ES544235A0 - Un procedimiento para la produccion de compuestos de 2-azetidinona 4-sustituidos. - Google Patents

Un procedimiento para la produccion de compuestos de 2-azetidinona 4-sustituidos.

Info

Publication number
ES544235A0
ES544235A0 ES544235A ES544235A ES544235A0 ES 544235 A0 ES544235 A0 ES 544235A0 ES 544235 A ES544235 A ES 544235A ES 544235 A ES544235 A ES 544235A ES 544235 A0 ES544235 A0 ES 544235A0
Authority
ES
Spain
Prior art keywords
azetidinone
procedure
production
substituted compounds
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES544235A
Other languages
English (en)
Other versions
ES8604208A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58048989A external-priority patent/JPS59225182A/ja
Priority claimed from JP58221470A external-priority patent/JPS60115578A/ja
Priority claimed from JP58221469A external-priority patent/JPS60115577A/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES544235A0 publication Critical patent/ES544235A0/es
Publication of ES8604208A1 publication Critical patent/ES8604208A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES544235A 1983-03-25 1985-06-14 Un procedimiento para la produccion de compuestos de 2-azetidinona 4-sustituidos. Expired ES8604208A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58048989A JPS59225182A (ja) 1983-03-25 1983-03-25 ２−アゼチジノン−４−カルボン酸の誘導体
JP58221470A JPS60115578A (ja) 1983-11-25 1983-11-25 ２−アゼチジノン−４−置換化合物
JP58221469A JPS60115577A (ja) 1983-11-25 1983-11-25 ２−アゼチジノン−４−置換体

Publications (2)

Publication Number Publication Date
ES544235A0 true ES544235A0 (es) 1986-01-16
ES8604208A1 ES8604208A1 (es) 1986-01-16

Family

ID=27293483

Family Applications (4)

Application Number Title Priority Date Filing Date
ES530960A Granted ES530960A0 (es) 1983-03-25 1984-03-23 Un procedimiento para la produccion de compuestos de 2-azetidinona 4-sustituidos
ES85544234A Expired ES8604209A1 (es) 1983-03-25 1985-06-14 Un procedimiento para la produccion de compuestos de 2-aze- tidinona 4-sustituidos
ES544235A Expired ES8604208A1 (es) 1983-03-25 1985-06-14 Un procedimiento para la produccion de compuestos de 2-azetidinona 4-sustituidos.
ES544236A Expired ES8604136A1 (es) 1983-03-25 1985-06-14 Un procedimiento para la produccion de compuestos de 2-aze- tidinona 4-sustituidos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES530960A Granted ES530960A0 (es) 1983-03-25 1984-03-23 Un procedimiento para la produccion de compuestos de 2-azetidinona 4-sustituidos
ES85544234A Expired ES8604209A1 (es) 1983-03-25 1985-06-14 Un procedimiento para la produccion de compuestos de 2-aze- tidinona 4-sustituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544236A Expired ES8604136A1 (es) 1983-03-25 1985-06-14 Un procedimiento para la produccion de compuestos de 2-aze- tidinona 4-sustituidos

Country Status (8)

