol. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES484150A Expired ES484150A1 (es) | 1978-05-24 | 1979-09-13 | Procedimiento para la preparacion de derivados de tiadiazol |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US4242350A (es) |
| EP (1) | EP0006679B1 (es) |
| JP (1) | JPS54160376A (es) |
| AT (1) | ATE1353T1 (es) |
| AU (1) | AU529253B2 (es) |
| CA (1) | CA1124729A (es) |
| CS (2) | CS207790B2 (es) |
| DD (1) | DD143772A5 (es) |
| DE (1) | DE2963363D1 (es) |
| DK (1) | DK209079A (es) |
| ES (3) | ES480894A1 (es) |
| FI (1) | FI791656A7 (es) |
| GR (1) | GR73611B (es) |
| HU (1) | HU179492B (es) |
| IE (1) | IE48221B1 (es) |
| IL (1) | IL57388A0 (es) |
| NO (1) | NO791710L (es) |
| NZ (1) | NZ190448A (es) |
| PL (1) | PL118387B1 (es) |
| PT (1) | PT69651A (es) |
| SU (1) | SU1037839A3 (es) |
| ZA (1) | ZA792202B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE1353T1 (de) * | 1978-05-24 | 1982-08-15 | Imperial Chemical Industries Plc | Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
| DE3069889D1 (en) * | 1979-01-18 | 1985-02-14 | Ici Plc | Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| GR71929B (es) * | 1979-11-13 | 1983-08-19 | Ici Ltd | |
| US4375547A (en) * | 1980-10-02 | 1983-03-01 | Eli Lilly And Company | N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine |
| DE3270716D1 (en) * | 1981-02-27 | 1986-05-28 | Ici Plc | Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activity |
| CA1209998A (en) * | 1981-03-09 | 1986-08-19 | David J. Gilman | Amide derivatives as histamine h-2 receptor antagonists |
| CA1233818A (en) * | 1981-03-09 | 1988-03-08 | David J. Gilman | Guanidine derivatives as histamine h-2 receptor antagonists |
| US4460584A (en) * | 1981-03-13 | 1984-07-17 | Imperial Chemical Industries Plc | Nitrogen heterocycles |
| US4463005A (en) * | 1981-03-18 | 1984-07-31 | Imperial Chemical Industries Plc | Bicyclic guanidines |
| IN158869B (es) * | 1981-03-18 | 1987-02-07 | Ici Plc | |
| US4451463A (en) * | 1981-03-24 | 1984-05-29 | Imperial Chemical Industries Plc | Alcohol derivatives |
| EP0065823A1 (en) * | 1981-05-13 | 1982-12-01 | Imperial Chemical Industries Plc | Heterocyclic guanidines as histamine H-2 antagonists |
| US4607105A (en) * | 1981-05-18 | 1986-08-19 | Bristol-Myers Company | 3-cyclobutene-1,2-dione intermediates |
| US4395553A (en) * | 1981-05-18 | 1983-07-26 | Bristol-Myers Company | Chemical compounds |
| US4526973A (en) * | 1981-05-18 | 1985-07-02 | Bristol-Myers Company | Chemical compounds |
| DE3267110D1 (de) * | 1981-05-18 | 1985-12-05 | Ici Plc | Amidine derivatives |
| US4522943A (en) * | 1981-05-18 | 1985-06-11 | Bristol-Myers Company | Chemical compounds |
| US4546188A (en) * | 1981-05-18 | 1985-10-08 | Bristol-Myers Company | Substituted 1,2-diaminocyclobutene-3,4-diones |
| US4390701A (en) * | 1981-05-18 | 1983-06-28 | Bristol-Myers Company | 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione |
| US4539316A (en) * | 1981-05-18 | 1985-09-03 | Bristol-Myers Company | Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones |
| GB8419223D0 (en) * | 1984-07-27 | 1984-08-30 | Hoechst Uk Ltd | Sulphamoylguanidine derivatives |
| JPS60255756A (ja) * | 1984-06-01 | 1985-12-17 | Ikeda Mohandou:Kk | アミノアルキルフエノキシ誘導体 |
| RU2348623C1 (ru) * | 2007-05-21 | 2009-03-10 | Государственное образовательное учреждение высшего профессионального образования "Ивановский государственный химико-технологический университет" (ИГХТУ) | Способ получения 3,5-диамино-1,2,4-тиадиазола |
| US20230349922A1 (en) | 2020-08-11 | 2023-11-02 | Université De Strasbourg | H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE842346C (de) * | 1950-10-14 | 1952-06-26 | Joachim Dipl-Chem Dr Goerdeler | Verfahren zur Darstellung von 5-Amino-1, 2, 4-thiodiazolen |
| DE955684C (de) * | 1953-10-14 | 1957-01-10 | Bayer Ag | Verfahren zur Herstellung von 5-Amino-1, 2, 4-thiodiazolen |
| NL266116A (es) | 1960-06-22 | |||
| GB1305549A (es) | 1969-10-29 | 1973-02-07 | ||
| BE758146A (fr) | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Derives de l'amidine |
| GB1338169A (en) | 1971-03-09 | 1973-11-21 | Smith Kline French Lab | Ureas thioureas and guanidines |
