ES482134A1 - Un procedimiento para preparar derivados de 1-(3-mercapto- 2-metilpropanoil)-prolil-aminoacido. - Google Patents

Un procedimiento para preparar derivados de 1-(3-mercapto- 2-metilpropanoil)-prolil-aminoacido.

Info

Publication number
ES482134A1
ES482134A1 ES482134A ES482134A ES482134A1 ES 482134 A1 ES482134 A1 ES 482134A1 ES 482134 A ES482134 A ES 482134A ES 482134 A ES482134 A ES 482134A ES 482134 A1 ES482134 A1 ES 482134A1
Authority
ES
Spain
Prior art keywords
salts
compounds
lower alkyl
alkyl group
methylpropanoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES482134A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of ES482134A1 publication Critical patent/ES482134A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Un procedimiento para preparar derivados de 1-(3- mercapto-2-metilpropancil)-prolil-aminoácido de la fórmula: **(Fórmula-01)** en la que R representa un átomo de hidrógeno, un grupo alcohilo inferior, un grupo fenilo-alcohilo inferior, o un grupo fenilo sustituido-alcohilo inferior, R1 representa un átomo de hidrógeno, **(Fórmula-02)**, R2 representa un átomo de hidrógeno o un grupo alcohilo inferior, R3 representa un átomo de hidrógeno, un grupo fenilo, un grupo alcohilo inferior, o un grupo alcohilo inferior sustituido en el que el sustituyente es hidroxi, fenilo-alcoxi inferior, amino, guanidino, N-nitroguanidino, carboxilo, alcoxicarbonilo inferior, fenilo-alcohixarbonilo inferior, carbamoilo, mercapto, alcohiltio inferior, fenilo, hidroxifenilo, indolilo o imidazolilo, o R2 y R3 forman un anillo heterocíclico junto con los átomos de nitrógeno y carbono a los que están unidos respectivamente, R4 representa un grupo alcohilo inferior, un grupo alcoxi inferior, un grupo fenilo, un grupo fenilo sustituido, un grupo fenilo-alcohilo inferior, un grupo fenilo sustituido-alcohilo inferior, un grupo fenilo- alcoxi inferior, un grupo fenilo sustituido-alcoxi inferior, un grupo fenoxi o un grupo fenoxi sustituido, R5 representa un grupo alcohilo inferior, un grupo fenilo, un grupo fenilo sustituido, un grupo fenilo-alxohilo inferior, un grupo fenilo sustituido-alcohilo inferior, **(Fórmula-03)** o un grupo amino (-carboxi)-alcohilo inferior, R6 representa un átomo de hidrógeno o un grupo alcohilo inferior, R7 representa un grupo alcohilo inferior, un grupo fenilo o un grupo fenilo o un grupo fenilo sustituido, X representa un átomo de oxígeno o azufre, y el sustituyente en el grupo fenilo sustituido es halógeno, alcohilo inferior o alcoxi inferior, o sus sales, que comprende hacer reaccionar un compuesto de la fórmula **(Fórmula-04)** en la que R1 es como se ha definido antes, o uno de sus derivados reactivos en su grupo carboxilo con un compuesto de la fórmula **(Fórmula-05)** enla que R, R2 y R3 son como se han definido antes, y puede estar protegido un grupo funcional que está opcionalmente presente en R3, o hacer reaccionar un compuesto de la fórmula **(Fórmula-05)** en la que R1 es como se ha definido antes, o uno de sus derivados reactivos en su grupo carboxilo con un compuesto de la fórmula **(Fórmula-06)** en la que R,R2 y R3 son como se han definido antes, y puede estar protegido un grupo funcional que está opcionalmente presente en R3; y si se desea, escindir el grupo protector presente en el compuesto resultante para convertir el grupo protegido en un grupo funcional libre; y si se desea, convertir el compuesto de fórmula (I) en otro compuesto de fórmula (I); y/o si se desea, convertir el compuesto de fórmula (I) en su sal; y/o si se desea, cuando el compuesto de fórmula (I) está presente como una mezcla de estereoisómeros, separarla en los isómeros individuales.
ES482134A 1978-07-06 1979-07-03 Un procedimiento para preparar derivados de 1-(3-mercapto- 2-metilpropanoil)-prolil-aminoacido. Expired ES482134A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8280978A JPS559058A (en) 1978-07-06 1978-07-06 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative

