ES481873A1 - Procedimiento para la preparacion de 2-(2-alcoxietil)-2'- hidroxi-6,7-benzomorfanos. - Google Patents

Procedimiento para la preparacion de 2-(2-alcoxietil)-2'- hidroxi-6,7-benzomorfanos.

Info

Publication number
ES481873A1
ES481873A1 ES481873A ES481873A ES481873A1 ES 481873 A1 ES481873 A1 ES 481873A1 ES 481873 A ES481873 A ES 481873A ES 481873 A ES481873 A ES 481873A ES 481873 A1 ES481873 A1 ES 481873A1
Authority
ES
Spain
Prior art keywords
acids
preparation
para
general formula
benzomorfanos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES481873A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
C.H. Boehringer Sohn AG and Co KG
Original Assignee
C.H. Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn AG and Co KG filed Critical C.H. Boehringer Sohn AG and Co KG
Publication of ES481873A1 publication Critical patent/ES481873A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES481873A 1978-06-26 1979-06-25 Procedimiento para la preparacion de 2-(2-alcoxietil)-2'- hidroxi-6,7-benzomorfanos. Expired ES481873A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782828039 DE2828039A1 (de) 1978-06-26 1978-06-26 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ES481873A1 true ES481873A1 (es) 1980-02-16

Family

ID=6042819

Family Applications (1)

Application Number Title Priority Date Filing Date
ES481873A Expired ES481873A1 (es) 1978-06-26 1979-06-25 Procedimiento para la preparacion de 2-(2-alcoxietil)-2'- hidroxi-6,7-benzomorfanos.

Country Status (19)

Country Link
US (1) US4293556A (2)
EP (1) EP0006449B1 (2)
JP (1) JPS5513278A (2)
AT (1) ATE1947T1 (2)
AU (1) AU518470B2 (2)
CA (1) CA1107280A (2)
DE (2) DE2828039A1 (2)
DK (1) DK156719C (2)
ES (1) ES481873A1 (2)
FI (1) FI65064C (2)
GR (1) GR69233B (2)
IE (1) IE48430B1 (2)
IL (1) IL57648A (2)
MX (1) MX5680E (2)
NO (1) NO149888C (2)
NZ (1) NZ190816A (2)
PH (1) PH15864A (2)
PT (1) PT69823A (2)
ZA (1) ZA793150B (2)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
GB2144639B (en) * 1983-08-11 1986-10-15 Edward Carden Jetting tube for use in micro-laryngeal surgery
JPS61294094A (ja) * 1985-06-24 1986-12-24 東洋ベントナイト株式会社 シ−ルド堀進に於ける裏込補助工法
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
JPH05312414A (ja) * 1992-05-12 1993-11-22 Yukimatsu Fujimoto 集熱器二段の太陽熱温水器
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
DE19740110A1 (de) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
JP5451611B2 (ja) 2007-07-26 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
US8859580B2 (en) 2007-11-16 2014-10-14 Boehringer Ingelheim International Gmbh Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
KR20110002492A (ko) 2008-05-01 2011-01-07 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
TW201004945A (en) 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291370B1 (en) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8765780B2 (en) 2008-05-13 2014-07-01 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
WO2010011314A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
AR078887A1 (es) 2009-11-06 2011-12-07 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3417094A (en) * 1965-05-05 1968-12-17 Geigy Chem Corp Optically active 1,2,3,4,5,6-hexahydro-6-phenyl - 2,6 - methano - 3 - benzazocines an
NL132138C (2) * 1966-05-20
US3499906A (en) * 1966-05-20 1970-03-10 Merck & Co Inc 5,9-diethyl-2'-hydroxy-2-substituted-6,7-benzomorphans
BR6914879D0 (pt) * 1969-01-23 1973-02-08 Merck & Co Inc Processos quimicos
JPS55383B2 (2) * 1971-09-13 1980-01-08
DE2233088A1 (de) * 1972-06-30 1974-01-17 Schering Ag Benzomorphanderivate
US4020164A (en) * 1972-06-30 1977-04-26 Schering Aktiengesellschaft Benzomorphan derivatives
DE2411382C3 (de) * 1974-03-09 1979-09-06 C.H. Boehringer Sohn, 6507 Ingelheim 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates

Also Published As

Publication number Publication date
AU4832779A (en) 1980-01-03
ATE1947T1 (de) 1982-12-15
EP0006449A1 (de) 1980-01-09
IL57648A (en) 1984-01-31
JPH0159271B2 (2) 1989-12-15
PT69823A (de) 1979-07-01
NO149888C (no) 1984-07-11
PH15864A (en) 1983-04-13
DK156719C (da) 1990-02-19
IE48430B1 (en) 1985-01-23
CA1107280A (en) 1981-08-18
FI792005A7 (fi) 1979-12-27
EP0006449B1 (de) 1982-12-08
IL57648A0 (en) 1979-10-31
US4293556A (en) 1981-10-06
DE2964196D1 (en) 1983-01-13
MX5680E (es) 1983-12-08
IE791189L (en) 1979-12-26
ZA793150B (en) 1981-03-25
DK156719B (da) 1989-09-25
NO149888B (no) 1984-04-02
AU518470B2 (en) 1981-10-01
DK266179A (da) 1979-12-27
NO792119L (no) 1979-12-28
JPS5513278A (en) 1980-01-30
FI65064C (fi) 1984-03-12
DE2828039A1 (de) 1980-01-10
FI65064B (fi) 1983-11-30
GR69233B (2) 1982-05-10
NZ190816A (en) 1980-11-28

Similar Documents

Publication Publication Date Title
DE2964196D1 (en) 2-(2-alkoxyethyl)-2'-hydroxy-6.7-benzomorphane derivatives, their acid addition salts, medicaments containing them and process for their preparation
ES480542A1 (es) Metodo para producir derivados de imidazol.
IE811250L (en) Imidazole derivatives
IE46278L (en) Tri-phenyl-substituted-piperazine derivatives
SE7905402L (sv) Fenyl-piperazinderivat
ES8401961A1 (es) Procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil-bencimidazolonas sustituidas.
ES468173A1 (es) Un procedimiento para la preparacion de derivados de morfina
ES482472A1 (es) Procedimiento para la preparacion de isoquinoleinas.
ES8303402A1 (es) Un procedimiento para preparar un compuesto anti-hipertension.
ES466366A1 (es) Un procedimiento para preparar derivados de metasulfonamido-benzamida.
ES8800122A1 (es) Un procedimiento para la preparacion de derivados de indeno y naftaleno.
ES482917A1 (es) Procedimiento para la preparacion de polialcoxifenilpirroli-donas
SE7906011L (sv) Nya imidazokinoxaliner och salter derav, sett for framstellning och anvendning derav sasom lekemedel samt farmaceutiska kompositioner innehallande dessa foreningar
ES480827A1 (es) Procedimiento para la preparacion de acidos fenilaminotiofe-noaceticos.
ES468170A1 (es) Un procedimiento para la preparacion de un nuevo derivado demorfina
DE3362301D1 (en) Thieno-thiazole derivatives, process for their preparation and medicaments containing them
ES474367A1 (es) Procedimiento de preparacion de nuevos derivados del benzo- (d)tiazol.
ATE37368T1 (de) Benzothiazolon-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ES8200648A2 (es) Procedimiento de preparacion de compuestos opacificantes para radiografia y similares
JPS5553291A (en) Naphthylidine derivative and its preparation
ES2002113A6 (es) Procedimiento para la preparacion de derivados de 1-alquil-ergolinil-tiourea
ES8201575A1 (es) Procedimiento de obtencion de nuevos 2-aminoetanoles
IE780742L (en) Isoxazolylmethyl-benzomorphanes
ES481416A1 (es) Un procedimiento para la preparacion de un derivado monoami-da de acido tereftalico.
ES479233A1 (es) Procedimiento para la obtencion de derivados de antraquinona.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401