ES544420A0 - Dprocedimiento para preparar derivados de acido 4-hidroxi-3-quinoleino-carboxilico substituidos en posicion 2 con una funcion amino. - Google Patents

Dprocedimiento para preparar derivados de acido 4-hidroxi-3-quinoleino-carboxilico substituidos en posicion 2 con una funcion amino.

Info

Publication number: ES544420A0
Authority: ES; Spain
Prior art keywords: group; carbon atoms; alkyl; hydroxy; hydrogen
Prior art date: 1984-06-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES544420A

Other languages

English (en)

Other versions

ES8608517A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Roussel Uclaf SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-25

Filing date

1985-06-21

Publication date

1986-06-16

1985-06-21 Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA

1986-06-16 Publication of ES8608517A1 publication Critical patent/ES8608517A1/es

1986-06-16 Publication of ES544420A0 publication Critical patent/ES544420A0/es

Status Expired legal-status Critical Current

Links

-1 AMINO FUNCTION Chemical group 0.000 title abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
AMQGNUPODKGSPM-UHFFFAOYSA-N 2-amino-4-oxo-1h-quinoline-3-carboxylic acid Chemical class C1=CC=C2C(O)=C(C(O)=O)C(N)=NC2=C1 AMQGNUPODKGSPM-UHFFFAOYSA-N 0.000 abstract 1
125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
125000002971 oxazolyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Quinoline Compounds (AREA)

ES544420A 1984-06-25 1985-06-21 Dprocedimiento para preparar derivados de acido 4-hidroxi-3-quinoleino-carboxilico substituidos en posicion 2 con una funcion amino. Expired ES8608517A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8409960A FR2566405B1 (fr)	1984-06-25	1984-06-25	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus

Publications (2)

Publication Number	Publication Date
ES8608517A1 ES8608517A1 (es)	1986-06-16
ES544420A0 true ES544420A0 (es)	1986-06-16

Family

ID=9305386

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES544420A Expired ES8608517A1 (es)	1984-06-25	1985-06-21	Dprocedimiento para preparar derivados de acido 4-hidroxi-3-quinoleino-carboxilico substituidos en posicion 2 con una funcion amino.

Country Status (10)

Country	Link
US (1)	US4636512A (es)
EP (1)	EP0169755B1 (es)
JP (1)	JPH064628B2 (es)
AT (1)	ATE52508T1 (es)
AU (1)	AU578479B2 (es)
CA (1)	CA1251446A (es)
DE (1)	DE3577558D1 (es)
ES (1)	ES8608517A1 (es)
FR (1)	FR2566405B1 (es)
ZA (1)	ZA854376B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2572404B2 (fr) *	1984-10-30	1987-12-11	Roussel Uclaf	Nouveaux derives de l'acide 4-oh-3-quinoleine carboxylique substitues en 2, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
FR2585356B1 (fr) *	1985-07-25	1987-10-23	Roussel Uclaf	Nouveaux derives de l'acide 4-oh quinoleine carboxylique substitues en 2 par deux fonctions hydroxyle eventuellement etherifiees ou esterifiees, leurs procedes de preparation, les nouveaux intermediaires obtenus, leur application comme medicaments et les compositions les renfermant
US4845105A (en) *	1984-10-30	1989-07-04	Roussel Uclaf	4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity
GB8726950D0 (en) *	1987-11-18	1987-12-23	Boots Co Plc	Chemical process
IE68593B1 (en) *	1989-12-06	1996-06-26	Sanofi Sa	Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
FR2701708B1 (fr) *	1993-02-19	1995-05-19	Sanofi Elf	Dérivés de 2-amido-4-phénylthiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament.
CN102267984B (zh) *	2010-06-04	2014-07-30	中国人民解放军军事医学科学院毒物药物研究所	4-羟基喹啉-3-酰胺衍生物及其制备方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3534031A (en) *	1965-05-17	1970-10-13	American Home Prod	Acetoxymethyl acetamides and acetamidoacetamides and their preparation
FR2281761A1 (fr) *	1974-08-13	1976-03-12	Roussel Uclaf	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2340735A1 (fr) *	1976-02-11	1977-09-09	Roussel Uclaf	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2443467A1 (fr) *	1978-12-08	1980-07-04	Roussel Uclaf	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
DE3000309A1 (de) *	1980-01-05	1981-07-09	Basf Ag, 6700 Ludwigshafen	4h-3,1-benzoxazinderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
HU190796B (en) *	1981-06-12	1986-11-28	Roussel Uclaf,Fr	Process for producing n-dihydrothiazolyl-3-quinoline-carboxamide derivatives
FR2509728A1 (fr) *	1981-07-17	1983-01-21	Roussel Uclaf	Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2530633A1 (fr) *	1982-06-03	1984-01-27	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant
FR2532939A1 (fr) *	1982-09-13	1984-03-16	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
CA1263651A (en) *	1984-07-09	1989-12-05	Ciba-Geigy Ag	Certain ring-fused pyrazolo ¬3,4-d\|-pyridin-3-one derivatives

