ES531986A0 - Un metodo de producir una forma geneticamente estable de vidrio cholerae - Google Patents

Un metodo de producir una forma geneticamente estable de vidrio cholerae

Info

Publication number
ES531986A0
ES531986A0 ES531986A ES531986A ES531986A0 ES 531986 A0 ES531986 A0 ES 531986A0 ES 531986 A ES531986 A ES 531986A ES 531986 A ES531986 A ES 531986A ES 531986 A0 ES531986 A0 ES 531986A0
Authority
ES
Spain
Prior art keywords
cholerae
genetically stable
glass
producing
stable form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES531986A
Other languages
English (en)
Other versions
ES8600649A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of ES531986A0 publication Critical patent/ES531986A0/es
Publication of ES8600649A1 publication Critical patent/ES8600649A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/107—Vibrio
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/909—Vibrio

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES531986A 1983-04-29 1984-04-27 Un metodo de producir una forma geneticamente estable de vidrio cholerae Expired ES8600649A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/489,958 US4882278A (en) 1983-04-29 1983-04-29 Non-toxinogenic vibrio cholerae mutants

Publications (2)

Publication Number Publication Date
ES531986A0 true ES531986A0 (es) 1985-09-01
ES8600649A1 ES8600649A1 (es) 1985-09-01

Family

ID=23945983

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531986A Expired ES8600649A1 (es) 1983-04-29 1984-04-27 Un metodo de producir una forma geneticamente estable de vidrio cholerae

Country Status (20)