Publications (1)

Publication Number Publication Date
ES482134A1 true ES482134A1 (es) 1980-04-01

Family

ID=13784732

Family Applications (1)

Application Number Title Priority Date Filing Date
ES482134A Expired ES482134A1 (es) 1978-07-06 1979-07-03 Un procedimiento para preparar derivados de 1-(3-mercapto- 2-metilpropanoil)-prolil-aminoacido.

Country Status (8)

Country Link
US (1) US4248883A (es)
EP (1) EP0007477B1 (es)
JP (1) JPS559058A (es)
AU (1) AU524132B2 (es)
CA (1) CA1288547C (es)
DE (1) DE2962619D1 (es)
DK (1) DK148711C (es)
ES (1) ES482134A1 (es)

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ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
US4410542A (en) * 1978-12-30 1983-10-18 Santen Pharmaceutical Co., Ltd. Disulfide compounds
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
US4684660A (en) * 1979-04-02 1987-08-04 E. R. Squibb & Sons, Inc. Mercaptoacyldepeptides
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
JPS56139455A (en) 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
US4310461A (en) * 1980-06-23 1982-01-12 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4313948A (en) * 1980-11-20 1982-02-02 E. R. Squibb & Sons, Inc. Hypotensive imidazole substituted mercapto-1-oxopropyl-L-prolines
JPS58188847A (ja) * 1982-04-26 1983-11-04 Takeda Chem Ind Ltd ペプチド誘導体
US4642315A (en) * 1982-11-18 1987-02-10 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4587234A (en) * 1982-11-18 1986-05-06 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
US4560506A (en) * 1984-05-25 1985-12-24 E. R. Squibb & Sons, Inc. Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
ES2154277T3 (es) * 1993-07-15 2001-04-01 Hoffmann La Roche Combinacion farmaceutica que contiene un inhibidor del sistema renina-angiotensina y un antagonista de endotelina.
EP1545519B1 (en) 2002-08-19 2011-03-23 Pfizer Inc. Combination therapy for hyperproliferative diseases
CL2004000366A1 (es) * 2003-02-26 2005-01-07 Pharmacia Corp Sa Organizada B USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
CN1812983A (zh) * 2003-05-30 2006-08-02 兰贝克赛实验室有限公司 取代的吡咯衍生物及其作为hmg－co抑制剂的用途
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
AU2005308575A1 (en) * 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
SG166829A1 (en) * 2005-11-08 2010-12-29 Ranbaxy Lab Ltd Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
WO2008020314A2 (en) * 2006-03-14 2008-02-21 Ranbaxy Laboratories Limited Statin stabilizing dosage formulations
WO2008010087A2 (en) * 2006-07-14 2008-01-24 Ranbaxy Laboratories Limited Polymorphic forms of an hmg-coa reductase inhibitor and uses thereof
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
GB2470187A (en) * 2009-05-11 2010-11-17 Pharmapatents Global Ltd Captopril polymers
SG11201507496UA (en) 2013-04-17 2015-11-27 Pfizer N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN105777712B (zh) * 2016-03-31 2018-05-22 沈阳药科大学 四氢异喹啉类衍生物及其应用
US11248001B2 (en) 2019-01-18 2022-02-15 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
JPS52142064A (en) * 1976-05-18 1977-11-26 Squibb & Sons Inc Inhibitor of peptidase
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives

Also Published As

Publication number Publication date
DK148711C (da) 1986-02-17
AU524132B2 (en) 1982-09-02
DK148711B (da) 1985-09-09
CA1288547C (en) 1991-09-03
EP0007477B1 (en) 1982-04-28
AU4853079A (en) 1980-01-10
DK283479A (da) 1980-01-07
EP0007477A1 (en) 1980-02-06
DE2962619D1 (en) 1982-06-09
JPS559058A (en) 1980-01-22
US4248883A (en) 1981-02-03
JPS6134409B2 (es) 1986-08-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612