Country Link
US (3) US4564609A (es)
EP (1) EP0123444B1 (es)
KR (3) KR870000357B1 (es)
CA (1) CA1256650A (es)
DE (1) DE3476399D1 (es)
DK (1) DK164684A (es)
ES (4) ES530960A0 (es)
NO (1) NO158740C (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719207A (en) * 1984-06-25 1988-01-12 Yamanouchi Pharmaceutical Co., Ltd. CNS active substituted azetidinone compounds
JPS6253994A (ja) 1985-05-09 1987-03-09 Yamanouchi Pharmaceut Co Ltd １−置換シリル−４−オキソ−２−アゼチジンカルボン酸低級アルキルエステル
ZA868957B (en) * 1985-12-06 1987-07-29 Yamanouchi Pharma Co Ltd Crystals of nalpha-(((s)-4-oxo-2-azetidinyl)carbonyl)-l-histidyl-l-prolinamide and process for producing the crystals
US5686420A (en) * 1987-06-05 1997-11-11 Georgetown University Thyrotropin-releasing hormone analogs and method of use
US5151497A (en) * 1989-02-21 1992-09-29 Japan Tobacco Inc. Histidyl peptide derivatives
DK437289D0 (da) * 1989-09-04 1989-09-04 Hans Bundgaard Prodrug derivatives of thyrotropin-releasing hormone (trh)
IT1249728B (it) * 1991-11-06 1995-03-09 Sigma Tau Ind Farmaceuti Derivati delle prolinammide quali attivatori della memoria e dei processi di apprendimento e composizioni farmaceutiche che li contengono
CA2288986A1 (en) * 1997-05-09 1998-11-12 Smithkline Beecham Corporation Beta-lactam inhibitors of coa-it
US20020151502A1 (en) * 1997-10-09 2002-10-17 Albert Sattin Tri-peptides for neurological and neurobehavior applications
US7202279B1 (en) * 1998-02-11 2007-04-10 Georgetown University Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
JP4812225B2 (ja) * 2000-07-11 2011-11-09 塩野義製薬株式会社 生理活性ペプチド含有腸溶性製剤
KR20050105290A (ko) 2000-08-31 2005-11-03 시오노기세이야쿠가부시키가이샤 파킨슨씨병 치료제
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
PL364178A1 (en) * 2001-01-26 2004-12-13 Schering Corporation Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
AU2002241956A1 (en) * 2001-01-26 2002-08-06 Schering Corporation Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US20020183305A1 (en) * 2001-01-26 2002-12-05 Schering Corporation Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
IL156585A0 (en) * 2001-01-26 2004-01-04 Schering Corp Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
HU230253B1 (hu) * 2001-01-26 2015-11-30 Merck Sharp & Dohme Corp Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
DK1355644T3 (da) * 2001-01-26 2006-10-23 Schering Corp Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi
JP2004532868A (ja) * 2001-05-25 2004-10-28 シェーリング　コーポレイション アルツハイマー病の処置におけるアゼチジノン置換誘導体の使用
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
AU2002335770B2 (en) * 2001-09-21 2005-08-18 Merck Sharp & Dohme Corp. Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s)
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
JP2005504091A (ja) * 2001-09-21 2005-02-10 シェーリング　コーポレイション ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置
WO2004043457A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (ja) * 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
CA2517571C (en) * 2003-03-07 2011-07-05 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2006519869A (ja) * 2003-03-07 2006-08-31 シェーリング　コーポレイション 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
EP1680189A2 (en) * 2003-11-05 2006-07-19 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
US7462595B2 (en) * 2004-09-17 2008-12-09 Prange Jr Arthur Jergen Methods for treating cancer-related fatigue
KR101137503B1 (ko) * 2009-07-14 2012-04-20 웰이앤씨 주식회사 고분자 고체 지지체를 이용한 히스티딜-프롤린아미드 유도체의 제조 방법
CN105452198B (zh) * 2013-08-16 2019-09-03 洛斯阿拉莫斯国家安全股份有限公司 用于改善植物性能的化合物和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959248A (en) * 1974-04-03 1976-05-25 Merck & Co., Inc. Analogs of thyrotropin-releasing hormone
GB1523598A (en) * 1975-03-08 1978-09-06 Reckitt & Colmann Prod Ltd Tripeptides
US4271164A (en) * 1979-04-16 1981-06-02 Warner-Lambert Company 6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives
HU180926B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for preparing trh analogues,tripeptide amides infectives on the central nerve sysrhem
US4328134A (en) * 1980-05-06 1982-05-04 Schally Andrew Victor Anorexigenic peptides
US4426378A (en) * 1981-04-09 1984-01-17 The United States Of America As Represented By The Secretary Of The Army Thyrotropin releasing hormone in therapy of shock and as a central nervous system stimulant

Also Published As

Publication number Publication date
CA1256650A (en) 1989-06-27
EP0123444B1 (en) 1989-01-25
US4564609A (en) 1986-01-14
NO841158L (no) 1984-09-26
KR890002104B1 (ko) 1989-06-19
NO158740C (no) 1988-10-26
KR880009549A (ko) 1988-09-15
KR870000357B1 (ko) 1987-03-05
ES8604208A1 (es) 1986-01-16
EP0123444A1 (en) 1984-10-31
US4636567A (en) 1987-01-13
DK164684A (da) 1984-09-26
DK164684D0 (da) 1984-03-23
ES8600279A1 (es) 1985-10-01
NO158740B (no) 1988-07-18
ES8604209A1 (es) 1986-01-16
KR890002105B1 (ko) 1989-06-19
DE3476399D1 (en) 1989-03-02
ES530960A0 (es) 1985-10-01
ES544236A0 (es) 1986-01-16
US4610821A (en) 1986-09-09
KR840008021A (ko) 1984-12-12
ES544234A0 (es) 1986-01-16
ES8604136A1 (es) 1986-01-16
KR880009550A (ko) 1988-09-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303