ES518145A0 - Procedimiento para preparar 18-sustituidas pregn-4-ene-3,20-dionas y compuestos especificos de 18-eti ilpregn- y vinilidenopregn-4-eno-3,20-diona. - Google Patents

Procedimiento para preparar 18-sustituidas pregn-4-ene-3,20-dionas y compuestos especificos de 18-eti ilpregn- y vinilidenopregn-4-eno-3,20-diona.

Info

Publication number: ES518145A0
Authority: ES; Spain
Prior art keywords: vinylidenopregn; ilpregn; dionas; diona; eti
Prior art date: 1980-09-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES518145A

Other languages

English (en)

Other versions

ES8404375A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharmaceuticals Inc

Original Assignee

Merrell Dow Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-02

Filing date

1982-12-13

Publication date

1984-05-01

1982-12-13 Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc

1984-05-01 Publication of ES8404375A1 publication Critical patent/ES8404375A1/es

1984-05-01 Publication of ES518145A0 publication Critical patent/ES518145A0/es

Status Granted legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title abstract 3
PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 abstract 1
PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 abstract 1
229960002478 aldosterone Drugs 0.000 abstract 1
125000002573 ethenylidene group Chemical group [*]=C=C([H])[H] 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000003145 progesterone derivatives Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polyamides (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

ES518145A 1980-09-02 1982-12-13 Procedimiento para preparar 18-sustituidas pregn-4-ene-3,20-dionas y compuestos especificos de 18-eti ilpregn- y vinilidenopregn-4-eno-3,20-diona. Granted ES518145A0 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/183,534 US4293548A (en)	1980-09-02	1980-09-02	18-Substituted pregn-4-ene-3,20-diones

Publications (2)

Publication Number	Publication Date
ES8404375A1 ES8404375A1 (es)	1984-05-01
ES518145A0 true ES518145A0 (es)	1984-05-01

Family

ID=22673212

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES505051A Expired ES8304585A1 (es)	1980-09-02	1981-08-28	Procedimiento para preparar 18-sustituidas pregn-4-ene-3,20-dionas
ES518145A Granted ES518145A0 (es)	1980-09-02	1982-12-13	Procedimiento para preparar 18-sustituidas pregn-4-ene-3,20-dionas y compuestos especificos de 18-eti ilpregn- y vinilidenopregn-4-eno-3,20-diona.
ES529488A Granted ES529488A0 (es)	1980-09-02	1984-02-06	Procedimiento para preparar 18-sustituidas pregn-4-ene-3, 20-dionas y compuestos especificos de 18-etinilpregn- y vinilidenopregn-4-eno-3, 20-diona

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES505051A Expired ES8304585A1 (es)	1980-09-02	1981-08-28	Procedimiento para preparar 18-sustituidas pregn-4-ene-3,20-dionas

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES529488A Granted ES529488A0 (es)	1980-09-02	1984-02-06	Procedimiento para preparar 18-sustituidas pregn-4-ene-3, 20-dionas y compuestos especificos de 18-etinilpregn- y vinilidenopregn-4-eno-3, 20-diona

Country Status (15)

Country	Link
US (1)	US4293548A (es)
EP (1)	EP0047016B1 (es)
JP (1)	JPS5777698A (es)
AT (1)	ATE4645T1 (es)
AU (1)	AU542864B2 (es)
CA (1)	CA1175041A (es)
DE (1)	DE3160879D1 (es)
DK (1)	DK161255C (es)
ES (3)	ES8304585A1 (es)
IE (1)	IE51578B1 (es)
IL (1)	IL63680A (es)
NO (1)	NO157176C (es)
NZ (1)	NZ198190A (es)
PH (1)	PH17253A (es)
ZA (1)	ZA815963B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4910191A (en) *	1988-06-28	1990-03-20	Merrell Dow Pharmaceuticals Inc.	19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
US4920114A (en) *	1988-06-28	1990-04-24	Merrell Dow Pharmaceuticals Inc.	19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3796728A (en) *	1967-06-06	1974-03-12	Schering Corp	Steroidal derivatives,methods for their manufacture,and compounds produced thereby
GB1247661A (en) *	1967-07-11	1971-09-29	Philips Nv	NEW 9beta,10alpha-STEROIDS AND METHODS OF PRODUCING THE SAME
SE374363B (es) *	1967-12-22	1975-03-03	Ciba Geigy Ag
CH606101A5 (es) *	1975-01-30	1978-10-13	Ciba Geigy Ag

1980
- 1980-09-02 US US06/183,534 patent/US4293548A/en not_active Expired - Lifetime
1981
- 1981-08-27 PH PH26114A patent/PH17253A/en unknown
- 1981-08-27 ZA ZA815963A patent/ZA815963B/xx unknown
- 1981-08-27 IL IL63680A patent/IL63680A/xx not_active IP Right Cessation
- 1981-08-27 AU AU74759/81A patent/AU542864B2/en not_active Ceased
- 1981-08-27 NZ NZ198190A patent/NZ198190A/en unknown
- 1981-08-27 CA CA000384716A patent/CA1175041A/en not_active Expired
- 1981-08-27 DK DK380881A patent/DK161255C/da not_active IP Right Cessation
- 1981-08-28 ES ES505051A patent/ES8304585A1/es not_active Expired
- 1981-08-31 JP JP56135639A patent/JPS5777698A/ja active Granted
- 1981-08-31 IE IE1990/81A patent/IE51578B1/en not_active IP Right Cessation
- 1981-09-01 DE DE8181106838T patent/DE3160879D1/de not_active Expired
- 1981-09-01 AT AT81106838T patent/ATE4645T1/de not_active IP Right Cessation
- 1981-09-01 NO NO812957A patent/NO157176C/no not_active IP Right Cessation
- 1981-09-01 EP EP81106838A patent/EP0047016B1/en not_active Expired
1982
- 1982-12-13 ES ES518145A patent/ES518145A0/es active Granted
1984
- 1984-02-06 ES ES529488A patent/ES529488A0/es active Granted