Country Link
US (1) US4882278A (es)
EP (1) EP0125228B1 (es)
JP (1) JPH0740921B2 (es)
AT (1) ATE35152T1 (es)
AU (1) AU585481B2 (es)
CA (1) CA1326218C (es)
DE (1) DE3472114D1 (es)
DK (1) DK213784A (es)
DZ (1) DZ634A1 (es)
EG (1) EG17879A (es)
ES (1) ES8600649A1 (es)
GR (1) GR81986B (es)
IE (1) IE57266B1 (es)
IL (1) IL71652A (es)
PH (1) PH25301A (es)
PT (1) PT78478B (es)
YU (1) YU45616B (es)
ZA (1) ZA843142B (es)
ZM (1) ZM2884A1 (es)
ZW (1) ZW6884A1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399494A (en) * 1983-03-04 1995-03-21 The University Of Maryland System Vibrio cholerae strain CVD103Hgr, method of making same, and vaccines derived therefrom
US5882653A (en) * 1983-03-04 1999-03-16 The University Of Maryland System Vibrio cholerae 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroup vaccine strains, methods of making same and products thereof
US5470729A (en) * 1983-03-04 1995-11-28 University Of Maryland At Baltimore Method of isolating restriction fragment deletions in Vibrio cholerae, and products thereof
US5135862A (en) * 1983-03-04 1992-08-04 University Of Maryland Method of isolating restriction fragment deletions in vibrio cholerae, products thereof
CA1340372C (en) * 1984-07-09 1999-02-02 John D. Clements Production of e. coli lt-b enterotoxin subunit
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
US5308835A (en) * 1984-07-09 1994-05-03 Praxis Biologics, Inc. Production of the E. coli LT-B enterotoxin subunit
EP0249449A1 (en) * 1986-06-11 1987-12-16 Enterovax Research Pty. Ltd. Bacterial strain for live vaccines
US6043057A (en) * 1988-09-16 2000-03-28 Vitec Aktiebolag Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
SE462285B (sv) * 1988-09-16 1990-05-28 Jan Roland Holmgren Expression av koleratoxinets bindande subenhet med hjaelp av fraemmande promotor- och/eller ledarpeptidstrukturer
AU656730B2 (en) * 1990-06-05 1995-02-16 University Of Maryland At Baltimore Method of isolating restriction fragment deletions in vibrio cholerae, and products thereof
IL101715A (en) * 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
US5874088A (en) * 1992-07-06 1999-02-23 President And Fellows Of Harvard College Deletion mutants of cholera vaccines expressing heterologous antigens
ZA934736B (en) * 1992-07-06 1994-01-24 Harvard College Deletion mutants as vaccines for cholera
EP0692031B1 (en) * 1993-02-22 2007-04-11 The General Hospital Corporation Heterologous antigens in live cell vaccine strains
US6203799B1 (en) 1993-07-01 2001-03-20 Presidents And Fellows Of Harvard College Vibrio cholerae mutants which are soft-agar penetration defective and lack a functional CtxA subunit
WO1997049289A1 (en) * 1996-06-27 1997-12-31 President And Fellows Of Harvard College Vibrio cholerae having increased sensitivity to antibiotics
WO1998023763A1 (en) * 1996-11-29 1998-06-04 The General Hospital Corporation Heterologous antigens in live cell v. cholerae strains
JP4086945B2 (ja) * 1996-12-10 2008-05-14 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 非毒性Ｖ．Ｃｈｏｌｅｒａｅ株の単離法およびその株由来のコレラワクチンの製造法
EP0928831B1 (en) * 1997-12-10 2006-05-03 Council of Scientific and Industrial Research Cholera organisms, vaccines and preparation thereof
US7390619B1 (en) 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
MXPA00007893A (es) * 1998-02-11 2002-10-23 Maxygen Inc Direccion de vectores de vacunas geneticas.
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
US6693087B1 (en) 1998-08-20 2004-02-17 Aventis Pasteur Limited Nucleic acid molecules encoding POMP91A protein of Chlamydia
US6686339B1 (en) 1998-08-20 2004-02-03 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
CA2340330A1 (en) 1998-08-20 2000-03-02 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein c of chlamydia
RU2155227C1 (ru) * 1999-06-07 2000-08-27 Иркутский научно-исследовательский противочумный институт Сибири и Дальнего Востока Штамм бактерий vibrio cholerae cholerae 5 серовара огава - продуцент антител холерной огава сыворотки
ATE395930T1 (de) 1999-10-22 2008-06-15 Aventis Pasteur Verfahren zur erregung und/oder verstärkung der immunantwort gegen tumorantigene
EP1792995A3 (en) 2000-05-08 2007-06-13 Sanofi Pasteur Limited Chlamydia secretory locus orf and uses thereof
DK1282702T3 (da) * 2000-05-10 2007-04-02 Sanofi Pasteur Ltd Immunogene polypeptider, som er kodet af KAGE-minigener, og anvendelser deraf
CN1484700A (zh) * 2000-11-02 2004-03-24 �¼��¹�����ѧ aopB基因,蛋白,同系物,片段和它们的变体,以及它们在细胞表面展示方面的应用
EP1864691B1 (en) 2002-04-09 2011-07-20 Sanofi Pasteur Limited Modified CEA nucleic acid and expression vectors
AU2004280608B2 (en) * 2002-04-09 2012-04-05 Sanofi Pasteur, Inc. Modified CEA/B7 vector
RU2222594C1 (ru) * 2002-07-15 2004-01-27 Федеральное государственное учреждение Российский научно-исследовательский противочумный институт "Микроб" Штамм бактерий vibrio cholerae км206 классического биовара серовара огава - продуцент протективных антигенов
US20060251667A1 (en) * 2002-08-29 2006-11-09 Chua Kaw Y Recombinant nucleic acid useful for inducing protective immune response against allergens
US20060099229A1 (en) * 2004-11-05 2006-05-11 Universiti Sains Malaysia Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof
US7049423B2 (en) 2003-12-19 2006-05-23 The General Hospital Corporation Use of the RTX secretion system to achieve heterologous polypeptide secretion by Vibrio cholerae

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264737A (en) * 1978-09-21 1981-04-28 President And Fellows Of Harvard College Method of making genetically stable mutants of vibrio cholerae
US4328209A (en) * 1979-04-11 1982-05-04 Board Of Regents, The University Of Texas System Cholera vaccine
JPS5893837A (ja) * 1981-11-30 1983-06-03 Toyota Motor Corp 複合材料及びその製造方法
US4666837A (en) * 1982-05-24 1987-05-19 Smithkline-Rit DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
ZA841557B (en) * 1983-03-04 1984-10-31 Univ Maryland Method of isolating restriction fragment deletions in vibrio chlolerae,and products thereof
US5135862A (en) * 1983-03-04 1992-08-04 University Of Maryland Method of isolating restriction fragment deletions in vibrio cholerae, products thereof