1984
- 1984-06-25 FR FR8409960A patent/FR2566405B1/fr not_active Expired
1985
- 1985-06-10 ZA ZA854376A patent/ZA854376B/xx unknown
- 1985-06-20 DE DE8585401233T patent/DE3577558D1/de not_active Expired - Fee Related
- 1985-06-20 EP EP85401233A patent/EP0169755B1/fr not_active Expired - Lifetime
- 1985-06-20 AT AT85401233T patent/ATE52508T1/de not_active IP Right Cessation
- 1985-06-21 ES ES544420A patent/ES8608517A1/es not_active Expired
- 1985-06-21 CA CA000484818A patent/CA1251446A/fr not_active Expired
- 1985-06-24 JP JP60136224A patent/JPH064628B2/ja not_active Expired - Lifetime
- 1985-06-24 AU AU44117/85A patent/AU578479B2/en not_active Ceased
- 1985-06-25 US US06/748,743 patent/US4636512A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES8608517A1 (es)	1986-06-16
JPS6115876A (ja)	1986-01-23
CA1251446A (fr)	1989-03-21
AU4411785A (en)	1986-01-02
US4636512A (en)	1987-01-13
AU578479B2 (en)	1988-10-27
FR2566405B1 (fr)	1986-09-26
FR2566405A1 (fr)	1985-12-27
EP0169755B1 (fr)	1990-05-09
ATE52508T1 (de)	1990-05-15
DE3577558D1 (de)	1990-06-13
ZA854376B (en)	1986-08-27
EP0169755A3 (en)	1986-04-09
EP0169755A2 (fr)	1986-01-29
JPH064628B2 (ja)	1994-01-19

Legal Events

Date	Code	Title	Description
1997-12-01	FD1A	Patent lapsed	Effective date: 19971103

Publication	Publication Date	Title
IE44879L (en)	1977-08-11	Quinoline derivatives
FI952014A0 (fi)	1995-04-27	Uusia bisyklisiä merkaptoasetyyliamidilaktaamijohdannaisia, jotka ovat hyödyllisiä enkefalinaasin ja ACE:n inhibiittoreina
BR9401503A (pt)	1994-10-25	Derivados de cefalosporina, compostos, processo para a fabricação dos ditos compostos, preparação farmacêutica e uso dos ditos compostos
FI875666A0 (fi)	1987-12-22	Menetelmä terapeuttisesti aktiivisen kinoliiniyhdisteen valmistamiseksi
ES8103045A1 (es)	1981-02-16	Procedimiento para preparar nuevos derivados del acido 3- quinoleincarboxilico
ES8304567A1 (es)	1983-03-01	"un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida".
ES544420A0 (es)	1986-06-16	Dprocedimiento para preparar derivados de acido 4-hidroxi-3-quinoleino-carboxilico substituidos en posicion 2 con una funcion amino.
IE780145L (en)	1978-07-27	Meta-sulphonamido-benzamides
ES8802152A1 (es)	1988-04-01	Procedimiento para preparar un derivado de 1,3-oxazolidina-2-ona.
DK671688A (da)	1989-06-02	2-(piperazinyl)-2-oxoethylensubstituerede flavonoidderivater, fremgangsmaader til fremstilling heraf samt farmaceutiske midler indeholdende disse
ES8800237A1 (es)	1987-11-01	Procedimiento para la fabricacion de un ester del acido 7beta-(2(2-amino-4-tiazolil)alquenoilamino)-3-cefem-4-carboxilico
SE8703886L (sv)	1987-10-08	Nya mellanprodukter anvendbara for framstellning av 4-hydroxi-3-kinolinkarboxylsyraderivat
SE8901060D0 (sv)	1989-03-28	New compounds
AU601942B2 (en)	1990-09-27	New esters derived from 4-hydroxy-3-quinoline carboxylic acid substituted by an alpha-hydroxyl chain at position 2, their preparation, their use as a medicament and the compositions containing them
DK611987D0 (da)	1987-11-20	Cephalosporinderivater og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende derivaterne
FI844131A0 (fi)	1984-10-19	Menetelmä 2-substituoitujen 3-kinoliinikarboksamidien valmistuksessa välituotteina käytettävien 2-asyyliamino- -oksobentseenipropaaniamidien valmistamiseksi