DK380881A - Fremgangsmaade til fremstilling af 18-substituerede pregn-4-en3,20-dioner - Google Patents

Fremgangsmaade til fremstilling af 18-substituerede pregn-4-en3,20-dioner

Info

Publication number: DK380881A
Authority: DK; Denmark
Prior art keywords: pregnes; diones; substituted; procedure; preparation
Prior art date: 1980-09-02

Application number

DK380881A

Other languages

English (en)

Other versions

DK161255C (da

DK161255B (da

Inventor

B W Metcalf

J O N Johnston

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-02

Filing date

1981-08-27

Publication date

1982-03-03

1981-08-27 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1982-03-03 Publication of DK380881A publication Critical patent/DK380881A/da

1991-06-17 Publication of DK161255B publication Critical patent/DK161255B/da

1992-01-06 Application granted granted Critical

1992-01-06 Publication of DK161255C publication Critical patent/DK161255C/da

Links

150000001875 compounds Chemical class 0.000 abstract 2
PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 abstract 1
PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 abstract 1
229960002478 aldosterone Drugs 0.000 abstract 1
125000002573 ethenylidene group Chemical group [*]=C=C([H])[H] 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000003145 progesterone derivatives Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polyamides (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

DK380881A 1980-09-02 1981-08-27 Analogifremgangsmaade til fremstilling af terapeutisk aktive 18-substituerede pregn-4-en-3,20-dioner DK161255C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18353480		1980-09-02
US06/183,534 US4293548A (en)	1980-09-02	1980-09-02	18-Substituted pregn-4-ene-3,20-diones

Publications (3)

Publication Number	Publication Date
DK380881A true DK380881A (da)	1982-03-03
DK161255B DK161255B (da)	1991-06-17
DK161255C DK161255C (da)	1992-01-06

Family

ID=22673212

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK380881A DK161255C (da)	1980-09-02	1981-08-27	Analogifremgangsmaade til fremstilling af terapeutisk aktive 18-substituerede pregn-4-en-3,20-dioner

Country Status (15)

Country	Link
US (1)	US4293548A (da)
EP (1)	EP0047016B1 (da)
JP (1)	JPS5777698A (da)
AT (1)	ATE4645T1 (da)
AU (1)	AU542864B2 (da)
CA (1)	CA1175041A (da)
DE (1)	DE3160879D1 (da)
DK (1)	DK161255C (da)
ES (3)	ES8304585A1 (da)
IE (1)	IE51578B1 (da)
IL (1)	IL63680A (da)
NO (1)	NO157176C (da)
NZ (1)	NZ198190A (da)
PH (1)	PH17253A (da)
ZA (1)	ZA815963B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4910191A (en) *	1988-06-28	1990-03-20	Merrell Dow Pharmaceuticals Inc.	19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
US4920114A (en) *	1988-06-28	1990-04-24	Merrell Dow Pharmaceuticals Inc.	19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3796728A (en) *	1967-06-06	1974-03-12	Schering Corp	Steroidal derivatives,methods for their manufacture,and compounds produced thereby
GB1247661A (en) *	1967-07-11	1971-09-29	Philips Nv	NEW 9beta,10alpha-STEROIDS AND METHODS OF PRODUCING THE SAME
SE374363B (da) *	1967-12-22	1975-03-03	Ciba Geigy Ag
CH606101A5 (da) *	1975-01-30	1978-10-13	Ciba Geigy Ag

1980
- 1980-09-02 US US06/183,534 patent/US4293548A/en not_active Expired - Lifetime
1981
- 1981-08-27 PH PH26114A patent/PH17253A/en unknown
- 1981-08-27 ZA ZA815963A patent/ZA815963B/xx unknown
- 1981-08-27 IL IL63680A patent/IL63680A/xx not_active IP Right Cessation
- 1981-08-27 AU AU74759/81A patent/AU542864B2/en not_active Ceased
- 1981-08-27 NZ NZ198190A patent/NZ198190A/en unknown
- 1981-08-27 CA CA000384716A patent/CA1175041A/en not_active Expired
- 1981-08-27 DK DK380881A patent/DK161255C/da not_active IP Right Cessation
- 1981-08-28 ES ES505051A patent/ES8304585A1/es not_active Expired
- 1981-08-31 JP JP56135639A patent/JPS5777698A/ja active Granted
- 1981-08-31 IE IE1990/81A patent/IE51578B1/en not_active IP Right Cessation
- 1981-09-01 DE DE8181106838T patent/DE3160879D1/de not_active Expired
- 1981-09-01 AT AT81106838T patent/ATE4645T1/de not_active IP Right Cessation
- 1981-09-01 NO NO812957A patent/NO157176C/no not_active IP Right Cessation
- 1981-09-01 EP EP81106838A patent/EP0047016B1/en not_active Expired
1982
- 1982-12-13 ES ES518145A patent/ES518145A0/es active Granted
1984
- 1984-02-06 ES ES529488A patent/ES529488A0/es active Granted

Also Published As

Publication number	Publication date
NO157176B (no)	1988-02-22
ES8506046A1 (es)	1985-07-01
NO157176C (no)	1988-06-01
EP0047016A1 (en)	1982-03-10
ES8404375A1 (es)	1984-05-01
ES529488A0 (es)	1985-07-01
NZ198190A (en)	1984-03-16
NO812957L (no)	1982-03-03
ES518145A0 (es)	1984-05-01
AU542864B2 (en)	1985-03-21
ZA815963B (en)	1982-09-29
JPH0261480B2 (da)	1990-12-20
IL63680A0 (en)	1981-11-30
CA1175041A (en)	1984-09-25
AU7475981A (en)	1982-03-11
JPS5777698A (en)	1982-05-15
PH17253A (en)	1984-07-03
EP0047016B1 (en)	1983-09-14
DK161255C (da)	1992-01-06
ES505051A0 (es)	1983-03-01
IL63680A (en)	1985-05-31
IE51578B1 (en)	1987-01-21
US4293548A (en)	1981-10-06
ATE4645T1 (de)	1983-09-15
DE3160879D1 (en)	1983-10-20
ES8304585A1 (es)	1983-03-01
DK161255B (da)	1991-06-17
IE811990L (en)	1982-03-02

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Legal Events

Date	Code	Title	Description
2001-04-17	PBP	Patent lapsed