Also Published As

Publication number Publication date
DK213784A (da) 1984-10-30
US4882278A (en) 1989-11-21
ZA843142B (en) 1985-03-27
PT78478B (en) 1986-05-27
IE57266B1 (en) 1992-07-01
EG17879A (en) 1991-08-30
ZW6884A1 (en) 1984-09-19
ZM2884A1 (en) 1985-04-22
CA1326218C (en) 1994-01-18
PH25301A (en) 1991-04-30
IE841043L (en) 1984-10-29
IL71652A (en) 1988-11-30
DE3472114D1 (en) 1988-07-21
IL71652A0 (en) 1984-07-31
AU585481B2 (en) 1989-06-22
EP0125228A1 (en) 1984-11-14
DZ634A1 (fr) 2004-09-13
DK213784D0 (da) 1984-04-27
ES8600649A1 (es) 1985-09-01
GR81986B (es) 1984-12-12
ATE35152T1 (de) 1988-07-15
YU76384A (en) 1989-08-31
JPS6037980A (ja) 1985-02-27
AU2727084A (en) 1984-11-01
EP0125228B1 (en) 1988-06-15
PT78478A (en) 1984-05-01
JPH0740921B2 (ja) 1995-05-10
YU45616B (sh) 1992-07-20

Similar Documents

Publication Publication Date Title
ES531986A0 (es) Un metodo de producir una forma geneticamente estable de vidrio cholerae
DK219087A (da) Vektorsystem til brug ved transformation af trichoderma, transformerede trichodermastammer og fremgangsmaade til fremstilling af proteiner heri
DK160998C (da) Plasmid indeholdende dna fra en plasmidfraktion af b.thuringiensis, e.coli bakteriestamme indeholdende plasmidet, gensplejset e.coli bakteriestamme, fremgangsmaade til fremstilling af plasmidet, fremgangsmaade til at skabe en gensplejset e.coli bakteriestamme, fremgangsmaade til fremstilling af bacillus thuringiensis krystalprotein og fremgangsmaade til at opnaa insekticid virkning i et miljoe
ATE120487T1 (de) Therapeutische zusammensetzungen gegen streptokokken-infektionen, transformierte wirte, verfahren zur immunisierung und gentechnologisch hergestellte produkte.
EP0434713A4 (en) Hiv-1 envelope muteins lacking hypervariable domains
FI823021A7 (fi) Tuotteet, jotka osoittavat hepatitis B virus e antigeenin antigeenisuuden ja menetelmät näiden antigeenien vavalmistamiseksi.
CA2089753A1 (en) Interleukin-2-leukotoxin gene fusions and uses therefor
ES8900007A1 (es) Un metodo para producir normas orales frente a virus de hepatitis-b.
BG41137A3 (bg) Метод за получаване на днк преносен вектор,предназначен за поддържане и репликация на дезоксинуклеотидна последо- вателност,кодираща човешки препроинсулин
AU566528B2 (en) Method of isolation of restriction fragment deletions in vibrio cholerae
FI850814A7 (fi) Proteiineja, farmaseuttisia seoksia, geenejä, vektoreita, isäntäorgan ismeja ja menetelmiä niiden tuottamiseksi.
HUT44609A (en) Process for preparing new polypeptides
NO862898D0 (no) Fremgangsmaate for utvinning av kjoennsprodukter, egnet for kunstig og naturlig befruktning fra pattedyr.
SE8205247L (sv) Fiskvacciner
AU1321988A (en) The cloning of malaria-specific dna sequences: isolation of the gene for the 140 kd protein
JO1343B1 (en) Non-toxic gene variant strains of vibro cholera
ES548457A0 (es) Procedimiento para la preparacion de penicilin-g-amidasa por expresion de la enzima en el seno de un microorganismo.
AU2484488A (en) Method for the production of antigenic protein-hapten conjugates, and antibodies corresponding thereto
EP0293201A3 (en) Method of vaccination for hepatitis b virus
IT1206039B (it) Procedimento per la produzione di etanolo mediante ceppi di microorganismo ad elevata resistenza
IT7830203A0 (it) Procedimento per rinforzare prodotti di carbone dolce.
ATE26799T1 (de) Oraler impfstoff zur immunisierung gegen enterische krankheiten.
AU2713488A (en) Process for manufacturing antigens, vaccines and sera to combat bacterial or viral diseases and composition for implementing said process
IT8124936A0 (it) Procedimento per la combustione diprodotti, essenzialmente legnosi, polverizzati nella conduzione di forni per calce.
IT8719613A0 (it) Procedimento per il ricupero di polvere di fornace.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050228