Also Published As

Publication number	Publication date
NO157176B (no)	1988-02-22
ES8506046A1 (es)	1985-07-01
NO157176C (no)	1988-06-01
DK380881A (da)	1982-03-03
EP0047016A1 (en)	1982-03-10
ES8404375A1 (es)	1984-05-01
ES529488A0 (es)	1985-07-01
NZ198190A (en)	1984-03-16
NO812957L (no)	1982-03-03
AU542864B2 (en)	1985-03-21
ZA815963B (en)	1982-09-29
JPH0261480B2 (es)	1990-12-20
IL63680A0 (en)	1981-11-30
CA1175041A (en)	1984-09-25
AU7475981A (en)	1982-03-11
JPS5777698A (en)	1982-05-15
PH17253A (en)	1984-07-03
EP0047016B1 (en)	1983-09-14
DK161255C (da)	1992-01-06
ES505051A0 (es)	1983-03-01
IL63680A (en)	1985-05-31
IE51578B1 (en)	1987-01-21
US4293548A (en)	1981-10-06
ATE4645T1 (de)	1983-09-15
DE3160879D1 (en)	1983-10-20
ES8304585A1 (es)	1983-03-01
DK161255B (da)	1991-06-17
IE811990L (en)	1982-03-02

Legal Events

Date	Code	Title	Description
2007-12-16	FD1A	Patent lapsed	Effective date: 20000228

Publication	Publication Date	Title
AU531537B2 (en)	1983-08-25	Method for sanitizing toilets
DK161333C (da)	1991-12-09	Analogifremgangsmaade til fremstilling af 11beta-substituerede 4,9-dien-steroider
NL187391C (nl)	1991-09-16	Werkwijze voor het zuiveren van een ester.
NL191149B (nl)	1994-09-16	Werkwijze voor de bereiding van 3-trifluormethyl pyridinederivaten.
UA6044A1 (uk)	1994-12-29	Спосіб одержання метіленових похідних андроста-1,4 -діен-3,17-діона
FI803025A7 (fi)	1981-01-01	Menetelmä farmakologisesti aktiivisten ergoliinijohdannaisten valmistamiseksi.
DK157079A (da)	1979-10-18	Fremgangsmaade til selektiv sidekaedenedbrydning af steroidforbindelser og til fremstilling af hertil egnede mikroorganismedefektblokmutanter samt hidtil ukendte mikroorganismestammer
ES529488A0 (es)	1985-07-01	Procedimiento para preparar 18-sustituidas pregn-4-ene-3, 20-dionas y compuestos especificos de 18-etinilpregn- y vinilidenopregn-4-eno-3, 20-diona
NL7809943A (nl)	1979-04-06	Werkwijze voor de bereiding van sarcosine-oxydase.
PT73360A (fr)	1981-08-01	Procede de preparation de steroides 17alpha hydroxy 20-ceto
ES522251A0 (es)	1984-08-16	Procedimiento para la obtencion de espumas poliolefinicas dielectricamente calentables.
PT70458A (fr)	1979-12-01	Procede de preparation de steroides
PT70575A (fr)	1980-01-01	Procede de preparation de nouveaux derives 2-substitues 19-nor steroides
DE3061656D1 (en)	1983-02-24	Microbiological method for the preparation of 7-alpha-hydroxylated steroids
YU176780A (en)	1984-02-29	Process for obtaining steroids of the pregnane structure
NL188998C (nl)	1992-12-01	Werkwijze voor de bereiding van indolinederivaten.
MX9300677A (es)	1994-07-29	Procedimiento mejorado para la preparacion de dienos esteroidales substituidos.
DK146007C (da)	1983-10-17	Analogifremgangsmaade til fremstilling af d-homosteroider
MX4866E (es)	1982-11-10	Procedimiento microbiologico para preparar esteroides con o sin cadena 17-alquilo de 2a 10 atomos de carbono
NL7811806A (nl)	1979-06-06	Werkwijze voor de bereiding van steroidale 3-oxo-4,6-dienen, zoals 17-hydroxy-3-oxo-17alfa-pregna-4,6-dieen-21-carbon- zuur nu-lacton.
FI875322A7 (fi)	1987-12-02	Menetelmä 17a -hydroksi-D-homo-1,4 -pregnadieeni-3,20-dionin valmista miseksi.
ES521601A0 (es)	1984-07-01	Metodo de obtencion de derivados n-metilcarbamaticos utiles para insecticidas.
JPS53130815A (en)	1978-11-15	Method of joinning members for pipe construction
CS192811B1 (en)	1979-09-17	Method for the isolation of 2-mercapto benzimidazole
ES507089A0 (es)	1982-08-16	Procedimiento para la obtencion de esteres salicilicos o a- cetilisalicilicos en c-21 de esteroides hidroxilados de la serie pregnanica.