| GB1400319A (en) | 1972-04-20 | 1975-07-16 | Smith Kline French Lab | Pharmaceutical compositions |
| GB1397436A (en) | 1972-09-05 | 1975-06-11 | Smith Kline French Lab | Heterocyclic n-cyanoguinidines |
| GB1398426A (en) | 1972-09-05 | 1975-06-18 | Smith Kline French Lab | Heterocyclic substituted guanidines |
| GB1421999A (en) | 1973-02-08 | 1976-01-21 | Smith Kline French Lab | Heterocyclic containing sulphoxides |
| GB1419994A (en) | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
| GB1421792A (en) | 1973-05-17 | 1976-01-21 | Smith Kline French Lab | Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them |
| GB1497260A (en) | 1974-06-28 | 1978-01-05 | Smith Kline French Lab | Guanidine derivatives |
| GB1533380A (en) | 1974-09-02 | 1978-11-22 | Smith Kline French Lab | Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines |
| GB1533379A (en) | 1974-09-02 | 1978-11-22 | Smith Kline French Lab | Process for the preparation of heterocyclic substituted ureas |
| GB1531231A (en) | 1974-09-02 | 1978-11-08 | Smith Kline French Lab | Process for the production of cyanoguanidine derivatives |
| GB1574214A (en) | 1976-03-11 | 1980-09-03 | Smith Kline French Lab | Amidines |
| US4165378A (en) * | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
| NO781300L (no) * | 1977-04-20 | 1978-10-23 | Ici Ltd | Fremgangsmaate for fremstilling av fysiologisk aktive guanidinderivater |
| ATE1353T1 (de) * | 1978-05-24 | 1982-08-15 | Imperial Chemical Industries Plc | Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
-
1979
- 1979-05-02 AT AT79300754T patent/ATE1353T1/de not_active IP Right Cessation
- 1979-05-02 EP EP79300754A patent/EP0006679B1/en not_active Expired
- 1979-05-02 DE DE7979300754T patent/DE2963363D1/de not_active Expired
- 1979-05-07 US US06/036,360 patent/US4242350A/en not_active Expired - Lifetime
- 1979-05-08 ZA ZA792202A patent/ZA792202B/xx unknown
- 1979-05-11 CA CA327,472A patent/CA1124729A/en not_active Expired
- 1979-05-14 NZ NZ190448A patent/NZ190448A/xx unknown
- 1979-05-16 AU AU47114/79A patent/AU529253B2/en not_active Ceased
- 1979-05-22 PT PT69651A patent/PT69651A/pt unknown
- 1979-05-22 CS CS793518A patent/CS207790B2/cs unknown
- 1979-05-22 DK DK209079A patent/DK209079A/da unknown
- 1979-05-22 CS CS798890A patent/CS207791B2/cs unknown
- 1979-05-22 PL PL1979215764A patent/PL118387B1/pl unknown
- 1979-05-22 HU HU79IE874A patent/HU179492B/hu unknown
- 1979-05-23 NO NO791710A patent/NO791710L/no unknown
- 1979-05-23 IL IL57388A patent/IL57388A0/xx unknown
- 1979-05-24 ES ES480894A patent/ES480894A1/es not_active Expired
- 1979-05-24 FI FI791656A patent/FI791656A7/fi not_active Application Discontinuation
- 1979-05-24 SU SU792772852A patent/SU1037839A3/ru active
- 1979-05-24 DD DD79213131A patent/DD143772A5/de unknown
- 1979-05-24 JP JP6330479A patent/JPS54160376A/ja active Pending
- 1979-08-08 IE IE902/79A patent/IE48221B1/en unknown
- 1979-09-13 ES ES484149A patent/ES484149A1/es not_active Expired
- 1979-09-13 ES ES484150A patent/ES484150A1/es not_active Expired
-
1980
- 1980-08-01 US US06/174,494 patent/US4332949A/en not_active Expired - Lifetime
-
1981
- 1981-01-27 GR GR59132A patent/GR73611B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DD143772A5 (de) | 1980-09-10 |
| PL118387B1 (en) | 1981-09-30 |
| PT69651A (en) | 1979-06-01 |
| CA1124729A (en) | 1982-06-01 |
| US4242350A (en) | 1980-12-30 |
| AU529253B2 (en) | 1983-06-02 |
| US4332949A (en) | 1982-06-01 |
| EP0006679B1 (en) | 1982-07-21 |
| AU4711479A (en) | 1979-11-29 |
| EP0006679A1 (en) | 1980-01-09 |
| GR73611B (es) | 1984-03-26 |
| NZ190448A (en) | 1980-12-19 |
| CS207791B2 (en) | 1981-08-31 |
| PL215764A1 (es) | 1980-06-16 |
| ATE1353T1 (de) | 1982-08-15 |
| FI791656A7 (fi) | 1981-01-01 |
| DE2963363D1 (en) | 1982-09-09 |
| CS207790B2 (en) | 1981-08-31 |
| HU179492B (en) | 1982-10-28 |
| IL57388A0 (en) | 1979-09-30 |
| JPS54160376A (en) | 1979-12-19 |
| ES484150A1 (es) | 1980-04-16 |
| DK209079A (da) | 1979-11-25 |
| IE48221B1 (en) | 1984-10-31 |
| ZA792202B (en) | 1980-05-28 |
| SU1037839A3 (ru) | 1983-08-23 |
| NO791710L (no) | 1979-11-27 |
| ES480894A1 (es) | 1980-02-01 |
| IE790902L (en) | 1979-11-24 |
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